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| 1 | Improved skin regeneration with acellular fish skin grafts显示文摘Fish skin graft,a novel skin substitute,has seen a widespread clinical application since the approval for wound coverage by the FDA.Due to its properties in promoting wound healing and its efficient cost in manufacturing,fish skin grafts are a potential alternative to allograft and xenograft sources including,but not limited to cadaver and porcine grafts in a variety of applications.Additionally,fish skin grafts show promising results in treating diabetic foot ulcers(DFUs),venous leg ulcers(VLUs)and some evidence worthy of further exploration in treating a host of other acute and chronic wounds.Here we summarize the material and biological properties of fish skin grafts.How this graft compares to other prevailing skin substitutes on the market for different wound types was also explored.Fish skin grafts have many uses in clinical applications of the future. | Gabriella Fiakos Zeming Kuang Evan Lo | 2020 | Engineered Regeneration2020，1，1： | 2 |
| 2 | Mechanical and antibacterial properties of tannic acid-encapsulated carboxymethyl chitosan/polyvinyl alcohol hydrogels显示文摘The objective of this study was to develop an effective,potential wound dressing,which was constructed with a composite hydrogel of poly(vinyl alcohol)(PVA),carboxymethyl chitosan(CMC)and tannic acid(TA)by cryogenic treatment and freeze-drying method.The as-prepared TA-crosslinked PVA/CMC hydrogels exhibited interconnected pore structure with the mean pore size of roughly 3.7��m.We found that the compressive strength and stiffness of composite hydrogel increased when the TA component was introduced.However,the PVA/CMC-TA hydrogel possessed obviously lower swell property than that of the TA-free PVA/CMC hydrogel.We also found that the TA addition significantly improved the antibacterial capacity of the as-prepared hydrogel.Moreover,the inhibition zone test showed that the antibacterial activity of PVA/CMC-TA against S.aureus bacteria was greater than that against E.coli.The biological results indicated that the PVA/CMC-TA hydrogel exhibited good cytocompatibility to natural human dermal fibroblasts.In summary,our PVA/CMC-TA composite hydrogel exhibited promising mechanical and antibacterial properties,which showed great potential application as wound healing materials. | Xiaofan Feng Xiuling Hou Congjing Cui Shibin Sun Sahiya Sadik Shaohua Wu Fang Zhou | 2021 | Engineered Regeneration2021，2，1： | 2 |
| 3 | Living Materials for Regenerative Medicine显示文摘Regenerative medicine has been attracting tremendous attention during the past few decades because it is promising in overcoming the limitations of donor shortage and immune complications in direct transplantations.The ongoing progress in this field calls for the rapid growth of living materials,which consist of live biological agents and can be designed together with synthetic materials to meet the application demands of regenerative medicine.In this review,we present a summary of the state-of-the-art progress of living materials that are applied in regenerative medicine.We first introduce the advanced engineering approaches that are employed to prepare living materials containing live cells,typically including genetic engineering,cell coating,microfluidics,and bioprinting,etc.Afterwards,we enumerate different application aspects of living materials in regenerative medicine,including tissue scaffold,cell therapy,tissue models,and so on.Finally,we give a concise conclusion and provide a perspective of this field. | Yunru Yu Qiao Wang Chong Wang Luoran Shang | 2021 | Engineered Regeneration2021，2，1： | 2 |
| 4 | Designing bioactive micro-/nanomotors for engineered regeneration显示文摘Micro/nanoscale motors(MNMs)have been regarded as promising tools in the field of engineered regeneration due to unique property of autonomous motion.Herein,a review on the advancements of MNMs in the area of engineered regeneration is presented,covering aspects from their propulsion mechanisms to their frontiers in engineered regeneration,listing the revolutionary applications in biosensing,medical imaging,drug delivery and tissue engineering.Finally,challenges and future directions of MNMs are finally discussed on the basis of the achievements. | Lijun Cai Dongyu Xu Hanxu Chen Li Wang Yuanjin Zhao | 2021 | Engineered Regeneration2021，2，1： | 2 |
| 5 | Living cell for drug delivery显示文摘The living cells have been emerged as useful platforms for drug delivery due to their advantages of good liquidity,stability,and low immunogenicity.In this review,we summarized the development of living cells-based drug delivery systems.The drug loading methods,applications,and advantages of living cell drug delivery systems were summarized.Different living cells for drug delivery,the mechanisms of action,therapeutic applications,as well as main features were summarized and highlighted.The recent research progress and challenges were discussed.The future directions and prospects were proposed. | Yuwei Wu Yanfei Liu Ting Wang Qiao Jiang Feng Xu Zhenbao Liu | 2022 | Engineered Regeneration2022，3，2： | 1 |
| 6 | Driving modes and characteristics of biomedical micro-robots显示文摘Micro-robots(MRs)are miniature machines with dimensions smaller than 1 mm and have semior fully-autonomous capabilities,including sensing,decision-making,and performing operations.These MRs have garnered significant attention in the precision medicine and personalized treatment field due to their ability to navigate narrow areas of the human body with non-desirable fluid flow.Specifically,MRs are actuated by a mechanism that generates propulsive force through the interaction between MRs’actuation modules and external energy sources in a specific direction.This driving mechanism enables the precise execution of medical treatment such as targeted drug delivery and minimally invasive surgeries.Nonetheless,MRs currently encounter certain challenges in clinical practice,including reliance on external energy sources,short lifespan,and difficulties in degradation or recovery within the human body.This article aims to review the common components and characteristics of driving mechanism for MRs’actuation modules,propose possible solutions to address current clinical challenges,and ultimately,explore the desirable structural and functional composition for the future development of MRs.Through these efforts,this review hopes to provide guidance for the future development of MRs in the field of precision medicine. | Libing Huang Yueyuan Pan Miao Wang Lei Ren | 2023 | Engineered Regeneration2023，4，4： | 1 |
| 7 | Acoustofluidics for cell patterning and tissue engineering显示文摘Acoustofluidics has been a promising approach using sound waves to manipulate particles and actuate fluids in biomedical applications.It usually generates acoustic radiation force and acoustic streaming to initiate diffraction,reflection and interference,building up a pressure distribution to facilitate accurate manipulation of micro-or nano-scale particles and fluids.Owing to its remarkable contact-free and biocompatible advantages,acoustoflu-idics has been used in high-throughput cell analysis,size-controllable organoid structures,and functional tissue mimics.We enumerate the basic concepts and the sufficient research of acoustofluidics in precise patterning and tissue engineering in this review,including the design and function of four typical acoustofluidic devices,var-ious forms of cell patterning and 3D tissue engineering.Meanwhile,we outlined current challenges and future directions of acoustofluidics in biomedicine and tissue engineering. | Zhuhao Wu Meidie Pan Jinglin Wang Baojie Wen Ling Lu Haozhen Ren | 2022 | Engineered Regeneration2022，3，4： | 1 |
| 8 | Current developments in biofilm treatments:Wound and implant infections显示文摘Biofilm formation in wounds and implants can have numerous negative effects on a patient’s health,including delayed healing and implant removal.Current treatments for biofilms do not completely eradicate microbial colonies or prevent their formation,implying the need for further investigation.Recent research into treatments for wound and implant biofilm infections focus on nanotechnology-based mechanisms for drug delivery,com-bined therapies,and implant modifications.Ultrasound debridement and hydrogels,and new developments in implant modifications possess great potential for application in wound and implant treatments respectively.The aim of this review is to summarize recent developments in biofilm treatments and to understand the direction of current research. | Yosman Dhar Yangha Han | 2020 | Engineered Regeneration2020，1，1： | 1 |
| 9 | An Overview on Materials and Techniques in 3D Bioprinting Toward Biomedical Application显示文摘Three-dimensional(3D)bioprinting,an additive manufacturing based technique of biomaterials fabrication,is an innovative and auspicious strategy in medical and pharmaceutical fields.The ability of producing regenerative tissues and organs has made this technology a pioneer to the creation of artificial multi-cellular tissues/organs.A broad variety of biomaterials is currently being utilized in 3D bioprinting as well as multiple techniques employed by researchers.In this review,we demonstrate the most common and novel biomaterials in 3D bioprinting technology further with introducing the related techniques that are commonly taking into account by researchers.In addition,an attempt has been accomplished to hand over the most relevant application of 3D bioprinting techniques such as tissue regeneration,cancer investigations,etc.by presenting the most important works.The main aim of this review paper is to emphasis on strengths and limitations of existence biomaterials and 3D bioprinting techniques in order to carry out a comparison through them. | S.Vanaei M.S.Parizi S.Vanaei F.Salemizadehparizi H.R.Vanaei | 2021 | Engineered Regeneration2021，2，1： | 1 |
| 10 | Orthopedic implants and devices for bone fractures and defects:Past,present and perspective显示文摘Bone is a unique tissue that is capable of repairing itself after damage.However,there are certain instances of fractures and defects that require clinical intervention for proper alignment and healing.As with any implant,careful consideration of the material used to create the implants to treat these problems is needed.If the incorrect material is chosen,the implants themselves can lead to bone fractures or defects,or bone healing may not take place at all.All three classes of biomaterials-metals,ceramics,and polymers-have been used in the treatment of both bone fractures and bone defects,and each has its own unique benefits and limitations for its applications.Furthermore,composites of these different materials have also been created to try to take advantage of all the different benefits offered by each different material.This review highlights different materials that have been used for the development of internal fixators and bone graft substitutes to treat fracture and bone defects as well as their limitations and needed future research. | Tiffany Kim Carmine Wang See Xiaochun Li Donghui Zhu | 2020 | Engineered Regeneration2020，1，1： | 1 |
| 11 | Breathable,stretchable and adhesive nanofibrous hydrogels as wound dressing materials显示文摘In spite of the great progress of wound healing materials,the development of dressing with moisture permeabil-ity,stretchable capability,and adhesive performance remains a huge challenge.In this study,gelatin-dopamine(GT-DA)nanofiber membrane was prepared by introducing dopamine(DA)into gelatin(GT)via electrospinning followed by in-situ reaction.The effects of DA dosage,crosslinking condition and crosslinking time on the mechanical properties of the fiber membrane were studied systematically.The resultant GT-DA nanofibrous hydrogels exhibited integrated stress strength of 1.96 MPa,good water absorption of 700%,and water vapor transmission(WVT:4.3 kg m^(-2)d^(-1)),which were superior than those of Mepiform■,a commercial adhesive silicone dressing.In addition,Fe^(3+)were introduced into one side of the nanofiber membrane.A stronger adhesion strength of 2.5 KPa on the porcine skin,which was 1.6 times higher than that of Mepiform■was achieved.Our research showed that the prepared nanofibrous hydrogel has potential as wound dressing and could be used in post-traumatic tissue healing engineering.This work presented a type of breathable,stretchable and adhesive nanofibrous hydrogels,which would ensure the stable attachment on wounds during movement as a wound healing material. | Xueting Liu Yumin Liu Jingtao Du Xiaoran Li Jianyong Yu Bin Ding | 2021 | Engineered Regeneration2021，2，1： | 1 |
| 12 | Oral biomaterials for intestinal regulation显示文摘Intestinal diseases have always been a highly focused concern since recorded.Although endless efforts have been devoted,the underlying pathogenesis of alimentary canal disease remains mysterious and effective therapies are still in development.Intriguingly,the emerging of biomedical engineering has sprung up to unveil the enigmas of alimentary canal diseases,thus ameliorating the therapies and relieving the sufferings of patients.In this review,we present a comprehensive and deep-going perception into therapies of digestive disease with the assistance of biomaterials,involving the constructions of biomaterials and their mechanisms in digestive disease therapy.This review aims at conveying fundamentals of biomaterials in treating alimentary canal diseases,a critical analysis of their current applications and challenges,and a perspective on their future development.It is believed that this review will facilitate the communications between material science and medical fields. | Cheng Zhao Lijun Cai Hanxu Chen Hui Tan Dewen Yan | 2021 | Engineered Regeneration2021，2，1： | 1 |
| 13 | 3D bioprinting of cell-laden constructs for regenerative medicine显示文摘Human tissue consists of various tissue-specific cells,extracellular matrix components and microstructures,and growth factors.With promising multi-cell and multi-material integration manufacturing feature,3D extrusion bioprinting has shown outstanding application potential in the field of regenerative medicine.For functional tissue regeneration,bioprinted constructs not only play the role of a cell-delivery system,but also serve as an important host niche for cell proliferation and work.In order to meet the specific requirements of different tissue regeneration,development of bio-inks that provide tissue-specific biophysical cues and biochemical microenvironments is an important research topic.Furthermore,reconstruction of tissues with anisotropic structure,such as articular cartilage and meniscus,largely depend on the design of 3D bioprinting path for accurate arrangement of specific bio-inks.This review summarizes the advanced designs of tissue-specific 3D bioprinting of cell-laden constructs for functional regeneration of skeletal and locomotor systems such as bone,cartilage,skeletal muscle,and blood vessels via the collaboration of bio-ink and printing processes.It may provide a basis for synergistic design for functional regenerative constructs bioprinting in the future. | Cuidi Li Wenguo Cui | 2021 | Engineered Regeneration2021，2，1： | 1 |
| 14 | Mechanical performance and cyocompatibility of PU/PLCL nanofibrous electrospun scaffolds for skin regeneration显示文摘Skin tissue engineering with considerable skin regeneration capability is an urgent need for the wound site.The current challenge for researchers is to develop a bionic scaffold that imitates the extracellular matrix for the regeneration of the damaged regions.In our study,poly(L-lactide-co-caprolactone)(PLCL)was blended with polyurethane(PU)to obtain nanofibrous scaffolds via electrospinning.The electrospun fibers with 50%PLCL content had a certain number of intersections and jointing points,and exhibited significantly enhanced mechani-cal properties combined with suitable porosity.Moreover,cell activities demonstrated that PU/PLCL membranes had significantly biological advantages in enhanced growth of human skin fibroblasts with spreading morphology compared with PU membranes,indicating good cytocompatibility of composite scaffolds.These findings proved that PU/PLCL electrospun membranes have great potential in applications of skin tissue engineering. | Xiang Gao Meiling Wen Yang Liu Tian Hou Meiwen An | 2022 | Engineered Regeneration2022，3，1： | 1 |
| 15 | Natural Biopolymers for Bone Tissue Engineering:A Brief Review显示文摘Tissue engineering is a well-proven technique for the creation of functional alternatives for regenerative medicine and plays a critical role in patient treatment.Several natural-origin biopolymers such as chitosan,hyaluronic acid,gelatin,collagen,etc.are extensively explored for various biomedical applications.Among,these polymers are exclusively investigated in tissue engineering applications due to their highly favorable properties,such as high biocompatibility,slow degradation,mechanical tenability,structural similarity with native tissues,bioactivity,etc.The present review summarizes the recent advances of biopolymers in bone tissue engineering It also covers the topic of natural polymer modification to achieve superior characteristics primarily mechanical properties towards bone regeneration and discussed the best methods for dealing with them.Therefore,the review can drive the development of biomimetic materials for futuristic applications. | Sheersha Pramanik Shubham Kharche Namdev More Deepak Ranglani Gajendra Singh Govinda Kapusetti | 2023 | Engineered Regeneration2023，4，2： | 0 |
| 16 | X-reality for phantom limb management for amputees:A systematic review and meta-analysis显示文摘Phantom limb is a disabling neuropsychiatric condition among amputees resulting in pain and disturbance that impact their functions,quality of life,and autonomy.While pharmacological approaches appeared to be ineffec-tive,the emergence and integration of X-reality,including virtual reality,augmented reality,and mixed reality,might elevate the effectiveness of mirror therapy in managing phantom limb.The objective of this study is to review X-reality for managing phantom pain.A systematic search was conducted on PubMed,Scopus,Web of Science,PsycINFO,Embase,and CINAHL.Sixteen(n=16)studies containing 66 lower-limb and 53 upper-limb amputees were included for the review over the thematic framework of amputee characteristics and intervention designs,while thirteen(n=13)studies were further proceeded for the meta-analysis.We found eleven studies on virtual reality(n=11),four studies on marker-based augmented reality(n=4)and one study on mixed reality(n=1)with a total of 40 game/task themes involving,motor skills,motor control,and stimulus-sensing.Regardless,all these interventions adopted the movement representation strategies with different techniques.Overall,the X-reality interventions reduced the pain level of the amputees(mean difference:-2.30,95%CI,-3.38 to-1.22),especially the virtual reality subgroup(mean difference:-2.83,95%CI,-4.43 to-1.22).However,there were substantial heterogeneity and partially explained by the subgroup analysis on publication year.The strength of evidence was limited by case reports and case series in this review. | James Chung-Wai Cheung Daphne Sze Ki Cheung Ming Ni Kam-Wai Chen Ye-Jiao Mao Lin Feng Wing-Kai Lam Duo Wai-Chi Wong Aaron Kam-Lun Leung | 2023 | Engineered Regeneration2023，4，2： | 0 |
| 17 | Biomimetic selenium nanosystems for infectious wound healing显示文摘Bacteria-related wound infection and healing have been a major issue for patients and health-care systems for decades.The rise and evolution of effective treatment will result in significant benefits to human beings.In ad-dition to standard antibacterial drugs,a combination of nanoparticles(NPs)and biological membranes is widely applied as a novel antibacterial agent against infectious pathogens.In this paper,the red blood cell membrane-encapsulated selenium nanoparticles(R-SeNPs)were fabricated for infectious wound healing.The stability,the immune evading capability,and the internal circulation time of the R-SeNPs were notably enhanced compared with those of bare selenium nanoparticles(SeNPs).Moreover,in vivo studies demonstrated the outstanding per-formance of the R-SeNPs in infectious wound healing.The biomimetic selenium nanosystem demonstrated the benefits of the combination of nanotechnology and bionics design and will contribute to wound healing in the future. | Mengkun Fang Han Zhang Yuze Wang Hui Zhang Dagan Zhang Peipei Xu | 2023 | Engineered Regeneration2023，4，2： | 0 |
| 18 | Treatment of Alzheimer’s disease by microcapsule regulates neurotransmitter release via microfluidic technology显示文摘Alzheimer’s disease(AD)is a progressive neurodegenerative disease with a complex etiology.The main neu-ropathological feature is the accumulation of amyloid-beta(Aβ),and the dysregulation of the cholinergic system is well associated with its mechanism of occurrence,for which no effective treatment is yet available.Daily oral administration remains the mainstay of treatment with AD,and how to improve the efficacy,prolong adsorp-tion and medication compliance is still the focus of the current solution.We proposed a microcapsule based on microfluidic electrospray to form an intestinal epithelial lining for AD treatment,reducing the frequency of administration.Microfluidic electrospray technology was recruited to overcome the limitations associated with the variability in the microencapsulation production process and to produce functional microcapsules with finely adapted chemical composition,capsule thickness and encapsulant volume ratio.These microcapsules could slowly release drugs after adhering to the intestine,and their effectiveness and safety were further evaluated using cell culture studies and animal model studies.The results from the in vivo and in vitro experiments showed a significant reduction in administration frequency(i.e.,from daily medication to once every five days),superior therapeutic efficacy and sufficient safety of these microcapsules in cell culture and APP/PS1 mice.These features make the microcapsules an excellent drug delivery system and represent great potential for clinical applications in AD. | Weina Yao Junyi Che Cheng Zhao Xiao Zhang Huijuan Zhou Feng Bai | 2023 | Engineered Regeneration2023，4，2： | 0 |
| 19 | Structure and mechanics of native and decellularized porcine cranial dura mater显示文摘The dura mater is the outermost layer of meninges and consists of a dense elastic membrane that keeps cere-brospinal fluid inside the cavity.In most cranial surgical interventions,the dura mater is incised and needs to be repaired with a graft replacement.We assessed decellularized porcine dura mater as a novel graft material by quantifying the mechanical and structural properties of the dura membrane.Porcine dura mater was decellular-ized using the Sodium Dodecyl Sulfate(SDS)technique and subjected to uniaxial tensile testing,micro indentation testing,histological analysis,and Transmission Electron Microscopy(TEM).For native dura,we found the tensile modulus in the linear region(15%-25%strain)to be 19.31±1.23 MPa,with an initial tensile modulus(0%-3.5%strain range)of 451±0.30 kPa,and the failure stress as 4.61±1.50 MPa at 35%strain.For decellularized dura,the tensile modulus in the linear region was 10.81±0.88 MPa,the initial tensile modulus was 226±22 kPa,and the failure stress was 4.55±1.05 MPa at 55%strain.The effective compressive modulus was 7 to 19 kPa and 19-57 kPa for the native dura and the decellularized dura,respectively.Our histological and TEM observations showed that the orientation of fibers within the dura was maintained after decellularization.In short,our study demonstrated that decellularized porcine dura was able to maintain its overall morphological/structural integrity and preserve the native dura’s mechanical behavior,which provides a solid foundation for its use as a functional grafting material. | Ashma Sharma Jun Liao Lakiesha N.Williams | 2023 | Engineered Regeneration2023，4，2： | 0 |
| 20 | Conductive PS inverse opals for regulating proliferation and differentiation of neural stem cells显示文摘The development of neural tissue engineering has brought new hope to the treatment of spinal cord injury(SCI).Up to date,various scaffolds have been developed to induce the oriented growth and arrangement of nerves to facilitate the repair after injury.In this work,a conductive and anisotropic inverse opal substrate was presented by modifying polystyrene(PS)inverse opal films with carbon nanotubes and then stretching them to varying degrees.The film had good biocompatibility,and neural stem cells(NSCs)grown on the film displayed good orientation along the stretching direction.In addition,benefiting from the conductivity and anisotropy of the film,NSCs differentiated into neurons significantly.These results suggest that the conductive and anisotropic PS inverse opal substrates possess value in nerve tissue engineering regeneration. | Yangnan Hu Han Zhang Hao Wei Menghui Liao Xiaoyan Chen Jiayue Xing Lian Duan Cuntu Cheng Weicheng Lu Xuechun Yang Peina Wu Huan Wang Jingdun Xie Renjie Chai | 2023 | Engineered Regeneration2023，4，2： | 0 |
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