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| 1 | Anti-hepatoma activity and mechanism of ursolic acid and its derivatives isolated from Aralia decaisneana显示文摘瞄准:为了调查 ursolic (UA ) 和它的衍生物的反肿瘤活动,在肝细胞癌上从美┦木孤立 decaisneana 在试管内和在活体内。方法:在活体内细胞毒性被 3- 首先屏蔽[4,5-dimethylthiazol-2-yl ]-2, 5-diphenyltetrazolium 溴化物(MTT ) 试金。词法观察, DNA 梯子,流动血细胞计数分析,西方的污点和实时 PCR 被采用阐明 UA 的细胞毒素的机制。植入的老鼠肝细胞瘤 H22 被用来评估生长 UA 的禁止的效果在活体内。结果:UA 能显著地禁止 HepG2 和它的药抵抗的增长紧张, R-HepG2 房间,而是首先有教养的正常老鼠 hepatocytes 上的有的不禁止的效果而 UA 的所有六衍生物不能禁止所有的生长,测试房间排队。机制上的进一步的学习证明那 apoptosis 和 G0/G1 拘捕涉及多(自动数据处理核糖) 的细胞毒性和劈开聚合酶(PARP ) 。cyclooxygenase-2 (COX-2 ) 的 Downregulation 蛋白质并且在热吃惊蛋白质(HSP ) 的规定上面, 105 mRNA 相关到与 UA 对待的 HepG2 房间的 apoptosis。另外, UA 能也禁止 H22 肝细胞瘤在活体内的生长。结论:UA 是一个有希望的反肿瘤代理人,但是推进工作需要被做改进它的溶解度。 | Ze Tian Geng Lin Rui-Xia Zheng Feng Huang Meng-Su Yang Pei-Gen Xiao | 2006 | World Journal of Gastroenterology2006，12，6： | 31 |
| 2 | Polymorphism of p16INK4a gene and rare mutation of p15INK4b gene exon2 in primary hepatocarcinoma显示文摘INTRODUCTION Hepatocellular carcinoma(HCC)is the mostcommon cause of death from cancer in China.Themechanisms of hepatocarcinogenesis are not yetknown clearly,p16INK4a gene,the multiple tumorsuppressor gene 1(MTS1),encodes P16 protein,which acts as an inhibitor by binding directly toCDK4 and CDK6 and preventing its association | Yang Qin Bo Li Yong Shu Tan Zhi Lin Sun Feng Qiong Zuo Ze Fang Sun Institute of Biochemistry and Molecular Biology,West China University of Medical Sciences,Chengdu 610041,Sichuan Province,China Department of General Surgery,The First Affiliated Hospital,West China University of Medical Sciences,Chengdu 610041,Sichuan Province,China Department of Pathology,The First Affiliated Hospital,West China University of Medical Sciences,Chengdu 610041,Sichuan Province,China | 2000 | World Journal of Gastroenterology2000，6，3： | 30 |
| 3 | Genetic correction of p-thalassemia patient-specific iPS cells and its use in improving hemoglobin production in irradiated SCID mice显示文摘 | Yixuan Wang Chen-Guang Zheng Yonghua Jiang Jiqin Zhang Jiayu Chen Chao Yao Qingguo Zhao Sheng Liu Ke Chen Juan Du Ze Yang Shaorong Gao | 2012 | Cell Research2012，22，4： | 27 |
| 4 | Identification of higenamine in Radix Aconiti Lateralis Preparata as a beta2-adrenergic receptor agonist显示文摘瞄准:屏蔽 beta2 肾上腺素能的受体(从同样潜在的药为气喘带使用敏感基于房间的收缩筋试金的根值 Aconiti Lateralis Preparata (RALP ) 的 β
2-AR) 收缩筋。方法:β
2-AR 基因被汉语稳定地表示仓鼠卵巢(CHO ) 房间稳定地也表示周期的腺苷单音的磷酸盐(安培) 反应连接元素的提高的绿荧光灯的蛋白质记者基因。房间被用来从高效的液体屏蔽收缩筋 RALP 的一篇摘录的色析法的部分。有最高的活动的部分为进一步复合的隔离和结构活动关系的学习被选择。它的活跃混合物被层析和集体 spectrometry 进一步识别。结果:RALP 的粗略的摘录的指导 Bioactivity 的分别导致了有效混合物的隔离和描述,也就是 hignamine。它能 dose-dependently 与 EC 50 价值与醋胆素放松孤立的畿尼猪气管长带预约离子(2.60 ± 0 .36 ) × 10 −5 mol/L。进一步,在 vivo,研究也显示了那 hignamine 能保护组织安在畿尼猪劝诱延长气喘的潜伏期的试验性的气喘模型。结论:作为在 RALP 的摘录存在的 β
2-AR 收缩筋, Hignamine 是贡献 bronchoconstriction 的成功的消除的关键混合物。 | Gang BAI Yang YANG Qian SHI Ze LIU Qi ZHANG Yuan-yuan ZHU | 2008 | Acta Pharmacologica Sinica2008，29，10： | 24 |
| 5 | Identification of anti-asthmatic compounds in Pericarpium citri reticulatae and evaluation of their synergistic effects显示文摘 | Qian SHI Ze LIU Yang YANG Peng GENG Yuan-yuan ZHU Qi ZHANG Fang BAI Gang BAI | 2009 | Acta Pharmacologica Sinica2009，30，5： | 23 |
| 6 | Carbon carry capacity and carbon sequestration potential in China based on an integrated analysis of mature forest biomass显示文摘Forests play an important role in acting as a carbon sink of terrestrial ecosystem.Although global forests have huge carbon carrying capacity(CCC)and carbon sequestration potential(CSP),there were few quantification reports on Chinese forests.We collected and compiled a forest biomass dataset of China,a total of 5841 sites,based on forest inventory and literature search results.From the dataset we extracted 338 sites with forests aged over 80 years,a threshold for defining mature forest,to establish the mature forest biomass dataset.After analyzing the spatial pattern of the carbon density of Chinese mature forests and its controlling factors,we used carbon density of mature forests as the reference level,and conservatively estimated the CCC of the forests in China by interpolation methods of Regression Kriging,Inverse Distance Weighted and Partial Thin Plate Smoothing Spline.Combining with the sixth National Forest Resources Inventory,we also estimated the forest CSP.The results revealed positive relationships between carbon density of mature forests and temperature,precipitation and stand age,and the horizontal and elevational patterns of carbon density of mature forests can be well predicted by temperature and precipitation.The total CCC and CSP of the existing forests are 19.87 and 13.86 Pg C,respectively.Subtropical forests would have more CCC and CSP than other biomes.Consequently,relying on forests to uptake carbon by decreasing disturbance on forests would be an alternative approach for mitigating greenhouse gas concentration effects besides afforestation and reforestation. | LIU Ying Chun YU Gui Rui WANG Qiu Feng ZHANG Yang Jian XU Ze Hong | 2014 | Science China(Life Sciences)2014，57，12： | 15 |
| 7 | A case-control study of risk factors for severe hand-foot-mouth disease in Yuxi, China, 2010–2012显示文摘Dear Editor,Here,we report the risk factors for severe hand-foot-mouth disease(HFMD)determined by our case-controlstudy.Our findings could help disease prevention and in-tervention initiatives.Patients with severe HFMD displayfatal clinical manifestations with sequelae,requiring≥7days of hospitalization.A tota1 of 249 severe cases treat-ed at Yuxi Children’s Hospital were included in the | Ze Liu Shukun Wang Rusong Yang Xia Ou | 2014 | Virologica Sinica2014，29，2： | 14 |
| 8 | Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs显示文摘干皮病 pigmentosum (XP ) 是联系 XP 的基因的变化引起的一组基因混乱,导致 DNA 修理的缺陷。XP 病人经常展出神经病学的退化,而是内在的机制是未知的,部分地由于合适的疾病模型的缺乏。这里,我们产生了包括 XPA, XPB, XPC, XPG,和 XPV 在五不同 XP 基因怀有变化的病人特定的导致的 pluripotent 干细胞(iPSCs ) 。这些 iPSCs 进一步被区分到神经房间,并且他们到 DNA 损坏应力的危险性被调查。在神经干细胞(NSC ) 或神经原的 XPA 的变化导致了严重 DNA 损坏修理缺点,并且有变异的 XPA 的这些神经房间对 DNA 导致损坏的 apoptosis 过分敏感。因此, XP 变异的神经房间代表珍贵工具在 XP 病人澄清神经病学的畸形的分子的机制。 | Lina Fu Xiuling Xu Ruotong Ren Jun Wu Weiqi Zhang Jiping Yang Xiaoqing Ren Si Wang Yang Zhao Liang Sun Yang Yu Zhaoxia Wang Ze Yang Yun Yuan Jie Qiao Juan Carlos Izpisua Belmonte Jing Qu Guang-Hui Liu | 2016 | Protein & Cell2016，7，3： | 11 |
| 9 | CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs显示文摘 | Lixia Wang Fei Yi Lina Fu Jiping Yang Si Wang Zhaoxia Wang Keiichiro Suzuki Liang Sun Xiuling Xu Yang Yu Jie Qiao Juan Carlos Izpisua Belmonte Ze Yang Yun Yuan Jing Qu Guang-Hui Liu | 2017 | Protein & Cell2017，8，5： | 10 |
| 10 | Apolipoprotein E, amyloid-beta, and neuroinflammation in Alzheimer's disease显示文摘Alzheimer's disease(AD) is characterized by the accumulation and deposition of amyloid-beta(Aβ) peptides in the brain. Neuroinflammation occurs in the AD brain and plays a critical role in the neurodegenerative pathology. Particularly, Aβ evokes an inflammatory response that leads to synaptic dysfunction, neuronal death, and neurodegeneration. Apolipoprotein E(ApoE) proteins are involved in cholesterol transport, Aβ binding and clearance, and synaptic functions in the brain. The ApoE4 isoform is a key risk factor for AD, while the ApoE2 isoform has a neuroprotective effect. However, studies have reached different conclusions about the roles of the isoforms; some show that both ApoE3 and ApoE4 have anti-infl ammatory effects, while others show that ApoE4 causes a predisposition to inflammation or promotes an inflammatory response following lipopolysaccharide treatment. These discrepancies may result from the differences in models, cell types, experimental conditions, and inflammatory stimuli used. Further, little was known about the role of ApoE isoforms in the Aβ-induced inflammatory response and in the neuroinflammation of AD. Our recent work showed that ApoE isoforms differentially regulate and modify the Aβ-induced infl ammatory response in neural cells, with ApoE2 suppressing and ApoE4 promoting the response. In this article, we review the roles, mechanisms, and interrelations among Aβ, ApoE, and neuroinfl ammation in AD. | Evan Dorey Nina Chang Qing Yan Liu Ze Yang Wandong Zhang | 2014 | Neuroscience Bulletin2014，30，2： | 9 |
| 11 | The synergistic anti-asthmatic effects of glycyrrhizin and salbutamol显示文摘 | Yang YANG Qian SHI Ze LIU Ruo-jie LI Peng-wei PAN Yuan-yuan HOU Wan-ge LU Gang BAI | 2010 | Acta Pharmacologica Sinica2010，31，4： | 8 |
| 12 | Effect of SiO_2/Na_2O mole ratio on the properties of foam geopolymers fabricated from circulating fluidized bed fly ash显示文摘Geopolymers are three-dimensional aluminosilicates formed in a short time at low temperature by geopolymerization. In this paper, alkali-activated foam geopolymers were fabricated from circulating fluidized bed fly ash(CFA), and the effect of SiO2/Na2O mole ratio(0.91–1.68) on their properties was studied. Geopolymerization products were characterized by mechanical testing, scanning electron microscopy(SEM), energy-dispersive X-ray spectroscopy(EDX), and X-ray diffraction(XRD). The results show that SiO2/Na2O mole ratio plays an important role in the mechanical and morphological characteristics of geopolymers. Foam samples prepared in 28 d with a SiO2/Na2O mole ratio of 1.42 exhibit the greatest compressive strength of 2.52 MPa. Morphological analysis reveals that these foam geopolymers appear the relatively optimized pore structure and distribution, which are beneficial to the structure stability. Moreover, a combination of the Si/Al atomic ratio ranging between 1.47 and 1.94 with the Na/Al atomic ratio of about 1 produces the samples with high strength. | Ze Liu Ning-ning Shao Tian-yong Huang Jun-feng Qin Dong-min Wang Yu Yang | 2014 | International Journal of Minerals,Metallurgy and Materials2014，21，6： | 8 |
| 13 | Three interpenetrated copper(Ⅱ) coordination polymers based on a V-shaped ligand:Synthesis,structures,sorption and magnetic properties显示文摘Three new CuⅡ coordination polymers,[Cu2(oba)2(H2O)(DMF)].3H2O(1),[Cu4(oba)4(DMF)4].4H2O.DMF(2) and [Cu2(oba)(hmp)2](3)(H2oba = 4,4'-oxybis(benzoic acid),Hhmp = 2-pyridine methanol,DMF = N,N'-dimethylformamide) were synthesized by solvothermal reactions and characterized by single-crystal X-ray diffraction.Both complexes 1 and 2 take three-dimensional(3D) three-fold interpenetrating PtS topology with 1D channels.In complex 3,Cu4 clusters were formed by the chelating hmp ligands,and then the clusters were further linked by oba ligands to form a 3D three-fold interpenetrating dia topology network.For 2,N2 sorption shows type I isotherm with BET surface areas of 562 m2 g-1 and Langmuir surface area of 747 m2 g-1,respectively.At 77 and 87 K,the hydrogen uptakes of complex 2 are 0.89 wt% and 0.57 wt%,respectively.Magnetic investigation showed the ferromagnetic coupling between CuII ions and very weak antiferromagnetic interaction between Cu4 clusters in complex 3. | ZHANG XiaoFeng YANG Qian ZHAO JiongPeng HU Tong-Liang CHANG Ze BU Xian-He | 2011 | Science China Chemistry2011，54，9： | 7 |
| 14 | Changes in Activities of Glutamine Synthetase during Grain Filling and Their Relation to Rice Quality显示文摘Four japonica rice varieties differed in cooking and eating qualities were used in a pot experiment to study the relationship between the activities of glutamine synthetase during grain filling and rice quality. The activities of glutamine synthetase gradually increased and then declined as a single peak curve in the course of grain filling. The 15th day after heading was a turning point, before which the enzymatic activities in the inferior rice varieties with high protein content were higher than those in the superior rice varietie with low protein content, and after which it was converse. The activity of glutamine synthetase in grain was correlated with the taste meter value, peak viscosity and breakdown negatively at the early stage of grain filling whereas positively at the middle and late stages. Moreover, it was correlated with the protein content of rice grain and setback positively at the early stage and negatively at the middle and late stages. The correlation degree varied with the course of grain filling. From 15 days to 20 days after heading was a critical stage, in which the direction of correlation between the activity of glutamine synthetase and taste meter value and RVA properties of rice changed. | JIN Zheng xun QIAN Chun rong YANG Jing LIU Hai ying PIAO Zhong ze | 2007 | Rice science2007，14，3： | 6 |
| 15 | Ab-Induced Insulin Resistance and the Effects of Insulin on the Cholesterol Synthesis Pathway and Ab Secretion in Neural Cells显示文摘Alzheimer's disease(AD) is characterized by amyloid-b(Ab) toxicity,tau pathology,insulin resistance,neuroinflammation,and dysregulation of cholesterol homeostasis,all of which play roles in neurodegeneration.Insulin has polytrophic effects on neurons and may be at the center of these pathophysiological changes.In this study,we investigated possible relationships among insulin signaling and cholesterol biosynthesis,along with the effects of Ab42 on these pathways in vitro.We found that neuroblastoma 2a(N2a) cells transfected with the human gene encoding amyloid-b protein precursor(Ab PP)(N2aAb PP) produced Ab and exhibited insulin resistance by reduced p-Akt and a suppressed cholesterol-synthesis pathway following insulin treatment,and by increased phosphorylation of insulin receptor subunit-1 at serine 612(p-IRS-S612) as compared to parental N2 a cells.Treatment of human neuroblastoma SH-SY5 Y cells with Ab42 also increased p-IRS-S612,suggesting that Ab42 is responsible for insulin resistance.The insulin resistance was alleviated when N2a-Ab PP cells were treated with higher insulin concentrations.Insulin increased Ab release from N2 aAb PP cells,by which it may promote Ab clearance.Insulin increased cholesterol-synthesis gene expression in SHSY5 Y and N2 a cells,including 24-dehydrocholesterol reductase(DHCR24) and 3-hydroxy-3-methyl-glutaryl-Co A reductase(HMGCR) through sterol-regulatory element-binding protein-2(SREBP2).While Ab42-treated SH-SY5 Y cells exhibited increased HMGCR expression and c-Jun phosphorylation as pro-inflammatory responses,they also showed down-regulation of neuro-protective/antiinflammatory DHCR24.These results suggest that Ab42 may cause insulin resistance,activate JNK for c-Jun phosphorylation,and lead to dysregulation of cholesterol homeostasis,and that enhancing insulin signaling may relieve the insulin-resistant phenotype and the dysregulated cholesterol-synthesis pathway to promote Ab release for clearance from neural cells. | Dema Najem Michelle Bamji-Mirza Ze Yang Wandong Zhang | 2016 | Neuroscience Bulletin2016，32，3： | 6 |
| 16 | Efficient and stable planar all-inorganic perovskite solar cells based on high-quality CsPbBr3 films with controllable morphology显示文摘All-inorganic cesium lead bromide(CsPbBr3)perovskite is attracting growing interest as functional materials in photovoltaics and other optoelectronic devices due to its superb stability.However,the fabrication of high-quality CsPbBr3 films still remains a big challenge by solution-process because of the low solubility of the cesium precursor in common solvents.Herein,we report a facile solution-processed approach to prepare high-quality CsPbBr3 perovskite films via a two-step spin-coating method,in which the Cs Br methanol/H2 O mixed solvent solution is spin-coated onto the lead bromide films,followed by an isopropanol-assisted post-treatment to regulate the crystallization process and to control the film morphology.In this fashion,dense and uniform CsPbBr3 films are obtained consisting of large crystalline domains with sizes up to microns and low defect density.The effectiveness of the resulting CsPbBr3 films is further examined in perovskite solar cells(PSCs)with a simplified planar architecture of fluorine–doped tin oxide/compact Ti O2/CsPbBr3/carbon,which deliver a maximum power conversion efficiency of 8.11%together with excellent thermal and humidity stability.The present work offers a simple and effective strategy in fabrication of high-quality CsPbBr3 films for efficient and stable PSCs as well as other optoelectronic devices. | Xiaojing Wan Ze Yu Wenming Tian Fuzhi Huang Shengye Jin Xichuan Yang Yi-Bing Cheng Anders Hagfeldt Licheng Sun | 2020 | Journal of Energy Chemistry2020，29，7： | 6 |
| 17 | Expert Consensus on Wenxin Granule for Treatment of Cardiac Arrhythmias显示文摘 | Guo, Ji-Hong Yan, Gan-Xin Wu, Lin Zhao, Bu-Chang Wang, Yi-Min Gu, Fu-Sheng Zhou, Yu-Ping Antzelevitch, Charles Guo, Jing-Xuan Yang, Jie-Fu Yang, Xin-Chun Ding, Yan-Sheng Zhang, Ping Zhang, Hai-Cheng Liu, Hong-Xu Lu, Wei-Xing Xing, Yan-Wei Fan, Jian-Feng Ze, Feng Li, Guang-ping Li, Yi-Gang Liao, De-Ning Xue, Xiao-Lin | 2017 | Chinese Medical Journal2017，，2： | 6 |
| 18 | The combination of PD-1 blockade with interferon-αhas a synergistic effect on hepatocellular carcinoma显示文摘Background The efficacy of immune checkpoint inhibitors(ICIs),such as programmed cell death protein-1(PD-1)or its ligand 1(PD-L1)antibody,in hepatocellular carcinoma(HCC)is limited,and it is recommended that they be combined with other therapies.We evaluated the combination of pegylated interferon-α(Peg-IFNα)with PD-1 blockade in HCC mouse models.Methods We analyzed the effects of Peg-IFNαon tumor-infiltrating immune cells and PD-1 expression in the HCC immune microenvironment and examined the underlying mechanism of its unique effect on the PD-1 pathway.The in vivo efficacy of anti-PD-1 and Peg-IFNαwas evaluated in both subcutaneous and orthotopic mouse models of HCC.Results The combination of Peg-IFNαwith PD-1 blockade dramatically enhanced T-cell infiltration,improved the efficacy of PD-1 antibody and prolonged mouse survival compared with PD-1 antibody monotherapy.Mechanistically,Peg-IFNαcould recruit cytotoxic CD8+T cells to infiltrate the HCC microenvironment by inducing tumor cells to secrete the chemokine CCL4.Nevertheless,the HCC microenvironment quickly overcame the immune responses by upregulating PD-1 expression in CD8+T cells via the IFNα-IFNAR1-JAK1-STAT3 signaling pathway.The combination of PD-1 blockade with Peg-IFNαcould restore the cytotoxic capacity of CD8+T cells and exerted a significant synergistic effect on HCC.Conclusion These results indicate that in addition to initiating the antitumor immune response itself,Peg-IFNαcan also generate a microenvironment favoring PD-1 blockade.Thus,the combination of Peg-IFNαand PD-1 blockade can be a promising strategy for HCC. | Ying Zhu Mo Chen Da Xu Tian-En Li Ze Zhang Jian-Hua Li Xiang-Yu Wang Xin Yang Lu Lu Hu-Liang Jia Qiong-Zhu Dong Lun-Xiu Qin | 2022 | Cellular & Molecular Immunology2022，19，6： | 6 |
| 19 | AOF1 is a histone H3K4 demethylase possessing demethylase activity-independent repression function显示文摘LSD1 (在新名称下面的 KDM1 ) 是属于黄素依赖者胺 oxidase 家庭的首先识别的离氨酸特定的 histone demethylase。这里,我们报导那 AOF1 (在新名称下面的 KDM1B ) ,与 LSD1 有关的哺乳动物的蛋白质,也为 H3K4me1 和 H3K4me2 与特性拥有 histone demethylase 活动。象 LSD1 一样,高度保存的 SWIRM 领域为它的酶的活动被要求。然而, AOF1 在几个方面不同于 LSD1。首先, AOF1 不看起来形成包含 histone deacetylases 的稳定的蛋白质建筑群。第二, AOF1 被发现在房间周期的有丝分裂的阶段期间本地化到染色体,而 LSD1 不做。第三, AOF1 镇压抄写什么时候拴住到 DNA 和这项压抑活动,独立于它的 demethylase 活动。结构、功能的分析为 demethylase 作为必要识别了它的唯一的 N 终端 Zf-CW 领域活动无关的压抑功能。一起,我们的学习在黄素依赖者胺 oxidases 的家庭作为第二 histone demethylase 识别 AOF1 并且揭示 AOF1 的 demethylase 独立的压抑功能。 | Ze Yang Jun Jiang David M Stewart Shankang Qi Kenichi Yamane Jiwen Li Yi Zhang Jiemin Wong | 2010 | Cell Research2010，20，3： | 6 |
| 20 | Interpretation of the Traditional Chinese Medicine portion of the diagnosis and treatment protocol for corona virus disease 2019(Trial Version 7)显示文摘The TCM protocol in the Diagnosis and Treatment Protocol for corona virus disease 2019(COVID-19)(Trial Version 7) has been updated from previous versions. The protocol was formulated under the direct leadership of the National Administration of Traditional Chinese Medicine, based on the experience of a panel of experts, supported by evidence from fever clinics and from the outcomes of emergency(EM) observation rooms and inpatients throughout China(especially in Wuhan, Hubei Province) in combination with the latest scientific research results and data. The present interpretation of the TCM protocol is based on an overall understanding of the revised content, and aims to guide and standardize its clinical application to provide a reference for clinicians. | Song Ping Zhao Linhua Li Xiuyang Su Jiansen Jiang Zhaoyuan Song Bin Liu Wenke Tang Shuang Lei Ye Ding Qiyou Yang Ze Lin Jiaran Wei Yu Tong Xiaolin | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 5 |
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