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| 1 | 国际疼痛研究协会疼痛定义修订版:概念、挑战和折中显示文摘现行国际疼痛研究协会(IASP)将疼痛定义为'与实际或潜在组织损伤,或描述的类似损伤相关的一种不愉快的感觉和情感体验',该定义是由一个分类小组委员会推荐,并于1979年被IASP理事会所采纳。这一定义已被疼痛领域的卫生保健专业人士和研究人员广泛接受,并被一些行业、政府及非政府组织(包括世界卫生组织)所采用。近年来,一些业内人士认为,随着对疼痛更深入的了解,有必要对这个定义重新审定,并提出了修改建议。因此,2018年,IASP成立了一个主席特别工作小组,该小组是由14名来自多个国家的在疼痛相关的临床和基础科学方面拥有广泛专业知识的人员组成,其任务是评估现行定义及其附带注释,并对其保留还是修改提出建议。本文提供了关键概念的摘要、对IASP会员和公众评论的分析以及两年内委员会对疼痛定义和注释的最终修订意见。特别工作小组最后建议将疼痛定义修改为'与组织损伤或潜在组织损伤相关或类似相关的一种不愉快的感觉和情感体验',并将原来的附带注释更新为一系列简要说明并提供相关词源。今年年初,IASP理事会一致接受了修订后的定义和注释。 | Raja SN.Carr DB Cohen M.Finnerup NB Flor H.Gibson S Keefe FJ.Mogil JS Ringkamp M.Sluka KA Song XJ.Stevens B Sullivan MD.Tutelman PR Ushida T.Vader K 程志祥(译) 许继军(译) 程建国(审校) 刘先国(审校) 刘延青(审校) | 2020 | 中华疼痛学杂志2020，16，5： | 137 |
| 2 | Guidelines for evaluation and management of cerebral collateral circulation in ischaemic stroke 2017显示文摘Collateral circulation plays a vital role in sustaining blood flow to the ischaemic areas in acute,subacute or chronic phases after an ischaemic stroke or transient ischaemic attack.Good collateral circulation has shown protective effects towards a favourable functional outcome and a lower risk of recurrence in stroke attributed to different aetiologies or undergoing medical or endovascular treatment.Over the past decade,the importance of collateral circulation has attracted more attention and is becoming a hot spot for research.However,the diversity in imaging methods and criteria to evaluate collateral circulation has hindered comparisons of findings from different cohorts and further studies in exploring the clinical relevance of collateral circulation and possible methods to enhance collateral flow.The statement is aimed to update currently available evidence and provide evidence-based recommendations regarding grading methods for collateral circulation,its significance in patients with stroke and methods under investigation to improve collateral flow. | Liping Liu Jing Ding Xinyi Leng Yuehua Pu Li-An Huang Anding Xu Ka Sing Lawrence Wong Xin Wang Yongjun Wang 无 | 2018 | Stroke & Vascular Neurology2018，3，3： | 37 |
| 3 | Inflammatory bowel disease:definition,epidemiology,etiologic aspects,andimmunogenetic studies显示文摘DISEASEDEFINITIONSeveralcausesexistforinflammationofthegutsuchasinfection,toxin,autoimmunereaction,radiationandischemia.Whenn... | XIA Bing 1, JBA Crusius 2, SGM Meuwissen 2 and AS Pe*ka 2 | 1998 | World Journal of Gastroenterology1998，4，5： | 30 |
| 4 | Proso Millet Protein Elevates Plasma Level of High-Density Lipoprotein:A New Food Function of Proso Millet显示文摘We examined the effects of dietary proso-millet protein on plasma levels of high-density lipoprotein (HDL) cholesterol in different rats from animals reported in our previous studies. The results showed also, in this animal, that the ingestion of the millet protein elevates plasma levels of HDL-cholesterol like our earlier works. Taking into account the anti-atherogenic function of HDL, therefore, the millet protein would be useful as a new food ingredient which has the function that regulates cholesterol | N. NISHIZAWA S. SHIMANUKI H. FUJIHASHI H. WATANABE Y. FUDAMOTO AND T. NAGASAWA (Department of Bioscience and Technology, Faculty of Agriculture, Iwate University Morioka, Iwate 020, Japan Research Laboratory,Nitto Best Co., Ltd, Sagae, Yamagata 991 Ka | 1996 | Biomedical and Environmental Sciences1996，9，2： | 24 |
| 5 | Rutaecarpine ameliorates hyperlipidemia and hyperglycemia in fat-fed, streptozotocin-treated rats via regulating the IRS-1/PI3K/Akt and AMPK/ACC2 signaling pathways显示文摘瞄准:我们显示出从 Benth (吴·竹·尤) 支持的中国植物茱萸 rutaecarpa (法) 的弄干的水果提取的那 rutaecarpine 在胰岛素抵抗的主要骨胳的肌肉房间的葡萄糖消费和反煽动性的 cytokine 表示。在我们调查了 rutaecarpine 是否改善了的这研究,在老鼠的肥胖侧面,类脂化合物反常,葡萄糖新陈代谢和胰岛素抵抗 hyperlipidemia 和 hyperglycemia.Methods 当模特儿:在高脂肪的节食喂 8 个星期的老鼠,由 streptozotocin 的注射列在后面(30 mg/kg, ip ) 导致 hyperlipidemia 和多糖症。在 streptozotocin 注射以后的一个星期,喂脂肪的、对待 streptozotocin 的老鼠口头上地与 rutaecarpine 被对待(25 mg· kg −1·d−1) 或积极控制药 metformin (250 mg·为 7 个星期的 kg −1·d−1) 。身体重量,内脏的脂肪,血类脂化合物侧面和葡萄糖铺平,胰岛素敏感被测量。煽动性的 cytokines 的浆液层次被分析。IRS-1 和 Akt/PKB phosphorylation, PI3K 和 NF-κ在肝纸巾的 B 蛋白质层次被估计;肝和胰的病理学的变化被检验。葡萄糖举起和 AMPK/ACC2 phosphorylation 在有教养的老鼠被学习在 vitro.Results 的骨胳的肌肉房间:rutaecarpine 或 metformin 的管理显著地减少了肥胖,内脏的胖累积,水消费,和浆液 TC, TG 和 LDL 胆固醇在喂脂肪的、对待 streptozotocin 的老鼠铺平。二药也稀释了多糖症并且提高了胰岛素敏感。而且,二药显著地减少了 NF-κ在肝纸巾的 B 蛋白质层次和血浆 TNF-α, IL-6, CRP 和 MCP-1 铺平,并且改善在肝和胰的病理学的变化。另外,二药增加了 PI3K p85 子单元层次和 Akt/PKB phosphorylation,但是减少在肝纸巾的 IRS-1 phosphorylation。有 rutaecarpine 的有教养的骨胳的肌肉房间的治疗(20-180 μ mol/L ) 或 metformin (20 μ mol/L ) 支持了 AMPK 和 ACC2 的 phosphorylation,并且增加了葡萄糖 uptake.Conclusion:Rutaecarpine 改善在经由调整在骨胳的肌肉在肝和 AMPK/ACC2 发信号小径表明小径的 IRS-1/PI3K/Akt 的喂脂肪的、对待 streptozotocin 的老鼠的 hyperlipidemia 和多糖症。 | Xu-qiang NIE Huai-hong CHEN Jian-yong ZHANG Yu-jing ZHANG Jian-wen YANG Hui-jun PAN Wen-xia SONG Ferid MURAD Yu-qi HE Ka BIAN | 2016 | Acta Pharmacologica Sinica2016，37，4： | 23 |
| 6 | Effect of ulinastatin combined rivaroxaban on deep vein thrombosis in major orthopedic surgery显示文摘Objective:To explore the effect of ulinastatin(UTI) continuous infusion combined Rivaroxaban on the deep vein thrombosis in patients undergoing major orthopedic surgery.Methods:Forty-five patients undergoing major orthopedic surgery were randomly divided into three groups:ulinastatin continuous infusion(Uc) group,ulinastatin single injection(Us) group and control(C) group.All patients received patient-controlled intravenous analgesia(PCIA) after operation,and took Rivaroxaban 10 mg orally 12 hours after operation.Ulinastatin(5 000 U/kg)was given intravenously to both Uc and Us groups preoperatively.Group C was given isometric normal saline,group Uc was pumped UTI continuous intravenously at the end of surgery(10 000U/kg) to 48 hours through PCIA pump.The values of hematocrit(HCT),thrombomodulin(TM),Interleukin(IL-6),thrombin-antithrombin complex(TAT),D-Dimer(D-D) were normally tested before surgery(T1),at the end of the surgery(T2),12 hours(T3).24 hours(T4) and 48 hours(T5)after surgery.Results:Compared with T1,there was an upward tendency in TM,IL-6,TAT,and D-D after operation in group C group(P <0.05).The values of them were significandy increased from nearly 24-hour after surgery in Us group(P<0.05).In group Uc.there were no significant changes in these indices after operation(P>0.05).Conclusions:During the perioperative period,ulinastatin continuous infusion combined Rivaroxaban can correct blood hypercoagulability through different approaches in patients undergoing major orthopedic surgery. | Xi Yu Yi Tian Ka Wang Ying-Lin Wang Guo-Yi Lv Guo-Gang Tian | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，11： | 17 |
| 7 | Brain metastases as preventive and therapeutic targets显示文摘 | Steeg PS Camphausen KA Smith QR | 2011 | 中国神经肿瘤杂志2011，9，1： | 16 |
| 8 | Acute-on-chronic liver failure:recent update显示文摘Acute on chronic liver failure(ACLF) was first described in 1995 as a clinical syndrome distinct to classic acute decompensation.Characterized by complications of decompensation,ACLF occurs on a background of chronic liver dysfunction and is associated with high rates of organ failure and significant short-term mortality estimated between45%and 90%.Despite the clinical relevance of the condition,it still remains largely undefined with continued disagreement regarding its precise etiological factors,clinical course,prognostic criteria and management pathways.It is concerning that,despite our relative lack of understanding of the condition,the burden of ACLF among cirrhotic patients remains significant with an estimated prevalence of 30.9%.This paper highlights our current understanding of ACLF,including its etiology,diagnostic and prognostic criteria and pathophysiology.It is evident that further refinement of the ACLF classification system is required in order to detect high-risk patients and improve short-term mortality rates.The field of metabolomics certainly warrants investigation to enhance diagnostic and prognostic parameters,while the use of granulocyte-colony stimulating factor is a promising future therapeutic intervention for patients with ACLF. | Azeem Alam Ka Chun Suen Daqing Ma | 2017 | The Journal of Biomedical Research2017，31，4： | 16 |
| 9 | Role of antispasmodics in the treatment of irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS)is a long-lasting,relapsing disorder characterized by abdominal pain/discomfort and altered bowel habits.Intestinal motility impairment and visceral hypersensitivity are the key factors among its multifactorial pathogenesis,both of which require effective treatment.Voltage-gated calcium channels mediate smooth muscle contraction and endocrine secretion and play important roles in neuronal transmission.Antispasmodics are a group of drugs that have been used in the treatment of IBS for decades.Alverine citrate,a spasmolytic,decreases the sensitivity of smooth muscle contractile proteins to calcium,and it is a selective 5-HT1A receptor antagonist.Alverine,in combination with simethicone,has been demonstrated to effectively reduce abdominal pain and discomfort in a large placebo-controlled trial.Mebeverine is a musculotropic agent that potently blocks intestinal peristalsis.Non-placebo-controlled trials have shown positive effects of mebeverine in IBS regarding symptom control;nevertheless,in recent placebo-controlled studies,mebeverine did not exhibit superiority over placebo.Otilonium bromide is poorly absorbed from the GI tract,where it acts locally as an L-type calcium channel blocker,an antimuscarinic and a tachykinin NK2receptor antagonist.Otilonium has effectively reduced pain and improved defecation alterations in placebocontrolled trials in IBS patients.Pinaverium bromide is also an L-type calcium channel blocker that acts locally in the GI tract.Pinaverium improves motility disorders and consequently reduces stool problems in IBS patients.Phloroglucinol and trimethylphloroglucinol are non-specific antispasmodics that reduced pain in IBS patients in a placebo-controlled trial.Antispasmodics have excellent safety profiles.T-type calcium channel blockers can abolish visceral hypersensitivity in animal models,which makes them potential candidates for the development of novel therapeutic agents in the treatment of IBS. | Anita Annaházi Richárd Róka András Rosztóczy Tibor Wittmann | 2014 | World Journal of Gastroenterology2014，20，20： | 15 |
| 10 | Chinese progress in geomorphometry显示文摘Geomorphometry,the science of digital terrain analysis(DTA),is an important focus of research in both geomorphology and geographical information science(GIS).Given that 70% of China is mountainous,geomorphological research is popular among Chinese scholars,and the development of GIS over the last 30 years has led to significant advances in geomorphometric research.In this paper,we review Chinese progress in geomorphometry based on the published literature.There are three major areas of progress:digital terrain modelling methods,DTA methods,and applications of digital terrain models(DTMs).First,traditional vector-and raster-based terrain modelling methods,including the assessment of uncertainty,have received widespread attention.New terrain modelling methods such as unified raster and vector,high-fidelity,and real-time dynamic geographical scene modelling have also attracted research attention and are now a major focus of digital terrain modelling research.Second,in addition to the popular DTA methods based on topographical derivatives,geomorphological features,and hydrological factors extracted from DTMs,DTA methods have been extended to include analyses of the structure of underlying strata,ocean surface features and even socioeconomic spatial structures.Third,DTMs have been applied to fields including global climate change,analysis of various typical regions,lunar surface and other related fields.Clearly,Chinese scholars have made significant progress in geomorphometry.Chinese scholars have had the greatest international impact in areas including high-fidelity digital terrain modelling and DTM-based regional geomorphological analysis,particularly in the Loess Plateau and the Tibetan Plateau regions. | LV Guonian XIONG Liyang CHEN Min TANG Guoan SHENG Yehua LIU Xuejun SONG Zhiyao LU Yuqi YU Zhaoyuan ZHANG Ka WANG Meizhen | 2017 | Journal of Geographical Sciences2017，27，11： | 14 |
| 11 | Perfluorooctane sulfonate(PFOS) and related fluorochemicals in chicken egg in China显示文摘The ubiquitous occurrence of perfluorinated compounds(PFCs) in environmental samples has drawn much attention.Recent human exposure studies found relatively high perfluorooctane sulfonate(PFOS) concentrations in blood samples from several cities in China when compared with other countries.The objectives of the present study were:(1) to measure PFC concentrations and compositions in chicken egg samples from local markets in China;and(2) to conduct a preliminary human health risk assessment of egg consumption.Eight pooled egg samples from eight locations were analyzed for 11 PFCs.The results showed that close to 100% of the PFOS in the egg was distributed in egg yolk and PFOS was not detected in egg white(<0.08 ng/g wet weight,w/w).Of the perfluoroalkylsulfonates,only PFOS was detected in all egg samples,while of the perfluoroalkylcarboxylates,perfluoroundecanoic acid(PFUnDA) was detected in all samples,followed by perfluorooctanoate(PFOA)(75% occurrence) and perfluorodecanoic acid(PFDA)(50% occurrence).PFOS concentrations in egg ranged from 45.0 to 86.9 ng/g w/w.The results suggested that current concentrations of PFOS in domestic chicken eggs are unlikely to cause immediate harm to Chinese populations. | WANG Yuan YEUNG Leo Wai Yin YAMASHITA Nobuyoshi TANIYASU Sachi SO Man Ka Margaret B. MURPHY LAM Paul Kwan Sing | 2008 | Chinese Science Bulletin2008，53，4： | 13 |
| 12 | Gastrointestinal stromal tumors in a cohort of Chinese patients in Hong Kong显示文摘瞄准:用香港汉语调查流行和胃肠的基质肿瘤(大意) 的临床的模式,并且估计发病率的 CD117 的介绍的影响。方法:从 Yan Chai 医院的病理的部门的数据库, 47 个病人,在这研究与到 2003 年 12 月的从 1995 年 9 月的大意被包括。十大意在 CD117 的介绍前被诊断。临床的特征,肿瘤特征,和治疗被分析。预言肿瘤的因素联系了死亡或复发与比例的危险建模的考克斯一起被学习。结果:病人包括了 26 男性和 21 女性,与 66.6 年的吝啬的年龄(SD 13.1,范围 29-87 年) 。大意的估计的流行每 100,000 个人是 13.4-15.6,与每 100,000 个人的 1.68-1.96 的年度发生。在 CD117 的介绍前后的大意的年度发生每 100,000 个人是 1.1 并且 2.1 每 100,000 个人分别地。胃(34 个病人, 72.3%) 是为肿瘤的最普通的地点,由小肠列在后面(8 个病人, 17.0%) ,食管(2 个病人, 4.3%) ,网膜(2 个病人, 4.3%) 并且冒号(1 个病人, 2.1%) 。31 个病人(66%) 有完全的肿瘤切除术。十一从 16 死亡(23%) 是肿瘤相关的。中部的生存时间是 26 瞬间。五年的幸存率是 61.3% 。与肿瘤相关的死亡或复发联系的重要因素是不完全的切除术,肿瘤尺寸 5 厘米以上,侵略到转移的邻近的机关或存在。结论:在香港的大意的发生在美国比得上那,但是在芬兰比那降低。大意的真发生能在 CD117 的介绍前被低估。不完全的切除术,肿瘤尺寸 5 厘米以上,到转移的邻近的机关或存在的侵略是预言肿瘤相关的死亡或复发的因素。 | Kam Hoi Chan Chun Wing Chan Wai Hung Chow Wai Keung Kwan Chi Kwan Kong Ka Fung Mak Miu Yi Leung Lin Kiu Lau | 2006 | World Journal of Gastroenterology2006，12，14： | 12 |
| 13 | 膝关节粘连:治疗和预防研究新进展显示文摘背景:膝关节粘连严重影响了患者术后的日常生活,而传统的治疗方式疗效有限。降低膝关节粘连发生率是提高手术预期疗效的关键,也是临床医学上需要急待解决的重要问题。目的:对膝关节粘连的各类研究文献进行分析,总结近10年的研究成果,为防治膝关节粘连提供新的思路和方法。方法:由第一作者检索Pub Med数据库,查找2006至2016年的文献,英文检索词为'tissue adhesions,arthrofibrosis,joint stiffness,prevent,treatment',共检索到1 500余篇相关文献,59篇符合纳入标准。结果与结论:(1)近年来大量学者研究发现,创伤/手术引起膝关节出血、炎症反应,造成血管内皮细胞生长因子和白细胞介素6高表达,增加了成纤维细胞的活性,导致大量胶原蛋白沉积,发生粘连;(2)改进传统治疗方式和运用微创技术治疗膝关节粘连取得了一定的疗效,但仍存在再粘连风险;(3)关节腔内用药预防膝关节粘连在基础研究方面获得了显著成果,可成为预防膝关节粘连的一种有效方案,但临床可行性存在争议,需进一步深入研究,寻找疗效确切、不良反应小的药物。 | 吴海啸 王鹏 张超 Egiazaryan KA Ratyev AP Melnichenko SY Kuzin VV Skoroglyadov AV | 2017 | 中国组织工程研究2017，21，36： | 12 |
| 14 | 口服抗栓药物预防非瓣膜性房颤患者的卒中:美国心脏协会/美国卒中协会的科学建议显示文摘成年房颤患者的卒中发生率,依据合并症和既往脑血管事件史,为每年1%~20%不等(平均每年为4.5%)。对卒中风险的分层非常重要,因为用抗栓药降低房颤导致卒中的主要风险是出血。如华法令在减少缺血性事件风险的同时,每年有1%~12% | 戴若莲 糜建华 华驾略 董荃 苏爱萍 李焰生 Furie KL Goldstein LB Albers GW Khatri P Neyens R Turakhia MP Turan TN Wood KA | 2012 | 神经病学与神经康复学杂志2012，9，3： | 12 |
| 15 | Epac2-deficiency leads to more severe retinal swelling, glial reactivity and oxidative stress in transient middle cerebral artery occlusion induced ischemic retinopathy显示文摘Ischemia occurs in diabetic retinopathy with neuronal loss, edema, glial cell reactivity and oxidative stress. Epacs, consisting of Epac1 and Epac2, are c AMP mediators playing important roles in maintenance of endothelial barrier and neuronal functions. To investigate the roles of Epacs in the pathogenesis of ischemic retinopathy, transient middle cerebral artery occlusion(t MCAO) was performed on Epac1-deficient(Epac1-/-) mice, Epac2-deficient(Epac2-/-) mice, and their wild type counterparts(Epac1+/+ and Epac2+/+). Two-hour occlusion and 22-hour reperfusion were conducted to induce ischemia/reperfusion injury to the retina. After t MCAO, the contralateral retinae displayed similar morphology between different genotypes. Neuronal loss, retinal edema and increase in immunoreactivity for aquaporin 4(AQP4), glial fibrillary acidic protein(GFAP), peroxiredoxin 6(Prx6) were observed in ipsilateral retinae. Epac2-/- ipsilateral retinae showed more neuronal loss in retinal ganglion cell layer, increased retinal thickness and stronger immunostaining of AQP4, GFAP, and Prx6 than those of Epac2+/+. However, Epac1-/- ipsilateral retinae displayed similar pathology as those in Epac1+/+ mice. Our observations suggest that Epac2-deficiency led to more severe ischemic retinopathy after retinal ischemia/reperfusion injury. | LIU Jin YEUNG Patrick Ka Kit CHENG Lu LO Amy Cheuk Yin CHUNG Stephen Sum Man CHUNG Sookja Kim | 2015 | Science China(Life Sciences)2015，58，6： | 12 |
| 16 | Synthesis of an AIE-active fluorogen and its application in cell imaging显示文摘A fluorogen named 1-decyl-1-methyl-2,5-bis{4-[(N,N-diethylamino)methyl]phenyl}-3,4-diphenylsilole (3) was synthesized. It emitted weakly as isolated molecule but strongly as supramolecular aggregate, showing a characteristic behavior of aggregation-induced emission (AIE). The molecules of 3 formed highly emissive nanoparticles in aqueous media, which quickly and selectively marked cytoplasm of HeLa cells and posed no toxicity to the living cells. The fluorogen is thus a promising candidate mate-rial for cell imaging as a sensitive, selective and cytocompatible biosensor. | LAM Jacky Wing Yip FAISAL Mahtab NG Ka Ming LUO Kathy Qian | 2009 | Science China Chemistry2009，52，1： | 12 |
| 17 | Interplay between nitric oxide and VIP in CCK-8-induced phasic contractile activity in the rabbit sphincter of Oddi显示文摘AIM: The sphincter of Oddi (SO) plays an important role in delivery of bile into the duodenum. To establish whether vasoactive intestinal polypeptide (VIP) and nitric oxide (NO) were involved in phasic contractile activity of the rabbit SO stimulated by cholecystokinin-octapeptide (CCK-8).METHODS: Isolated SO muscle rings were cleaned of fat and mounted horizontally on two small L-shaped hooksone of which was connected to a force transducer for the measurement of isometric tension. The experiments were carried out in a thermostatically controlled (37±0.2℃)organ bath (5 mL) containing Krebs solution. The organ fluid was gassed with 95% O2 and 50 mL/L CO2 to keep the pH at 7.40±0.05. Contractile responses to CCK-8 (1μmol/L) were evaluated in the presence and absence of N^G-nitro-L-arginine (LNNA), an inhibitor of NO synthase (100μmol/L), and (p-chloro-D-Phe^6-Leu^17)-VIP (VIPa,30μmol/L), a VIP receptor antagonist.RESULTS: CCK-8 stimulated the phasic activity of the SO.NO synthase inhibition increased the frequency and amplitude of contractions with a slight increase in developed tension.Pre-incubation with VIPa also attenuated this CCK-8 effect.The combined application of LNNA and VIPa abolished the phasic activity of the muscle rings with a marked increase in tension in response to CCK-8.CONCLUSION: VIP and NO together contribute to an increase in phasic activity of SO. | Attila Pálv(o|¨)lgyi Réka Sári József Németh Annamária Szabolcs István Nagy Péter Hegyi János Lonovics Zoltán Szilvássy | 2005 | World Journal of Gastroenterology2005，11，21： | 11 |
| 18 | First observation of tropospheric nitrogen dioxide from the Environmental Trace Gases Monitoring Instrument onboard the GaoFen-5 satellite显示文摘The Environmental Trace Gases Monitoring Instrument(EMI)is the first Chinese satellite-borne UV–Vis spectrometer aiming to measure the distribution of atmospheric trace gases on a global scale.The EMI instrument onboard the GaoFen-5 satellite was launched on 9 May 2018.In this paper,we present the tropospheric nitrogen dioxide(NO2)vertical column density(VCD)retrieval algorithm dedicated to EMI measurement.We report the first successful retrieval of tropospheric NO_(2) VCD from the EMI instrument.Our retrieval improved the original EMI NO_(2) prototype algorithm by modifying the settings of the spectral fit and air mass factor calculations to account for the on-orbit instrumental performance changes.The retrieved EMI NO_(2) VCDs generally show good spatiotemporal agreement with the satellite-borne Ozone Monitoring Instrument and TROPOspheric Monitoring Instrument(correlation coefficient R of ~0.9,bias<50%).A comparison with ground-based MAX-DOAS(Multi-Axis Differential Optical Absorption Spectroscopy)observations also shows good correlation with an R of 0.82.The results indicate that the EMI NO_(2) retrieval algorithm derives reliable and precise results,and this algorithm can feasibly produce stable operational products that can contribute to global air pollution monitoring. | Chengxin Zhang Cheng Liu Ka Lok Chan Qihou Hu Haoran Liu Bo Li Chengzhi Xing Wei Tan Haijin Zhou Fuqi Si Jianguo Liu | 2020 | Light(Science & Applications)2020，9，1： | 11 |
| 19 | Emerging role of Hippo pathway in gastric and othergastrointestinal cancers显示文摘More evidence has underscored the importance of Hippo signaling pathway in gastrointestinal tissue homeostasis, whereas its deregulation induces tumorigenesis. Yes-associated protein 1(YAP1) and its close paralog TAZ, transcriptional co-activator with a PDZbinding motif, function as key effectors negatively controlled by the Hippo pathway. YAP1/TAZ exerts oncogenic activities by transcriptional regulation via physical interaction with TEAD transcription factors. In various cancers, Hippo pathway cross-talks with pro- or anti-tumorigenic pathways such as GPCR, Wnt/β-catenin, Notch and TGF-β signaling and is deregulated by multiple factors including cell density/junction and micro RNAs. As YAP1 expression is significantly associated with poor prognosis of gastric and other gastrointestinal cancers, detailed delineation of Hippo regulation in tumorigenesis provides novel insight for therapeutic intervention. In current review, we summarized the recent research progresses on the deregulation of Hippo pathway in the gastrointestinal tract including stomach and discuss the molecular consequences leading to tumorigenesis. | Wei Kang Alfred SL Cheng Jun Yu Ka Fai To | 2016 | World Journal of Gastroenterology2016，22，3： | 11 |
| 20 | On Problems of Multicomponent System Maintenance Modelling显示文摘We present an overview of some recent developments in the area of mathematical modeling of maintenance decisions for multi-unit systems. The emphasis is on three main groups of multicomponent maintenance optimization models:the block replacement models, group maintenance models, and opportunistic maintenance models. Moreover, an example of a two-unit system maintenance process is provided in order to compare various maintenance policies. | Tomasz Nowakowski Sylwia Werbin'ka | 2009 | International Journal of Automation and computing2009，6，4： | 10 |
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