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| 1 | Factors determining delay in relaparotomy for anastomotic leakage after colorectal resection显示文摘AIM: To analyze the time interval ('delay') between the first occurrence of clinical parameters associated with anastomotic leakage after colorectal resection and subsequent relaparotomy. METHODS: In 36 out of 289 consecutive patients with colorectal anastomosis, leakage was confirmed at relaparotomy. The medical records of these patients were retrospectively analysed and type and time of appearance of clinical parameters suggestive of anastomotic leakage were recorded. These parameters included heart rate, body temperature, local or generalized peritoneal reaction, leucocytosis, ileus and delayed gastric emptying. Factors influencing delay of relaparotomy and consequences of delayed recognition and treatment were determined. RESULTS: First documentation of at least one of the predefined parameters for anastomotic leakage was after a median interval of 4 ± 1.7 d after the operation. The median number of days between first parameter(s) associated with leakage and relaparotomy was 3.5 ± 5.7 d. The time interval between the first signs of leakage and relaparotomy was significantly longer when a weekend was included (4.2 d vs 2.4 d, P = 0.021) or radiological evaluation proved to be false-negative (8.1 d vs 3.5 d, P = 0.007). No significant association between delay and number of additional relaparotomies, hospital stay or mortality could be demonstrated. CONCLUSION: An intervening weekend and negative diagnostic imaging reports may contribute to a delay in diagnosis and relaparotomy for anastomotic leakage. That delay was more than two days in two-thirds of the patients. | A Doeksen PJ Tanis BC Vrouenraets JJB Lanschot van WF Tets van | 2007 | World Journal of Gastroenterology2007，13，27： | 17 |
| 2 | Management of recurrent rectal cancer:A population based study in greater Amsterdam显示文摘AIM: To analyze,retrospectively in a population-based study,the management and survival of patients with recurrent rectal cancer initially treated with a macroscopically radical resection obtained with total mesorectal excision (TME). METHODS: All rectal carcinomas diagnosed during 1998 to 2000 and initially treated with a macroscopically radical resection (632 patients) were selected from the Amsterdam Cancer Registry. For patients with recurrent disease,information on treatment of the recurrence was collected from the medical records. RESULTS: Local recurrence with or without clinically apparent distant dissemination occurred in 62 patients (10%). Thirty-two patients had an isolated local recurrence. Ten of these 32 patients (31%) underwent radical re-resection and experienced the highest survival (three quarters survived for at least 3 years). Eight patients (25%) underwent non-radical surgery (median survival 24 mo),seven patients (22%) were treated with radio-and/or chemotherapy without surgery (median survival 15 mo) and seven patients (22%) only received best supportive care (median survival 5 mo). Distant dissemination occurred in 124 patients (20%) of whom 30 patients also had a local recurrence. The majority (54%) of these patients were treated with radio-and/or chemotherapy without surgery (median survival 15 mo). Twenty-seven percent of these patients only received best supportive care (median survival 6 mo),while 16% underwent surgery for their recurrence. Survival was best in the latter group (median survival 32 mo). CONCLUSION: Although treatment options and survival are limited in case of recurrent rectal cancer after radical local resection obtained with TME,patients can benefit from additional treatment,especially if a radical resection is feasible. | Roel Bakx Otto Visser Judith Josso Sybren Meijer J Frederik M Slors J Jan B van Lanschot | 2008 | World Journal of Gastroenterology2008，14，39： | 17 |
| 3 | Randomised comparison of morbidity after D1 and D2 dissection for gastric cancer in 996 Dutch patients显示文摘 | J.J. Bonenkamp I. Songun K. Welvaart C.J.H. van de Velde J. Hermans M. Sasako J.T.M. Plukker P. van Elk H. Obertop D.J. Gouma C.W. Taat J. van Lanschot S. Meyer P.W. de Graaf M.F. von Meyenfeldt H. Tilanus | 1995 | The Lancet . 1995 (8952)1995，，： | 2 |
| 4 | Comparison of the 6th and 7th Editions of the UICC-AJCC TNM Classification for Esophageal Cancer显示文摘 | Koen Talsma Pieter Hagen Brechtje Grotenhuis Ewout Steyerberg Hugo Tilanus Jan Lanschot Bas Wijnhoven | 2012 | Annals of Surgical Oncology2012，，7： | 2 |
| 5 | Extended Transthoracic Resection Compared With Limited Transhiatal Resection for Adenocarcinoma of the Mid/Distal Esophagus: Five-Year Survival of a Randomized Clinical Trial显示文摘 | Jikke M. T. Omloo Sjoerd M. Lagarde Jan B. F. Hulscher Johannes B. Reitsma Paul Fockens Herman van Dekken Fiebo J. W. ten Kate Huug Obertop Hugo W. Tilanus J Jan B. van Lanschot | 2007 | Annals of Surgery2007，，6： | 2 |
| 6 | Preoperative risk assessment and prevention of complications in patients with esophageal cancer显示文摘 | Brechtje A.Grotenhuis Bas P.L.Wijnhoven FrankGrüne Jaspervan Bommel Hugo W.Tilanus J. Jan B.van Lanschot | 2010 | Oncol2010，，3： | 2 |
| 7 | Transthoracic versus transhiatal resection for carcinoma of the esophagus: a meta-analysis显示文摘 | Jan B.F Hulscher Jan G.P Tijssen Hugo Obertop J.Jan B van Lanschot | 2001 | The Annals of Thoracic Surgery2001，，1： | 2 |
| 8 | Sacral resection in cancer surgery:surgical technique and experience in 26 procedures显示文摘 | Bakx R Van Lanschot JJ Zoetmulder FA | 2004 | J Am Coll Surg2004，198，5： | 1 |
| 9 | Preoperative chemoradiation combined with regional hyperthermia for patients with resectable esophageal cancer显示文摘 | M. C. C. M. Hulshof P. M. A. Van Haaren J. J. B. Van Lanschot D. J. Richel P. Fockens S. Oldenborg E. D. Geijsen M. I. Van Berge Henegouwen J. Crezee | 2009 | International Journal of Hyperthermia2009，，1： | 1 |
| 10 | Preoperative chemoradiotherapy for esophageal or junctional cancer显示文摘 | Van Hagen P Hulshof M Van Lanschot J J B | 2012 | New Eng- land Journal of Medicine2012，366，22： | 1 |
| 11 | Preoperative chemoradiotherapy for esophageal or junctional cancer显示文摘 | van Hagen P Hulshof MC van Lanschot J J | 2012 | N Engl J Med2012，366，22： | 1 |
| 12 | Neoadjuvant chemoradiotherapy for esophageal cancer: a review of meta-analyses 显示文摘 | Wijnhoven BP van Lanschot J J Tilanus HW | 2009 | World J Surg2009，33，12： | 1 |
| 13 | Predicting Systemic Disease in Patients With Esophageal Cancer After Esophagectomy: A Multinational Study on the Significance of the Number of Involved Lymph Nodes显示文摘 | Christian G. Peyre Jeffrey A. Hagen Steven R. DeMeester Jan J. B. Van Lanschot Arnulf H?lscher Simon Law Alberto Ruol Ermanno Ancona S Michael Griffin Nasser K. Altorki Thomas W. Rice John Wong Toni Lerut Tom R. DeMeester | 2008 | Annals of Surgery2008，，6： | 1 |
| 14 | Recurrence pattern of oesophageal carcinoma after limited resection does not support wide local excision with extensive lymph node dissection显示文摘 | van Lanschot J J B Tilanus H W Voormolen M H J | 1994 | Br J Surg1994，81，9： | 1 |
| 15 | Improving outcomes after esophagectomy:the impact of operative volume显示文摘 | Casson AG van Lanschot JJ | 2005 | J Surg Oncol2005，92，3： | 1 |
| 16 | The influence of preoperative weight loss on the postoperative course after esophageal cancer resection显示文摘 | van der Schaaf MK Tilanus HW van Lanschot JJ | 2014 | J Thorac Cardiovasc Surg2014，147，1： | 1 |
| 17 | Neoadjuvant chemoradiation followed by surgery versus surgery alone for patients with adenocarcinoma or squamous cell carcinoma of the esophagus显示文摘 | van Heijl M van Lanschot J J Koppert L B | 2008 | BMC Surg2008，26，8： | 1 |
| 18 | J‐pouch vs side‐to‐end coloanal anastomosis after preoperative radiotherapy and total mesorectal excision for rectal cancer: a multicentre randomized trial显示文摘 | A.Doeksen R.Bakx A.Vincent W. F.van Tets M. A. G.Sprangers M. F.Gerhards W. A.Bemelman J. J. B.van Lanschot | 2012 | Colorectal Disease2012，，6： | 1 |
| 19 | Preoperative chemoradiotherapy for esophageal or junctional cancer 显示文摘 | Hagen P Lanschot H | 2012 | N Engl J Med2012，366，22： | 1 |
| 20 | Radiological evaluation of colorectal anastomoses显示文摘 | A. Doeksen P. J. Tanis A. F. J. Wüst B. C. Vrouenraets J. J. B. Lanschot W. F. Tets | 2008 | International Journal of Colorectal Disease2008，，9： | 1 |
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