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| 1 | Advantage of autologous blood transfusion in surgery for hepatocellular carcinoma显示文摘AIM: To evaluate the significance of autologous blood transfusion (AT) in reducing homologous blood transfusion (HT) in surgery for hepatocellular carcinoma (HCC). METHODS: The proportion of patients who received HT was compared between two groups determined by the time of AT introduction; period A (1991-1994, n = 93) and period B (1995-2000, n = 201). Multivariate logistic regression analysis was performed in order to identify independent significant predictors of the need for HT. We also investigated the impact of AT and HT on long-term postoperative outcome after curative surgery for HCC. RESULTS: The proportion of patients with HT was significantly lower in period B than period A (18.9% vs 60.2%, P < 0.0001). Multivariate logistic regression analysis identified AT administration as a significant independent predictor of the need for HT (P < 0.0001). Disease-free survival in patients with AT was comparable to that without any transfusion. Multivariate analysis identified HT administration as an independent significant factor for poorer disease-free survival (P = 0.0380). CONCLUSION: AT administration significantly decreased the need for HT. Considering the postoperative survival disadvantage of HT, AT administration could improve the long-term outcome of HCC patients. | Yoshito Tomimaru Hidetoshi Eguchi Shigeru Marubashi Hiroshi Wada Shogo Kobayashi Masahiro Tanemura Koji Umeshita Yuichiro Doki Masaki Mori Hiroaki Nagano | 2011 | World Journal of Gastroenterology2011，17，32： | 8 |
| 2 | Sclerosing epithelioid fibrosarcoma of the liver infiltrating the inferior vena cava显示文摘Sclerosing epithelioid fibrosarcoma (SEF) is a rare and distinct variant of fibrosarcoma, composed of epithelioid tumor cells arranged in strands, nests, cords, or sheets embedded within a sclerotic collagenous matrix. We report a 39-year-old man with SEF of the liver, which infiltrated the inferior vena cava (IVC). The SEF of the liver was successfully resected, and the infiltrated IVC was also removed together with the liver tumor. Histopathological examination of the tumor showed typical histopathology of SEF. Immunohistochemically, the tumor was positive for vimentin. Recurrence was noted 7 mo after surgery. After chemotherapy, the recurrent tumor was resected surgically, and histopathological examination showed similar findingsto those of the primary tumor. To our knowledge, this is the first report of SEF of the liver with tumor invasion of the IVC. | Yoshito Tomimaru Hiroaki Nagano Shigeru Marubashi Shogo Kobayashi Hidetoshi Eguchi Yutaka Takeda Masahiro Tanemura Toru Kitagawa Koji Umeshita Nobuyuki Hashimoto Hideki Yoshikawa Kenichi Wakasa Yuichiro Doki Masaki Mori | 2009 | World Journal of Gastroenterology2009，15，33： | 5 |
| 3 | Fresh frozen plasma transfusion does not affect outcomes following hepatic resection for hepatocellular carcinoma显示文摘AIM:To investigate whether fresh frozen plasma (FFP) transfusion affects outcomes following hepatic resection for hepatocellular carcinoma (HCC) in terms of liver function,postoperative complications and cancer prognosis.METHODS:We retrospectively compared the incidence of postoperative complications between 204 patients who underwent hepatectomy for HCC with routine FFP transfusion in an early period (1983-1993,Group A) and 293 with necessity for FFP transfusion during a later period (1998-2006,Group B),and also between two subgroups of Group B [22 patients with FFP transfusion (Group B1) and 275 patients without FFP transfusion (Group B2)].Additionally,only in limited patients in Group B1 and Group B2 with intraoperative blood loss≥ 2000 mL (Group B1 ≥ 2000 mL and Group B2 ≥ 2000 mL),postoperative complications,liver function tests,and cancer prognosis were compared.RESULTS:No mortality was registered in Group B,compared to 8 patients (3.9%) of Group A.The incidence of morbidity in Group B2 [23.2% (64/275)] was not significantly different from Group B1 [40.9% (9/22)] and Group A [27.0% (55/204)].The incidence of complications and postoperative liver function tests were comparable between Group B1 ≥ 2000 mL vs Group B2 ≥ 2000 mL.Postoperative prognosis did not correlate with administration of FFP,but with tumor-related factors.CONCLUSION:The outcome of hepatectomy for HCC is not influenced by FFP transfusion.We suggest FFP transfusion be abandoned in patients who undergo hepatectomy for HCC. | Yoshito Tomimaru Hiroshi Wada Shigeru Marubashi Shogo Kobayashi Hidetoshi Eguchi Yutaka Takeda Masahiro Tanemura Takehiro Noda Koji Umeshita Yuichiro Doki Masaki Mori Hiroak Nagano | 2010 | World Journal of Gastroenterology2010，16，44： | 5 |
| 4 | Circulating microRNA-21 as a novel biomarker for hepatocellular carcinoma显示文摘 | Yoshito Tomimaru Hidetoshi Eguchi Hiroaki Nagano Hiroshi Wada Shogo Kobayashi Shigeru Marubashi Masahiro Tanemura Akira Tomokuni Ichiro Takemasa Koji Umeshita Tatsuya Kanto Yuichiro Doki Masaki Mori | 2011 | Journal of Hepatology2011，，1： | 3 |
| 5 | Equivalent Outcomes After Anatomical and Non-anatomical Resection of Small Hepatocellular Carcinoma in Patients with Preserved Liver Function显示文摘 | Yoshito Tomimaru Hidetoshi Eguchi Shigeru Marubashi Hiroshi Wada Shogo Kobayashi Masahiro Tanemura Koji Umeshita Yuichiro Doki Masaki Mori Hiroaki Nagano | 2012 | Digestive Diseases and Sciences2012，，7： | 2 |
| 6 | MicroRNA-21 induces resistance to the anti-tumour effect of interferon-a/5-fluorouraeil in hepatocellular carci- noma cells 显示文摘 | Y Tomimaru H Eguchi H Nagano | 2010 | British Journal of Cancer2010，103，10： | 1 |
| 7 | MieroRNA-29a in- duces resistance to gemcitabine through tile Wnt/beta-catenin signaling pathway in pancreatic cancer ceils 显示文摘 | Nagano H Tomimaru Y Eguchi H | 2013 | Int J Oncol2013，43，4： | 1 |
| 8 | A resected case of liver metas- tases from extra-adrenal retropefitoneal paraganglioma with von Reck- linghausen' s disease 16 years after the initial surgery 显示文摘 | Sakai K Tomimaru Y Egnchi H | 2015 | Surg Case Rep2015，1，1： | 1 |
| 9 | Plasma D-dimer levels show correlation with number of lymph node metastases in patients with esophageal cancer显示文摘 | Tomimaru Y Yano M Takachi K | 2006 | J Am Coll Surg2006，202，1： | 1 |
| 10 | Combined IFN-α and 5-FU treatment as a postoperative adjuvant followingsurgery for hepatocellular carcinoma with portal venous tumor thrombus显示文摘 | Hiroaki Nagano Shogo Kobayashi Shigeru Marubashi Hiroshi Wada Hidetoshi Eguchi Masahiro Tanemura Yoshito Tomimaru Koji Umeshita Yuichiro Doki Masaki Mori | 2013 | Experimental and Therapeutic Medicine2013，，1： | 1 |
| 11 | MicroRNA-21 induces resistance to the anti-tumour effect of interferon-α/5-fluorouracil in hepatocellular carcinoma cells显示文摘 | Tomimaru Y Eguchi H Nagano H | 2010 | Br J Cancer2010，103，10： | 1 |
| 12 | MicroRNA-29a induces resistance to gemcitabine through the Wnt/fl-catenin signalingpathway in pancreatic cancer cells 显示文摘 | Nagano H Tomimaru Y Eguchi H | 2013 | Int J Oncol2013，43，4： | 1 |
| 13 | Correlation between pretherapeutic D-dimer levels and response to neoadjuvant hemotherapy in patients with advanced esophageal cancer显示文摘 | Tomimaru Y Yano M Takachi K | 2008 | Dis Esophagus2008，21，4： | 1 |
| 14 | Circulating mi- croRNA-21 as a novel biomarker for hepatocellular carcino- ma显示文摘 | Tomimaru Y Eguchi H Nagano H | 2012 | J Hepatol2012，56，1： | 1 |
| 15 | Plasma D- dimer levels show correlation with number of lymph node metastases in patients with esophageal cancer 显示文摘 | Tomimaru Y Yano M Takachi K | 2006 | J Am Coll Surg2006，202，1： | 1 |
| 16 | MicroRNA-21 induces resistance to the anti-tumour effect of interferon-a /5-flurouracil in hepatocellular carcinoma显示文摘 | Tomimaru Y Eguchi H Nagano H | 2010 | PNAS2010，103，10： | 1 |
| 17 | Circulating mi- croRNA-21 as a novel biomarker for hepatocellular carci- noma 显示文摘 | Tomimaru Y Eguchi H Nagana H | 2012 | J Hepatol2012，56，： | 1 |
| 18 | MicroRNA -21 induces resistance to the anti - tumour effect of interferon - o/5 - fluorouracil in hepatoeellular carcinoma cells 显示文摘 | TOMIMARU Y EGUCHI H NAGANO H | 2010 | Br J Cancer2010，103，10： | 1 |
| 19 | Correlation between pretherapeutic D- dimer levels and response to neoadjuvant chemotherapy in patients with advanced esophageal cancer显示文摘 | Y Tomimaru M Yano K Takachi | 2008 | Diseases of the Esophagus2008，21，： | 1 |
| 20 | Circulating microRNA-21 as a novel biomarker for hepatocellular carcinoma显示文摘 | Tomimaru Y Eguehi H Nagano H | 2012 | J Hepatol2012，56，1： | 1 |
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