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| 1 | 生态系统服务价值评估方法综述显示文摘基于相关科学研究文献,首先对生态系统服务价值评估的国内外研究现状进行追踪与分析;其次,从评估过程的角度,将生态系统服务价值评估方法分为两类:直接评估法和间接评估法,同时进一步对这两类方法进行了分类,并对分类后的评估方法在概念内涵、计算方法等方面进行了总结;最后,文章讨论了目前价值评估方面存在的问题,对生态系统服务价值的评估理论、评估方法及评估结果表现形式进行了总结,并对其未来发展方向提出了建议:加强不同生态系统服务价值评估方法的对比验证及综合应用研究,加强植被覆盖较少或无植被覆盖地区的生态系统服务价值评估研究,加强复合生态系统和精细尺度的生态系统服务价值评估研究。 | 李丽 王心源 骆磊 冀欣阳 赵燕 赵颜创 Nabil Bachagha | 2018 | 生态学杂志2018，37，4： | 127 |
| 2 | 青藏高原多年冻土区天然气水合物形成条件模拟研究显示文摘基于野外气体地球化学调查研究,以及前人有关冻土表层温度、冻土层内地温梯度、冻土层下地温梯度等的资料,对青藏高原多年冻土区天然气水合物的形成条件开展了模拟研究.结果显示:研究区冻土条件能够满足天然气水合物形成的基本要求;气体组成、冻土特征(如冻土厚度或冻土表层温度、冻土层内地温梯度、冻土层下地温梯度等)是影响研究区天然气水合物稳定带厚度的最重要因素,其在不同点位上的差异性可能导致天然气水合物分布的不均匀性的主要原因;研究区最可能的天然气水合物为甲烷与重烃(乙烷和丙烷)的混合气体型天然气水合物;在天然气水合物分布的区域,其产出的上临界点深度在几十至一百多米间,下临界点深度在几百至近一千米间,厚度可达到几百米.与CanadianMallik三角洲多年冻土区相比,青藏高原多年冻土区除了冻土厚度小些外,其他条件,如冻土层内地温梯度、冻土层下地温梯度、气体组成等条件较为相近,具有一定的可比性,预示着良好的天然气水合物潜力. | 卢振权 SULTAN Nabil 金春爽 饶竹 罗续荣 吴必豪 祝有海 | 2009 | 地球物理学报2009，52，1： | 35 |
| 3 | 天然气水合物形成条件与含量影响因素的半定量分析显示文摘天然气水合物形成条件及其含量的研究是天然气水合物调查研究中最为关心的两个问题.从天然气水合物形成过程的热动力学理论模型出发,半定量地探讨了不同因素(温度、压力、气体组成、孔隙水盐度、沉积物孔隙大小等)对天然气水合物形成作用及含量的影响程度.结果显示,气体组成特别是丙烷的加入对天然气水合物形成的温度和压力条件影响最大,孔隙水盐度也会对天然气水合物形成的温度和压力条件产生重要影响,沉积物孔隙在一定范围内(1×10-6m^4×10-8m)对天然气水合物形成的温度和压力条件影响有限.天然气水合物含量受孔隙大小和盐度影响较小,主要只与气体的供应大小有关. | 卢振权 SULTAN Nabil 金春爽 王明君 祝有海 吴必豪 | 2008 | 地球物理学报2008，51，1： | 32 |
| 4 | An overview of occult hepatitis B virus infection显示文摘Occult hepatitis B virus (HBV) infection (OBI), alternatively defined as occult hepatitis B (OHB), is a challenging clinical entity. It is recognized by two main characteristics: absence of HBsAg, and low viral replication. The previous two decades have witnessed a remarkable progress in our understanding of OBI and its clinical implications. Appropriate diagnostic techniques must be adopted. Sensitive HBV DNA amplification assay is the gold standard assay for detection of OBI. Viral as well as host factors are implicated in the pathogenesis of OBI. However, published data reporting the infectivity of OBI by transfusion are limited. Several aspects including OBI transmission, infectivity and its relation to the development of chronic liver diseases and hepatocellular carcinoma have to be resolved. The aim of the present review is to highlight recent data on OBI with a focus on its virological diagnosis and clinical outcome. | Zeinab Nabil Ahmed Said | 2011 | World Journal of Gastroenterology2011，17，15： | 20 |
| 5 | 下颌骨放射性骨坏死临床诊疗专家共识显示文摘下颌骨放射性骨坏死(osteoradionecrosis,ORN)是头颈部大剂量放疗后的一种严重并发症,常以慢性坏死及感染为主要特征,临床表现为局部红肿、疼痛、吞咽困难、开口受限、咀嚼及语言障碍、面部软组织瘘管经久不愈、死骨暴露,严重者甚至造成病理性骨折,给患者的身心带来巨大痛苦,已成为口腔颌面外科及头颈外科领域棘手的临床难题。迄今为止,国内外对于下颌骨ORN缺乏统一的分类、分期及相关治疗共识或指南,不同单位对于下颌骨ORN的诊治水平参差不齐,缺乏统一科学的诊疗标准与规范,对该疾病的处理仍以个人或单位经验作为治疗依据,同时也缺乏客观有效的下颌骨ORN治疗后评价体系。为进一步统一和规范下颌骨ORN的诊疗标准,减少医疗资源的浪费,提高治疗效果,中华口腔医学会口腔颌面外科专业委员会召集国内颌骨放射性骨坏死研究领域的专家进行反复讨论,汇集全国17家著名医学院校及附属医院专家的诊治意见,同时借鉴和参考国内外近年来对下颌骨ORN的研究成果与诊治经验,最终制订'下颌骨放射性骨坏死临床诊疗专家共识',供临床医师参考。 | 何悦 侯劲松 李晓光 马春跃 彭歆 王慧明 王松灵 刘磊 刘冰 田磊 刘忠龙 刘习强 徐昕 张东升 蒋灿华 王军 姚原 朱国培 白永瑞 王胜资 孙长伏 李劲松 何三纲 王成 Nabil Samman 孙坚 张陈平 张志愿 邱蔚六 | 2017 | 中国口腔颌面外科杂志2017，15，5： | 17 |
| 6 | Trends and outcomes of pancreaticoduodenectomy for periampullary tumors: A 25-year single-center study of 1000 consecutive cases显示文摘AIM To evaluate the evolution, trends in surgical approaches a n d r e c o n s t r u c t i o n t e c h n i q u e s, a n d i m p o r t a n t lessons learned from performing 1000 consecutive pancreaticoduodenectomies(PDs) for periampullary tumors.METHODS This is a retrospective review of the data of all patients who underwent PD for periampullary tumor during the period from January 1993 to April 2017. The data were categorized into three periods, including early period(1993-2002), middle period(2003-2012), and late period(2013-2017).RESULTS The frequency showed PD was increasingly performed after the year 2000. With time, elderly, cirrhotic and obese patients, as well as patients with uncinate process carcinoma and borderline tumor were increasingly selected for PD. The median operative time and postoperative hospital stay decreased significantly over the periods. Hospital mortality declined significantly, from 6.6% to 3.1%. Postoperative complications significantly decreased, from 40% to 27.9%. There was significant decrease in postoperative pancreatic fistula in the second 10 years, from 15% to 12.7%. There was a significant improvement in median survival and overall survival among the periods.CONCLUSION Surgical results of PD significantly improved, with mortality rate nearly reaching 3%. Pancreatic reconstruction following PD is still debatable. The survival rate was also improved but the rate of recurrence is still high, at 36.9%. | ayman el nakeeb waleed askar ehab atef ehab el hanafy ahmad m sultan tarek salah ahmed shehta mohamed el sorogy emad hamdy mohamed el hemly ahmed a el-geidi tharwat kandil mohamed el shobari talaat abd allah amgad fouad mostafa abu zeid ahmed abu el eneen nabil gad el-hak gamal el ebidy omar fathy ahmed sultan mohamed abdel wahab | 2017 | World Journal of Gastroenterology2017，23，38： | 15 |
| 7 | Diagnosis and management of choledochal cyst: 20 years of single center experience显示文摘We report the first case series from Africa and the Middle East on choledochal cyst,a disease which shows significant geographical distribution with high incidence in the Asian population.In this study,the epidemiological data of the patients are presented and analyzed.Attention was paid to diagnostic imaging and its accuracy in the diagnosis and classification of choledochal cyst.Most cases of choledochal cyst disease have type?ⅠandⅣ-A cysts according to the Todani classification system,which support the etiological theories of choledochal cyst,especially Babbitt’s theory of the anomalous pancreaticobiliary duct junction,which are clearly stated.The difficulties and hazards of surgical management and methods used to avoid operative complications are clarified.Early and late postoperative complications are also included.This study should be followed by multicenter studies throughout Egypt to help assess the incidence of choledochal cysts in one of the largest populations in Africa and the Middle East. | Nabil Gadelhak Ahmed Shehta Hosam Hamed | 2014 | World Journal of Gastroenterology2014，20，22： | 13 |
| 8 | Distal tibial fracture: An ideal indication for external fixation using locking plate显示文摘 | Jing-wei Zhang Nabil A. Ebraheim Ming Li Xian-Feng He Joshua Schwind Li-Mei Zhu Yi-Hui Yu | 2016 | Chinese Journal of Traumatology2016，19，2： | 10 |
| 9 | Novel association between sperm deformity index and oxidative stress-induced DNA damage in infertile male patients显示文摘Aim: To investigate the impact of abnormal sperm morphology using the sperm deformity index (SDI) on reactive oxygen species (ROS) production and its correlation with sperm DNA damage. Methods: Semen samples were collected from men undergoing infertility screening (n=7) and healthy donors (n=6). Mature spermatozoa were isolated and incubated with 5mmol/L β-nicotinamide adenine dinucleotide phosphate (NADPH) for up to 24h to induce ROS. Sperm morphology was evaluated using strict Tygerberg's criteria and the SDI. ROS levels and DNA damage were assessed using chemiluminescence and terminal deoxynucleotidyl transferase-mediated fluoresceindUTP nick end labeling (TUNEL) assays, respectively. Results: SDI values (median [interquartiles]) were higher in patients than donors (2 [1.8,2.1] vs. 1.53 [1.52, 1.58], P=0.008). Aliquots treated with NADPH showed higher ROS levels (1.22 [0.30, 1.87] vs. 0.39 [0.10, 0.57], P=0.03) and higher incidence of DNA damage than those not treated (10 [4.69, 24.85] vs. 3.85 [2.58, 5.10], P=0.008). Higher DNA damage was also seen following 24h of incubation in patients compared to donors. SDI correlated with the percentage increase in sperm DNA damage following incubation for 24h in samples treated with NADPH (r=0.7, P=0.008) and controls (r=0.58, P=0.04).Conclusion: SDI may be a useful tool in identifying potential infertile males with abnormal prevalence of oxidative stress (OS)-induced DNA damage. NADPH plays a role in ROS-mediated sperm DNA damage, which appears to be more evident in infertile patients with semen samples containing a high incidence of morphologically abnormalspermatozoa. | Tamer M.Said Nabil Aziz Rakesh K.Sharma Iwan Lewis-Jones AnthonyJ.ThomasJr AshokAgarwal | 2005 | Asian Journal of Andrology2005，7，2： | 10 |
| 10 | Measurement of total phenolic content and antioxidant activity of aerial parts of medicinal plant Coronopus didymus显示文摘Objective: To evaluate the total phenolic content and compare the antioxidant activity of various solvent extracts and fractions from the aerial parts of Coronopus didymus through various assays. Methods: Total phenolic content was determined using the Folin-Ciocalteu assay and the in vitro antioxidant activity of a number of different extracts was investigated in a dose-dependent manner with three different methods: the 2,2-diphenyl-1-picrylhydrazyl(DPPH), 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt(ABTS) and ferric reducing antioxidant power(FRAP) assays. A flavone was isolated from the most active ethanolic extract with high antioxidant activity using size exclusion chromatography. IC_(50) values were calculated for the DPPH and ABTS methods. The FRAP activity was assessed in terms of μM Fe(II) equivalent. Results: The phenolic content was found to be highest in the ethanol extract(CDA Et; 47.8 mM GAE) and the lowest in the dichloromethane extract(CDA DCM; 3.13 mM GAE). The ethanol extract showed high radical scavenging activity towards DPPH and ABTS radicals with IC_(50) values of(7.80 × 10~2) and(4.32 × 10~2) μg/m L, respectively. The most active ethanol extract had a FRAP value of 1 921.7 μM Fe(Ⅱ) equivalent. The isolated flavone F10C(5,7,4'-trihydroxy-3'-methoxy flavone) was far more effective for scavenging free radicals in the DPPH and ABTS assays with IC_(50) of 43.8 and 0.08 μg/m L, than the standard trolox, with IC_(50) values of 97.5 and 21.1 μg/m L, respectively. In addition, the flavone F10C and the standard ascorbic acid had FRAP values of 1 621.7 and 16 038.0 μM Fe(Ⅱ) equivalents, respectively. Conclusions: The total phenolic content of extracts in decreasing order is ethanol extract(CDA Et)> acetone extract(CDA ACE)> phenolic extract(CDA MW)> n-hexane extract(CDA nHX)> chloroform extract(CDA CHL)> dichloromethane extract(CDA DCM). The ordering of extracts in terms of antioxidant activity from highest to lowest is CDA Et> CDA MW> CDA DCM> CDA CHL> CDA ACE> CDA nHX in DPPH, ABTS and FRAP assays. A significant relationship is found between antioxidant potential and total phenolic content, suggesting that phenolic compounds are the major contributors to the antioxidant activity of Coronopus didymus. | Hafiza Noreen Nabil Semmar Muhammad Farman James S.O.McCullagh | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，8： | 9 |
| 11 | 牛角瓜(Calotropis procera Ait.)提取物对非洲瓜瓢虫(Henosepilachna elaterii Rossi)的杀虫潜能评价(英文)显示文摘室内评价了牛角瓜(Calotropis proceraAit.)提取物对非洲瓜瓢虫(Henosepilachna elateriiRossi)的生物活性及提取方法.结果表明,浸泡提取法的提取效率显著比电动振荡提取法高;植物的不同部分提取效率存在显著差异,以叶最高,花次之,根最低;叶提取物的生物活性高于花和根;初孵的幼虫不取食牛角瓜叶、花和根提取物处理过的南瓜叶;用提取物处理过的南瓜叶饲养4龄幼虫,幼虫不能化蛹就死亡;4龄幼虫前胸背板点滴牛角瓜叶或花提取物试验表明,点滴处理后幼虫的死亡率、随后的蛹死亡率和羽化的畸形成虫比例增加.但4龄幼虫先用牛角瓜叶、花和根提取物处理过的南瓜叶饲养2天,随后用未经提取物处理的南瓜叶饲养,则这些幼虫仍能完成幼虫和蛹的发育,而且育出的成虫寿命和生殖力不受影响. | Umsalama A.M.AHMED Nabil H.H.BASHIER 施祖华 | 2006 | 浙江大学学报(农业与生命科学版)2006，32，3： | 8 |
| 12 | 一种基于神经网络的遥感图像压缩编码显示文摘为了更好地在恒定压缩率条件下,实现卫星遥感图像的压缩,提出1种将像素分为3类的编码方案.每类采用基于Levenberg-Marquardt算法的双层神经网络进行预测,和基于偏置学习规则的竞争神经网络实现量化.对长城、珠峰、香港等地遥感图像的压缩试验证实了算法的有效性.同时还表明该算法压缩图像的MSE高于距离-权值方法与最小均方误差法,且时间复杂度为O(n). | 张煜东 吴乐南 王水花 Neggaz Nabil 孙晓燕 | 2009 | 南京信息工程大学学报(自然科学版)2009，1，1： | 7 |
| 13 | Linkage of microbiota and osteoporosis:A mini literature review显示文摘The gut microbiota(GM) has become a recent topic of interest in the role of many disease states. Assessing patients with osteoporosis(OP), there is a strong correlation between gut microbe dysregulation and decreased bone density. Gut dysbiosis may lead to inflammation, dysregulation of nutrient and calcium transport across the intestine into circulation and systemic inflammation.Investigation of microbial profile relative to normal gut microbiomes, assessment of inflammatory markers such as interleukin-1(IL-1), IL-6, and tumor necrosis factor-alpha. Therapies to normalize GM in patients with OP or prevent occurrence of OP to be investigated include: High fiber prebiotic diets to promote growth of normal gut bacteria and short chain fatty acid production, Probiotics to encourage growth of normal gut microbes, and antibiotic treatment followed by fecal matter transplant. | David Yatsonsky Ⅱ Karen Pan Vithal B Shendge Jiayong Liu Nabil A Ebraheim | 2019 | World Journal of Orthopedics2019，10，3： | 7 |
| 14 | 细粒棘球绦虫转醛醇酶基因的克隆、表达及其潜在免疫诊断价值的研究显示文摘目的对细粒棘球绦虫转醛醇酶(Echinococcus granulosus transaldolase,EgTAL)编码基因进行生物信息学分析、克隆和表达,并对其作为药物靶标及其潜在的免疫诊断价值进行初步评价。方法运用多种软件分析EgTAL的理化性质、保守功能域、同源性和三级结构等。从重组质粒pBluescript ⅡSK Egtal中PCR扩增Egtal基因,克隆至pET30a,构建表达载体pET30a-Egtal,转化大肠埃希菌(Escherichia coli)BL21(DE3),异丙基-β-D-硫代半乳糖苷(IPTG)诱导表达,十二烷基硫酸钠-聚丙烯酰胺凝胶电泳(SDS-PAGE)分析表达产物,抗His标签镍亲和层析柱纯化重组蛋白EgTAL,与细粒棘球蚴病患者血清进行蛋白质印迹(Western blotting)分析。用20份已确诊的细粒棘球蚴病患者血清和20份健康者血清,ELISA法评价重组蛋白EgTAL的免疫诊断效果。分光光度法检测重组蛋白EgTAL的酶活性。结果 Egtal基因长981 bp,编码的蛋白含326个氨基酸,理论相对分子质量(M_r)为36 332,等电点为5.11,含TAL标识序列DATTNPSLI(31~39 aa)及酶活性催化部位,EgTAL与人TAL的同源性为62%。三级结构分子建模显示,EgTAL具有A和B两条完整的蛋白链。成功构建重组质粒pET30a-Egtal。SDS-PAGE和Western blotting分析结果显示,重组蛋白EgTAL在E.coli BL21(DE3)中获得高效表达,在M_r36 332处可见重组蛋白EgTAL条带,主要以可溶性形式存在,EgTAL可被细粒棘球蚴病患者血清识别。ELISA分析结果显示,20份细粒棘球蚴病患者血清和20份健康者血清的平均A_(450)值分别为1.189±0.384和0.325±0.078,其中17份细粒棘球蚴病患者血清检测结果为阳性。酶活性检测结果显示,纯化后的EgTAL具有高效酶活性,60μg EgTAL加入酶促反应体系催化反应30 min后,体系的吸光度(A_(340)值)由1.684±0.103降至0.139±0.009。结论克隆了细粒棘球绦虫Egtal基因,并在E.coli BL21(DE3)中表达出有酶催化活性和潜在免疫诊断价值的EgTAL重组蛋白。 | 辛奇 景涛 宋晓霞 高海军 孙旭东 吕薇 Nabil Pervaiz 鲁俊 | 2017 | 中国寄生虫学与寄生虫病杂志2017，35，4： | 7 |
| 15 | Defective Etioplasts Observed in Variegation Mutants May Reveal the Light-Independent Regulation of White/Yellow Sectors of Arabidopsis Leaves显示文摘Leaf variegation resulting from nuclear gene mutations has been used as a model system to elucidate the molecular mechanisms of chloroplast development. Since most variegation genes also function in photosynthesis, it remains unknown whether their roles in photosynthesis and chloroplast development are distinct. Here, using the variegation mutant thylakoid formation1 (thf1) we show that variegation formation is light independent. It was found that slow and uneven chloroplast development in thf1 can be attributed to defects in etioplast development in darkness. Ultrastructural analysis showed the coexistence of plastids with or without prolamellar bodies (PLB) in cells of thf1, but not of WT. Although THF1 mutation leads to significant decreases in the levels of Pchlide and Pchllide oxidoreductase (POR) expression, genetic and 5-aminolevulinic acid (ALA)-feeding analysis did not reveal Pchlide or POR to be critical factors for etioplast formation in thf1. Northern blot analysis showed that plastid gene expression is dramatically reduced in thf1 compared with that in WT, particularly in the dark. Our results also indicate that chlorophyll biosynthesis and expression of plastidic genes are coordinately suppressed in thf1. Based on these results, we propose a model to explain leaf variegation formation from the plastid development perspective. | Wenjuan Wu Nabil Elsheery Qing Wei Lingang Zhang Jirong Huang | 2011 | Journal of Integrative Plant Biology2011，53，11： | 6 |
| 16 | 几何增强的装配工艺本体建模显示文摘包含产品几何与非几何信息的产品装配要求是装配工艺设计的主要依据,对装配工艺设计决策结果具有决定性的影响。在装配工艺模型中描述产品的几何相关信息能够更好地表达如装配顺序,装配路径等内容,同时可以更好地辅助装配工艺决策,提高决策的自动化水平。提出一种几何增强的装配工艺本体模型,利用语义本体技术,建立产品几何信息在装配工艺中的描述方法,数据结构与关系描述。并以该模型为基础,建立基于几何增强装配工艺本体的装配工艺决策框架。该框架分为两部分:一是采用几何增强的装配工艺本体模型描述产品几何信息和装配工艺信息的数据结构和相互关系;二是为了让几何信息与装配工艺信息之间存在的丰富的隐含关系显性化,对语义本体推理机制进行增强,提出推理单元的概念,使决策框架具有从产品几何信息中推理装配工艺相关信息的能力,有效地支持装配工艺决策。以针对某传动器产品装配顺序决策的过程,验证所提出的几何增强装配工艺本体模型与框架的有效性。 | 乔立红 朱怡心 ANWER Nabil | 2015 | 机械工程学报2015，51，22： | 6 |
| 17 | Clinical asthma phenotyping:A trial for bridging gaps in asthma management显示文摘Asthma is a common disease affecting millions of people worldwide and exerting an enormous strain on health resources in many countries. Evidence is increasing that asthma is unlikely to be a single disease but rather a series of complex, overlapping individual diseases or phenotypes, each defined by its unique interaction between genetic and environmental factors. Asthma phenotypes were initially focused on combinations ofclinical characteristics, but they are now evolving to link pathophysiological mechanism to subtypes of asthma. Better characterization of those phenotypes is expected to be most useful for allocating asthma therapies. This article reviews different published researches in terms of unbiased approaches to phenotype asthma and emphasizes how the phenotyping exercise is an important step towards proper asthma treatment. It is structured into three sections; the heterogeneity of asthma, the impact of asthma heterogeneity on asthma management and different trials for phenotyping asthma. | Magdy Mohamed Zedan Wafaa Nabil Laimon Amal Mohamed Osman Mohamed Magdy Zedan | 2015 | World Journal of Clinical Pediatrics2015，4，2： | 5 |
| 18 | Malnutrition in Relation with Dietary, Geographical, and Socioeconomic Factors among Older Chinese显示文摘Objective Nutrition is closely related to the health of the elderly population. This study aimed to provide a comprehensive picture of the nutrition status of elderly Chinese and its related dietary,geographical, and socioeconomic factors.Methods A total of 13,987 ≥ 60-year-old persons from the 2010–2013 Chinese National Nutrition and Health Survey were included to evaluate various aspects of malnutrition, including underweight,overweight or obesity, and micronutrient inadequacy.Results Overall, the prevalence of obesity, overweight, and underweight was 12.4%, 34.8%, and 5.7%,respectively, with disparities both geographically and socioeconomically. The prevalence of underweight was higher among the older old(≥ 75 years), rural residents and those with low income, with low education status, and residing in undeveloped West areas. More than 75% of the elderly do not meet the Dietary Reference Intakes for vitamins A, B1, B2, and E, folate, calcium, selenium, potassium, biotin,and choline, with the prevalence of inadequate intake increasing with age for most nutrients. At the population level, the mean intakes of numerous food groups did not meet the recommendations by the Chinese Dietary Guideline.Conclusions Obesity epidemic, inadequacy of micronutrient intake, and high prevalence of underweight and anemia in susceptible older people are the major nutrition challenges for the rapidly aging population in China. | ZHANG Jian SONG Peng Kun ZHAO Li Yun SUN Ye YU Kai YIN Jing PANG Shao Jie LIU Zhen MAN Qing Qing HE Li LI Cheng ARIGONI Fabrizio BOSCO Nabil DING Gang Qiang ZHAO Wen Hua | 2021 | Biomedical and Environmental Sciences2021，34，5： | 5 |
| 19 | Investigation into improving the efficiency and accuracy of CFD/DEM simulations显示文摘The Euler-Lagrange approach combined with a discrete element method has frequently been applied to elucidate the hydrodynamic behavior of dense fluid-solid flows in fluidized beds.In this work,the efficiency and accuracy of this model are investigated.Parameter studies are performed;in these studies,the stiffness coefficient,the fluid time step and the processor number are varied under conditions with different numbers of particles and different particle diameters.The obtained results are compared with measurements to derive the optimum parameters for CFD/DEM simulations.The results suggest that the application of higher stiffness coefficients slightly improves the simulation accuracy.However,the average computing time increases exponentially.At larger fluid time steps,the results show that the average computation time is independent of the applied fluid time step whereas the simulation accuracy decreases greatly with increasing the fluid time step.The use of smaller time steps leads to negligible improvements in the simulation accuracy but results in an exponential rise in the average computing time.The parallelization accelerates the DEM simulations if the critical number for the domain decomposition is not reached.Above this number,the performance is no longer proportional to the number of processors.The critical number for the domain decomposition depends on the number of particles.An increase in solid contents results in a shift of the critical decomposition number to higher numbers of CPUs. | Falah Alobaid Nabil Baraki Bernd Epple | 2014 | Particuology2014，12，5： | 5 |
| 20 | Managements of osteoporotic vertebral compression fractures:A narrative review显示文摘Osteoporotic vertebral compression fractures(OVCFs)are the most common fragility fracture and significantly influence the quality of life in the elderly.Currently,the literature lacks a comprehensive narrative review of the management of OVCFs.The purpose of this study is to review background information,diagnosis,and surgical and non-surgical management of the OVCFs.A comprehensive search of PubMed and Google Scholar for articles in the English language between 1980 and 2021 was performed.Combinations of the following terms were used:compression fractures,vertebral compression fractures,osteoporosis,osteoporotic compression fractures,vertebroplasty,kyphoplasty,bisphosphonates,calcitonin,and osteoporosis treatments.Additional articles were also included by examining the reference list of articles found in the search.OVCFs,especially those that occur over long periods,can be asymptomatic.Symptoms of acute OVCFs include pain localized to the mid-line spine,a loss in height,and decreased mobility.The primary treatment regimens are pain control,medication management,vertebral augmentation,and anterior or posterior decompression and reconstructions.Pain control can be achieved with acetaminophen or nonsteroidal anti-inflammatory drugs for mild pain or opioids and/or calcitonin for moderate to severe pain.Bisphosphonates and denosumab are the first-line treatments for osteoporosis.Vertebroplasty and kyphoplasty are reserved for patients who have not found symptomatic relief through conservative methods and are effective in achieving pain relief.Vertebroplasty is less technical and cheaper than kyphoplasty but could have more complications.Calcium and vitamin D supplementation can have a protective and therapeutic effect.Management of OVCFs must be combined with multiple approaches.Appropriate exercises and activity modification are important in fracture prevention.Medication with different mechanisms of action is a critical long-term causal treatment strategy.The minimally invasive surgical interventions such as vertebroplasty and kyphoplasty are reserved for patients not responsive to conservative therapy and are recognized as efficient stopgap treatment methods.Posterior decompression and fixation or Anterior decompression and reconstruction may be required if neurological deficits are present.The detailed pathogenesis and related targeted treatment options still need to be developed for better clinical outcomes. | Devon Patel Jiayong Liu Nabil A Ebraheim | 2022 | World Journal of Orthopedics2022，13，6： | 5 |
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