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| 1 | Different cava reconstruction techniques in liver transplantation:piggyback versus cava resection显示文摘BACKGROUND: Originally, cava reconstruction(CR) in liver transplantation meant complete resection and reinsertion of the donor cava. Alternatively, preservation of the recipients inferior vena cava(IVC) with side-to-side anastomosis(known as 'piggyback') can be performed. Here, partial clamping maintains blood flow of the IVC, which may improve cardiovascular stability, reduce blood loss and stabilize kidney function. The aim of this study was to compare both techniques with particular focus on kidney function.METHODS: A series of 414 patients who had had adult liver transplantations(2006-2009) were included. Among them,176(42.5%) patients had piggyback and 238 had classical CR operation, 112(27.1%) of the patients underwent CR accompanied with veno-venous bypass(CR-B) and 126(30.4%)without a bypass. The choice of either technique was based on the surgeons' individual preference. Kidney function [serum creatinine, calculated glomerular filtration rate(GFR), RIFLE stages] was assessed over 14 days.RESULTS: Lab-MELD scores were significantly higher in CR-B(22.5±11.0) than in CR(17.3±9.0) and piggyback(18.8±10.0)(P=0.008). Unexpectedly, the incidences of arterial stenoses(P=0.045) and biliary leaks(P=0.042) were significantly increased in piggyback. Preoperative serum creatinine levels were the highest in CR-B [1.45±1.17 vs 1.25±0.85(piggyback)and 1.13±0.60 mg/dL(CR); P=0.033]. Although a worsening of postoperative kidney function was observed among all groups,this was most pronounced in CR-B [creatinine day 14: 1.67±1.40 vs 1.35±0.96(piggyback) and 1.45±1.03 mg/dL(CR); P=0.102].Accordingly, the proportion of patients displaying RIFLE stages≥2 was the highest in CR/CR-B(26%/19%) when compared to piggyback(18%).CONCLUSIONS: Piggyback revealed a shorter warm ischemic time, a reduced blood loss, and a decreased risk of acute kidney failure. Thus, piggyback is a useful technique, which should be applied in standard procedures. When piggyback is unfeasible,cava replacement, which displayed a lower incidence of vascular and biliary complications in our study, remains as a safe alternative. | Volker Schmitz Wenzel Schoening Ines Jelkmann Brigitta Globke Andreas Pascher Marcus Bahra Peter Neuhaus Gero Puhl | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，3： | 5 |
| 2 | Oncological Superiority of Hilar En Bloc Resection for the Treatment of Hilar Cholangiocarcinoma显示文摘 | Peter Neuhaus Armin Thelen Sven Jonas Gero Puhl Timm Denecke Wilfried Veltzke-Schlieker Daniel Seehofer | 2012 | Annals of Surgical Oncology2012，，5： | 2 |
| 3 | Gender-dependent association of CTLA4 polymorphisms with resolution of hepatitis C virus infection显示文摘 | Eckart Schott Heiko Witt Holger Hinrichsen Konrad Neumann Viola Weich Alexandra Bergk Juliane Halangk Tobias Müller Sebastian Tinjala Gero Puhl Peter Neuhaus Bertram Wiedenmann Thomas Berg | 2006 | Journal of Hepatology2006，，3： | 2 |
| 4 | Warm HTK donor pretreatment reduces liver injury during static cold storage in experimental rat liver transplantation显示文摘BACKGROUND: Organ shortage has led to an increased number of transplantations from extended criteria donors. These organs are more vulnerable to ischemia-reperfusion injury. Thus,improvement of organ preservation is needed. HTK is a widely used preservation solution for static cold storage in liver transplantation. The present study was to investigate the beneficial effect of warm HTK donor pretreatment on liver preservation.METHODS: Male inbred Wistar rats(weighing 230-260 g) served as donors and recipients(n=6/group). Donors of treatment groups received i.v. 0.01 m L/g body weight(BW) warm(21 ℃) HTK systemically 15 minutes prior to cold perfusion. Control groups received 0.01 m L/g BW warm(21 ℃) Na Cl 0.9%. Following pretreatment,donors were flushed with 4 ℃ cold HTK,livers were explanted and stored in 4 ℃ HTK for six hours. Thereafter orthotopic liver transplantation was performed. Recipients were harvested four hours,two and five days after reperfusion and blood and liver tissue samples were obtained. Blood samples were analyzed for AST,ALT,lactate dehydrogenase and bilirubin. Liver histological analysis as well as tissue analysis for pro-MMP2,MMP2 and pro-MMP9 using zymography was conducted.RESULTS: Treatment groups showed significantly lower ALT and lactate dehydrogenase levels as well as significantly lower activities of pro-MMP2,MMP2 and pro-MMP9. Histological analysis revealed only minor damage in all groups.CONCLUSIONS: The new concept of warm HTK pretreatment significantly reduced ischemia-reperfusion injury. The reduced ischemia-reperfusion injury was due to MMP inhibition. Warm HTK donor pretreatment is easy to handle and could further improve HTK's potency in liver preservation. | Wenzel Schoening Veeravorn Ariyakhagorn Thomas Schubert Peter Olschewski Andreas Andreou Peter Neuhaus Johann Pratschke Gero Puhl | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，6： | 2 |
| 5 | Petrogenesis and geotectonic setting of ultramafic rocks in the Eastern Alpes: constraints from geochemistry显示文摘 | Melcher F Meisel T Puhl J | 2002 | Lithos2002，65，12： | 1 |
| 6 | Spondylolisthesis and pseudospondylolisthesis:treatment by segmental reposition and interbody fusion with fixateur interne显示文摘 | Kluger P Weidt F Puhl W | 1997 | Orthopade1997，26，9： | 1 |
| 7 | Donor age does not influence 12-month outcome after orthotopic liver transplantation显示文摘 | Faber W Seehofer D Puhl G | 2011 | Transplantation Proceedings2011，43，10： | 1 |
| 8 | Measurement of radiation-induced demagnetization of NdFeB permanent magnets显示文摘 | J ALDERMAN P K JOB J PUHL | 2002 | Nuel Instr Meth A2002，481，： | 1 |
| 9 | Multiple risk pathways for schizo- phrenia converge in serine racemase knockout mice,a mouse mod- el of NMDA receptor hypofunction显示文摘 | Balu DT Li Y Puhl MD | 2013 | Proe Natl Aead Sci U S A2013，110，26： | 1 |
| 10 | Low expression of MRP1/GS-X pump ATPase in lymphocytes of Walker 256 tumour-bearing rats is associated with cyclopentenone prostaglandin accumulation and cancer immunodeficiency显示文摘 | Kolberg A Rosa TG Puhl MT | 2006 | Cell Biochem Funct2006，24，1： | 1 |
| 11 | Oncological Superiority of Hilar En Bloc Resection for the Treatment of Hilar Cholangiocarcinoma显示文摘 | Peter Neuhaus MD Armin Thelen MD Sven Jonas MD Gero Puhl MD Timm Denecke MD Wilfried Veltzke-Schlieker MD Daniel Seehofer MD | 2012 | Annals of Surgical Oncology2012，，5： | 1 |
| 12 | Measurement of FRET efficiency and ratio of donor to acceptor concentration in living cells 显示文摘 | CHEN H PUHL H L 3RD KOUSHIK S V | 2006 | Biophys J2006，91，5： | 1 |
| 13 | 3D CT angiography in patients before a nd after liver transplantation显示文摘 | Weszelits V Doros A Puhl M | 2001 | Abdom Imaging2001，26，2： | 1 |
| 14 | Continuous monitoring of oxidation of human LDL in vivo显示文摘 | Esterbauer H Striegl G Puhl H | 1989 | Free Radic Res Commun1989，6，： | 1 |
| 15 | Changes in strain distribution of loaded proximal femora caused by different types of cementless femoral stems 显示文摘 | Decking R Puhl W Simon U | 2006 | Clin Biomech (Bristol Avon)2006，21，5： | 1 |
| 16 | Recent advances in crystalline and amorphous particulate protein formulations for controlled delivery显示文摘The number of particulate delivery systems for biologics is negligible compared to liquid dosage forms, signifying the complications associated with development of solid protein delivery systems. Particulate protein delivery systems can improve stability, reduce viscosity of suspensions at high protein concentration and allow for controlled drug release. This review discusses current advances in controlled delivery of particulate protein formulations. While the focus lies on protein crystals and delivery systems employing protein crystals,amorphous protein particles will also be addressed. Crystallization and precipitations methods and modifications allowing controlled delivery with and without encapsulation are summarized and discussed. | Sebastian Puhl Lorenz Meinel Oliver Germershaus | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，4： | 1 |
| 17 | 3D CT angiography in patients before and after liver transplantation显示文摘 | Weszelits V Doros A Puhl M | 2001 | Transplant Proc2001，33，12： | 1 |
| 18 | Low expression of MRP1/GS- X pump ATP ase in lymphocytes of Walker 256 tumour-bearing rats is associated with cyclopentenone prostaglandin accumulation and cancer immunodeficiency 显示文摘 | Kolberg A Rosa TG Puhl MT | 2006 | Cell Biochem Funct2006，24，1： | 1 |
| 19 | Patient and tumour biology predict survival beyond the M ilan criteria in liver transplantation for hepatocellular carcinoma显示文摘 | Andreas Andreou Safak Gül Andreas Pascher Wenzel Sch?ning Hussein Al‐Abadi Marcus Bahra Fritz Klein Timm Denecke Benjamin Strücker Gero Puhl Johann Pratschke Daniel Seehofer | 2015 | HPB2015，，2： | 1 |
| 20 | 显示文摘 | Mootz D Puhl H | 1967 | Acta Crystallogr1967，23，： | 1 |
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