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| 1 | Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by azoxymethane in mice显示文摘AIM:To investigate the causal relationship between hypoadiponectinemia and colorectal carcinogenesis in in vivo experimental model,and to determine the con-tribution of adiponectin defi ciency to colorectal cancer development and proliferation.METHODS:We examined the influence of adiponectin defi ciency on colorectal carcinogenesis induced by the administration of azoxymethane(AOM)(7.5 mg/kg,in-traperitoneal injection once a week for 8 wk),by using adiponectin-knockout(KO) mice.RESULTS:At 53 wk after the fi rst AOM treatment,KOmice developed larger and histologically more progres-sive colorectal tumors with greater frequency com-pared with wild-type(WT) mice,although the tumor incidence was not different between WT and KO mice.KO mice showed increased cell proliferation of colorec-tal tumor cells,which correlated with the expression levels of cyclooxygenase-2(COX-2) in the colorectal tumors.In addition,KO mice showed higher incidence and frequency of liver tumors after AOM treatment.Thirteen percent of WT mice developed liver tumors,and these WT mice had only a single tumor.In contrast,50% of KO mice developed liver tumors,and 58% of these KO mice had multiple tumors.CONCLUSION:Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by AOM in mice.This study strongly suggests that hypoadiponectinemia could be involved in the pathogenesis for colorectal cancer and liver tumor in human subjects. | Tamao Nishihara Miyako Baba Morihiro Matsuda Masahiro Inoue Yasuko Nishizawa Atsunori Fukuhara Hiroshi Araki Shinji Kihara Tohru Funahashi Shinji Tamura Norio Hayashi Hiroyasu Iishi Iichiro Shimomura | 2008 | World Journal of Gastroenterology2008，14，42： | 12 |
| 2 | Clinical significance of visceral adiposity assessed by computed tomography: A Japanese perspective显示文摘Abdominal obesity,rather than total amount of fat,is linked to obesity-related disorders.Visceral adiposity is an important component of obesity-related disorders in Japanese individuals with a mild degree of adiposity compared with Western subjects.In 1983,our group reported techniques for body fat analysis using computed tomography(CT)and established the concept of visceral fat obesity in which intra-abdominal fat accumulation is an important factor in the development of obesity-related complications,such as diabetes,lipid disorders,hypertension and atherosclerosis.Our group also established ideal imaging conditions for determining abdominal fat area at the umbilical level CT scan.Visceral fat area(VFA)measured in a single slice at L4level correlated significantly with the total abdominal visceral fat volume measured on multislice CT scan.In a large-scale study of a Japanese population,the mean number of obesity-related cardiovascular risk factors(hypertension,low high-density lipoprotein cholesterolemia and/or hypertriglyceridemia,and hyperglycemia)was greater than 1.0 at 100 cm2 of VFA,irrespective of gender,age and body mass index.Our group also demonstrated that reduction of visceral fat accumulation subsequent to voluntary lifestyle modification,'Hokenshido',correlated with a decrease in the number of obesity-related cardiovascular risk factors.It is important to select the most appropriate subjects from the general population(e.g.,non-obese subjects with a cluster of risk factors for the metabolic syndrome)that are most suitable for body weight reduction,with the goal of preventing atherosclerotic cardiovascular diseases. | Miwa Ryo Ken Kishida Tadashi Nakamura Tohru Yoshizumi Tohru Funahashi Iichiro Shimomura | 2014 | World Journal of Radiology2014，6，7： | 11 |
| 3 | Adiponectin deficiency exacerbates lipopolysaccharide/ D-galactosamine-induced liver injury in mice显示文摘瞄准:在 Kupffer 房间的功能上检验 adiponectin 的效果,脂肪的多糖(LPS ) 的关键调节的人导致了肝损伤。方法:D-galactosamine (GalN ) 和 LPS intraperitoneally 被注入 adiponectin-/- 老鼠和野类型老鼠。Kupffer 房间,从 Sprague-Dawley 孤立老鼠,是 preincubated 与或没有 adiponectin,然后与 LPS 对待。结果:在猛烈老鼠, GalN/LPS 注射显著地降低了幸存率,显著地提起了丙氨酸转氨酶和肿瘤坏死 factor-alpha (TNF-alpha ) 的血浆层次并且显著地减少了与野类型老鼠相比的 IL-10 层次。在肝的 TNF-alpha 基因表示是哪个更高并且 IL-10 的那些比在野类型老鼠在猛烈老鼠是更低的。在有教养的 adiponectin-pre-treated Kupffer 房间, LPS 显著地降低了 TNF-alpha 层次并且在培养基和他们的各自的基因表示层次提起了 IL-10 层次,与没有 adiponectin-pre-treatment 的 Kupffer 房间相比。结论:Adiponectin supresses TNF-alpha 生产并且响应 LPS 刺激由 Kupffer 房间导致 IL-10 生产,并且 adiponectin 的缺乏提高导致 LPS 的肝损伤。 | Hitoshi Matsumoto Shinji Tamura Yoshihiro Kamada Shinichi Kiso Juichi Fukushima Akira Wada Norikazu Maeda Shinji Kihara Tohru Funahashi Yuji Matsuzawa Iichiro Shimomura Norio Hayashi | 2006 | World Journal of Gastroenterology2006，12，21： | 5 |
| 4 | Strategies for gastric cancer in the modern era显示文摘Gastric cancer is one of the most common neoplasms in Japan, and it is also the second leading cause of cancer-related deaths worldwide. Nowadays, infection with Helicobacter pylori (H. pylori) is a known risk factor for the development of gastric cancer. Therefore, gastric cancer should be considered as an infectious disease, and in fact, prophylactic eradication of H. pylori may prevent the development of metachronous gastric carcinoma. Before the role of H. pylori was understood, a different approach was used. Recently even after the cancer has developed, some newer therapeutic approaches have been pursued. These newer treatments have been summarized as 'minimally invasive therapies' and use endoscopic or laparoscopic techniques. In addition, robotic approaches are being developed that seem to hold a great potential to change the surgical approach. Since basic understanding and treatment of the disease have both changed signif icantly over the last decade, we present a review of current advances in gastric cancer research and therapy. | Satoru Takayama Takehiro Wakasugi Hitoshi Funahashi Hiromitsu Takeyama | 2010 | World Journal of Gastrointestinal Oncology2010，2，9： | 5 |
| 5 | Single-particle-diagnosis approach: An efficient strategy for discovering new nitride phosphors显示文摘Discovery of novel phosphors is extremely important to target the ever change of the solid state lighting technology. In this paper, we present a high-speed way to discover new phosphors, namely singleparticle-diagnosis approach. This approach is based on investigating the crystal structure and luminescence of a tiny single crystal, without the necessity of the growth of large-size single crystals or the preparation of single phase powder samples. The concept of the approach and some new nitride phosphors explored by this approach are shown in this paper. | Xiaojun Wang Takashi Takeda Naoto Hirosaki Shiro Funahashi Rong-Jun Xie | 2018 | Journal of Rare Earths2018，36，1： | 4 |
| 6 | Neuronal mechanisms of executive control by the prefrontal cortex显示文摘 | Shintaro Funahashi | 2001 | Neuroscience Research2001，，2： | 3 |
| 7 | Clinical benefit of surgery for stage IV colorectal cancer with synchronous peritoneal metastasis显示文摘 | Hirotoshi Kobayashi Kenjiro Kotake Kimihiko Funahashi Kazuo Hase Koichi Hirata Tsuneo Iiai Shingo Kameoka Yukihide Kanemitsu Koutarou Maeda Akihiko Murata Masayuki Ohue Kazuo Shirouzu Keiichi Takahashi Toshiaki Watanabe Hideaki Yano Toshimasa Yatsuoka Yoj | 2014 | Journal of Gastroenterology2014，，4： | 2 |
| 8 | Adipocyte-Derived Plasma Protein, Adiponectin, Suppresses Lipid Accumulation and Class A Scavenger Receptor Expression in Human Monocyte-Derived Macrophages显示文摘 | Noriyuki Ouchi Shinji Kihara Yukio Arita Makoto Nishida Akifumi Matsuyama Yoshihisa Okamoto Masato Ishigami Hiroshi Kuriyama Ken Kishida Hitoshi Nishizawa Kikuko Hotta Masahiro Muraguchi Yasukazu Ohmoto Shizuya Yamashita Tohru Funahashi Yuji Matsuzawa | 2001 | Circulation: Journal of the American Heart Association2001，，8： | 2 |
| 9 | Effect of Adiponectin on Murine Colitis Induced by Dextran Sulfate Sodium显示文摘 | Tamao Nishihara Morihiro Matsuda Hiroshi Araki Kazuya Oshima Shinji Kihara Tohru Funahashi Iichiro Shimomura | 2006 | Gastroenterology2006，，3： | 2 |
| 10 | Adiponectin Inhibits Murine Pancreatic Cancer Growth显示文摘 | Motohiko Kato Kenji Watabe Masahiko Tsujii Tohru Funahashi Iichiro Shimomura Tetsuo Takehara | 2014 | Digestive Diseases and Sciences2014，，6： | 2 |
| 11 | Dynamic Changes of Adiponectin and S100A8 Levels by the Selective Peroxisome Proliferator–Activated Receptor-γ Agonist Rivoglitazone显示文摘 | Aki Hiuge-Shimizu Norikazu Maeda Ayumu Hirata Hideaki Nakatsuji Kouichi Nakamura Akira Okuno Shinji Kihara Tohru Funahashi Iichiro Shimomura | 2011 | Arteriosclerosis Thrombosis and Vascular Biology2011，，4： | 2 |
| 12 | Adiponectin, an Adipocyte-Derived Plasma Protein, Inhibits Endothelial NF-κB Signaling Through a cAMP-Dependent Pathway显示文摘 | Noriyuki Ouchi Shinji Kihara Yukio Arita Yoshihisa Okamoto Kazuhisa Maeda Hiroshi Kuriyama Kikuko Hotta Makoto Nishida Masahiko Takahashi Masahiro Muraguchi Yasukazu Ohmoto Tadashi Nakamura Shizuya Yamashita Tohru Funahashi Yuji Matsuzawa | 2000 | Circulation: Journal of the American Heart Association2000，，11： | 2 |
| 13 | Adipocyte-Derived Plasma Protein, Adiponectin, Suppresses Lipid Accumulation and Class A Scavenger Receptor Expression in Human Monocyte-Derived Macrophages显示文摘 | Noriyuki Ouchi Shinji Kihara Yukio Arita Makoto Nishida Akifumi Matsuyama Yoshihisa Okamoto Masato Ishigami Hiroshi Kuriyama Ken Kishida Hitoshi Nishizawa Kikuko Hotta Masahiro Muraguchi Yasukazu Ohmoto Shizuya Yamashita Tohru Funahashi Yuji Matsuzawa | 2001 | Circulation: Journal of the American Heart Association2001，，8： | 2 |
| 14 | Adiponectin is inversely related to plasminogen activator inhibitor type 1 in patients with stable exertional angina显示文摘 | Mamyoshi H Kojima S Funahashi T | 2004 | Thromb Haemost2004，91，： | 1 |
| 15 | Thermoelectric Properties of the Bi-and Na-substituted Ca3 Co4O9 System 显示文摘 | Gaojie Xu Ryoji Funahashi | 2002 | Appl Phys Lett2002，80，20： | 1 |
| 16 | Clinical usefulness of carcinoembryonic antigen measurement in nipple discharge as an adjunctive tool for diagnosis of breast cancer显示文摘 | NISHIGUCHI T HISHIMOTO T FUNAHASHI S | 1992 | Rinsho Byori1992，40，1： | 1 |
| 17 | Hypoadiponectinemia inobesity and type 2 diabetes: close association with insulin resistanceand hyperinsulinemia 显示文摘 | Weyer C Funahashi T Tanaka S | 2001 | J Clin Endocrinol Metab2001，86，： | 1 |
| 18 | Circulating concentrations of the adipocyte protein adiponectin are decrdased in with reduced insulin sensitivity during the progression to type2 diabetes in rhesus monkeys显示文摘 | HOTTA K FUNAHASHI T BODKIN N L | 2001 | Diahetes2001，50，： | 1 |
| 19 | Predicting corrosion-free service life of a concrete structure in a chloride environment显示文摘 | FUNAHASHI M | 1990 | ACI Materials Jour-nal1990，87，6： | 1 |
| 20 | Wnt/beta-catenin signaling induces proliferation, survival and interleukin-8 in human endothelial ceils显示文摘 | Masckauchan T N Shawber C J Funahashi Y | 2005 | Angiogenesis2005，8，1： | 1 |
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