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| 1 | P2Y12-ADP receptor antagonists: Days of future and past显示文摘Antiplatelet therapy is the cornerstone of the therapeutic arsenal in coronary artery disease.Thanks to a better understanding in physiology,pharmacology and pharmacogenomics huge progress were made in the field of platelet reactivity inhibition thus allowing theexpansion of percutaneous coronary intervention.Stent implantation requires the combination of two antiplatelet agents acting in a synergistic way.Asprin inhibit the cyclo-oxygenase pathway of platelet activation while clopidogrel is a P2Y12 adenosine diphosphate(ADP)-receptor antagonist.This dual antiplatelet therapy has dramatically improved the prognosis of stented patients.However,due to pharmacological limitations of clopidogrel(interindividual variability in its biological efficacy,slow onset of action,mild platelet reactivity inhibition)ischemic recurrences remained high following stent implantation especially in acute coronary syndrome patients.Thus,more potent P2Y12-ADP receptor inhibitors were developped including prasugrel,ticagrelor and more recently cangrelor to overcome these pitfalls.These new agents reduced the rate of thrombotic events in acute coronary syndrome patients at the cost of an increased bleeding risk.The abundance in antiplatelet agents allow us to tailor our strategy based on the thrombotic/bleeding profile of each patient.Recently,the ACCOAST trial cast a doubt on the benefit of pre treatment in non-ST segment elevation acute coronary syndrome.The aim of the present review is to summarize the results of the main studies dealing with antiplatelet therapy in stented/acute coronary syndromes patients. | Marc Laine Franck Paganelli Laurent Bonello | 2016 | World Journal of Cardiology2016，8，5： | 4 |
| 2 | Consensus and Future Directions on the Definition of High On-Treatment Platelet Reactivity to Adenosine Diphosphate显示文摘 | Laurent Bonello Udaya S. Tantry Rossella Marcucci Ruediger Blindt Dominick J. Angiolillo Richard Becker Deepak L. Bhatt Marco Cattaneo Jean Philippe Collet Thomas Cuisset Christian Gachet Gilles Montalescot Lisa K. Jennings Dean Kereiakes Dirk Sibbing Die | 2010 | Journal of the American College of Cardiology2010，，12： | 3 |
| 3 | Machine Learning-Based Presymptomatic Detection of Rice Sheath Blight Using Spectral Profiles显示文摘Early detection of plant diseases,prior to symptom development,can allow for targeted and more proactive disease management.The objective of this study was to evaluate the use of near-infrared(NIR)spectroscopy combined with machine learning for early detection of rice sheath blight(ShB),caused by the fungus Rhizoctonia solani.We collected NIR spectra from leaves of ShBsusceptible rice(Oryza sativa L.)cultivar,Lemont,growing in a growth chamber one day following inoculation with R.solani,and prior to the development of any disease symptoms.Support vector machine(SVM)and random forest,two machine learning algorithms,were used to build and evaluate the accuracy of supervised classification-based disease predictive models.Sparse partial least squares discriminant analysis was used to confirm the results.The most accurate model comparing mockinoculated and inoculated plants was SVM-based and had an overall testing accuracy of 86.1%(N=72),while when control,mock-inoculated,and inoculated plants were compared the most accurate SVM model had an overall testing accuracy of 73.3%(N=105).These results suggest that machine learning models could be developed into tools to diagnose infected but asymptomatic plants based on spectral profiles at the early stages of disease development.While testing and validation in field trials are still needed,this technique holds promise for application in the field for disease diagnosis and management. | Anna O.Conrad Wei Li Da-Young Lee Guo-Liang Wang Luis Rodriguez-Saona Pierluigi Bonello | 2020 | Plant Phenomics2020，2，1： | 3 |
| 4 | Temporal relation between clopi- dogrel cessation and stent thrombosis after drug-eluting stent implantation 显示文摘 | Roy P Bonello L Torguson R | 2009 | Am J Cardiol2009，103，6： | 1 |
| 5 | Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphatc 显示文摘 | Bonello L Tantry US Mareucei R et ai | 2010 | JACC2010，56，： | 1 |
| 6 | Consensus andfuture directions on the definition of high on-treatmentplatelet reactivity to adenosine diphosphate 显示文摘 | Bonello L Tantry US Marcucci R | 2010 | J Am CollCardiol2010，56，12： | 1 |
| 7 | Consensus and future di- rections on the definition of high on - treatment platelet reactivity to a- denosine diphosphate 显示文摘 | Bonello L Tantry US Marcucci R | 2010 | J Am Coil Cardiol2010，56，12： | 1 |
| 8 | A Receptance Iqarmon- ic Balance Technique for the Computation of the Vibra- tion of a Whole Aero-Engine Model with Nonlinear Bear- ings 显示文摘 | Philip Bonello PhamMinhHai | 2009 | Journal of Sound and Vibration2009，324，1： | 1 |
| 9 | Breast MR with special focus on DW-MRI and DCE-MRI显示文摘 | Petralia 6 Bonello L Priolo F | 2011 | Cancer Imanging2011，11，： | 1 |
| 10 | Human urotensin Ⅱis a novel activator of NADPH oxidase in human pulmonary artery smooth muscle cells显示文摘 | BelAiba RS Bonello S Pfeilschifter J Hess J Gorlach A | 2005 | Arterioscler Thromb Vasc Biol2005，25，3： | 1 |
| 11 | Clopidogrel loading dose adjustment according to platelet reactivity monitoring in patients carrying the 2C19 *2loss of function polymorphism显示文摘 | Bonello L Armero S Ait Mokhtar O | 2010 | J Am Coll Cardiol2010，56，20： | 1 |
| 12 | Human urotensin Ⅱ is a novel activator of NADPH oxidase in human pulmonary artery smooth muscle cells 显示文摘 | Djordjevic T BelAiba RS Bonello S | 2005 | Arterioscler Thromb Vasc Biol2005，25，3： | 1 |
| 13 | The cross-talk between NF-kappaB and HIF-1:further evidence for a significant liaison显示文摘 | Gorlach A Bonello S | 2008 | Biochem J2008，412，3： | 1 |
| 14 | Primary linitis plastica of the rectum显示文摘 | Dr. Julius C. Bonello M.D. Stuart H. Q. Quan M.D. Stephen S. Sternberg M.D | 1980 | Diseases of the Colon & Rectum1980，，5： | 1 |
| 15 | An Impulsive Recep- tance Technique for the Time Domain Computation of the Vibration of a Whole Aero-Engine Model with Non- linear Bearings 显示文摘 | Pham Minh Hai Philip Bonello | 2008 | Journal of Sound and Vibration2008，318，3： | 1 |
| 16 | Tailored clopidogrel loading dose according to platelet reactivity monitoring to prevent acute and subacute stent thrombosis 显示文摘 | BONELLO L CAMOIN -JAU L ARMERO S | 2009 | AmJ Cardiol2009，103，1： | 1 |
| 17 | History and evolution of the vascular access for hemodialysis 显示文摘 | Bonello M Levin N W Ronco C | 2004 | Contrib Nephrol2004，142，： | 1 |
| 18 | Extracorporeal therapies innon-renal disease:treatment of sepsis and the peak concentration hypothesis显示文摘 | Ronco C Bonello M Bordoni V | 2004 | Blood Purif2004，22，1： | 1 |
| 19 | Adjusted clopidogrel loading doses according to vasodilator-stimulated phosphoprotein phosphorylation index decrease rate of major adverse cardiovascular events in patients with clopidogrel resistance:a multicenter randomized prospective study显示文摘 | Bonello L Camoin-Jau L Arques S | 2008 | J Am Coll Cardiol2008，51，： | 1 |
| 20 | Vasodilator-stimulated phospho-protein phosphorylation analysis prior to percutaneous coronary intervention forexclusion of postprocedural major adverse cardiovascular events显示文摘 | Bonello L Paganelli F Arpin-Bornet M | 2007 | J ThrombHaemost2007，5，8： | 1 |
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