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| 1 | The molecular machinery of regulated cell death显示文摘Cells may die from accidental cell death(ACD)or regulated cell death(RCD).ACD is a biologically uncontrolled process,whereas RCD involves tightly structured signaling cascades and molecularly defined effector mechanisms.A growing number of novel nonapoptotic forms of RCD have been identified and are increasingly being implicated in various human pathologies.Here,we critically review the current state of the art regarding non-apoptotic types of RCD,including necroptosis,pyroptosis,ferroptosis,entotic cell death,netotic cell death,parthanatos,lysosome-dependent cell death,autophagy-dependent cell death,alkaliptosis and oxeiptosis.The in-depth comprehension of each of these lethal subroutines and their intercellular consequences may uncover novel therapeutic targets for the avoidanee of pathogenic cell loss. | Daolin Tang Rui Kang Tom Vanden Berghe Peter Vandenabeele Guido Kroemer | 2019 | Cell Research2019，29，5： | 143 |
| 2 | 地氟烷与七氟烷在门诊手术全身麻醉维持中的对比研究:对苏醒早晚期及围手术期咳嗽的影响显示文摘背景目前地氧垸已经用于门诊全身麻醉手术的维持阶段,其相对于七氖烷在围手术期的优略性尚存争议。尽管各研究一致指出,地氟烷比七氟烷苏醒更快,但这种差异对苏醒晚期的影响却未有明确报道。并且,地氟烷与七氟烷相比,对咳嗽发生率的影响也存在争议。方法本研究中纳入了130例在全身麻醉下行浅表门诊手术的患者,随机分为2组。所有患者都静脉注射丙泊酚2mg/kg诱导,置入喉罩,采用1%-3%的七氟烷或3%-8%的地氟炕维持麻醉,吸入混合空气或氧气。调节吸入麻醉药的浓度,维持血流动力学稳定,并维持脑电双频谱指数(BIS)于50—60。并用局部浸润和静脉注射酮洛酸30mg镇痛。在手术结束时给予预防性止吐药物,包括昂丹司琼4mg、地塞米松4mg及甲氧氨普胺10mg。评估标准包括睁眼恢复时间,对指令做出反应的时间,定向力恢复的时间,14分快通道评分,首次进食时间,能坐立,可站立,独立行走及出院时间。手术后早期及离院后24小时内,记录患者对于麻醉的满意度,手术后第1天恢复正常活动的能力,不良反应的发生(如咳嗽、意向性运动、氧饱和度〈90%、咽痛及手术后恶心、呕吐),手术后镇痛药及止吐药的使用情况。结果2组患者的流行病学资料相近。尽管围手术期地氯烷组咳嗽的总体发生率高于七氟烷组(分别为60%和32%,P〈0.05),然而在真正应用吸入麻醉药期间(即麻醉维持中),咳嗽发生率的组间差异无显著性。地氧烷组患者苏醒较快,但两组所有患者在离开手术室之前都达到了快通道恢复标准(快通道评分≥12)。此外,离院时间(七氟炕组90±31分钟,地氟炕组98±5分钟)及手术后第1天能恢复正常活动的患者比率(七氟烷48%,地氟炕60%),在两组间的差异无显著性。结论用地氧烷进行维持全身麻醉具有苏醒迅速、咳嗽发生率高的特点。尽管与七氟烷相比,地氟炕在麻醉早期恢复较快,但两组晚期恢复的差异无显著性。两种吸入麻醉药都适用于门诊手术的麻醉。 | Paul F. White Jun Tang Ronald H. Wender Roya Yumul O. lameson Stokes Alexander Sloninsky Robert Naruse Robert Kariger Evelyn Norel Steven Mandel Tom Webb Alan Zaentz 王琦(译) 李文志(校) | 2011 | 麻醉与镇痛2011，7，1： | 1 |
| 3 | Minimum inventory variability schedule with applications in semiconductor fabrication显示文摘 | Li Shu Tang Tom Collins Donald W | 1996 | IEEE Transactions on Semiconductor Manufacturing1996，9，1： | 1 |
| 4 | The Recovery of Cognitive Function After General Anesthesia in Elderly Patients: A Comparison of Desflurane and Sevoflurane显示文摘 | Xiaoguang Chen Manxu Zhao Paul F. White Shitong Li Jun Tang Ronald H. Wender Alexander Sloninsky Robert Naruse Robert Kariger Tom Webb Eve Norel | 2001 | Anesthesia & Analgesia2001，，6： | 1 |
| 5 | Khawia abbottinae sp. n. (Cestoda: Caryophyllidea) from the Chinese false gudgeon Abbottina rivularis (Cyprinidae: Gobioninae) in China: morphological and molecular data显示文摘 | Xi Bing Wen Oros Mikul?s Wang Gui Tang Scholz Tom?s Xie Jun | 2013 | Folia Parasitologica2013，，2： | 1 |
| 6 | Results of the PROspective MInnesota Study of ECHO/TDI in Cardiac Resynchronization Therapy (PROMISE-CRT) Study显示文摘 | Alan J. Bank Christopher L. Kaufman Aaron S. Kelly Kevin V. Burns Stuart W. Adler Tom S. Rector Steven R. Goldsmith Maria-Teresa P. Olivari Chuen Tang Linda Nelson Andrea Metzig | 2009 | Journal of Cardiac Failure2009，，： | 1 |
| 7 | 设计酚类抗氧剂保护润滑油的技术显示文摘抗氧剂是润滑油配方中的关键成分,通过有效地牺牲自身来保护润滑系统,即清除润滑油在使用过程中产生的自由基或分解氧化过程中形成的过氧化物,且抗氧剂在抗氧化反应中所产生的副产物不会对润滑体系造成不可控伤害。3,5-二叔丁基-4-轻基苯基丙酸酯(HPP)是位阻酚类抗氧剂的关键分子结构。在HPP衍生物中发现含有C8~C15烷基的化合物是理想的润滑油抗氧剂,如室温下是液态,非常便于在调配润滑油时使用,耐高温性能优异,且在各种试验条件下具有高效的抗氧化性能。抗氧剂和润滑油中其他成分的协同效应是理想商用抗氧剂的一种特性。二苯胺类抗氧剂和二硫代磷酸锌是两种常见的润滑油成分。在抗氧剂的评估过程中观察到,酚类抗氧剂与二苯胺类抗氧剂、二硫代磷酸锌均有显著的协同抗氧化作用,因为二硫代磷酸锌容易形成积炭而破坏汽车的催化转换器,润滑油工业界都在限制它的使用量。在积炭实验中发现,优化酚类氧化剂与二硫代磷酸锌的配比不仅可以减少二硫代磷酸锌的使用量,而且在最大限度减少积炭形成的同时显著提高润滑油抗氧化性能。 | Tom Tang Gertrude Jacobs | 2020 | 润滑油2020，35，4： | 1 |
| 8 | Comparative Genomic Hybridization in Combination with Flow Cytometry Improves Results of Cytogenetic Analysis of Spontaneous Abortions显示文摘 | Brenda Lomax Steven Tang Evica Separovic Don Phillips E. Hillard Tom Thomson Dagmar K. Kalousek | 2000 | The American Journal of Human Genetics2000，，5： | 1 |
| 9 | SET1 and p300 Act Synergistically, through Coupled Histone Modifications, in Transcriptional Activation by p53显示文摘 | Zhanyun Tang Wei-Yi Chen Miho Shimada Uyen T.T. Nguyen Jaehoon Kim Xiao-Jian Sun Toru Sengoku Robert K. McGinty Joseph P. Fernandez Tom W. Muir Robert G. Roeder | 2013 | Cell2013，，2： | 1 |
| 10 | CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function显示文摘 | Ya Guo Quan Xu Daniele Canzio Jia Shou Jinhuan Li David U. Gorkin Inkyung Jung Haiyang Wu Yanan Zhai Yuanxiao Tang Yichao Lu Yonghu Wu Zhilian Jia Wei Li Michael Q. Zhang Bing Ren Adrian R. Krainer Tom Maniatis Qiang Wu | 2015 | Cell2015，，： | 1 |
| 11 | 东莨菪碱透皮贴剂:可替代昂丹司琼和氟哌利多用于预防手术后呕吐症状的新制剂显示文摘背景鉴于对使用氟哌利多的争议和5-HT3受体拮抗剂的高昂价格,人们期望出现一种效价合理、可常规用于预防呕吐的药物来替代它们。我们设计了两个平行、随机、双盲、空白和安慰剂对照研究来比较东莨菪碱透皮贴剂(TDS)1.5mg和静脉注射昂丹司琼4mg及氟哌利多1.25mg作为多模式给药方案的一部分,对手术后呕吐“高危”人群早期和晚期的止吐效果及其副作用。方法150例患者参与本研究,其中包括腹腔镜手术(n=80)和整形外科手术(n=70)。患者入手术室前60分钟接受一枚有效的TDS贴剂(含东莨菪碱1.5mg)或一个外表相同的空白贴片。所有患者均接受标准全身麻醉。第2次给药是在手术接近结束时给予患者静脉注射2ml生理盐水(TDS贴剂的两组)、氟哌利多1.25mg或昂丹司琼4mg(空白贴片组)。记录患者手术后恶心、呕吐/干呕的发生率、是否需要止吐药物治疗、用药后的完全有效率(即用药后既无迁延性恶心亦无反复发生呕吐,无需使用止吐药物进行治疗)。此外,对手术后72小时之内的视觉紊乱、口干、昏睡和烦躁不安等不良反应进行记录。结果手术后72小时内,TDS贴剂组、氟哌利多组和昂丹司琼组患者呕吐和需要止吐药物治疗的患者差异无显著性。各治疗组中完全有效率为41%-51%,各组间差异无显著性。TDS组口干的发生率显著高于氟哌利多组和昂丹司琼组(21%vs3%)。结论TDS贴剂作为手术前给药用于预防手术后早期和晚期恶心、呕吐与氟哌利多1.25mg或昂丹司琼4mg效果相同,但是TDS贴剂更易引起口干。 | Patti F. White, PhD, MD Jun Tang, MD Dajun Song, MD, PhD Jayne E. Coleman, MD Ronald H. Wender, MD Babatunde Ogunnaike, MD Alexander Sloninsky, MD Rajani Kapu, MD Mary Shah, MD Tom Webb, MD 潘明(译) 王多友(校) | 2008 | 麻醉与镇痛2008，4，1： | 1 |
| 12 | Advancing multispecies fishery management in China:Lessons from international experience显示文摘China’s 13th Five-Year Plan elevated the national mandate for environmental sustainability.Chinese fisheries are characterized by full retention of high diversity catch harvested using unselective gears,creating ecological risks.Therefore,China launched pilot projects in management by Total Allowable Catch(TAC)in five coastal provinces in 2017 and 2018 to build experience with output controls.Fujian province launched an important pilot in its swimming crab fishery,the first to adopt a multispecies approach.To guide Fujian and other provinces in multispecies management,a workshop in April 2018 shared international experience.The workshop considered 13 case studies spanning a wide range of underlying scientific models and types of harvest controls.Multispecies harvest controls based on simple survey-or index-based models that aggregate trends for many species are typically operationally easier for managers and fishers.However,inadequate management can cause declines of individual species,sometimes leading to adoption of species-specific models and then species-specific harvest controls.This transition often incurs economic costs through scientific and management demands,and constraints on harvest of co-occurring species.The lessons revealed by the case studies suggest multispecies TACs might be effective in the Fujian swimming crab fishery given the modest number of species with similar and productive life history traits,and the market demand for all species.Continued experimentation with different management approaches through pilot projects can enable China to maintain progress toward sustainable fisheries goals under the 14th Five-Year Plan. | Jacob PKritzer Yi Tang Yong Chen Chris Costello Sarah Gaichas Tom Nies Ernesto Penas Keith Sainsbury Changchun Shen Cody Szuwalski Wenbin Zhu | 2023 | Aquaculture and Fisheries2023，8，3： | 0 |
| 13 | 有数据记录功能的无线温度监控器显示文摘成对地使用一只局部温度传感器和一只ASK(幅移键控)发射器/接收器,就可以设计出一个简单的无线温度监控系统,并且具有数据记录功能。微控制器负责处理数据,并将温度读数显示给用户。微控制器的片上UART(通用异步接收器/发射器)能够用于数据记录应用。 | Tom Au-Yeung Wilson Tang | 2012 | 电子设计技术 EDN CHINA2012，19，4： | 0 |
| 14 | 用于汽车防盗告警系统的ASK发送器/接收器显示文摘当你开车回家,停好车走进家门,是否担心车会被盗?本文介绍如何利用简单的收发器电路实现汽车防盗功能。 | Tom Au Yeung Wilson Tang | 2013 | 中国集成电路2013，22，1： | 0 |
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