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| 1 | B7-H7 (HHLA2) inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling显示文摘Modulation of T-cell responses has played a key role in treating cancers and autoimmune diseases.Therefore,understanding how different receptors on T cells impact functional outcomes is crucial.The influence of B7-H7(HHLA2)and CD28H(TMIGD2)on T-cell activation remains controversial.Here we examined global transcriptomic changes in human T cells induced by B7-H7.Stimulation through TCR with OKT3 and B7-H7 resulted in modest fold changes in the expression of select genes;however,these fold changes were significantly lower than those induced by OKT3 and B7-1 stimulation.The transcriptional changes induced by OKT3 and B7-H7 were insufficient to provide functional stimulation as measured by evaluating T-cell proliferation and cytokine production.Interestingly,B7-H7 was coinhibitory when simultaneously combined with TCR and CD28 stimulation.This inhibitory activity was comparable to that observed with PD-L1.Finally,in physiological assays using T cells and APCs,blockade of B7-H7 enhanced T-cell activation and proliferation,demonstrating that this ligand acts as a break signal.Our work defines that the transcriptomic changes induced by B7-H7 are insufficient to support full costimulation with TCR signaling and,instead,B7-H7 inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling. | Sadiye Amcaoglu Rieder Jingya Wang Natalie White Ariful Qadri Catherine Menard Geoffrey Stephens Jodi LKarnell Christopher ERudd Roland Kolbeck | 2021 | Cellular & Molecular Immunology2021，18，6： | 9 |
| 2 | Tissue distribution and tumor uptake of folate receptor–targeted epothilone folate conjugate,BMS-753493,in CD2F1 mice after systemic administration显示文摘To assess targeting of an epothilone folate conjugate(BMS-753493) to the folate receptor(FR)-overexpressed tumor in mice bearing both FRt and FR– tumors,a series of experiments were conducted by quantitative whole-body autoradiography(QWBA) and LC–MS/MS following i.v.administration of BMS-753493 or its active moiety,BMS-748285 in mice bearing FRt(98M109) and FR–(M109) tumors.QWBA showed [3H]BMS-753493–derived radioactivity was extensively distributed to various tissues.The FR over-expressing 98M109 tumors showed consistently higher level of radioactivity than FR-negative tumors(i.e.,M109 tumors) up to 48 h post dose of [3H]BMS-753493,despite the magnitude of difference between the tumors is relatively small(generally 3 5-fold).The radioactivity level in 98M109 tumors was 2 12-fold of normal tissues except intestine/content at 48 h post dose.No selective radioactivity uptake into 98M109 tumors over M109 or normal tissues was observed after i.v.administration of the active epothilone,[3H]BMS-748285.LC–MS/MS measurements demonstrated that the concentrations of BMS-748285,presumably from hydrolysis of the folate conjugate,in 98M109 tumors were greater than those in M109 tumors after i.v.administration of BMS-753493(2–3-fold) whereas no differential uptake in the tumors following BMS-748285 administration.Those data were consistent with radioactivity determinations.Those results demonstrated that the folate conjugation in BMS-753493 enabled moderately preferential distribution of the active epothilone to FR overexpressing 98M109 tumors,thereby supporting targeted delivery of cytotoxics through the folate receptor. | Hong Shen Lifei Wang Weiqi Chen Krista Menard Yang Hong Yuan Tian Samuel J.Bonacorsi W.Griffith Humphreys Francis Y.Lee Jinping Gan | 2016 | Acta Pharmaceutica Sinica B2016，6，5： | 3 |
| 3 | Determinants of angiotensin II generation during converting enzyme inhibition 显示文摘 | Juillerat L Nussberger J Menard J | 1990 | Hypertension1990，16，5： | 1 |
| 4 | Lactic acid bacteria secrete metabolites retaining anti-inflammatory properties after intestinal transport显示文摘 | MENARD S CANDALH C BAMBOU JC | 2004 | Gut2004，53，： | 1 |
| 5 | Elevated IL-6 levels in the synovial fluid of osteoarthritis patients stem from plasma cells 显示文摘 | Doss F Menard J Hauschild M | 2007 | Scand J Rheumatol2007，36，2： | 1 |
| 6 | Theoretical and Practical Aspects of Dynamic Consolidation 显示文摘 | Menard L | 1975 | Geotechnique1975，25，1： | 1 |
| 7 | Theoretical and practical aspects of dynamic consolidation显示文摘 | Menard L Broise Y | 1975 | Journal of Geotechnical Engineering ASCE1975，25，1： | 1 |
| 8 | Abstract: (in French) Muscle metastases of cancers显示文摘 | MENARD O PARACHE RM | 1991 | Ann Med Interne (Paris)1991，142，6： | 1 |
| 9 | HER2 as a prognostic factor in breast cancer显示文摘 | Menard S Fortis S Castiglioni F | 2001 | Oncology2001，61，： | 1 |
| 10 | Vascular damage without hypertension in transgenic rats expression prorenin exclusively in the liver显示文摘 | Veniant M Menard J Bruneval P | 1996 | J Clin Invest1996，98，9： | 1 |
| 11 | HER2 as a prognostic factor in breast cancer显示文摘 | Menard S Fortis S Castiglioni F | 2001 | Oncology2001，61，2： | 1 |
| 12 | Evaluation of controlled- release dinoprostone propess for labor induction显示文摘 | Mazouni C provensal M Menard JP | 2006 | Gynecol obstet Fertil2006，34，6： | 1 |
| 13 | 查看详情显示文摘 | Gohil P Evans T E Ferron J R Moyer R A Petty C C Burrell K H Casper T A Garofalo A M Hyatt A W Jayakumar R J Kessel C Kim J Y La Haye R J Lohr J Luce T C Makowski M A Mazon D Menard J Murakami M Politzer P A Prater R Wade M R | | 0，，： | 1 |
| 14 | Evaluation of controlled- relesase dinoprostone Propess for labor induction 显示文摘 | Mazouni C Provensal M Menard JP | 2006 | Gynecol Obstet Fertil2006，34，6： | 1 |
| 15 | Repaid detection of group B streptococci in pregnancy woman at delivery显示文摘 | Bergeron MG Ke D Menard C | 2000 | N Engl J Med2000，343，1： | 1 |
| 16 | Active p21-activated kinase 1 rescues MCF10A breast epithelial cells from undergoing anoikis显示文摘 | Menard RE Jovanovski AP Mattingly RR | 2005 | Neoplasia2005，7，7： | 1 |
| 17 | c-erbB-2 expression in primary breast cancer显示文摘 | Menard S Robertson JF | 1999 | Int J Biol Markers1999，14，1： | 1 |
| 18 | FHIT loss of function in human primary breast cancer correlates with advanced stage of the disease 显示文摘 | Pekarsky Y Menard S | 1999 | Cancer Res1999，59，： | 1 |
| 19 | New insighls into the role of extracellular matrix during tumor onset and progression 显示文摘 | Pupa SM Menard S Forti S | 2002 | J Cell Physiol2002，192，3： | 1 |
| 20 | Unplaned extubation:risk factors of de-velopment and predictive criterial for reintubation显示文摘 | Chevron V Menard JF Richard JC | 1998 | Crit Care Med1998，26，6： | 1 |
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