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| 1 | Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs显示文摘干皮病 pigmentosum (XP ) 是联系 XP 的基因的变化引起的一组基因混乱,导致 DNA 修理的缺陷。XP 病人经常展出神经病学的退化,而是内在的机制是未知的,部分地由于合适的疾病模型的缺乏。这里,我们产生了包括 XPA, XPB, XPC, XPG,和 XPV 在五不同 XP 基因怀有变化的病人特定的导致的 pluripotent 干细胞(iPSCs ) 。这些 iPSCs 进一步被区分到神经房间,并且他们到 DNA 损坏应力的危险性被调查。在神经干细胞(NSC ) 或神经原的 XPA 的变化导致了严重 DNA 损坏修理缺点,并且有变异的 XPA 的这些神经房间对 DNA 导致损坏的 apoptosis 过分敏感。因此, XP 变异的神经房间代表珍贵工具在 XP 病人澄清神经病学的畸形的分子的机制。 | Lina Fu Xiuling Xu Ruotong Ren Jun Wu Weiqi Zhang Jiping Yang Xiaoqing Ren Si Wang Yang Zhao Liang Sun Yang Yu Zhaoxia Wang Ze Yang Yun Yuan Jie Qiao Juan Carlos Izpisua Belmonte Jing Qu Guang-Hui Liu | 2016 | Protein & Cell2016，7，3： | 11 |
| 2 | Unruptured pregnancy in a noncommunicating rudimentary horn at37 weeks with a live fetus:a case report显示文摘We report an extremely rare case of an unruptured non-communicating rudimentary horn full-term pregnancy.A woman who had a uterine malformation was misdiagnosed as uterus didelphys and gave birth to a live,healthy fetus.The correct diagnosis was not made until cesarean section at 37 4/7 weeks.The case suggests that women who are pregnant in a rudimentary horn could obtain a full-term delivery and give birth to a live and healthy baby. | Chen Cheng Weiwei Tang Lei Zhang Mei Luo Meihua Huang Xiuling Wu Guiping Wan | 2015 | The Journal of Biomedical Research2015，29，1： | 11 |
| 3 | Bio-geomorphologic features and growth process of Tamarix nabkhas in Hotan River Basin, Xinjiang显示文摘Tamarix nabkha 是最普遍的 nabkhas 之一,在中国的干旱区域散布。在实验室基于户外的观察和模拟实验,在这份报纸的分析在 Hotan 河的中间、更低的活动范围指生物 geomorphologic 特征和 Tamarix nabkhas 的生长过程, Xinjiang。并且结果显示在学习区域的 Tamarix 的生态的类型基于 Populus Diversifolia 森林和灌木的深土壤是一种 Tugaic 土壤产地。这类产地能被划分成在微分发达阶段期间表明 Tamarix nabkhas 的生态的环境的特征的三种亚产地。同时, Tamarix nabkha 能在地面,和它的根和茎上在风沙流动上施加加强的骚乱电流不仅有发芽的强壮的潜力但是风侵蚀忍耐是特征的,被沙并且分别地要埋葬的电阻木质化的分支僵硬的流氓,为它有相当更长的一生。因此, Tamarix nabkha 影响的风速度侧面与 Phragmites nabkha 和 Alhagi nabkha 不同。并且风流动的结构对风神的沙在里面 / 附近 Tamarix 积累有益灌木,它能与更高平均的坡度和生活的更长的频率创造唯一的 Tamarix nabkhas。在区域的 Tamarix nabkha 进化经历了三个阶段:生长舞台,成熟、稳定的阶段和凋谢的舞台。在每个阶段,词法特征和 Tamarix nabkha 的似地球形状的过程由于在 nabkha 和风神的沙流动之间的差异的相互作用是不同的。 | LI Zhizhong WU Shengli CHEN Shujiang CHEN Xiuling JIN Jianhui LIU QI | 2010 | Journal of Geographical Sciences2010，20，2： | 10 |
| 4 | Spatial and Temporal Variability of Thermal Stress to China's Coral Reefs in South China Sea显示文摘Coral bleaching, caused by elevated sea surface temperature(SST), is occurring more frequently and seriously worldwide. Due to the lack of field observations, we understand little about the large-scale variability of thermal stress in the South China Sea(SCS) and its effect on China's coral reefs. This paper used 4-km high resolution gap-filled SST(Filled SST) data and thermal stress data related to coral bleaching derived from Coral Reef Temperature Anomaly Database(Co RTAD) to quantify the spatial and temporal characteristics of chronic thermal stress and acute thermal stress to China's coral reefs in SCS from 1982 to 2009. We analyzed the trend of SST in summer and the thermal stress frequency, intensity and duration during this period. The results indicate that, as a chronic thermal stress, summer mean SST in SCS shows an average upward trend of 0.2℃/decade and the spatial pattern is heterogeneous. Waters of Xisha Islands and Dongsha Islands of the northern SCS are warming faster through time compared to Zhongsha Islands and Nansha Islands sea areas of the southern SCS. High frequency bleaching related thermal stress events for these reefs are seen in the area to the northwest of Luzon Island. Severe anomaly thermal stress events are more likely to occur during the subsequent year of the El Nino year for these coral reefs. Besides, the duration of thermal stress varies considerably by anomaly year and by region. | ZUO Xiuling SU Fenzhen WU Wenzhou CHEN Zhike SHI Wei | 2015 | Chinese Geographical Science2015，25，2： | 7 |
| 5 | Galectin-3-centered paracrine network mediates cardiac inflammation and fibrosis upon β-adrenergic insult显示文摘Rapid over-activation of β-adrenergic receptors (β-AR) following acute stress initiates cardiac inflammation and injury by activating interleukin-18 (IL-18),however,the process of inflammation cascades has not been fully illustrated.The present study aimed to determine the mechanisms of cardiac inflammatory amplification following acute sympathetic activation.With bioinformatics analysis,galectin-3 was identified as a potential key downstream effector of β-AR and IL-18 activation.The serum level of galectin-3 was positively correlated with norepinephrine or IL-18 in patients with chest pain.In the heart of mice treated with β-AR agonist isoproterenol (ISO,5 mg kg^(-1)),galectin-3 expression was upregulated markedly later than IL-18 activation,and Nlrp3^(-/-)and Il18^(-/-)mice did not show ISO-induced galectin-3 upregulation.It was further revealed that cardiomyocyte-derived IL-18 induced galectin-3 expression in macrophages following ISO treatment.Moreover,galectin-3deficiency suppressed ISO-induced cardiac inflammation and fibrosis without blocking ISO-induced IL-18 increase.Treatment with a galectin-3 inhibitor,but not a β-blocker,one day after ISO treatment effectively attenuated cardiac inflammation and injury.In conclusion,galectin-3 is upregulated to exaggerate cardiac inflammation and injury following acute β-AR activation,a galectin-3 inhibitor effectively blocks cardiac injury one day after β-AR insult. | Guomin Hu Jimin Wu Huijun Gu Xiangning Deng Wenli Xu Shan Feng Shuaixing Wang Yao Song Zhengda Pang Xiuling Deng Aleksandr E.Vendrov Nageswara R.Madamanchi Marschall S.Runge Xinyu Wang Youyi Zhang Han Xiao Erdan Dong | 2023 | Science China(Life Sciences)2023，66，5： | 3 |
| 6 | Seismic Denoising with Curvelet Shrinkage显示文摘 | Aidi Wu Xiuling Zhao | 2010 | 通讯和计算机(中英文版)2010，7，9： | 2 |
| 7 | TEM and HRTEM Study of Microstructures in Omphacite from UHP Eclogites at Shima,Dabie Mountains,China显示文摘Transmission electron microscope (TEM) and high resolution transmission electron microscope (HRTEM) analyses have been performed on omphacite from ultra-high pressure (UHP) eclogites at the locality of Shima, Dabie Mountains, China. TEM reveals that the microstructures consist dominantly of dislocation substructures, including free dislocations, loops, tiltwalls, dislocation tangles and subboundaries. They were produced by high-temperature ductile deformation, of which the main mechanism was dislocation creep. Antiphase domain (APD) boundaries are common planar defects; an age of 470±6 Ma for UHP eclogite formation has been obtained from the equiaxial size of APDs in ordered omphacites from Shima, coincident with ages given by single-zircon U-Pb dating (471±2 Ma). HRTEM reveals C2/c and P2ln space groups in different parts of one single omphacite crystal, and no exsolution is observed in the studied samples, which is attributed to rapid cooling. It is suggested that the UHP eclogites underwent a | WU Xiuling HAN Yujing MENG Dawei YANG Weiran LI Douxing | 2000 | Acta Geologica Sinica(English Edition)2000，74，2： | 2 |
| 8 | Antibiotic resistance gene abundances associated with antibiotics and heavy metals in animal manures and agricultural soils adjacent to feedlots in Shanghai; China显示文摘 | Xiuling Ji Qunhui Shen Fang Liu Jing Ma Gang Xu Yuanlong Wang Minghong Wu | 2012 | Journal of Hazardous Materials2012，，： | 2 |
| 9 | Cyclopalladated ferrocenylimines as efficient catalysts for homogeneous catalysis:A brief introduction to our preliminary achievements显示文摘Cyclopalladated ferrocenylimines as a novel kind of highly efficient palladium catalyst precursors, which are air-stable and easy to handle, have been successfully applied in a wide variety of catalytic reactions ranging from classical reactions, such as Heck, Suzuki, Sonogashira and Buchwald-Hartwig couplings, to cyanation, addition reactions of arylboronic acids, and coupling reactions involving terminal alkynes. The preliminary achievements regarding their applications to homogeneous catalysis are concisely described herein. | WU YangJie YANG Fan ZHANG JinLi CUI XiuLing GONG JunFang SONG MaoPing LI TieSheng | 2010 | Chinese Science Bulletin2010，55，25： | 2 |
| 10 | Mechanical and antibacterial properties of tannic acid-encapsulated carboxymethyl chitosan/polyvinyl alcohol hydrogels显示文摘The objective of this study was to develop an effective,potential wound dressing,which was constructed with a composite hydrogel of poly(vinyl alcohol)(PVA),carboxymethyl chitosan(CMC)and tannic acid(TA)by cryogenic treatment and freeze-drying method.The as-prepared TA-crosslinked PVA/CMC hydrogels exhibited interconnected pore structure with the mean pore size of roughly 3.7��m.We found that the compressive strength and stiffness of composite hydrogel increased when the TA component was introduced.However,the PVA/CMC-TA hydrogel possessed obviously lower swell property than that of the TA-free PVA/CMC hydrogel.We also found that the TA addition significantly improved the antibacterial capacity of the as-prepared hydrogel.Moreover,the inhibition zone test showed that the antibacterial activity of PVA/CMC-TA against S.aureus bacteria was greater than that against E.coli.The biological results indicated that the PVA/CMC-TA hydrogel exhibited good cytocompatibility to natural human dermal fibroblasts.In summary,our PVA/CMC-TA composite hydrogel exhibited promising mechanical and antibacterial properties,which showed great potential application as wound healing materials. | Xiaofan Feng Xiuling Hou Congjing Cui Shibin Sun Sahiya Sadik Shaohua Wu Fang Zhou | 2021 | Engineered Regeneration2021，2，1： | 2 |
| 11 | Antibiotic resistance gene abundances associated with antibiotics and heavy metals in animal manures and agricultural soils adjacent to feedlots in Shanghai; China显示文摘 | Xiuling Ji Qunhui Shen Fang Liu Jing Ma Gang Xu Yuanlong Wang Minghong Wu | 2012 | Journal of Hazardous Materials2012，，： | 1 |
| 12 | A Spatio-temporal Data Model for Road Network in Data Center Based on Incremental Updating in Vehicle Navigation System显示文摘The technique of incremental updating,which can better guarantee the real-time situation of navigational map,is the developing orientation of navigational road network updating.The data center of vehicle navigation system is in charge of storing incremental data,and the spatio-temporal data model for storing incremental data does affect the efficiency of the response of the data center to the requirements of incremental data from the vehicle terminal.According to the analysis on the shortcomings of several typical spatio-temporal data models used in the data center and based on the base map with overlay model,the reverse map with overlay model (RMOM) was put forward for the data center to make rapid response to incremental data request.RMOM supports the data center to store not only the current complete road network data,but also the overlays of incremental data from the time when each road network changed to the current moment.Moreover,the storage mechanism and index structure of the incremental data were designed,and the implementation algorithm of RMOM was developed.Taking navigational road network in Guangzhou City as an example,the simulation test was conducted to validate the efficiency of RMOM.Results show that the navigation database in the data center can response to the requirements of incremental data by only one query with RMOM,and costs less time.Compared with the base map with overlay model,the data center does not need to temporarily overlay incremental data with RMOM,so time-consuming of response is significantly reduced.RMOM greatly improves the efficiency of response and provides strong support for the real-time situation of navigational road network. | WU Huisheng LIU Zhaoli ZHANG Shuwen ZUO Xiuling | 2011 | Chinese Geographical Science2011，21，3： | 1 |
| 13 | Development and validation of a machine learning-based nomogram for prediction of intrahepatic cholangiocarcinoma in patients with intrahepatic lithiasis显示文摘Background:Accurate diagnosis of intrahepatic cholangiocarcinoma(ICC)caused by intrahepatic lithiasis(IHL)is crucial for timely and effective surgical intervention.The aim of the present study was to develop a nomogram to identify ICC associated with IHL(IHL-ICC).Methods:The study included 2,269 patients with IHL,who received pathological diagnosis after hepatectomy or diagnostic biopsy.Machine learning algorithms including Lasso regression and random forest were used to identify important features out of the available features.Univariate and multivariate logistic regression analyses were used to reconfirm the features and develop the nomogram.The nomogram was externally validated in two independent cohorts.Results:The seven potential predictors were revealed for IHL-ICC,including age,abdominal pain,vomiting,comprehensive radiological diagnosis,alkaline phosphatase(ALK),carcinoembryonic antigen(CEA),and cancer antigen(CA)19-9.The optimal cutoff value was 2.05μg/L for serum CEA and 133.65 U/mL for serum CA 19-9.The accuracy of the nomogram in predicting ICC was 82.6%.The area under the curve(AUC)of nomogram in training cohort was 0.867.The AUC for the validation set was 0.881 from The Second Affiliated Hospital of Wenzhou Medical University,and 0.938 from The First Affiliated Hospital of Fujian Medical University.Conclusions:The nomogram holds promise as a novel and accurate tool to predict IHL-ICC,which can identify lesions in IHL in time for hepatectomy or avoid unnecessary surgical resection. | Xian Shen Huanhu Zhao Xing Jin Junyu Chen Zhengping Yu Kuvaneshan Ramen Xiangwu Zheng Xiuling Wu Yunfeng Shan Jianling Bai Qiyu Zhang Qiqiang Zeng | 2021 | Hepatobiliary Surgery and Nutrition2021，10，6： | 1 |
| 14 | The epidemic status and genetic diversity of 14 highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) isolates from China in 2009显示文摘 | Zhi Zhou Jianqiang Ni Zhen Cao Xue Han Yingju Xia Zhanchao Zi Kun Ning Qi Liu Lin Cai Peng Qiu Xiaoyu Deng Dongmei Hu Qian Zhang Yunfeng Fan Jiajun Wu Lilin Wang Miaojie Zhang Xiuling Yu Xinyan Zhai Kegong Tian | 2011 | Veterinary Microbiology2011，，3： | 1 |
| 15 | Hydrothermal syn- thesis of Pbz SnO4 显示文摘 | Wu Mingmei Li Xiuling Shen Guoping | 1999 | Materials Research Bulletin1999，34，7： | 1 |
| 16 | Impact of Temperature on Absorption Coefficient of Pure Seawater in the Blue Wavelengths Inferred from Satellite and In Situ Measurements显示文摘There has been a long history of interest on how(if)the absorption coefficient of“pure”fresh water(a_(fw)(λ))and“pure”seawater(a_(sw)(λ))changes with temperature(T),yet the impact of T reported in the literature differs significantly in the blue domain.Unlike the previous studies based on laboratory measurements,we took an approach based on~18 years(2002–2020)of MODIS ocean color and temperature measurements in the oligotrophic oceans,along with field measured chlorophyll concentration and phytoplankton absorption coefficient,to examine the relationship between T and the total absorption coefficient(a(λ))at 412 and 443 nm.We found that the values of a(412)and a(443)in the summer are nearly flat(slightly decreasing)for the observed T range of~19–27℃.Since there are no detectable changes of chlorophyll during this period,the results suggest that T has a negligible impact on a_(sw)(412) and a_(sw)(443)in this T range.As a complement,the impact of salinity on a_(fw)(λ) was also evaluated using three independent determinations of a_(sw)(λ) and a_(fw)(λ),where good agreements were found from these observations. | Guomei Wei Zhongping Lee Xiuling Wu Xiaolong Yu Shaoling Shang Ricardo Letelier | 2021 | Journal of Remote Sensing2021，，1： | 1 |
| 17 | Cyclopalladated ferrocenylimines: efficient catalysts for homocoupling and Sonogashira reaction of terminal alkynes显示文摘 | Fan Yang Xiuling Cui Ya-nan Li Jinli Zhang Ge-rui Ren Yangjie Wu | 2007 | Tetrahedron2007，，9： | 1 |
| 18 | Cyclopalladated ferrocenylimines: highly active catalysts for Heck reactions显示文摘 | Yangjie Wu Jianjun Hou Hongying Yun Xiuling Cui Ruijuan Yuan | 2001 | Journal of Organometallic Chemistry2001，，： | 1 |
| 19 | Microstructural Features of Garnets in Jadeite Quartzite from Dabie Mountains, China显示文摘Garnet is an important rock forming mineral of high pressure and ultrahigh pressure metamorphic rocks. Its popular isomorphism complicates its chemical composition and crystal structure. The selected area electron diffraction (SAED) and the high resolution electron microscopy (HREM) are used in this work to study the microstructures and ultrastructures of garnets in the jadeite quartzite from Dabie Mountains, China. The microstructures of the garnet occur mainly as free dislocations, dislocation walls, stacking faults, dislocation networks and sub grain boundaries. The dislocation density is ρ=n ×10 8/cm 2 ( n =1.7—7.5) and the deformation mechanism is the dislocation glide and dynamic recovery. The superstructures of the garnet crystal revealed by HREM occur mainly as dislocations, faults, domain structures and lattice deformations, indicating the strong stress during the formation of the jadeite quartzite. | Wu Xiuling Mou Tao Han Yujing Test Center, China University of Geosciences, Wuhan 430074, China Li Douxing Laboratory of Atomic Imaging of Solid, Institute of Metal Research, Academia Sinica, Shenyang 110015, China | 2000 | Journal of Earth Science2000，19，3： | 1 |
| 20 | Pseudorabies Virus Variant in Bartha-K61-Vaccinated Pigs,China,2012显示文摘 | Tong-Qing An Xiuling Yu Rui Wu | 2013 | Emerg Infect Dis2013，19，11： | 1 |
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