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| 1 | Proposed approach to the challenging management of progressive gastroesophageal reflux disease显示文摘The progression of gastroesophageal reflux disease(GERD) in patients who are taking proton pump inhibitors(PPIs) has been reported by several investigators,leading to concerns that PPI therapy does not address all aspects of the disease.Patients who are at risk of progression need to be identified early in the course of their disease in order to receive preventive treatment.A review of the literature on GERD progression to Barrett's esophagus and the associated physiological and pathological changes was performed and risk factors for progression were identified.In addition,a potential approach to the prevention of progression is discussed.Current evidence shows that GERD can progress;however,patients at risk of progression may not be identified early enough for it to be prevented.Biopsies of the squamocolumnar junction that show microscopic intestinalization of metaplastic cardiac mucosa in endoscopically normal patients are predictive of future visible Barrett's esophagus,and an indicator of GERD progression.Such changes can be identified only through biopsy,which is not currently recommended for endoscopically normal patients.GERD treatment should aim to prevent progression.We propose that endoscopically normal patients who partially respond or do not respond to PPI therapy undergo routine biopsies at the squamocolumnar junction to identify histological changes that may predict future progression.This will allow earlier intervention,aimed at preventing Barrett's esophagus. | Joachim Labenz Parakrama T Chandrasoma Laura J Knapp Tom R DeMeester | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 7 |
| 2 | Thin layer thinkness measurements based on the acoustic-optic technique显示文摘 | Devolder S Wevers M DeMeester D | 1996 | Application Physical Letters1996，68，12： | 2 |
| 3 | Connexin32 hemichannels contribute to the apoptotic-to-necrotic transition during Fas-mediated hepatocyte cell death显示文摘 | Mathieu Vinken Elke Decrock Elke Vuyst Marijke Bock Roosmarijn E. Vandenbroucke Bruno G. Geest Joseph Demeester Niek N. Sanders Tamara Vanhaecke Luc Leybaert Vera Rogiers | 2010 | Cellular and Molecular Life Sciences2010，，6： | 2 |
| 4 | Mixed Reflux of Gastric and Duodenal Juices Is More Harmful to the Esophagus than Gastric Juice Alone: The Need for Surgical Therapy Re-Emphasized显示文摘 | Werner K. H. Kauer Jeffrey H. Peters Tom R. DeMeester Adrian P. Ireland Cedric G. Bremner Jeffrey A. Hagen | 1995 | Annals of Surgery1995，，4： | 2 |
| 5 | Pathophysiology and treatment of Barrett's esophagus显示文摘Gastroesophageal reflux disease (GERD) affects an estimated 20% of the population in the United States. About 10%-15% of patients with GERD develop Barrett’s esophagus, which can progress to adenocarcinoma, currently the most prevalent type of esophageal cancer. The esophagus is normally lined by squamous mucosa, therefore, it is clear that for adenocarcinoma to develop, there must be a sequence of events that result in transformation of the normal squamous mucosa into columnar epithelium. This sequence begins with gastroesophageal reflux, and with continued injury metaplastic columnar epithelium develops. This article reviews the pathophysiology of Barrett’s esophagus and implications for its treatment. The effect of medical and surgical therapy of Barrett’s esophagus is compared. | Daniel S Oh Steven R DeMeester | 2010 | World Journal of Gastroenterology2010，16，30： | 2 |
| 6 | Esophageal eosinophilia with dysphagia显示文摘 | Stephen E. A. Attwood Thomas C. Smyrk Tom R. Demeester James B. Jones | 1993 | Digestive Diseases and Sciences1993，，： | 2 |
| 7 | Vascular endothelial growth factor and basic fibroblast growth factor expression in esophageal adenocarcinoma and Barrett esophagus显示文摘 | Reginald V.N. Lord Ji Min Park Kumari Wickramasinghe Steven R. DeMeester Stefan Oberg Dennis Salonga Jon Singer Jeffrey H. Peters Kathleen D. Danenberg Tom R. DeMeester Peter V. Danenberg | 2003 | The Journal of Thoracic and Cardiovascular Surgery2003，，2： | 2 |
| 8 | Glucoseresponsive polyelectrolyte capsules 显示文摘 | DE GEEST BG JONAS AM DEMEESTER J | 2006 | Langmuir2006，22，11： | 1 |
| 9 | Inventory Reduction and Productivity Growth:Linkages in the Japanese Automotive Industry显示文摘 | M B Lieberman L Demeester | 1999 | Management Science1999，45，4： | 1 |
| 10 | Tailoring the swelling pressure of degrading dextran hydroxyethyl methacrylate hydrogels显示文摘 | Stubbe B G Horkay F Amsden B Hennink W E De Smedt S C Demeester J | 2003 | Biomacro-molecules2003，4，： | 1 |
| 11 | Swelling pressure observations on degrading dex-HEMA hydrogels 显示文摘 | Stubbe B G Braeckmans K Horkay F Hennink W E De Smedt S C Demeester J | 2002 | Maeromolecules2002，35，： | 1 |
| 12 | Omeprazole does not reduce gastroesophageal reflux: new insights using multichannel intraluminal impedance technology显示文摘 | Anand P. Tamhankar M.D. Jeffrey H. Peters M.D. Giussepe Portale M.D. Chih-Cheng Hsieh M.D. Jeffrey A. Hagen M.D. Cedric G. Bremner M.D. Tom R. DeMeester M.D | 2004 | Journal of Gastrointestinal Surgery2004，，7： | 1 |
| 13 | Predicting Systemic Disease in Patients With Esophageal Cancer After Esophagectomy: A Multinational Study on the Significance of the Number of Involved Lymph Nodes显示文摘 | Christian G. Peyre Jeffrey A. Hagen Steven R. DeMeester Jan J. B. Van Lanschot Arnulf H?lscher Simon Law Alberto Ruol Ermanno Ancona S Michael Griffin Nasser K. Altorki Thomas W. Rice John Wong Toni Lerut Tom R. DeMeester | 2008 | Annals of Surgery2008，，6： | 1 |
| 14 | Resilience in multilayer networks显示文摘 | Demeester P Gryseels M | 1999 | IEEE Communications Magazine1999，37，8： | 1 |
| 15 | Resilience in Multilayer Networks显示文摘 | DEMEESTER P GRYSEELS M AUTENRIETH A | 1999 | IEEE Communications Magazine1999，37，： | 1 |
| 16 | A Multicenter Study of Survival After Neoadjuvant Radiotherapy/Chemotherapy and Esophagectomy for ypT0N0M0R0 Esophageal Cancer显示文摘 | D. Vallb?hmer Arnulf H. H?lscher S. DeMeester T. DeMeester J. Salo J. Peters T. Lerut S. G. Swisher W. Schr?der E. Bollschweiler W. Hofstetter | 2010 | Annals of Surgery2010，，5： | 1 |
| 17 | Clinical biology of Barrett' metaplasia,dysplesia to carcinoma sequence显示文摘 | DeMeester T | 2001 | Surg Oneol2001，10，： | 1 |
| 18 | Hyaluronan : Preparation, Structure, Properties, and Applications 显示文摘 | Lapcik L De Smedt S Demeester J Chabrecek P | 1998 | Chem Rev1998，98，： | 1 |
| 19 | Ambulatory 24-H Esophageal pH monitoring: normal values, optimal thresholds, specificity, sensitivity, and reproducibility 显示文摘 | Jamieson JR stein H J deMeester TR | 1992 | Am J Gastroenterol1992，87，： | 1 |
| 20 | DNA methylation: an alternative pathway to cancer 显示文摘 | Wajed S A Laird P W DeMeester T R | 2001 | Ann Surg2001，234，： | 1 |
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