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| 1 | Current status of function-preserving surgery for gastric cancer显示文摘Recent advances in diagnostic techniques have allowed the diagnosis of gastric cancer(GC)at an early stage.Due to the low incidence of lymph node metastasis and favorable prognosis in early GC,function-preserving surgery which improves postoperative quality of life may be possible.Pylorus-preserving gastrectomy(PPG)is one such function-preserving procedure,which is expected to offer advantages with regards to dumping syndrome,bile reflux gastritis,and the frequency of flatus,although PPG may induce delayed gastric emptying.Proximal gastrectomy(PG)is another functionpreserving procedure,which is thought to be advantageous in terms of decreased duodenogastric reflux and good food reservoir function in the remnant stomach,although the incidence of heartburn or gastric fullness associated with this procedure is high.However,these disadvantages may be overcome by the reconstruction method used.The other important problem after PG is remnant GC,which was reported to occur in approximately 5%of patients.Therefore,the reconstruction technique used with PG should facilitate postoperativeendoscopic examinations for early detection and treatment of remnant gastric carcinoma.Oncologic safety seems to be assured in both procedures,if the preoperative diagnosis is accurate.Patient selection should be carefully considered.Although many retrospective studies have demonstrated the utility of function-preserving surgery,no consensus on whether to adopt functionpreserving surgery as the standard of care has been reached.Further prospective randomized controlled trials are necessary to evaluate survival and postoperative quality of life associated with function-preserving surgery. | Takuro Saito Yukinori Kurokawa Shuji Takiguchi Masaki Mori Yuichiro Doki | 2014 | World Journal of Gastroenterology2014，20，46： | 17 |
| 2 | Advantage of autologous blood transfusion in surgery for hepatocellular carcinoma显示文摘AIM: To evaluate the significance of autologous blood transfusion (AT) in reducing homologous blood transfusion (HT) in surgery for hepatocellular carcinoma (HCC). METHODS: The proportion of patients who received HT was compared between two groups determined by the time of AT introduction; period A (1991-1994, n = 93) and period B (1995-2000, n = 201). Multivariate logistic regression analysis was performed in order to identify independent significant predictors of the need for HT. We also investigated the impact of AT and HT on long-term postoperative outcome after curative surgery for HCC. RESULTS: The proportion of patients with HT was significantly lower in period B than period A (18.9% vs 60.2%, P < 0.0001). Multivariate logistic regression analysis identified AT administration as a significant independent predictor of the need for HT (P < 0.0001). Disease-free survival in patients with AT was comparable to that without any transfusion. Multivariate analysis identified HT administration as an independent significant factor for poorer disease-free survival (P = 0.0380). CONCLUSION: AT administration significantly decreased the need for HT. Considering the postoperative survival disadvantage of HT, AT administration could improve the long-term outcome of HCC patients. | Yoshito Tomimaru Hidetoshi Eguchi Shigeru Marubashi Hiroshi Wada Shogo Kobayashi Masahiro Tanemura Koji Umeshita Yuichiro Doki Masaki Mori Hiroaki Nagano | 2011 | World Journal of Gastroenterology2011，17，32： | 8 |
| 3 | CD13 is a therapeutic target in human liver cancer stem cells显示文摘 | Haraguchi Naotsugu Ishii Hideshi Mimori Koshi Tanaka Fumiaki Ohkuma Masahisa Kim Ho Min Akita Hirofumi Takiuchi Daisuke Hatano Hisanori Nagano Hiroaki Barnard Graham F Doki Yuichiro Mori Masaki | 2010 | Journal of Clinical Investigation2010，，9： | 7 |
| 4 | Sclerosing epithelioid fibrosarcoma of the liver infiltrating the inferior vena cava显示文摘Sclerosing epithelioid fibrosarcoma (SEF) is a rare and distinct variant of fibrosarcoma, composed of epithelioid tumor cells arranged in strands, nests, cords, or sheets embedded within a sclerotic collagenous matrix. We report a 39-year-old man with SEF of the liver, which infiltrated the inferior vena cava (IVC). The SEF of the liver was successfully resected, and the infiltrated IVC was also removed together with the liver tumor. Histopathological examination of the tumor showed typical histopathology of SEF. Immunohistochemically, the tumor was positive for vimentin. Recurrence was noted 7 mo after surgery. After chemotherapy, the recurrent tumor was resected surgically, and histopathological examination showed similar findingsto those of the primary tumor. To our knowledge, this is the first report of SEF of the liver with tumor invasion of the IVC. | Yoshito Tomimaru Hiroaki Nagano Shigeru Marubashi Shogo Kobayashi Hidetoshi Eguchi Yutaka Takeda Masahiro Tanemura Toru Kitagawa Koji Umeshita Nobuyuki Hashimoto Hideki Yoshikawa Kenichi Wakasa Yuichiro Doki Masaki Mori | 2009 | World Journal of Gastroenterology2009，15，33： | 5 |
| 5 | Fresh frozen plasma transfusion does not affect outcomes following hepatic resection for hepatocellular carcinoma显示文摘AIM:To investigate whether fresh frozen plasma (FFP) transfusion affects outcomes following hepatic resection for hepatocellular carcinoma (HCC) in terms of liver function,postoperative complications and cancer prognosis.METHODS:We retrospectively compared the incidence of postoperative complications between 204 patients who underwent hepatectomy for HCC with routine FFP transfusion in an early period (1983-1993,Group A) and 293 with necessity for FFP transfusion during a later period (1998-2006,Group B),and also between two subgroups of Group B [22 patients with FFP transfusion (Group B1) and 275 patients without FFP transfusion (Group B2)].Additionally,only in limited patients in Group B1 and Group B2 with intraoperative blood loss≥ 2000 mL (Group B1 ≥ 2000 mL and Group B2 ≥ 2000 mL),postoperative complications,liver function tests,and cancer prognosis were compared.RESULTS:No mortality was registered in Group B,compared to 8 patients (3.9%) of Group A.The incidence of morbidity in Group B2 [23.2% (64/275)] was not significantly different from Group B1 [40.9% (9/22)] and Group A [27.0% (55/204)].The incidence of complications and postoperative liver function tests were comparable between Group B1 ≥ 2000 mL vs Group B2 ≥ 2000 mL.Postoperative prognosis did not correlate with administration of FFP,but with tumor-related factors.CONCLUSION:The outcome of hepatectomy for HCC is not influenced by FFP transfusion.We suggest FFP transfusion be abandoned in patients who undergo hepatectomy for HCC. | Yoshito Tomimaru Hiroshi Wada Shigeru Marubashi Shogo Kobayashi Hidetoshi Eguchi Yutaka Takeda Masahiro Tanemura Takehiro Noda Koji Umeshita Yuichiro Doki Masaki Mori Hiroak Nagano | 2010 | World Journal of Gastroenterology2010，16，44： | 5 |
| 6 | Minute liver metastases from a rectal carcinoid: A case report and review显示文摘We here report a 43-year-old male patient with minute liver metastases from a rectal carcinoid.Hepatic nodules were diagnosed during surgery,although they were not diagnosed by preoperative computed tomography or ultrasound examination.The rectal carcinoid was resected together with liver metastases and the patient has had no disease recurrence for 5 years following postoperative treatment of hepatic arterial infusion chemotherapy(HAIC) using 5-fluorouracil(5-FU)and oral administration of 1-hexylcarbamoyl-5-fluorouracil(HCFU).In 2003,a health check examination indicated presence of occult blood in his stool.Barium enema study revealed a rectal tumor in the lower rectum and colonoscopy showed a yellowish lesion with a size of 30 mm in diameter.Pathological examination of the biopsy specimen indicated that the rectal tumor was carcinoid.Although preoperative imaging examinations failed to detect liver metastases,2 min nodules were found on the surface of liver during surgery.A rapid pathological examination revealed that they were metastatic tumors from the rectal carcinoid.Low anterior resection was performed for the rectal tumor and the pathological report indicated that there were 4 metastatic lymph nodes in the rectal mesentery.The patient received treatment by HAIC using 5-FU plus oral administration of HCFU and survived for 5 years.We also review world-wide current treatments and their efficacy for hepatic metastases of carcinoid tumors. | Hirofumi Yamamoto Hideyuki Hemmi Mitsugu Sekimoto Yuichiro Doki Masaki Mori | 2010 | World Journal of Gastrointestinal Surgery2010，2，3： | 3 |
| 7 | Circulating microRNA-21 as a novel biomarker for hepatocellular carcinoma显示文摘 | Yoshito Tomimaru Hidetoshi Eguchi Hiroaki Nagano Hiroshi Wada Shogo Kobayashi Shigeru Marubashi Masahiro Tanemura Akira Tomokuni Ichiro Takemasa Koji Umeshita Tatsuya Kanto Yuichiro Doki Masaki Mori | 2011 | Journal of Hepatology2011，，1： | 3 |
| 8 | Hepatic Artery Reconstruction in Living Donor Liver Transplantation: Risk Factor Analysis of Complication and a Role of MDCT Scan for Detecting Anastomotic Stricture显示文摘 | Shigeru Marubashi Shogo Kobayashi Hiroshi Wada Koichi Kawamoto Hidetoshi Eguchi Yuichiro Doki Masaki Mori Hiroaki Nagano | 2013 | World Journal of Surgery2013，，11： | 3 |
| 9 | Effects of ghrelin administration during chemotherapy with advanced esophageal cancer patients显示文摘 | Yuichiro Hiura Shuji Takiguchi Kazuyoshi Yamamoto Tsuyoshi Takahashi Yukinori Kurokawa Makoto Yamasaki Kiyokazu Nakajima Hiroshi Miyata Yoshiyuki Fujiwara Masaki Mori Kenji Kangawa Yuichiro Doki | 2012 | Cancer2012，，19： | 2 |
| 10 | Partial gastrectomy using natural orifice translumenal endoscopic surgery (NOTES) for gastric submucosal tumors: early experience in humans显示文摘 | Kiyokazu Nakajima Toshirou Nishida Tsuyoshi Takahashi Yoshihito Souma Johji Hara Takuya Yamada Toshiyuki Yoshio Tateki Tsutsui Takeshi Yokoi Masaki Mori Yuichiro Doki | 2009 | Surgical Endoscopy2009，，12： | 2 |
| 11 | Equivalent Outcomes After Anatomical and Non-anatomical Resection of Small Hepatocellular Carcinoma in Patients with Preserved Liver Function显示文摘 | Yoshito Tomimaru Hidetoshi Eguchi Shigeru Marubashi Hiroshi Wada Shogo Kobayashi Masahiro Tanemura Koji Umeshita Yuichiro Doki Masaki Mori Hiroaki Nagano | 2012 | Digestive Diseases and Sciences2012，，7： | 2 |
| 12 | Genetic detection of free cancer cells in the peritoneal cavity of the patient with gastric cancer: present status and future perspectives显示文摘 | Yoshiyuki Fujiwara Yuichiro Doki Hirokazu Taniguchi Itsuro Sohma Shuji Takiguchi Hiroshi Miyata Makoto Yamasaki Morito Monden | 2007 | Gastric Cancer2007，，： | 2 |
| 13 | Phase I/II study of S-1 plus cisplatin combined with peptide vaccinesfor human vascular endothelial growth factor receptor 1 and 2 in patients withadvanced gastric cancer显示文摘 | Toru Masuzawa Yoshiyuki Fujiwara Kaoru Okada Ayumu Nakamura Shuji Takiguchi Kiyokazu Nakajima Hiroshi Miyata Makoto Yamasaki Yukinori Kurokawa Ryuji Osawa Kazuyoshi Takeda Koji Yoshida Takuya Tsunoda Yusuke Nakamura Masaki Mori Yuichiro Doki | 2012 | International Journal of Oncology2012，，4： | 2 |
| 14 | Feasibility of laparoscopy-assisted total gastrectomy in patients with clinical stage I gastric cancer显示文摘 | Noriko Wada Yukinori Kurokawa Shuji Takiguchi Tsuyoshi Takahashi Makoto Yamasaki Hiroshi Miyata Kiyokazu Nakajima Masaki Mori Yuichiro Doki | 2014 | Gastric Cancer2014，，1： | 2 |
| 15 | Down-regulation of miR-125a-3p in human gastric cancer and its clinicopathologicalsignificance显示文摘 | Yojiro Hashiguchi Naohiro Nishida Koshi Mimori Tomoya Sudo Fumiaki Tanaka Kohei Shibata Hideshi Ishii Hidetaka Mochizuki Kazuo Hase Yuichiro Doki Masaki Mori | 2012 | International Journal of Oncology2012，，5： | 2 |
| 16 | Overexpression of Forkhead Box M1 Transcription Factor (FOXM1) is a Potential Prognostic Marker and Enhances Chemoresistance for Docetaxel in Gastric Cancer显示文摘 | Kaoru Okada Yoshiyuki Fujiwara Tsuyoshi Takahashi Yurika Nakamura Shuji Takiguchi Kiyokazu Nakajima Hiroshi Miyata Makoto Yamasaki Yukinori Kurokawa Masaki Mori Yuichiro Doki | 2013 | Annals of Surgical Oncology2013，，3： | 2 |
| 17 | Comparison of Perioperative and Long-term Outcomes of Total and Proximal Gastrectomy for Early Gastric Cancer: A Multi-institutional Retrospective Study显示文摘 | Toru Masuzawa Shuji Takiguchi Motohiro Hirao Hiroshi Imamura Yutaka Kimura Junya Fujita Isao Miyashiro Shigeyuki Tamura Masahiro Hiratsuka Kenji Kobayashi Yoshiyuki Fujiwara Masaki Mori Yuichiro Doki | 2014 | World Journal of Surgery2014，，5： | 2 |
| 18 | A comparison of postoperative quality of life and dysfunction after Billroth I and Roux-en-Y reconstruction following distal gastrectomy for gastric cancer: results from a multi-institutional RCT显示文摘 | Shuji Takiguchi Kazuyoshi Yamamoto Motohiro Hirao Hiroshi Imamura Junya Fujita Masahiko Yano Kenji Kobayashi Yutaka Kimura Yukinori Kurokawa Masaki Mori Yuichiro Doki | 2012 | Gastric Cancer2012，，2： | 2 |
| 19 | Survival benefit of bursectomy in patients with resectable gastric cancer: interim analysis results of a randomized controlled trial显示文摘 | Junya Fujita Yukinori Kurokawa Tomoyuki Sugimoto Isao Miyashiro Shohei Iijima Yutaka Kimura Shuji Takiguchi Yoshiyuki Fujiwara Masaki Mori Yuichiro Doki | 2012 | Gastric Cancer2012，，1： | 2 |
| 20 | Circulating miR-200c Levels Significantly Predict Response to Chemotherapy and Prognosis of Patients Undergoing Neoadjuvant Chemotherapy for Esophageal Cancer显示文摘 | Koji Tanaka Hiroshi Miyata Makoto Yamasaki Keijiro Sugimura Tsuyoshi Takahashi Yukinori Kurokawa Kiyokazu Nakajima Shuji Takiguchi Masaki Mori Yuichiro Doki | 2013 | Annals of Surgical Oncology2013，，3： | 2 |
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