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| 1 | Brain metastasis in advanced colorectal cancer: results from the South Australian metastatic colorectal cancer (SAmCRC) registry显示文摘Objective:Brain metastasis is considered rare in metastatic colorectal cancer(mCRC);thus,surveillance imaging does not routinely include the brain.The reported incidence of brain metastases ranges from 0.6% to 3.2%.Methods:The South Australian mCRC Registry(SAmCRC)was analyzed to assess the number of patients presenting with brain metastasis during their lifetime.Due to small numbers,a descriptive analysis is presented.Results:Only 59 patients of 4,100 on the registry at the time of analysis had developed brain metastasis(1.4%).The clinical characteristics of those with brain metastasis were as follows:the median age was 65.3 years and 51% were female.Where the V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog(KRAS)mutation status of the tumor was known,the majority harbored a KRAS mutation(55%);31(53%)underwent craniotomy and 55(93%)underwent whole-brain radiotherapy.The median survival time from diagnosis of brain metastasis was 4.2 months(95% confidence interval 2.9–5.5).Patients who underwent craniotomy and radiotherapy had superior survival compared to those who underwent whole-brain radiotherapy(8.5 months vs.2.2 months,respectively).Data from the SAmCRC(a population-based registry)confirm that brain metastases are rare and the median time to development is approximately 2 years.Conclusions:Brain metastasis is a rare outcome in advanced CRC.Patients within the registry tended to be female,young in age,and harbored with higher rates of KRAS mutations.Whether routine surveillance brain scanning should be considered remains controversial given the relative rarity of developing brain metastases in mCRC and ultimately,most patients with central nervous system involvement die from their extracranial disease. | Gonzalo Tapia Rico Timothy J. Price Christos Karapetis Cynthia Piantadosi Rob Padbury Amitesh Roy Guy Maddern James Moore Scott Carruthers David Roder Amanda R. Townsend | 2017 | Cancer Biology & Medicine2017，14，4： | 3 |
| 2 | Neuromuscular electrical stimulation and testosterone did not influence heterotopic ossification size after spinal cor injury: A case series显示文摘Neuromuscular electrical stimulation(NMES) and testosterone replacement therapy(TRT) are effective rehabilitation strategies to attenuate muscle atrophy and evoke hypertrophy in persons with spinal cord injury(SCI). However both interventions might increase heterotopic ossification(HO) size in SCI patients. We present the results of two men with chronic traumatic motor complete SCI who also had pre-existing HO and participated in a study investigating the effects of TRT or TRT plus NMES resistance training(RT) on body composition. The 49-year-old male, Subject A, has unilateral HO in his right thigh. The 31-year-old male, Subject B, has bilateral HO in both thighs. Both participants wore transdermal testosterone patches(4-6 mg/d) daily for 16 wk. Subject A also underwent progressive NMES-RT twice weekly for 16 wk. Magnetic resonance imaging scans were acquired prior to and post intervention. Cross-sectional areas(CSA) of thewhole thigh and knee extensor skeletal muscles, femoral bone, and HO were measured. In Subject A(NMES-RT + TRT), the whole thigh skeletal muscle CSA increased by 10%, the knee extensor CSA increased by 17%, and the HO + femoral bone CSA did not change. In Subject B(TRT), the whole thigh skeletal muscle CSA increased by 13% in the right thigh and 6% in the left thigh. The knee extensor CSA increased by 7% in the right thigh and did not change in the left thigh. The femoral bone and HO CSAs in both thighs did not change. Both the TRT and NMES-RT + TRT protocols evoked muscle hypertrophy without stimulating the growth of preexisting HO. | Pamela D Moore Ashraf S Gorgey Rodney C Wade Refka E Khalil Timothy D Lavis Rehan Khan Robert A Adler | 2016 | World Journal of Clinical Cases2016，4，7： | 3 |
| 3 | Management of the Open Abdomen: From Initial Operation to Definitive Closure显示文摘 | Vargo Daniel Richardson J David Campbell Andre Chang Michael Fabian Timothy Franz Michael Kaplan Mark Moore Frederick Reed R Lawrence Scott Bradford Silverman Ronald | 2009 | The American Surgeon2009，，11： | 2 |
| 4 | The role of specific interactions and transreactions on the compatibility of polyester lonomers with poly (Ethylene Terephthalate) and nylon 6,6显示文摘 | Timothy L Boykin Robert B Moore | 1998 | Polymer Engineering and Science1998，38，10： | 1 |
| 5 | Staged Management of Giant Abdominal Wall Defects: Acute and Long-Term Results显示文摘 | T. Wright Jernigan Timothy C. Fabian Martin A. Croce Natalie Moore F. Elizabeth Pritchard Gayle Minard Tiffany K. Bee | 2003 | Annals of Surgery2003，，3： | 1 |
| 6 | Kidney Transplantation for Primary Focal Segmental Glomerulosclerosis: Outcomes and Response to Therapy for Recurrence显示文摘 | LaTonya J. Hickson Manish Gera Hatem Amer Corey W. Iqbal Therese B. Moore Dawn S. Milliner Fernando G. Cosio Timothy S. Larson Mark D. Stegall Michael B. Ishitani James M. Gloor Matthew D. Griffin | 2009 | Transplantation2009，，8： | 1 |
| 7 | Suppression of bovine viral diarrhea virus replication by small interfering RNA and short hairpin RNA-mediated RNA interference显示文摘 | Luke S. Lambeth Robert J. Moore Morley S. Muralitharan Timothy J. Doran | 2006 | Veterinary Microbiology2006，，2： | 1 |
| 8 | Novel reduc- tion technique for thoracolumbar fracture dislocations显示文摘 | Timothy A Moore MD Michael P Steinmetz | 2011 | Neuros- urg Spine2011，15，： | 1 |
| 9 | Indications for Cardiac Catheterization and Intervention in Pediatric Cardiac Disease: A Scientific Statement From the American Heart Association显示文摘 | Timothy F. Feltes Emile Bacha Robert H. Beekman John P. Cheatham Jeffrey A. Feinstein Antoinette S. Gomes Ziyad M. Hijazi Frank F. Ing Michael de Moor W. Robert Morrow Charles E. Mullins Kathryn A. Taubert Evan M. Zahn | 2011 | Circulation2011，，22： | 1 |
| 10 | Computed tomographic coronary angiography:experience at Baylor University Medical Center/Baylor Jack and Jane Hamilton Heart and Vascular Hospital Proc显示文摘 | Jeffrey M Schussler M D William D Dockery M D Timothy R Moore M D | 2005 | Bayl Univ Med Cent2005，18，3： | 1 |
| 11 | 5-hydroxytryptamine-receptor antagonists versus prochlorperazine for control of delayed nausea caused by doxorubicin: a URCC CCOP randomised controlled trial显示文摘 | Jane T Hickok Joseph A Roscoe Gary R Morrow Christopher W Bole Hongwei Zhao Karen L Hoelzer Shaker R Dakhil Timothy Moore Tom R Fitch | 2005 | Lancet Oncology2005，，： | 1 |
| 12 | Spatial group choice: a SDSS tool for collaborative spatial decisionmaking显示文摘 | PIOTR JANKOWSKI TIMOTHY L. NYERGES ALAN SMITH T. J. MOORE EMORY HORVATH | 1997 | International Journal of Geographical Information Science1997，，6： | 1 |
| 13 | Novel reduc-tion technique for thoracolumbar fracture dislocations显示文摘 | Timothy A Moore MD Michael P Steinmetz | | 0，，： | 1 |
| 14 | Outcomes associated with Interstim therapy for medically refractory fecal incontinence显示文摘 | M Shane McNevin Michael Moore Timothy Bax | 2014 | The American Journal of Surgery2014，，： | 1 |
| 15 | Semianalytical model for the derivation of ocean color inherent optical properties:description,implementation,and performance assessment显示文摘 | SMYTH Timothy J MOORE Gerald F TAKAFUMI Hirata | 2006 | Appl Opt2006，45，31： | 1 |
| 16 | A clinically relevant combination treatment with doxorubicin and cyclophosphamide does not induce hepatotoxicity in C57BL/6J mice显示文摘Background and aims:Chronic exposure to chemotherapeutics can lead to severe adverse events including hepatotoxicity.A combination chemotherapy regimen of doxorubicin(DOX)and cyclophos-phamide(CPS)is employed in treatment of several cancers such as leukemia,lymphoma,and breast cancer.It is not well understood whether a combination therapy with DOX and CPS can induce hepa-totoxicity.We therefore sought to determine whether co-administration of DOX and CPS at their clini-cally relevant doses and frequency results in hepatotoxicity.Methods:Male C57BL/6J mice received one intraperitoneal injection of saline or DOX-2 mg/kg and CPS-50 mg/kg once a week for 4 weeks.After the treatment period,liver histology and various serum bio-markers of hepatotoxicity were assessed.Results:Co-treatment with DOX and CPS did not alter the serum levels of alanine aminotransferase(ALT),alkaline phosphatase(ALP),bilirubin,albumin,globulin,or total protein.Similarly,co-administration of DOX and CPS did not result in a noticeable change in liver histology.However,it was notable that the concomitant treatment with DOX and CPS resulted in a significant increase in serum levels of aspartate aminotransferase(AST).Elevated serum AST levels were also associated with increased serum creatinine kinase(CK)levels,suggesting that the elevated serum AST levels are likely due to muscle injury following the co-administration of DOX and CPS.Conclusions:Taken together,our results,for the first time,suggest that co-administration of DOX and CPS,at their clinically relevant doses and frequency does not induce a significant hepatotoxicity in the mice. | Satyanarayana R Pondugula Julia M Salamat Kodye L Abbott Patrick C Flannery Mohammed Majrashi Mohammed Almaghrabi Manoj Govindarajulu Sindhu Ramesh Maninder Sandey Suneel K Onterue Chen-Che J Huang Yoshimi Iwaki Kristina Gill Natasha Narayanan Edwin McElroy Darshini Desai Rishi Nadar Timothy Moore Muralikrishnan Dhanasekaran | 2021 | Liver Research2021，5，4： | 1 |
| 17 | Depletion of CD4+CD25+ Regulatory T Cells Promotes a Tumor-Specific Immune Response in Pancreas Cancer–Bearing Mice显示文摘 | Carsten T. Viehl MD Todd T. Moore BS Udaya K. Liyanage MD Daniel M. Frey MD Jesmin P. Ehlers BS Timothy J. Eberlein MD Peter S. Goedegebuure PhD David C. Linehan MD | 2006 | Annals of Surgical Oncology2006，，9： | 1 |
| 18 | Sequencing orphan species initiative (SOS): Filling the gaps in the 16S rRNA gene sequence database for all species with validly published names显示文摘 | Pablo Yarza Cathrin Spr?er Jolantha Swiderski Nicole Mrotzek Stefan Spring Brian J. Tindall Sabine Gronow Rüdiger Pukall Hans-Peter Klenk Elke Lang Susanne Verbarg Audra Crouch Timothy Lilburn Brian Beck Christel Unosson Sofia Cardew Edward R.B. Moore Mar | 2013 | Systematic and Applied Microbiology2013，，1： | 1 |
| 19 | Seasat—A 25-year legacy of success显示文摘 | Diane L. Evans Werner Alpers Anny Cazenave Charles Elachi Tom Farr David Glackin Benjamin Holt Linwood Jones W. Timothy Liu Walt McCandless Yves Menard Richard Moore Eni Njoku | 2005 | Remote Sensing of Environment2005，，3： | 1 |
| 20 | Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition显示文摘 | Randy K. Bledsoe Valerie G. Montana Thomas B. Stanley Chris J. Delves Christopher J. Apolito David D. McKee Thomas G. Consler Derek J. Parks Eugene L. Stewart Timothy M. Willson Millard H. Lambert John T. Moore Kenneth H. Pearce H.Eric Xu | 2002 | Cell2002，，1： | 1 |
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