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| 1 | Prospective observational multicenter study to define a diagnostic algorithm for biliary candidiasis显示文摘AIM:To develop an algorithm to improve the diagnosis and treatment of patients with biliary candidiasis.METHODS:We performed a prospective study of 127patients who underwent endoscopic retrograde cholangiopancreatography,for various biliary disorders,at 3 tertiary referral centers in Germany from July 2011through July 2012(ClinicalTrials.gov:NCT01109550).Bile,buccal,and stool samples were collected.When indicated,endoscopic transpapillary bile duct biopsies were performed to clarify the etiology of bile duct strictures and to prove invasive fungal infections.RESULTS:Candida species were detected in 38 of the 127 bile samples(29.9%).By multivariate analysis patients’age and previous endoscopic sphincterotomy were independent risk factors for biliary candidiasis(P<0.05).Patients with immunosuppression(P=0.058)and recent long-term antibiotic therapy(>7 d)(P=0.089)tend to be at risk for biliary candidiasis.One patient was negative in mycological culture of bile fluid but invasive biliary candidiasis was diagnosed histologically.Of Candida subspecies detected,36.7%were azole-resistant,such as C glabrata.Eight patients received anti-mycotic therapy,based on our algorithm.Of these,3 had cancer with biliary tract involvement,2had secondary sclerosing cholangitis,1 had retroperitoneal fibrosis,and 5 had septicemia.In all patients contamination was ruled out by smears of the endoscope channel.CONCLUSION:Gastroenterologists should be aware of frequent candida colonization in patients with cholangitis and biliary disorders.Our suggested algorithm facilitates the further clinical management. | Philipp Lenz Franziska Eckelskemper Thomas Erichsen Tim Lankisch Alexander Dechêne Gabriele Lubritz Frank Lenze Torsten Beyna Hansjorg Ullerich Andre Schmedt Dirk Domagk | 2014 | World Journal of Gastroenterology2014，20，34： | 2 |
| 2 | Rapid Allelic Discrimination by TaqMan PCR for the Detection of the Gilbert’s Syndrome Marker UGT1A1*28显示文摘 | Ursula Ehmer Tim O. Lankisch Thomas J. Erichsen Sandra Kalthoff Nicole Freiberg Michael Wehmeier Michael P. Manns Christian P. Strassburg | 2008 | The Journal of Molecular Diagnostics2008，，6： | 1 |
| 3 | Successful treatment of cervical esophageal leakage by endoscopic-vacuum assisted closure therapy显示文摘AIM: To evaluate the efficacy and safety of endoscopic-vacuum assisted closure (E-VAC) therapy in the treatment of cervical esophageal leakage. METHODS: Between May and November 2012, three male patients who developed post-operative cervical esophageal leakage were treated with E-VAC therapy. One patient had undergone surgical excision of a pharyngo-cervical liposarcoma with partial esophageal resection, and the other two patients had received surgical treatment for symptomatic Zenker's diverticulum. Following endoscopic verification of the leakage, a trimmed polyurethane sponge was fixed to the distal end of a nasogastric silicone tube and endoscopically positioned into the wound cavity, and with decreasing cavity size the sponge was positioned intraluminally to cover the leak. Continuous suction was applied, and the vacuum drainage system was changed twice a week.RESULTS: The initial E-VAC placement was technically successful for all three patients, and complete closure of the esophageal leak was achieved without any procedure-related complications. In all three patients, the insufficiencies were located either above or slightly below the upper esophageal sphincter. The median duration of the E-VAC drainage was 29 d (range: 19-49 d), with a median of seven sponge exchanges (range: 5-12 sponge exchanges). In addition, the E-VAC therapy reduced inflammatory markers to within normal range for all three patients. Two of the patients were immediately fitted with a percutaneous enteral gastric feeding tube with jejunal extension, and the third patient received parenteral feeding. All three patients showed normal swallow function and no evidence of stricture after completion of the E-VAC therapy. CONCLUSION: E-VAC therapy for cervical esophageal leakage was well tolerated by patients. This safe and effective procedure may significantly reduce morbidity and mortality following cervical esophageal leakage. | Henrike Lenzen Ahmed A Negm Thomas J Erichsen Michael P Manns Jochen Wedemeyer Tim O Lankisch | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，7： | 1 |
| 4 | Long-Term Results After Adult Ex Situ Split Liver Transplantation Since Its Introduction in 1987显示文摘 | Harald Schrem Moritz Kleine Tim Oliver Lankisch Alexander Kaltenborn Lampros Kousoulas Lea Zachau Frank Lehner Jürgen Klempnauer | 2014 | World Journal of Surgery2014，，7： | 1 |
| 5 | Changes in liver stiffness using acoustic radiation force impulse imaging in patients with obstructive cholestasis and cholangitis显示文摘 | Dina Attia Sven Pischke Ahmad A. Negm Kinan Rifai Michael P. Manns Michael J. Gebel Tim O. Lankisch Andrej Potthoff | 2014 | Digestive and Liver Disease2014，，： | 1 |
| 6 | Microbiologic analysis of peri-pancreatic fluid collected during EUS in patients with pancreatitis: impact on antibiotic therapy显示文摘 | Ahmed A. Negm Hendrik Poos Elmar Kruck Ralf-Peter Vonberg Dirk Domagk Ahmed Madisch Torsten Voigtl?nder Michael P. Manns Jochen Wedemeyer Tim O. Lankisch | 2013 | Gastrointestinal Endoscopy2013，，2： | 1 |
| 7 | Routine bile collection for microbiological analysis during cholangiography and its impact on the management of cholangitis显示文摘 | Ahmed A. Negm Anja Schott Ralf-Peter Vonberg Tobias J. Weismueller Andrea S. Schneider Stefan Kubicka Christian P. Strassburg Michael P. Manns Sebastian Suerbaum Jochen Wedemeyer Tim O. Lankisch | 2010 | Gastrointestinal Endoscopy2010，，2： | 1 |
| 8 | 用材料数据实现理想的成型模拟显示文摘在过去的20年中,大多数一直从事塑料行业的人已经积累了一些流动分析的经验。对于外行来说,流动分析是计算机模拟,它提供了一种方法来预测塑料在注塑模具中将如何流动以及这一过程将对充模压力、收缩、冷却和最后的翘曲产生怎样的影响。一般,有模拟经验的人能很快给出一个对于这种分析方法的意见,这些意见一般分为三类:它糟透了,无法正确预测任何事情;它足够接近,能提供一个相当好的趋势;它完全正确。 | Tim Lankisch | 2015 | 现代塑料2015，，4： | 0 |
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