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| 1 | A homeopathic nosode, Hepatitis C 30 demonstrates anticancer effect against liver cancer cells in vitro by modulating telomerase and topoisomerase Ⅱ activities as also by promoting apoptosis via intrinsic mitochondrial pathway显示文摘OBJECTIVE: Homeopathic nosodes have seldom been scientifically validated for their anticancer effects. This study was conducted to examine if a recently developed hepatitis C nosode has demonstrable anticancer potential in cancer cells in vitro.METHODS: Anticancer effects of Hepatitis C 30C(Hep C 30), if any, were initially tested on three cancer cell lines, HepG2(liver cancer), MCF-7(breast cancer) and A549(lung cancer) and one normal liver cell line WRL-68 cells and subsequently a more thorough study using further scientific protocols was undertaken on HepG2 cells(against WRL-68 cells as the normal control) as HepG2 cells showed better anticancer response than the other two. Three doses, one at 50% lethal dose(LD_(50)) and the other two below LD_(50), were used on HepG2 cells subsequently. Protocols like apoptosis induction and its possible signaling mechanism were deployed using immunoblots of relevant signal proteins and confocal microscopy, with particular reference to telomerase and topoisomerase Ⅱ(Top Ⅱ) activities, two strong cancer biomarkers for their direct relationship with divisional activities of cells and DNAs. RESULTS: Hep C 30 induced apoptosis, caused distorted cell morphology typical of apoptotic cells, increased reactive oxygen species generation and produced increased DNA nicks. Further it enhanced pro-apototic signal proteins like Bax, cytochrome c and inhibited anti-apoptotic signal proteins, Bcl-2, cytochrome c and caspase-3, changed mitochondrial membrane potential and caused externalization of phosphatidylserine. The drug also decreased expression of two cancer biomarkers, Top Ⅱ and telomerase, consistent with its anticancer effect. CONCLUSION: Hep C 30 has demonstrable anticancer effects against liver cancer cells in vitro. | Jesmin Mondal Jayeeta Das Rajesh Shah Anisur Rahman Khuda-Bukhsh | 2016 | Journal of Integrative Medicine2016，14，3： | 5 |
| 2 | In vivo anticancer activity of vanillin semicarbazone显示文摘Objective:To evaluate the anticancer activity of vanillin semicarbazone(VSC) against Ehrlich ascites carcinoma(EAC) cells in Swiss albino mice.Methods:The compound VSC at three doses(5, 7.5 and 10 mg/kg i.p.) was administered into the intraperitoneal cavity of the EAC inoculated mice to observe its efficiency by studying the cell growth inhibition, reduction of tumour weight,enhancement of survival time as well as the changes in depleted hematological parameters. Allsuch parameters were also studied with a known standard drug bleomycin at the dose of 0.3 mg/kg(i.p.).Results:Among the doses studied, 10 mg/kg(i.p.) was found to be quite comparable in potency to that of bleomycin at the dose of 0.3 mg/kg(i.p.). The host toxic effects of VSC was found to be negligible.Conclusions:It can be concluded that VSC can therefore be considered as potent anticancer agent. | Shaikh M Mohsin Ali M Abul Kalam Azad Mele Jesmin Shamim Ahsan M Mijanur Rahman Jahan Ara Khanam M Nazrul Islam Sha M Shahan Shahriar | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，6： | 2 |
| 3 | Changes in important apoptosis-related molecules in the endothelin-1-induced hypertrophied cardiomyocytes: effect of the pretreatment with eicosapentaenoic Acid 显示文摘 | Shimojo N Jesmin S Zaedi S | 2006 | Exp Biol Med (Maywood)2006，231，6： | 1 |
| 4 | VEGF signaling is disrupted in the hearts of mice laeking estrogen receptor alpha显示文摘 | Jesmin S Mowa CN Sultana SN | 2010 | Eur J Pharmacol2010，641，23： | 1 |
| 5 | Endothelin antagonism normalizes VEGF signaling and cardiac function in STZ-induced diabetic rat hearts显示文摘 | Jesmin S Zaedi S Shimojo N Iemitsu M Masuzaw a K Yamagu-chi N | 2007 | Am J Physiol Endoerinol Metab2007，292，4： | 1 |
| 6 | Temporal changes in pulmonary expression of key procoagulant molecules in rabbits with endotoxin-induced acute lung injury:elevated expression levels of protease-activated receptors显示文摘 | Jesmin S Gando N Matsuda A | 2004 | Thromb Haemost2004，92，5： | 1 |
| 7 | Diminished penile expression of vascular endothelial growth factor and its receptors at the insulin-resistant stage of a type II diabetic rat model:a possible cause for erectile dysfunction in diabetes显示文摘 | Jesmin S Sakuma I Salah-Eldin A | 2003 | J Mol Endocrinol2003，31，3： | 1 |
| 8 | Eicosapentaenoic acid prevents endothelin-1-induced cardiomyocyte hypertrophy in vitro through the suppression of TGF-β1 and phosphorylated JNK显示文摘 | Shimojo N Jesmin S Zaedi S | 2006 | Am J Physiol2006，291，2： | 1 |
| 9 | Antineoplas- tic activity of N-(2-hydroxybenzylidene) 2'-hydroxyphe- nylimine aqua nickel( II ) complex on ehrlich ascites carcinoma (EAC) in Swiss albino mice 显示文摘 | Hossain I A Khanam J A Jesmin M | 2016 | Exp Toxieol Pathol2016，68，1： | 1 |
| 10 | Estrogen receptor alpha and beta are both involved in the cerebral VEGF/Akt/NO pathway and cerebral angiogenesis in female mice显示文摘 | Jesmin S Mowa CN Sultana SN | | 0，，06： | 1 |
| 11 | Temporal effects of edaravone,a free radical scavenger, on transient ischemia-induced neuronal dysfunction in the rat hippocampus显示文摘 | Otani H Togashi H Jesmin S | 2005 | Eur J Pharmacol2005，512，12： | 1 |
| 12 | Estrogen receptor alpha and beta are both involved in the cerebral VEGF/Akt/NO pathway and cerebral angiogenesis in female mice显示文摘 | Jesmin S Mowa CN Sultana SN | | 0，，： | 1 |
| 13 | Low doses of ethanolic extract of Boldo(Peumus boldus) can ameliorate toxicity generated by cisplatin in normal liver cells of mice in vivo and in WRL-68 cells in vitro, but not in cancer cells in vivo or in vitro显示文摘OBJECTIVE: Use of cisplatin, a conventional anticancer drug, is restricted because it generates strong hepatotoxicity by accumulating in liver. Therefore its anticancer potential can only be fully exploited if its own toxicity is considerably reduced. Towards this goal, ethanolic extract of the plant, Boldo(Peumus boldus), known for its antihepatotoxic effects, was used simultaneously with cisplatin, to test its ability to reduce cisplatin's cytotoxicity without affecting its anticancer potential. METHODS: The cytotoxicity of Boldo extract(BE) and cisplatin, administered alone and in combination, was determined in three cancer cell lines(A549, HeLa, and HepG2) and in normal liver cells(WRL-68). Drug-DNA interaction, DNA damage, cell cycle, apoptosis, reactive oxygen species(ROS) and mitochondrial membrane potential(MMP, ΔΨ) were also studied. Hepatotoxicity and antioxidant activity levels were determined by alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase and glutathione assays in mice. The cytotoxicity of related proteins was tested by Western blotting. RESULTS: Co-administration of BE and cisplatin increased viability of normal cells, but had no effect on the viability of cancer cells. Boldo protected liver from damage and normalized different antioxidant enzyme levels in vivo and also reduced ROS and re-polarized MMP in vitro. Bax and cytochrome c translocation was reduced with caspase 3 down-regulation. Further, a drugDNA interaction study revealed that BE reduced cisplatin's DNA-binding capacity, resulting in a reduction in DNA damage. CONCLUSION: Results indicated that a low dose of BE could be used benefi cially in combination with cisplatin to reduce its toxicity without hampering cisplatin's anticancer effect. These fi ndings signify a potential future use of BE in cancer therapy. | Jesmin Mondal Kausik Bishayee Ashis Kumar Panigrahi Anisur Rahman Khuda-Bukhsh | 2014 | Journal of Integrative Medicine2014，12，5： | 1 |
| 14 | In vivo estrogen manipulation on coronary capillary network and angiogenic molecule exprexxion in middle-aged female rats显示文摘 | Jesmin S Sakuma I | 2002 | Arterioscler Thromb Vasc Biol2002，22，10： | 1 |
| 15 | Long-acting calcium channel blocker benidipine suppresses expression of angiogenic growth factors and prevents cardiac remodelling in a Type II diabetic rat model显示文摘 | Jesmin S Sakuma I Hattori Y | 2002 | Diabetologia2002，45，3： | 1 |
| 16 | Temporal effects ofedaravone,a free radical scavenger,on transient ischemicinduced neuronal dysfunction in the rat hippocampus 显示文摘 | Otani H Togashi H Jesmin S | 2005 | Eur J Pharmacol2005，512，1： | 1 |
| 17 | Dosing information in a standard drug reference : Are pediatrics still therapeutically neglected 显示文摘 | Jesmin Permala Mohamed Azmi Hassali Ahmed Awaisu | 2010 | Pediatrics International2010，52，2： | 1 |
| 18 | Subdepreesor dose of benidipine ameliorates diabetic cardiac remodeling accompanied by normalization of upregulated endothelin system in rats显示文摘 | Jesmin S Hattori Y Maeda S | | 0，，： | 1 |
| 19 | Changes in important apoptosis-related molecules in the endothelin-1-induced hypertrophied cardiomyocytes:effect of the pretreatment with eicosapentaenoic Acid显示文摘 | Shimojo N Jesmin S Zaedi S | 2006 | Exp Biol Med (Maywood)2006，231，6： | 1 |
| 20 | Activation pattern of MAPK signaling in the hearts of trained and untrained rats following a single bout of exercise显示文摘 | Motoyukl Iemitsu Seiji Maeda Subrina Jesmin | 2006 | J Appl Physiol2006，101，： | 1 |
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