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| 1 | Application of poly-lactide-co-glycolide-microspheres in the transarterial chemoembolization in an animal model of hepatocellular carcinoma显示文摘AIM:To introduce an animal model of hepatocellular carcinoma (HCC) in ACI-rats, and to evaluate the therapeutic effects of Poly-lactide-co-glycolide(PIcg)-microspheres in the transarterial chemoembolization (TACE) in this model, as well the value of this model in the experiments of interventional therapy. | Jochen Truebenbach Florian Graepler Philippe Pereira Peter Huppert Thomas Eul Gundula Wiemann Claus Claussen | 2003 | World Journal of Gastroenterology2003，9，1： | 24 |
| 2 | On the combined effect of soil fertility and topography on tree growth in subtropical forest ecosystems—a study from SE China显示文摘Aims The aim of our research was to understand small-scale effects of topography and soil fertility on tree growth in a forest biodiversity and ecosystem functioning(BEF)experiment in subtropical SE China.Methods Geomorphometric terrain analyses were carried out at a spatial resolution of 5×5 m.Soil samples of different depth increments and data on tree height were collected from a total of 566 plots(667 m2 each).The soils were analyzed for carbon(soil organic carbon[SOC]),nitrogen,acidity,cation exchange capacity(CEC),exchangeable cations and base saturation as soil fertility attributes.All plots were classified into geomorphological units.Analyses of variance and linear regressions were applied to all terrain,soil fertility and tree growth attributes.Important Findings In general,young and shallow soils and relatively small differences in stable soil properties suggest that soil erosion has truncated the soils to a large extent over the whole area of the experiment.This explains the concurrently increasing CEC and SOC stocks downslope,in hollows and in valleys.However,colluvial,carbon-rich sediments are missing widely due to the convexity of the footslopes caused by uplift and removal of eroded sediments by adjacent waterways.The results showed that soil fertility is mainly influenced by topography.Monte-Carlo flow accumulation(MCCA),curvature,slope and aspect significantly affected soil fertility.Furthermore,soil fertility was affected by the different geomorphological positions on the experimental sites with ridge and spur positions showing lower exchangeable base cation contents,especially potassium(K),due to leaching.This geomorphological effect of soil fertility is most pronounced in the topsoil and decreases when considering the subsoil down to 50 cm depth.Few soil fertility attributes affect tree height after 1-2 years of growth,among which C stocks proved to be most important while pH_(KCl)and CEC only played minor roles.Nevertheless,soil acidity and a high proportion of Al on the exchange complex affected tree height even after only 1-2 years growth.Hence,our study showed that forest nutrition is coupled to a recycling of litter nutrients,and does not only depend on subsequent supply of nutrients from the mineral soil.Besides soil fertility,topography affected tree height.We found that especially MCCA as indicator of water availability affected tree growth at small-scale,as well as aspect.Overall,our synthesis on the interrelation between fertility,topography and tree growth in a subtropical forest ecosystem in SE China showed that topographic heterogeneity lead to ecological gradients across geomorphological positions.In this respect,small-scale soil-plant interactions in a young forest can serve as a driver for the future development of vegetation and biodiversity control on soil fertility.In addition,it shows that terrain attributes should be accounted for in ecological research. | Thomas Scholten Philipp Goebes Peter Kühn Steffen Seitz Thorsten Assmann Jürgen Bauhus Helge Bruelheide Francois Buscot Alexandra Erfmeier Markus Fischer Werner Härdtle Jin-Sheng He Keping Ma Pascal A.Niklaus Michael Scherer-Lorenzen Bernhard Schmid Xuezheng Shi Zhengshan Song Goddert von Oheimb Christian Wirth Tesfaye Wubet Karsten Schmidt | 2017 | Journal of Plant Ecology2017，10，1： | 22 |
| 3 | Role of microparticles in endothelial dysfunction and arterial hypertension显示文摘Microparticles are small cell vesicles that can be released by almost all eukaryotic cells during cellular stress and cell activation. Within the last 1-2 decades it has been shown that microparticles are useful blood surrogate markers for different pathological conditions, such as vascular inflammation, coagulation and tumour diseases. Several studies have investigated the abundance of microparticles of different cellular origins in multiple cardiovascular diseases. It thereby has been shown that microparticles released by platelets, leukocytes and endothelial cells can be found in conditions of endothelial dysfunction, acute and chronic vascular inflammation and hypercoagulation. In addition to their function as surrogate markers, several studies indicate that circulating microparticles can fuse with distinct target cells, such as endothelial cells or leukocyte, and thereby deliver cellular components of their parental cells to the target cells. Hence, microparticles are a novel entity of circulating, paracrine, biological vectors which can influence the phenotype, the function and presumably even the transcriptome of their target cells.This review article aims to give a brief overview about the microparticle biology with a focus on endothelial activation and arterial hypertension. More detailed information about the role of microparticles in pathophysiology and disease can be found in already published work. | Thomas Helbing Christoph Olivier Christoph Bode Martin Moser Philipp Diehl | 2014 | World Journal of Cardiology2014，6，11： | 14 |
| 4 | Helicobacter pylori vac A genotype is a predominant determinant of immune response to Helicobacter pylori CagA显示文摘AIM To evaluate the frequency of Helicobacter pylori(H. pylori) Cag A antibodies in H. pylori infected subjects and to identify potential histopathological and bacterial factors related to H. pylori Cag A-immune response.METHODS Systematic data to H. pylori isolates, blood samples, gastric biopsies for histological and molecular analyses were available from 99 prospectively recruited subjects. Serological profile(anti-H. pylori, anti-Cag A) was correlated with H. pylori isolates(cag A, EPIYA, vac A s/m genotype), histology(Sydney classification) and mucosal interleukin-8(IL-8) m RNA and protein expression. Selected H. pylori strains were assessed for H. pylori Cag A protein expression and IL-8 induction in co-cultivation model with AGS cells.RESULTS Thirty point three percent of microbiologically confirmed H. pylori infected patients were seropositive for Cag A. Majority of H. pylori isolates were cag A gene positive(93.9%) with following vac A polymorphisms: 42.4% vac A s1m1, 23.2% s1m2 and 34.3% s2m2. Anti-Cag AIg G seropositivity was strongly associated with atrophic gastritis, increased mucosal inflammation according to the Sydney score, IL-8 and cag A m RNA expression. V a c A s a n d m p o l y m o r p h i s m s w e r e t h e m a j o r determinants for positive(vac A s1m1) or negative(vac A s2m2) anti-Cag A serological immune response, which also correlated with the in vitro inflammatory potential in AGS cells. In vitro co-cultivation of representative H. pylori strains with AGS cells confirmed functional Cag A translocation, which showed only partial correlation with Cag A seropositivity in patients, supporting vac A as major co-determinant of the immune response.CONCLUSION Serological immune response to H. pylori cag A + strain in H. pylori infected patients is strongly associated with vac A polymorphism, suggesting the crucial role of bacterial factors in immune and clinical phenotype of the infection. | Alexander Link Cosima Langner Wiebke Schirrmeister Wiebke Habendorf Jochen Weigt Marino Venerito Ina Tammer Dirk Schlüter Philipp Schlaermann Thomas F Meyer Thomas Wex Peter Malfertheiner | 2017 | World Journal of Gastroenterology2017，23，26： | 12 |
| 5 | Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages显示文摘How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated.Here,we perform single-cell deep-immune profiling of bronchoalveolar lavage(BAL)samples from 5 patients with mild and 26 with critical COVID-19 in comparison to BALs from non-COVID-19 pneumonia and normal lung.We use pseudotime inference to build T-cell and monocyte-to-macrophage trajectories and model gene expression changes along them.In mild COVID-19,CD8^(+)resident-memory(TRM)and CD4^(+)T-helper-17(T_(H17))cells undergo active(presumably antigen-driven)expansion towards the end of the trajectory,and are characterized by good effector functions,while in critical COVID-19 they remain more naïve.Vice versa,CD4^(+)T-cells with T-helper-1 characteristics(TH1-like)and CD8^(+)T-cells expressing exhaustion markers(T_(EX)-like)are enriched halfway their trajectories in mild COVID-19,where they also exhibit good effector functions,while in critical COVID-19 they show evidence of inflammation-associated stress at the end of their trajectories.Monocyte-to-macrophage trajectories show that chronic hyperinflammatory monocytes are enriched in critical COVID-19,while alveolar macrophages,otherwise characterized by anti-inflammatory and antigen-presenting characteristics,are depleted.In critical COVID-19,monocytes contribute to an ATP-purinergic signaling-inflammasome footprint that could enable COVID-19 associated fibrosis and worsen disease-severity.Finally,viral RNA-tracking reveals infected lung epithelial cells,and a significant proportion of neutrophils and macrophages that are involved in viral clearance. | Els Wauters Pierre Van Mol Abhishek Dinkarnath Garg Sander Jansen Yannick Van Herck Lore Vanderbeke Ayse Bassez Bram Boeckx Bert Malengier-Devlies Anna Timmerman Thomas Van Brussel Tina Van Buyten Rogier Schepers Elisabeth Heylen Dieter Dauwe Christophe Dooms Jan Gunst Greet Hermans Philippe Meersseman Dries Testelmans Jonas Yserbyt Sabine Tejpar Walter De Wever Patrick Matthys CONTAGIOUS collaborators Johan Neyts Joost Wauters Junbin Qian Diether Lambrechts | 2021 | Cell Research2021，31，3： | 11 |
| 6 | Role of immunosuppression and tumor differentiation in predicting recurrence after liver transplantation for hepatocellular carcinoma: A multicenter study of 412 patients显示文摘AIM: To assess pre-orthotopic liver transplantation (OLT) factors that could be evaluated pre-operatively or con- trolled post-operatively associated with hepatocellular carcinoma (HCC) recurrence and disease-free survival after liver transplantation (LT).METHODS: Four hundred and twelve patients trans- planted for HCC between 1988 and 1998 in 14 French centers, who survived the postoperative period were studied. Kaplan Meier estimates were calculated for 24 variables potentially associated with recurrence of HCC. Uni- and multivariate analyses were conducted to iden- tify independent predictors of recurrence. RESULTS: Overall 5-year disease-free survival was 57.1%. By univariate analysis, variables associated with disease-free survival were: presence of cirrhosis (P = 0.001), etiology of liver disease (P = 0.03), α fetoprotein level (< 200, 200 to 2000, or > 2000; P < 0.0001), γ-GT activity (N, N to 2N or > 2N; P = 0.02), the number of nodules (1, 2-3 or ≥ 4; P = 0.02), maximal diameter of the largest nodule (< 3 cm, 3 to 5 cm or > 5 cm; P < 0.0001), the sum of the diameter of the nodules (< 3 cm, 3 to 5 cm, 5 to 10 cm or >10 cm; P < 0.0001), bi- lobar location (P = 0.01), preoperative portal thrombosis (P < 0.0001), peri-operative treatment of the tumor (P = 0.002) and chemoembolization (P = 0.03), tumor differentiation (P = 0.01), initial type of calcineurin inhibitor (P = 0.003), the use of antilymphocyte antibodies (P = 0.02), rejection episodes (P = 0.003) and period of LT (P < 0.0001). By multivariate analysis, 6 variables were independently associated with HCC recurrence: maximal diameter of the largest nodule (P < 0.0001), time of LT (P < 0.0001), tumor differentiation (P < 0.0001), use of anti-lymphocyte antibody (ATG) or anti-CD3 antibody (OKT3) (P = 0.005), preoperative portal thrombosis (P = 0.06) and the number of nodules (P = 0.06). CONCLUSION: This study identif ies immunosuppression, through the use of ATG or OKT3, as a predictive factor of tumor recurrence, and confi rms the prognostic value of tumor differentiation. | Thomas Decaens Franoise Roudot-Thoraval Solange Bresson-Hadni Carole Meyer Jean Gugenheim Francois Durand Pierre-Henri Bernard Olivier Boillot Philippe Compagnon Yvon Calmus Jean Hardwigsen Christian Ducerf Georges Philippe Pageaux Sébastien Dharancy Olivier Chazouillères Daniel Cherqui Christophe Duvoux | 2006 | World Journal of Gastroenterology2006，12，45： | 10 |
| 7 | Natural hydroxyanthraquinoid pigments as potent food grade colorants:an overview显示文摘Natural pigments and colorants are widely used in the world in many industries such as textile dying,food processing or cosmetic manufacturing.Among the natural products of interest are various compounds belonging to carotenoids,anthocyanins,chlorophylls,melanins,betalains...The review emphasizes pigments with anthraquinoid skeleton and gives an overview on hydroxyanthraquinoids described in Nature,the first one ever published.Trends in consumption,production and regulation of natural food grade colorants are given,in the current global market.The second part focuses on the description of the chemical structures of the main anthraquinoid colouring compounds,their properties and their biosynthetic pathways.Main natural sources of such pigments are summarized,followed by discussion about toxicity and carcinogenicity observed in some cases.As a conclusion,current industrial applications of natural hydroxyanthraquinoids are described with two examples,carminic acid from an insect and Arpink red^(™)from a filamentous fungus. | Yanis CARO Linda ANAMALE Mireille FOUILLAUD Philippe LAURENT Thomas PETIT Laurent DUFOSSE | 2012 | Natural Products and Bioprospecting2012，2，5： | 8 |
| 8 | The human TTAGGG repeat factors I and 2 bind to a subsetof interstitial telomeric sequences and satellite repeats显示文摘 | Thomas Simonet Laure-Emmanuelle Zaragosi Claude Philippe Kevin Lebrigand Cldmentine Schouteden Adeline Augereau Serge Bauwens Jing Ye Marco Santagostino Elena Giulotto Frederique Magdinier Beatrice Horard Pascal Barbry Rainer Waldmann Eric Gilson | 2011 | Cell Research2011，21，7： | 7 |
| 9 | Renal sympathetic denervation in therapy resistant hypertension-pathophysiological aspects and predictors for treatment success显示文摘Many forms of human hypertension are associated with an increased systemic sympathetic activity. Especially the renal sympathetic nervous system has been found to play a prominent role in this context. Therefore, catheterinterventional renal sympathetic denervation(RDN) has been established as a treatment for patients suffering from therapy resistant hypertension in the past decade. The initial enthusiasm for this treatment was markedly dampened by the results of the Symplicity-HTN-3 trial, although the transferability of the results into clinical practice to date appears to be questionable. In contrast to the extensive use of RDN in treating hypertensive patients within or without clinical trial settings over the past years, its effects on the complex pathophysiological mechanisms underlying therapy resistant hypertension are only partly understood and are part of ongoing research. Effects of RDN have been described on many levels in human trials: From altered systemic sympathetic activity across cardiac and metabolic alterations down to changes in renal function. Most of these changes could sustainably change long-term morbidity and mortality of the treated patients, even if blood pressure remains unchanged. Furthermore, a number of promising predictors for a successful treatment with RDN have been identified recently and further trials are ongoing. This will certainly help to improve the preselection of potential candidates for RDN and thereby optimize treatment outcomes. This review summarizes important pathophysiologic effects of renal denervation and illustrates the currently known predictors for therapy success. | Karl Fengler Karl Philipp Rommel Thomas Okon Gerhard Schuler Philipp Lurz | 2016 | World Journal of Cardiology2016，8，8： | 5 |
| 10 | ACI大鼠肝细胞癌模型在介入治疗实验中的初步应用显示文摘目的 评价在ACI大鼠肝细胞癌模型进行多种介入治疗方案的疗效及该模型在介入治疗实验中的应用价值。方法 在 5 8只雄性ACI大鼠肝包膜下植入MorrisHepatoma 3 92 4A肝癌瘤块( 1mm3) ,移植术后 13d行MR检查 ,测量肿瘤体积 (V1) ,第 14天时 ,经腹部切开术及胃十二指肠动脉逆行插管而采取以下介入治疗方案 :(A)丝裂霉素 4只 ;(B)降解淀粉 4只 ;(C)碘油 5只 ;(D)肝动脉结扎 4只 ;(E)丝裂霉素 +降解淀粉 4只 ;(F)丝裂霉素 +动脉结扎 5只 ;(G)丝裂霉素 +碘油 5只 ;(H)降解淀粉 +动脉结扎 4只 ;(I)碘油 +动脉结扎 4只 ;(J)丝裂霉素 +聚丙交酯复合乙交酯 (poly lactid co glycolid ,Plcg)微球 4只 ;(K)丝裂霉素 +碘油 +动脉结扎 4只 ;(L)丝裂霉素 +降解淀粉 +动脉结扎4只 ;(M) 0 9%生理盐水 (对照组 ,7只 )。 13d后再次行磁共振检查以确定肿瘤体积 (V2 )变化 ,并对各组间V2 /V1的比值进行比较。结果 肝癌移植率为 10 0 %。介入治疗后肿瘤体积与治疗前肿瘤体积之比 (V2 /V1)分别为A组 4 5 0 ,B组 12 73 ,C组 15 84,D组 10 17,E组 90 2 0 ,F组 7 16,G组 4 0 8,H组 3 45 ,I组 9 99,J组 2 86,K组 3 76,L组 7 71,M组 2 7 12。与对照组相比 ,采取A、G、H、J和K组方法能明显抑制肿瘤生长 ( χ2 值分别为 5 | 钱骏 Truebenbach Jochen Eul Thomas Graepler Florian Pereira Philippe Huppert Peter 冯敢生 Claussen Claus | 2003 | 中华放射学杂志2003，37，1： | 5 |
| 11 | Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn’s disease: an open randomised trial显示文摘 | Geert D’Haens Filip Baert Gert van Assche Philip Caenepeel Philippe Vergauwe Hans Tuynman Martine De Vos Sander van Deventer Larry Stitt Allan Donner Severine Vermeire Frank J Van De Mierop Jean-Charles R Coche Janneke van der Woude Thomas Ochsenkühn Ad A | 2008 | The Lancet2008，，9613： | 5 |
| 12 | Spatial metabolomics for evaluating response to neoadjuvant therapy in non-small cell lung cancer patients显示文摘Background:The response to neoadjuvant chemotherapy(NAC)differs substantially among individual patients with non-small cell lung cancer(NSCLC).Major pathological response(MPR)is a histomorphological read-out used to assess treatment response and prognosis in patientsNSCLC afterNAC.Although spatial metabolomics is a promising tool for evaluating metabolic phenotypes,it has not yet been utilized to assess therapy responses in patients with NSCLC.We evaluated the potential application of spatial metabolomics in cancer tissues to assess the response to NAC,using a metabolic classifier that utilizes mass spectrometry imaging combined with machine learning.Methods:Resected NSCLC tissue specimens obtained after NAC(n=88)were subjected to high-resolution mass spectrometry,and these data were used to develop an approach for assessing the response to NAC in patients with NSCLC.The specificities of the generated tumor cell and stroma classifiers were validated by applying this approach to a cohort of biologically matched chemotherapy-naive patients with NSCLC(n=85).Results:The developed tumor cell metabolic classifier stratified patients into different prognostic groups with 81.6%accuracy,whereas the stroma metabolic classifier displayed 78.4%accuracy.By contrast,the accuracies of MPR and TNM staging for stratification were 62.5%and 54.1%,respectively.The combination of metabolic and MPR classifiers showed slightly lower accuracy than either individual metabolic classifier.In multivariate analysis,metabolic classifiers were the only independent prognostic factors identified(tumor:P=0.001,hazards ratio[HR]=3.823,95%confidence interval[CI]=1.716-8.514;stroma:P=0.049,HR=2.180,95%CI=1.004-4.737),whereasMPR(P=0.804;HR=0.913;95%CI=0.445-1.874)and TNM staging(P=0.078;HR=1.223;95%CI=0.977-1.550)were not independent prognostic factors.Using Kaplan-Meier survival analyses,both tumor and stroma metabolic classifiers were able to further stratify patients as NAC responders(P<0.001)and non-responders(P<0.001).Conclusions:Our findings indicate that the metabolic constitutions of both tumor cells and the stroma are valuable additions to the classical histomorphology-based assessment of tumor response. | Jian Shen Na Sun Philipp Zens Thomas Kunzke Achim Buck Verena M.Prade Jun Wang Qian Wang Ronggui Hu Annette Feuchtinger Sabina Berezowska Axel Walch | 2022 | Cancer Communications2022，42，6： | 3 |
| 13 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 14 | 活体牙周膜有限元仿真的可行性研究显示文摘目的通过现代有限元方法研究牙周膜上的静平衡应力状态。方法提出了两种用于分析牙周膜应力状态的有限元方法,把牙周膜看做是整个下颌模型的一部分,通过有限元方法来处理仿真的牙齿并加载,来研究牙周膜对牙周组织的应力应变分布的作用,计算得到的静平衡应力和牙齿根吸收状态进行比较。结果牙周膜的最大应力发生在接近最高点位置,在中跟位置附近存在局部最大应力,而牙周膜顶点区域的应力要大于牙周膜中根附近的局部最大应力。齿槽顶部的舌侧牙周膜部位可以发现静平衡应力。静平衡应力是和位置有关的,有静平衡应力的部位就会发生牙根吸收。结论人类切牙和单根前臼齿一样,植入物会导致其牙周膜顶点附近静平衡应力的增长,这一点同之前的发现相一致。人类切牙根吸收经常作用于牙周膜的顶点部位。 | Ansgar Hohmann Cornelia Kober Thomas Radtke Philippe Young Martin Geiger Andrew Boryor Christian Sander Franz Gunter Sander | 2008 | 医用生物力学2008，23，1： | 3 |
| 15 | Empirical estimates of regional carbon budgets imply reduced global soil heterotrophic respiration显示文摘Resolving regional carbon budgets is critical for informing land-based mitigation policy.For nine regions covering nearly the whole globe,we collected inventory estimates of carbon-stock changes complemented by satellite estimates of biomass changes where inventory data are missing.The net land–atmospheric carbon exchange(NEE)was calculated by taking the sum of the carbon-stock change and lateral carbon fluxes from crop and wood trade,and riverine-carbon export to the ocean.Summing up NEE from all regions,we obtained a global‘bottom-up'NEE for net land anthropogenic CO_(2)uptake of–2.2±0.6 Pg C yr^(-1)consistent with the independent top-down NEE from the global atmospheric carbon budget during 2000–2009.This estimate is so far the most comprehensive global bottom-up carbon budget accounting,which set up an important milestone for global carbon-cycle studies.By decomposing NEE into component fluxes,we found that global soil heterotrophic respiration amounts to a source of CO_(2)of 39 Pg C yr^(-1)with an interquartile of 33–46 Pg C yr^(-1)—a much smaller portion of net primary productivity than previously reported. | Philippe Ciais Yitong Yao Thomas Gasser Alessandro Baccini Yilong Wang Ronny Lauerwald Shushi Peng Ana Bastos Wei Li Peter A.Raymond Josep G.Canadell Glen P.Peters Rob J.Andres Jinfeng Chang Chao Yue A.Johannes Dolman Vanessa Haverd Jens Hartmann Goulven Laruelle Alexandra G.Konings Anthony W.King Yi Liu Sebastiaan Luyssaert Fabienne Maignan Prabir K.Patra Anna Peregon Pierre Regnier Julia Pongratz Benjamin Poulter Anatoly Shvidenko Riccardo Valentini Rong Wang Grégoire Broquet Yi Yin Jakob Zscheischler Bertrand Guenet Daniel SGoll Ashley-P.Ballantyne Hui Yang Chunjing Qiu Dan Zhu | 2021 | National Science Review2021，8，2： | 3 |
| 16 | Consensus and Future Directions on the Definition of High On-Treatment Platelet Reactivity to Adenosine Diphosphate显示文摘 | Laurent Bonello Udaya S. Tantry Rossella Marcucci Ruediger Blindt Dominick J. Angiolillo Richard Becker Deepak L. Bhatt Marco Cattaneo Jean Philippe Collet Thomas Cuisset Christian Gachet Gilles Montalescot Lisa K. Jennings Dean Kereiakes Dirk Sibbing Die | 2010 | Journal of the American College of Cardiology2010，，12： | 3 |
| 17 | 100 GHz silicon–organic hybrid modulator显示文摘Electro-optic modulation at frequencies of 100 GHz and beyond is important for photonic-electronic signal processing at the highest speeds.To date,however,only a small number of devices exist that can operate up to this frequency.In this study,we demonstrate that this frequency range can be addressed by nanophotonic,silicon-based modulators.We exploit the ultrafast Pockels effect by using the silicon–organic hybrid(SOH)platform,which combines highly nonlinear organic molecules with silicon waveguides.Until now,the bandwidth of these devices was limited by the losses of the radiofrequency(RF)signal and the RC(resistor-capacitor)time constant of the silicon structure.The RF losses are overcome by using a device as short as 500 μm,and the RC time constant is decreased by using a highly conductive electron accumulation layer and an improved gate insulator.Using this method,we demonstrate for the first time an integrated silicon modulator with a 3dB bandwidth at an operating frequency beyond 100 GHz.Our results clearly indicate that the RC time constant is not a fundamental speed limitation of SOH devices at these frequencies.Our device has a voltage–length product of only V_(π)L=11 V mm,which compares favorably with the best silicon-photonic modulators available today.Using cladding materials with stronger nonlinearities,the voltage–length product is expected to improve by more than an order of magnitude. | Luca Alloatti Robert Palmer Sebastian Diebold Kai Philipp Pahl Baoquan Chen Raluca Dinu Maryse Fournier Jean-Marc Fedeli Thomas Zwick Wolfgang Freude Christian Koos Juerg Leuthold | 2014 | Light(Science & Applications)2014，3，1： | 3 |
| 18 | Non-selective β Blockers Increase Risk for Hepatorenal Syndrome and Death in Patients with Cirrhosis and Spontaneous Bacterial Peritonitis显示文摘 | Mattias Mandorfer Simona Bota Philipp Schwabl Theresa Bucsics Nikolaus Pfisterer Matthias Kruzik Michael Hagmann Alexander Blacky Arnulf Ferlitsch Wolfgang Sieghart Michael Trauner Markus Peck-Radosavljevic Thomas Reiberger | 2014 | Gastroenterology2014，，： | 3 |
| 19 | Prospective observational multicenter study to define a diagnostic algorithm for biliary candidiasis显示文摘AIM:To develop an algorithm to improve the diagnosis and treatment of patients with biliary candidiasis.METHODS:We performed a prospective study of 127patients who underwent endoscopic retrograde cholangiopancreatography,for various biliary disorders,at 3 tertiary referral centers in Germany from July 2011through July 2012(ClinicalTrials.gov:NCT01109550).Bile,buccal,and stool samples were collected.When indicated,endoscopic transpapillary bile duct biopsies were performed to clarify the etiology of bile duct strictures and to prove invasive fungal infections.RESULTS:Candida species were detected in 38 of the 127 bile samples(29.9%).By multivariate analysis patients’age and previous endoscopic sphincterotomy were independent risk factors for biliary candidiasis(P<0.05).Patients with immunosuppression(P=0.058)and recent long-term antibiotic therapy(>7 d)(P=0.089)tend to be at risk for biliary candidiasis.One patient was negative in mycological culture of bile fluid but invasive biliary candidiasis was diagnosed histologically.Of Candida subspecies detected,36.7%were azole-resistant,such as C glabrata.Eight patients received anti-mycotic therapy,based on our algorithm.Of these,3 had cancer with biliary tract involvement,2had secondary sclerosing cholangitis,1 had retroperitoneal fibrosis,and 5 had septicemia.In all patients contamination was ruled out by smears of the endoscope channel.CONCLUSION:Gastroenterologists should be aware of frequent candida colonization in patients with cholangitis and biliary disorders.Our suggested algorithm facilitates the further clinical management. | Philipp Lenz Franziska Eckelskemper Thomas Erichsen Tim Lankisch Alexander Dechêne Gabriele Lubritz Frank Lenze Torsten Beyna Hansjorg Ullerich Andre Schmedt Dirk Domagk | 2014 | World Journal of Gastroenterology2014，20，34： | 2 |
| 20 | The second ESGAR consensus statement on CT colonography显示文摘 | Emanuele Neri Steve Halligan Mikael Hellstr?m Philippe Lefere Thomas Mang Daniele Regge Jaap Stoker Stuart Taylor Andrea Laghi | 2013 | European Radiology2013，，3： | 2 |
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