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| 1 | 常见金属元素对人体的作用及危害显示文摘金属元素与人类生活息息相关,金属的应用推动了人类生活的发展,同时也给人体带来一些副作用。金属元素中有的是人体必需元素,有的则是非必需元素,必需元素在人体内的平衡被打破(缺失、过量),也会对人体健康产生不利影响;而非必需元素,特别是一些重金属元素往往对人体有毒性,甚至会产生致癌作用。综述了铅、汞、镉、铬、铝、铜、镍、锌、铁、钴、钛、钡、锰13种金属对环境和人类健康的影响,介绍了金属元素的来源和人类摄入金属元素的方式。进一步阐述了金属元素的毒性机制,如刺激细胞氧化应激、抑制DNA表达、诱发突变导致癌细胞的产生和增殖等,旨在通过阐明金属元素与人体健康之间的关系,加强人类对金属元素的自我防范意识。 | 李争显 李伟 LEI Jiajun LI Qianyu 刘林涛 周廉 | 2020 | 中国材料进展2020，39，12： | 53 |
| 2 | Effect of Xiaoaiping injection on advanced hepatocellular carcinoma in patients显示文摘OBJECTIVE: To investigate the effect of Xiaoaiping Injection (XAP) on advanced hepatocellular carcinoma (HCC) in patients. METHODS: Sixty-eight patients with advanced HCC were assigned to a control group of 36 and a treatment group of 32.The control group was treated with best supportive treatment (BST) and the treatment group was given XAP plus BST. XAP was administered daily by iv and the treatment course was lasted for 30 days for both groups.The immediate therapeutic efficacy, Karnofsky performance status (KPS) scores, and the changes in immunity indicators (CD3+, CD4+ and CD8+ T cells) were measured and compared before and after treatment. The progression-free survival (PFS) rate and overall survival (OS) rate in the 2 groups were analyzed. RESULTS: The immediate therapeutic efficacy and KPS of the treatment group were better than those in the control group (P<0.05). Patients in the treat-ment group had higher percentages of CD3 and CD4 T-lymphocytes in peripheral blood than those in the control group (P<0.05). The median survival time was 27.0 weeks in the treatment group and 24.5 weeks in the control group. The 6-months cumulative survival rates in the treatment and control groups were 33.3% and 25.0% , respectively, with no significant difference (P>0.05). The PFS was 18 weeks in the treatment group and 15 weeks in control group (P<0.05). CONCLUSION: XAP enhances the quality of life (QOL) of patients with advanced HCC, improves their immunity and extends their PFS. | Zhengrong Huang Yong Wang Jiajun Chen Rongping Wang Qiang Chen | 2013 | Journal of Traditional Chinese Medicine2013，33，1： | 22 |
| 3 | Efficacy and safety of metformin and sitagliptin based triple antihyperglycemic therapy(STRATEGY):a multicenter,randomized,controlled,non-inferiority clinical trial显示文摘Despite the current guideline's recommendation of a timely stepwise intensification therapy,the 'clinical inertia',termed as the delayed treatment intensification,commonly exists in the real world,which may be partly due to the relatively little substantial evidence and no clear consensus regarding the efficacy and safety of triple oral agents in patients inadequately controlled with dual therapy.In this clinical trial performed in 237 centers in China,5,535 type 2 diabetic patients inadequately controlled by previous therapies were treated with a stable metformin/sitagliptin dual therapy for 20 weeks.The patients who did not reach the glycated hemoglobin A1c(HbA1c) goal were then further randomized into glimepiride,gliclazide,repaglinide,or acarbose group for an additional 24-week triple therapy.A mean HbAlc reduction of 0.85%was observed when sitagliptin was added to the patients inadequately controlled with metformin in 16 weeks.Further HbAlc reductions in the 24-week triple therapy stage were 0.65%in glimepiride group,0.70%in gliclazide group,0.61%in repaglinide group,and 0.45%in acarbose group.The non-inferiority criterion for primary hypotheses was met for gliclazide and repaglinide,but not for acarbose,compared with glimepiride,when added to metformin/sitagliptin dual therapy.The incidences of adverse events(AEs) were 29.2%in the dual therapy stage and30.3%in the triple therapy stage.Metformin/sitagliptin as baseline therapy,with the addition of a third oral antihyperglycemic agent,including glimepiride,gliclazide,repaglinide,or acarbose,was effective,safe and well-tolerated for achieving an HbAlc<7.0%goal in type 2 diabetic patients inadequately controlled with previous therapies.The timely augmentation of up to three oral antihyperglycemic agents is valid and of important clinical benefit to prevent patients from exposure to unnecessarily prolonged hyperglycemia. | Wen Xu Yiming Mu Jiajun Zhao Dalong Zhu Qiuhe Ji Zhiguang Zhou Bin Yao Anhua Mao Samuel S.Engel Bin Zhao Yan Bi Longyi Zeng Xingwu Ran Juming Lu Linong Ji Wenying Yang Weiping Jia Jianping Weng | 2017 | Science China(Life Sciences)2017，60，3： | 19 |
| 4 | Determination of focal depth by two waveform-based methods:A case study for the 2008 Panzhihua earthquake显示文摘With the 2008 M S 6.1 Panzhihua earthquake as a case study,we demonstrate that the focal depth of the main shock can be well constrained with two approaches:(1) using the depth phase sPL and (2) using full waveform inversion of local and teleseismic data.We also show that focal depths can be well constrained using the depth phase sPL with single broadband seismic station.Our study indicates that the main shock is located at a depth of 11 km,much shallower than those from other studies,confirming that the earthquake occurs in upper crust.Aftershocks are located in the depth range of 11-16 km,which is consistent with a ruptured near vertical fault whose width is about 10 km,as expected for an M S 6.1 earthquake. | Zhenjie Wang Jiajun Chong Sidao Ni Barbara Romanowicz | 2011 | Earthquake Science2011，24，4： | 17 |
| 5 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
| 6 | Analysis of the global T_m–T_s correlation and establishment of the latitude-related linear model显示文摘In this study,the correlation between Tm,a key variable in GNSS water vapor inversion,and surface temperature(Ts)was calculated on a global scale based on the global geodetic observing system(GGOS)atmosphere Tmdata and European centre for medium-range weather forecasts(ECMWF)surface temperature data.The results show that their correlation is mainly affected by latitudes,and the correlation is stronger at high latitudes and weaker at low latitudes.Although the correlation is relatively weak in the tropic areas,the temperature changes so little in a year in these areas that we can still achieve good Tmresults by linear regression model.Based on these facts,‘‘GGOS atmosphere’’Tmdata and ECMWF Tsdata from 2005 to2011 were used to establish the global latitude-related linear regression model.The new model has root mean square error(RMSE)of 3.2,3.3,and 4.4 K,respectively,compared with respect to the‘‘GGOS atmosphere’’data,COSMIC data,and radiosonde data and is more accurate than the Bevis Tm–Tsrelationship. | Yibin Yao Bao Zhang Chaoqian Xu Jiajun Chen | 2014 | Chinese Science Bulletin2014，59，19： | 14 |
| 7 | Parameter Optimization of Interval Type-2 Fuzzy Neural Networks Based on PSO and BBBC Methods显示文摘Interval type-2 fuzzy neural networks(IT2FNNs)can be seen as the hybridization of interval type-2 fuzzy systems(IT2FSs) and neural networks(NNs). Thus, they naturally inherit the merits of both IT2 FSs and NNs. Although IT2 FNNs have more advantages in processing uncertain, incomplete, or imprecise information compared to their type-1 counterparts, a large number of parameters need to be tuned in the IT2 FNNs,which increases the difficulties of their design. In this paper,big bang-big crunch(BBBC) optimization and particle swarm optimization(PSO) are applied in the parameter optimization for Takagi-Sugeno-Kang(TSK) type IT2 FNNs. The employment of the BBBC and PSO strategies can eliminate the need of backpropagation computation. The computing problem is converted to a simple feed-forward IT2 FNNs learning. The adoption of the BBBC or the PSO will not only simplify the design of the IT2 FNNs, but will also increase identification accuracy when compared with present methods. The proposed optimization based strategies are tested with three types of interval type-2 fuzzy membership functions(IT2FMFs) and deployed on three typical identification models. Simulation results certify the effectiveness of the proposed parameter optimization methods for the IT2 FNNs. | Jiajun Wang Tufan Kumbasar | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，1： | 14 |
| 8 | Enhanced flushing of polychlorinated biphenyls contaminated sands using surfactant foam: Effect of partition coefficient and sweep efficiency显示文摘Foam flushing is an in situ soil remediation technology based on the traditional surfactant flushing method. The contribution of mobility control to contaminant removal by foam is helpful for improving this technology. Foam flushing of polychlorinated biphenyl (PCB)- contaminated unconsolidated media was performed to evaluate the effect of the partition coefficient (PC) and sweep efficiency (SE) on PCB removal. Column flushing with surfactant solution and foam with different types and concentrations of surfactant was carried out for PCB removal. Two types of quartz sand were investigated to evaluate the Jamin effect on the SE value of the washing agent. The results demonstrate that a small PC value and large SE value are necessary to achieve high PCB removal for foam flushing. Compared with solution flushing, the introduction of foam can effectively control the mobility of the washing agent. Similar to solution flushing, solubilization is a key factor which dominates the removal of PCBs in foam flushing. In addition, the SE value and PCB removal by foam flushing is less affected by particle size. Therefore, foam flushing was proved to be more effective in porous media with low hydraulic conductivity and high porosity. An integrated flushing with water, surfactant solution and foam was performed and the results prove that this technology successfully combines the advantages of solution solubilization and mobility control by foam, and thus further increases the remediation efficiency of PCBs to 94.7% for coarse sand. | Hao Wang Jiajun Chen | 2012 | Journal of Environmental Sciences2012，24，7： | 13 |
| 9 | The mechanism of astragaloside Ⅳ promoting sciatic nerve regeneration显示文摘3-O-beta-D-xylopyranosyl-6-O-beta-D-glucopyranosyl-cycloastragenol (astragaloside Ⅳ), the main active component of the traditional Chinese medicine astragalus membranaceus, has been shown to be neuroprotective. This study investigated whether astragaloside Ⅳ could promote the repair of injured sciatic nerve. Denervated sciatic nerve of mice was subjected to anastomosis. The mice were intraperitoneally injected with 10, 5, 2.5 mg/kg astragaloside Ⅳ per day for 8 consecutive days. Western blot assay and real-time PCR results demonstrated that growth-associated protein-43 expression was upregulated in mouse spinal cord segments L4-6 after intervention with 10, 5, 2.5 mg/kg astragaloside Ⅳ per day in a dose-dependent manner. Luxol fast blue staining and electrophysiological detection suggested that astragaloside Ⅳ elevated the number and diameter of myelinated nerve fibers, and simultaneously increased motor nerve conduction velocity and action potential amplitude in the sciatic nerve of mice. These results indicated that astragaloside Ⅳ contributed to sciatic nerve regeneration and functional recovery in mice. The mechanism underlying this effect may be associated with the upregulation of growth-associated protein-43 expression. | Xiaohong Zhang Jiajun Chen | 2013 | Neural Regeneration Research2013，8，24： | 13 |
| 10 | Formation mechanism of in-situ volcanic reservoirs in eastern China:A case study from Xushen gasfield in Songliao Basin显示文摘A large number of in-situ volcanic reservoirs have been discovered from the Meso-Cenozoic rift basin group in eastern China.Based on drilling results in combination with geological and geophysical analysis,a case study from the Early Cretaceous Xujiaweizi fault-depression shows that the formation mechanism of in-situ volcanic reservoirs is characterized by'fault-controlled body,body-controlled facies,facies-controlled reservoir,and reservoir-controlled accumulation'.In other words,deep faults control the volcanic eruption type,volcanic body,and gas reservoir distribution;the volcanic body determines the spatial distribution of volcanic facies and volcanic gas reservoir size;the volcanic facies control reservoir physical properties and effective thickness of gas formation;the volcanic reservoir properties control gas reservoir type and gas productivity.The result is useful to guiding the discovery of in-situ volcanic gas reservoirs in faulted basins in both theory and practice. | FENG ZiHui YIN ChangHai LIU JiaJun ZHU YingKang LU JiaMin LI JiangHai | 2014 | Science China Earth Sciences2014，57，12： | 12 |
| 11 | Coupled dynamic model of state estimation for hypersonic glide vehicle显示文摘Aiming at handling complicated maneuvers or other unpredicted emergencies for hypersonic glide vehicle tracking,three coupled dynamic models of state estimation based on the priori information between guidance variables and aerodynamics are presented. Firstly, the aerodynamic acceleration acting on the target is analyzed to reveal the essence of the target's motion.Then three coupled structures for modeling aerodynamic parameters are developed by different ideas: the spiral model with a harmonic oscillator, the bank model with trigonometric functions of the bank angle and the guide model with the changing rule of guidance variables. Meanwhile, the comparison discussion is concluded to show the novelty and advantage of these models.Finally, a performance assessment in different simulation cases is presented and detailed analysis is revealed. The results show that the proposed models perform excellent properties. Moreover, the guide model produces the best tracking performance and the bank model shows the second; however, the spiral model does not outperform the maneuvering reentry vehicle(MaRV) model markedly. | ZHANG Kai XIONG Jiajun FU Tingting | 2018 | Journal of Systems Engineering and Electronics2018，29，6： | 12 |
| 12 | The Efficacy of High-Intensity Focused Ultrasound (HIFU) in Advanced Pancreatic Cancer显示文摘OBJECTIVE To observe the efficacy of high-intensity focused ultrasound (HIFU) in the treatment of late-stage pancreatic cancer. METHODS Sixteen patients with advanced pancreatic cancer received HIFU therapy.Evaluation of efficacy was made on the basis of changes in clinical symptoms and variations in the tumor echo and size. RESULTS Clinical symptoms such as pain were significantly alleviated,echo of the tumor was enhanced with B-US and the quality of life such as eating,sleeping and mental status was markedly improved;no serious complications were observed. CONCLUSION The use of HIFU in the treatment of advanced pancreatic cancer is feasible and safe.It is effective in killing the carcinoma cells and alleviating pain.This technique may offer non-invasive therapy for the treatment of patients with late-stage pancreatic cancer. | Bo Xie Jiajun Ling Weiming Zhang Xueqin Huang Jihua Zhen Yanzhe Huang | 2008 | Chinese Journal of Clinical Oncology2008，5，3： | 12 |
| 13 | Analysis of Types and Changes of Village-level Economy in Rural Gongyi City, Henan Province Since 1990显示文摘Based on the research on the rural living standard in China in terms of annual net income per capita, we de-fine six types of village-level economy, i.e. 'to be extremely poor', 'to make a basic living', 'to dress warmly and eat one's fill', 'to try to enrich (to disengage poverty)', 'to be well-off' and 'to be affluent'. The data of average annual net income of all the 292 villages between 1990 and 2004 in rural Gongyi City, Henan Province were collected, veri-fied and classified. By using standard deviation, coefficient of variation and regression analysis, it is found that the Gongyi's rural economy has boosted up remarkably from the relative-poverty and absolute-poverty stages in 1990 to the well-off in 2004. However, the absolute differences between villages present a trend of enlargement, while the rela-tive differences fluctuating. On the other hand, spatial analysis of village-level economy shows that most villages with relatively high economic development level were located along national expressway and most villages with abso-lute-poverty lay in remote mountainous areas in 1990. Since the 1990s, the rapid urbanization and industrialization have had strongly positive effects on rural economic growth. Initial economic foundation, natural resources and tradi-tional techniques also contribute to village economy. From the perspective of geography, villages with location advan-tages, such as near urban center or industrial parks, have more chances for their economic development and the 'core-periphery' economic structure has been presented in the process of rural development. | QIAO Jiajun KONG Yunfeng LI Xiaojian | 2008 | Chinese Geographical Science2008，18，2： | 11 |
| 14 | Organic carbon accumulation capability of two typical tidal wetland soils in Chongming Dongtan,China显示文摘We measured organic carbon input and content of soil in two wetland areas of Chongming Dongtan(Yangtze River Estuary) to evaluate variability in organic carbon accumulation capability in different wetland soils.Observed differences were investigated based on the microbial activity and environmental factors of the soil at the two sites.Results showed that the organic carbon content of wetland soil vegetated with Phragmites australis(site A) was markedly lower than that with P.australis and Spartina alterniflora(site B).Sites differences were due to higher microbial activity at site A,which led to higher soil respiration intensity and greater carbon outputs.This indicated that the capability of organic carbon accumulation of the site B soils was greater than at site A.In addition,petroleum pollution and soil salinity were different in the two wetland soils.After bio-remediation,the soil petroleum pollution at site B was reduced to a similar level of site A.However,the culturable microbial biomass and enzyme activity in the remediated soils were also lower than at site A.These results indicated that greater petroleum pollution at site B did not markedly inhibit soil microbial activity.Therefore,differences in vegetation type and soil salinity were the primary factors responsible for the variation in microbial activity,organic carbon output and organic carbon accumulation capability between site A and site B. | Shiping Zhang Lei Wang Jiajun Hu Wenquan Zhang Xiaohua Fu Yiquan Le Fangming Jin | 2011 | Journal of Environmental Sciences2011，23，1： | 11 |
| 15 | Neural machine translation:Challenges,progress and future显示文摘Machine translation(MT)is a technique that leverages computers to translate human languages automatically.Nowadays,neural machine translation(NMT)which models direct mapping between source and target languages with deep neural networks has achieved a big breakthrough in translation performance and become the de facto paradigm of MT.This article makes a review of NMT framework,discusses the challenges in NMT,introduces some exciting recent progresses and finally looks forward to some potential future research trends. | ZHANG JiaJun ZONG ChengQing | 2020 | Science China(Technological Sciences)2020，63，10： | 10 |
| 16 | Methane emissions during storage of different treatments from cattle manure in Tianjin显示文摘Many studies on methane emissions from animal manure have revealed that animal manure is a major source of methane emissions to the atmosphere that can have negative consequences for people,animals and environment.In general,the release of methane can be influenced by the type of feed taken by animals,temperature,manure characteristics and so on.This study aimed at quantifying and comparing methane release from dairy manure with different piling treatments.Four treatments were designed including manure piling height 30,45,60 cm and adding 6 cm manure every day until the piling height was 60 cm.Static chamber method and gas chromatography were adopted to measure the methane emissions from April to June in 2009.Methane emission rates of all four manure treatments were low in the first week and then increased sharply until reaching the peak values.Subsequently,all the methane emission rates decreased and fluctuated within the steady range till the end of the experiment.Wilcoxon nonparametric tests analysis indicated that methane emission rate was greatly influenced by manure piling height and manner.There were no significant relationships between methane emission rates and the temperatures of ambience and heap.However,regression analysis showed that the quadratic equations were found between emission rates of all treatments and the gas temperature in the barrels. | Jiajun Wang Chiqing Duan Yaqin Ji Yichao Sun | 2010 | Journal of Environmental Sciences2010，22，10： | 10 |
| 17 | S and Pb Isotopic Constraints on the Relationship between the Linong Granodiorite and the Yangla Copper Deposit,Yunnan,China显示文摘The Yangla copper deposit, located in western Yunnan Province, China, is a typical giant, newly started mining copper deposit with an estimated Cu reserves of about 1,200,000 tons. The deposit is spatially and temporally associated with the Linong granodiorite, which is rich in SiO2 (SiO2=58.25 wt%-69.84 wt%) and alkalis (Na2O+K2O=5.98 wt%-8.34 wt%), indicating an association with shoshonitic series to high-K calc-alkaline series granites, and shows low contents of TiO2 (0.35 wt%-0.48 wt%), MgO (1.51 wt%-1.72 wt%), and Al2O3 (13.38 wt%-19.75 wt%). The δ34S values of sulfides of the main ore stage from copper ores vary range from ?4.2‰ to ?0.9‰, indicating a much greater contribution from the mantle to the ore-forming fluids. The δ34S values of the late ore stage is 9.8‰, indicating enrichment of biogenic sulfur which may derive from the crustal hydrothermal fluid. The 208Pb/204Pb, 207Pb/204Pb and 206Pb/204Pb of sulfides of the main ore stage from copper ores range within 38.66-38.73, 15.71-15.74 and 18.35-19.04, respectively, implying that the Pb was derived from the mantle, with the crustal component, probably representing mixtures of mantle lead and crustal lead. Sulfide of the late ore stage in their Pb isotopic composition, 208Pb/204Pb= 38.69, 207Pb/204Pb=15.70, 206Pb/204Pb=18.35, implying that the Pb was derived from the crust. The Linong granodiorite is syn-collisional, produced by partial melting of thickened lower crust, which was triggered by the westward subduction of the Jinshajiang Oceanic plate. During a transition in geodynamic setting from collision-related compression to extension, gently dipping ductile shear zones (related to subduction) were transformed to brittle shear zones, consisting of a series of thrust faults in the Jinshajiang tectonic belt. The tensional thrust faults would have been a favorable environment for ore-forming fluids. The ascending magma provided a channel for the ore-forming fluid from the mantle wedge. After the magma arrived at the base of the early-stage Linong granodiorite, the platy granodiorite at the base of the body would have shielded the late-stage magma from the fluid. The magma would have cooled slowly, and some of the ore-forming fluid in the magma would have entered the gently dipping thrust faults near the Linong granodiorite, resulting in mineralization. | YANG Xi'an LIU Jiajun HAN Siyu WANG Huan CHEN Siyao | 2012 | Acta Geologica Sinica(English Edition)2012，86，6： | 9 |
| 18 | A bottom-up strategy toward metal nano-particles modified graphene nanoplates for fabricating aluminum matrix composites and interface study显示文摘To synthesize graphene economically and efficiently,as well as to improve the interface bonding between graphene and metal and to recede the aggregation issue of graphene,in this work,an easy and scalable bottom-up strategy for the mass production of metal nanoparticles modified graphene nanoplates(GNPs)was proposed.Cu nanoparticles modified GNPs(Cu-GNPs)and Ni nanoparticles modified GNPs(Ni-GNPs)were fabricated through this method,and then compounded with Al via ball milling technique.The asobtained Ni-GNPs/Al composite showed simultaneously improved strength and toughness compared with unreinforced Al,while the Cu-GNPs/Al composite presented a greater strengthening effect.The microstructure and interface of the two composites were carefully characterized and investigated to reveal the difference.First principle study was also adopted to explore the binding energy of different interface structures.This study could provide new insights into the fabrication of GNPs and the control of interface in GNPs/Al composites. | Tielong Han Enzuo Liu Jiajun Li Naiqin Zhao Chunnian He | 2020 | Journal of Materials Science & Technology2020，42，11： | 8 |
| 19 | Compound Danshen tablets downregulate amyloid protein precursor mRNA expression in a transgenic cell model of Alzheimer's disease Effects and a comparison with donepezil显示文摘After gene mutation, the pcDNA3.1/APP595/596 plasmid was transfected into HEK293 cells to establish a cell model of Alzheimer's disease. The cell model was treated with donepezil or compound Danshen tablets after culture for 72 hours. Reverse transcription-PCR showed that the mRNA expression of amyloid protein precursor decreased in all groups following culture for 24 hours, and that there was no significant difference in the amount of decrease between donepezil and compound Danshen tablets. Our results suggest that compound Danshen tablets can reduce expression of the mRNA for amyloid protein precursor in a transgenic cell model of Alzheimer's disease, with similar effects to donepezil. | Ren'an Qin Desheng Zhou Jiajun Wang Hua Hu Yang Yang Xiaoxuan Yao Xiaopeng Sun | 2012 | Neural Regeneration Research2012，7，9： | 8 |
| 20 | Breaking and Repairing the Certificateless Key Agreement Protocol from ASIAN 2006显示文摘The certificateless authenticated key agreement proto-col proposed by Mandt et al does not have the property of key-compromise impersonation (K-CI) resilience. An improved protocol with a simple modification of their protocol is proposed in this paper. In particular,our improved protocol is proved to be immune to the K-CI attack and at the same time possess other security properties. | XIA Liang WANG Shengbao SHEN Jiajun XU Guoming | 2008 | Wuhan University Journal of Natural Sciences2008，13，5： | 8 |
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