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| 1 | 植物表型组学:发展、现状与挑战显示文摘随着遥感、机器人技术、计算机视觉和人工智能的发展,植物表型组学研究已经步入了快速成长阶段。本文首先介绍了植物表型组学的发展简史,包括其理论核心、研究方法、在生物研究中的应用以及国际上最新的研究动向。然后,针对各类表型技术载体平台如手持、人载、车载、田间实时监控、大型室内外自动化平台和航空机载等,分析这些技术手段在室内、外植物研究中的应用情况和实际问题。为了对表型研究中产生的巨量图像和传感器数据进行量化分析,把大数据转化为有实际意义的性状信息和生物学知识,本文着重讨论了后期表型数据解析和相应的研发过程。最后,提出表型组学的应用前景与未来展望,以期为中国的表型研究提供指导和建议。 | 周济 Francois Tardieu Tony Pridmore John Doonan Daniel Reynolds Neil Hall Simon Griffiths 程涛 朱艳 王秀娥 姜东 丁艳锋 | 2018 | 南京农业大学学报2018，41，4： | 64 |
| 2 | Robotic surgery for rectal cancer: A systematic review of current practice显示文摘AIM: To give a comprehensive review of current litera-ture on robotic rectal cancer surgery.METHODS: A systematic review of current literature via PubMed and Embase search engines was per-formed to identify relevant articles from january 2007 to november 2013. The keywords used were: 'robotic surgery', 'surgical robotics', 'laparoscopic computer-assisted surgery', 'colectomy' and 'rectal resection'. RESULTS: After the initial screen of 380 articles, 20 pa-pers were selected for review. A total of 1062 patients(male 64.0%) with a mean age of 61.1 years and body mass index of 24.9 kg/m2 were included in the review.Out of 1062 robotic-assisted operations, 831(78.2%) anterior and low anterior resections, 132(12.4%) in-tersphincteric resection with coloanal anastomosis, 98(9.3%) abdominoperineal resections and 1(0.1%) Hart-mann's operation were included in the review. Robotic rectal surgery was associated with longer operative time but with comparable oncological results and anastomotic leak rate when compared with laparoscopic rectal surgery. CONCLUSION: Robotic colorectal surgery has con-tinued to evolve to its current state with promising re-sults; feasible surgical option with low conversion rate and comparable short-term oncological results. The challenges faced with robotic surgery are for more high quality studies to justify its cost. | Tony Wing Chung Mak Janet Fung Yee Lee Kaori Futaba Sophie Sok Fei Hon Dennis Kwok Yu Ngo Simon Siu Man Ng | 2014 | World Journal of Gastrointestinal Oncology2014，6，6： | 16 |
| 3 | Quality of life after laparoscopic vs open sphincter-preserving resection for rectal cancer显示文摘AIM: To compare quality of life (QoL) outcomes in Chinese patients after curative laparoscopic vs open surgery for rectal cancer. METHODS: Eligible Chinese patients with rectal cancer undergoing curative laparoscopic or open sphincterpreserving resection between July 2006 and July 2008 were enrolled in this prospective study. The QoL outcomes were assessed longitudinally using the validated Chinese versions of the European Organization for Research and Treatment of Cancer QLQ-C30 and QLQCR38 questionnaires before surgery and at 4, 8, and 12 mo after surgery. The QoL scores at the different time points were compared between the laparoscopic and open groups. A higher score on a functional scale indicated better functioning, whereas a higher score on a symptom scale indicated a higher degree of symptoms.RESULTS: Seventy-four patients (49 laparoscopic and 25 open) were enrolled. The two groups of patients were comparable in terms of sociodemographic data, types of surgery, tumor staging, and baseline mean QoL scores. There was no significant decrease from baseline in global QoL for the laparoscopic group at different time points, whereas the global QoL was worse compared to baseline beginning at 4 mo but returned to baseline by 12 mo for the open group (P = 0.019, Friedman test). Compared to the open group, the laparoscopic group had significantly better physical (89.9±1.4 vs 79.2±3.7, P = 0.016), role (85.0±3.4 vs 63.3±6.9, P = 0.005), and cognitive (73.5±3.4 vs 50.7±6.2, P = 0.002) functioning at 8 mo, fewer micturition problems at 4-8 mo (4 mo: 32.3±4.7 vs 54.7±7.1, P = 0.011; 8 mo: 22.8±4.0 vs 40.7±6.9, P = 0.020), and fewer male sexual problems from 8 mo onward (20.0±8.5 vs 76.7±14.5, P = 0.013). At 12 mo after surgery, no significant differences were observed in any functional or symptom scale between the two groups, with the exception of male sexual problems, which remained worse in the open group (29.2±11.3 vs 80.0±9.7, P = 0.026). CONCLUSION: Laparoscopic sphincter-preserving resection for rectal cancer is associated with better preservation of QoL and fewer male sexual problems when compared with open surgery in Chinese patients. These findings, however, should be interpreted with caution because of the small sample size of the study. | Simon Siu-Man Ng Wing-Wa Leung Cherry Yee-Ni Wong Sophie Sok-Fei Hon Tony Wing-Chung Mak Dennis KwokYu Ngo Janet Fung-Yee Lee | 2013 | World Journal of Gastroenterology2013，19，29： | 6 |
| 4 | Flow Field and Performance of Cross Flow Fans——Experimental and Theoretical Investigations显示文摘Due to the construction and the operaling principle the prediction of performance of Cross Flow Fans (CFF) is difficult and the knowledge about the internal flow regime is limited. To investigate the impact of geometrical parameters on the performance of CFF, experimental investigations, using Particle Imaging Velocimetry (PIV),and CFD calculations were carried out. Some results of PIV measurements and CFD calculations are presented,which give an impression of the internal flow and confirm the numerical calculations. | Martin Gabi Simon Dornstetter Toni Klemm | 2003 | Journal of Thermal Science2003，12，3： | 3 |
| 5 | Optimum Lymphadenectomy for Esophageal Cancer显示文摘 | Nabil P. Rizk Hemant Ishwaran Thomas W. Rice Long-Qi Chen Paul H. Schipper Kenneth A. Kesler Simon Law Toni E. M. R. Lerut Carolyn E. Reed Jarmo A. Salo Walter J. Scott Wayne L. Hofstetter Thomas J. Watson Mark S. Allen Valerie W. Rusch Eugene H. Blacksto | 2010 | Annals of Surgery2010，，1： | 2 |
| 6 | Motivating hotel employees 显示文摘 | Simons Tony | 1995 | The Comell Hotel and Restaurant Administration Quarterly1995，36，1： | 1 |
| 7 | Predicting Systemic Disease in Patients With Esophageal Cancer After Esophagectomy: A Multinational Study on the Significance of the Number of Involved Lymph Nodes显示文摘 | Christian G. Peyre Jeffrey A. Hagen Steven R. DeMeester Jan J. B. Van Lanschot Arnulf H?lscher Simon Law Alberto Ruol Ermanno Ancona S Michael Griffin Nasser K. Altorki Thomas W. Rice John Wong Toni Lerut Tom R. DeMeester | 2008 | Annals of Surgery2008，，6： | 1 |
| 8 | Endoscopic submucosal dissection vs laparoscopic colorectal resection for early colorectal epithelial neoplasia显示文摘AIM: To compare the short term outcome of endoscopic submucosal dissection(ESD) with that of laparoscopic colorectal resection(LC) for the treatment of early colorectal epithelial neoplasms that are not amenable to conventional endoscopic removal. METHODS: This was a retrospective cohort study. The clinical data of all consecutive patients who underwent ESD for endoscopically assessed benign lesions that were larger than 2 cm in diameter from 2009 to 2013 were collected. These patients were compared with a cohort of controls who underwent LC from 2005 to 2013. Lesions that were proven to be malignant by initial endoscopic biopsies were excluded. Mid and lower rectal lesions were not included because total mesorectal excision, which bears a more complicated postoperative course, is not indicated for lesions without histological proof of malignancy. Both ESD and LC were performed by the same surgical unit with a standardized technique. The patients were managed according to a standard protocol, and they were closely monitored for complications after the procedures. All hospital records were reviewed, and the following data were compared between the ESD and LC groups: patient demographics, size and location of the lesions, procedure time, shortterm clinical outcomes and pathology results. RESULTS: From 2005 to 2013, 65 patients who underwent ESD and 55 patients who underwent LC were included in this study. The two groups were similar in terms of sex(P = 0.41) and American Society of Anesthesiologist class(P = 0.58), although patients in the ESD group were slightly older(68.6 ± 9.4 vs 64.6 ± 9.9, P = 0.03). ESD could be accomplished with a shorter procedure time(113 ± 66 min vs 153 ± 43 min, P < 0.01) for lesions of comparable size(3.0 ± 1.2 cm vs 3.4 ± 1.4 cm, P = 0.22) and location(colon/rectum:59/6 vs colon/rectum: 52/3, P = 0.43). ESD appeared to be associated with a lower short-term complication rate, but the difference did not reach statistical significance(10.8% vs 23.6%, P = 0.06). In the LC arm, a total of 22 complications occurred in 13 patients. A total of 7 complications occurred in the ESD arm, including 5 perforations and 2 episodes of bleeding. All perforations were observed during the procedure and were successfully managed by endoscopic clipping without emergency surgical intervention. Patients in the ESD arm had a faster recovery than patients in the LC arm, which included shorter time to resume normal diet(2 d vs 4 d, P = 0.01) and a shorter hospital stay(3 d vs 6 d, P < 0.01). CONCLUSION: ESD showed better short-term clinical outcomes in this study. Further prospective randomized studies will be required to evaluate the efficacy and superiority of colorectal ESD over LC. | Sophie SF Hon Simon SM Ng Tiffany CL Wong Philip WY Chiu Tony WC Mak WW Leung Janet FY Lee | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，17： | 1 |
| 9 | Laparoscopic-assisted versus open total mesorectal excision with anal sphincter preservation for mid and low rectal cancer: a prospective, randomized trial显示文摘 | Simon S. M. Ng Janet F. Y. Lee Raymond Y. C. Yiu Jimmy C. M. Li Sophie S. F. Hon Tony W. C. Mak Dennis K. Y. Ngo Wing Wa Leung Ka Lau Leung | 2014 | Surgical Endoscopy2014，，1： | 1 |
| 10 | Poly ( DEAEMa-co- PEGMa): a new pH-responsive comb copolymer stabilizer for emulsions and dispersions显示文摘 | Sheikh Shahalom Tony Tong Simon Emmett | 2006 | Langmuir2006，22，20： | 1 |
| 11 | Electroacupuncture Reduces Duration of Postoperative Ileus After Laparoscopic Surgery for Colorectal Cancer显示文摘 | Simon S.M. Ng Wing Wa Leung Tony W.C. Mak Sophie S.F. Hon Jimmy C.M. Li Cherry Y.N. Wong Kelvin K.F. Tsoi Janet F.Y. Lee | 2012 | Gastroenterology2012，，： | 1 |
| 12 | Imaging proteins in vivo using fluorescence lifetime microscopy显示文摘 | Frederic Festy Simon M Ameer-Beg Tony Ng | | 0，，06： | 1 |
| 13 | Does the measurement of dispersion matter in multilevel research 显示文摘 | Roberson Quinetta M Micheal C Sturman and Simons Tony L | 2007 | Organizational Research Methods2007，10，4： | 1 |
| 14 | Asthma-associated polymorphisms in 17q12-21 locus modulate methylation and gene expression of GSDMA in naive CD4^+ T cells显示文摘The 17q12-21 locus harboring ORMDL sphingolipid biosynthesis regulator 3(ORMDL3)and Gasdermin B(GSDMB)genes exhibits one of the most significant and replicated associations with asthma[MIM:600807](Stein et al.,2018).Several studies explored the complex interactions between SNPs,gene expression and epigenetic modifications at this locus,primarily focusing on the levels of expressed ORMDL3 and GSDMB(Stein et al.,2018).Given that DNA methylation and gene expression signals are cell-type specific(Reinius et al.,2012),isolated materials such as lymphocytes from blood and,to a lesser extent,bronchial epithelial cells from biopsies of bronchi or bronchoalveolar lavages have been used in a number of studies to investigate such interactions(Stein et al.,2018). | Anne-Marie Madore Lucile Pain Anne-Marie Boucher-Lafleur Andréanne Morin Jolyane Meloche Marie-Michelle Simon Bing Ge Tony Kwan Warren A.Cheung Tomi Pastinen Catherine Laprise | 2020 | Journal of Genetics and Genomics2020，47，3： | 1 |
| 15 | CIRSE Guidelines: Quality Improvement Guidelines for Endovascular Treatment of Traumatic Hemorrhage显示文摘 | Sam Chakraverty Karen Flood David Kessel Simon McPherson Tony Nicholson Charles Ray Iain Robertson Otto Delden | 2012 | CardioVascular and Interventional Radiology2012，，： | 1 |
| 16 | Intensity-modulated radiation therapy for nasopharyngeal carcinoma: a review显示文摘 | Tony Wang Nadeem Riaz Simon Cheng Jiade Lu Nancy Lee | 2012 | Journal of Radiation Oncology2012，，： | 1 |
| 17 | The Number of Lymph Nodes Removed Predicts Survival in Esophageal Cancer: An International Study on the Impact of Extent of Surgical Resection显示文摘 | Christian G. Peyre Jeffrey A. Hagen Steven R. DeMeester Nasser K. Altorki Ermanno Ancona S Michael Griffin Arnulf H?lscher Toni Lerut Simon Law Thomas W. Rice Alberto Ruol Jan J. B. van Lanschot John Wong Tom R. DeMeester | 2008 | Annals of Surgery2008，，4： | 1 |
| 18 | Hepatic Artery Angiography and Embolization for Hemobilia Following Laparoscopic Cholecystectomy显示文摘 | Tony Nicholson Simon Travis Duncan Ettles John Dyet Peter Sedman Kevin Wedgewood Christopher Royston | 1999 | Cardiovascular and Interventional Radiology1999，，1： | 1 |
| 19 | Hepatic Artery Angiography and Embolization for Hemobilia Following Laparoscopic Cholecystectomy显示文摘 | Tony Nicholson Simon Travis Duncan Ettles John Dyet Peter Sedman Kevin Wedgewood Christopher Royston | 1999 | Cardiovascular and Interventional Radiology1999，，1： | 1 |
| 20 | Poly( DEAE- Ma- co- PEGMa) :a new pH -responsive eomb copolymer stabilizer for emulsions and dispersions 显示文摘 | SHEIKH SHAHALOM TONY TONG SIMON EMMETT | 2006 | Langmuir2006，22，20： | 1 |
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