|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Genetic evidence for asymmetric blocking of higher-order chromatin structure by CTCF/cohesin显示文摘Dear Editor,Similar to higher-order folding of polypeptide chains into functional proteins,linear DNA molecules are spatially folded in a hierarchical and dynamic manner into three-dimensional(3D)functional chromatin structures in eukaryotic nuclei(Huang and Wu,2016;Rowley and Corces,2018).This dynamic folding is closely related to many nuclear processes such as DNA replication and repair,chromosomal translocation,recombination,and segregation,as well as RNA transcription,splicing,and transport.In particular,dynamic long-distance chromatin looping interactions,which result in close spatial contacts between distal enhancers and target promoters,are thought to play a role in controlling precise spatiotemporal as well as cell-type specific gene expression during animal development(Rowley and Corces,2018).Mammalian genomes contain numerous noncoding regulatory elements that regulate these dynamic long-distance chromatin looping interactions. | Yujia Lu Jia Shou Zhilian Jia Yonghu Wu Jinhuan Li Ya Guo Qiang Wu | 2019 | Protein & Cell2019，10，12： | 7 |
| 2 | Three-dimensional genome architectural CCCTC-binding factor makes choice in duplicated enhancers at Pcdhα locus显示文摘During development, gene expression is spatiotemporally regulated by long-distance chromatin interactions between distal enhancers and target promoters. However, how specificity of the interactions between enhancers and promoters is achieved remains largely unknown. As there are far more enhancers than promoters in mammalian genomes, the complexities of enhancer choice during gene regulation remain obscure. CTCF, the CCCTC-binding factor that directionally binds to a vast range of genomic sites known as CBSs(CTCF-binding sites), mediates oriented chromatin looping between a substantial set of distal enhancers and target promoters. To investigate mechanisms by which CTCF engages in enhancer choice, we used CRISPR/Cas9-based DNA-fragment editing to duplicate CBS-containing enhancers and promoters in the native genomic locus of the clustered Pcdhα genes. We found that the promoter is regulated by the proximal one among duplicated enhancers and that this choice is dependent on CTCF-mediated directional enhancer-promoter looping. In addition, gene expression is unaltered upon the switch of enhancers. Moreover, after promoter duplication, only the proximal promoter is chosen by CTCF-mediated directional chromatin looping to contact with the distal enhancer. Finally, we demonstrated that both enhancer activation and chromatin looping with the promoter are essential for gene expression. These findings have important implications regarding the role of CTCF in specific interactions between enhancers and promoters as well as developmental regulation of gene expression by enhancer switching. | Yonghu Wu Zhilian Jia Xiao Ge Qiang Wu | 2020 | Science China(Life Sciences)2020，63，6： | 4 |
| 3 | Luminescence of halophosphate solid-solution Ca5(PO4)3(F0.8Cl0.2):Eu^2+,Mn^2+ for WLED显示文摘Solid-solution based luminescent materials have been widely explored due to their tunable optical properties in recent years. In this work, instead of more common cation-substitution approach, we investigated the luminescence properties of Eu^(2+) and Mn^(2+) co-doped halophosphate solid solution Ca_5(PO_4)_3(F_(0.8)Cl_(0.2)) via anion substitution synthesized by high temperature solid state reaction method.The formation of the solid solution was confirmed by X-ray diffraction(XRD) characterization, which indicates that the introduction of certain proportion of Cl^-will not make significant change on the Ca_5(PO_4)_3F lattice. We also studied the energy transfer from Eu^(2+) to Mn^(2+) in the host so as to obtain white light emission via adjusting the doping concentrations of Eu^(2+) and Mn^(2+). The white light emission was achieved through combination of Eu^(2+) blue emission and Mn^(2+) red-orange emission with appropriate proportions. The results suggest that Ca_5(PO_4)_3(F_(0.8)Cl_(0.2)):0.01Eu^(2+),0.18 Mn^(2+) could be a potential WLED phosphor working under ultraviolet excitation. | Jiashan Mao Hongwei Fang Yonghu Chen | 2018 | Journal of Rare Earths2018，36，11： | 4 |
| 4 | A novel oil spill detection method from synthetic aperture radar imageries via a bidimensional empirical mode decomposition显示文摘Oil spills pose a major threat to ocean ecosystems and their health. Synthetic aperture radar(SAR) sensors can detect oil spills on the sea surface. These oil spills appear as dark spots in SAR images. However, dark formations can be caused by a number of phenomena. It is aimed to distinguishing oil spills or look-alike objects. A novel method based on a bidimensional empirical mode decomposition is proposed. The selected dark formations are first decomposed into several bidimensional intrinsic mode functions and the residue. Subsequently, 64 dimension feature sets are calculated using the Hilbert spectral analysis and five new features are extracted with a relief algorithm. Mahalanobis distances are then used for classification. Three data sets containing oil spills or look-alikes are used to test the accuracy rate of the method. The accuracy rate is more than 90%. The experimental results demonstrate that the novel method can detect oil spills validly and accurately. | YANG Yonghu LI Ying ZHU Xueyuan | 2017 | Acta Oceanologica Sinica2017，36，7： | 2 |
| 5 | Prevention and Treatment of Leprosy--China,2009−2019显示文摘Since 1981,worldwide leprosy prevalence has declined sharply due to the implementation of multidrug therapy(MDT)conducted by the World Health Organization(WHO).The national prevalence of leprosy finally decreased to 0.05 per 10,000 population in 1998,which meant the WHO threshold of leprosy elimination(below 1 per 10,000 population)was reached in China through a wellorganized control network and through the implementation of MDT(1).However,the number of newly registered leprosy cases each year,the grade 2 disability(G2D)rate,as well as the rate of fatal adverse drug reactions(ADR)had not significantly changed since 1998(2–3),so leprosy is still seen as a public health problem in China.In addition,dermatological clinics rather than leprosy control stations became the main source for leprosy case finding at every level.Delayed diagnosis was common due to a general lack of awareness and adequately precise techniques among dermatologists to detect Mycobacterium leprae(M.leprae)that results in leprosy. | Qing Zhao Yonghu Sun Hong Liu Furen Zhang | 2020 | China CDC weekly2020，2，4： | 2 |
| 6 | Influence of Sb Doping on the Luminescent Properties of PbWO4 Single Crystals显示文摘 | Chen Yonghu Shi Chaoshu Hu Guanqin | 2000 | Journal of Applied Physics2000，87，3： | 1 |
| 7 | Influence of Sb doping on the luminescent properties of PbWO4 single crystals显示文摘 | CHEN Yonghu SHI Chaoshu HU Guanqin | 2000 | J Appl Phys2000，87，3： | 1 |
| 8 | VUV Spectroscopy of GdPO_4∶Eu^(3+) and GdBO_3∶Eu^(3+)显示文摘The emission and the excitation spectra of GdPO4∶Eu3+ and GdBO3∶Eu3+ prepared by solid state reaction method were investigated using the synchrotron radiation source of SUPERLUMI station of HASYLAB. The energy transfer between Gd3+ and Eu3+ was discussed with the probability of quantum cutting process. In the excitation spectra monitoring the red emission from Eu3+, the distinct lines corresponding to the intraconfigurational 4f-4f transitions from Gd3+ were observed for both samples, indicating an efficient energy transfer from host Gd3+ ions to the doped Eu3+ ions. The efficient energy transfer is necessary for the quantum cutting process based on the two-step energy transfer from Gd3+ to Eu3+. However, the overlapping of the lines corresponding to Gd3+∶8S7/2→6GJ and the broad excitation band (180~270 nm) due to Eu3+-O2- charge transfer states (CTS) around 200 nm cause excitation energy on ()6GJ levels to dissipate into CTS by direct energy transfer, unfavorable to the cross relaxation energy transfer between Gd3+ and Eu3+, thus unfavorable to the quantum cutting process. With the help of the general rules governing the energy positions of Eu3+-O2-∶CTS, the suggestions concerning searching suitable oxide hosts for Gd3+-Eu3+ quantum cutting were made. | Chen Yonghu Liu Bo Shi Chaoshu Zimmerer G | 2005 | Journal of Rare Earths2005，23，4： | 1 |
| 9 | Comparison study of the luminescent properties of the white-light long afterglow phosphors: Ca x MgSi 2 O 5+ x :Dy 3+ ( x =1, 2, 3)显示文摘 | Yonghu Chen Xuerui Cheng Miao Liu Zeming Qi Chaoshu Shi | 2008 | Journal of Luminescence2008，，5： | 1 |
| 10 | Recovery of transgenic plants by pollen-mediated transformation in Brassica juncea显示文摘 | Jingxue Wang Yonghu Li Chao Liang | 2008 | Transgenic Research2008，，3： | 1 |
| 11 | The roles of Eu 2+ and Dy 3+ in the blue long-lasting phosphor Sr 2 MgSi 2 O 7 : Eu 2+ , Dy 3+显示文摘 | Chaoshu Shi Yibing Fu Bo Liu Guobin Zhang Yonghu Chen Zeming Qi Xixian Luo | 2006 | Journal of Luminescence2006，，： | 1 |
| 12 | Prac- tice audits to reduce caesareans in a ter- tiary referralhospital in south- western China 显示文摘 | Runmei M Terence T L Yonghu S | 2012 | Bul| World Health Oigan2012，90，7： | 1 |
| 13 | Optical thermometry based on upconverted luminescence in transparent glass ceramics containing NaYF 4 :Yb 3+ /Er 3+ nanocrystals显示文摘 | Sha Jiang Peng Zeng Liqing Liao Shifeng Tian Hai Guo Yonghu Chen Changkui Duan Min Yin | 2014 | Journal of Alloys and Compounds2014，，： | 1 |
| 14 | Practice audits to reduce caesareans in a tertiary referral hospital in South-Western China 显示文摘 | Runmei M Terence TL Yonghu S | 2012 | Bull World Health Organ2012，90，7： | 1 |
| 15 | Comparison study of the luminescent properties of the white-light long afterglow phosphors: Cax MgSi2O5+x: Dy^3+ (x= 1,2,3) 显示文摘 | CHEN Yonghu CHENG Xuerui LIU Miao | 2009 | JLuminescence2009，129，： | 1 |
| 16 | Statistical modeling and analysis of the influence of antenna polarization error on received power显示文摘The problem of statistical modeling of antenna polarization error is studied and the statistical characteristics of antenna's received power are analyzed. A novel Stokes-vector-based method is presented to describe the conception of antenna's polarization purity. Statistical model of antenna's polarization error in polarization domain is then built up. When an antenna with polarization error of uniform distribution is illuminated by an arbitrary polarized incident field, the probability density of antenna's received power is derived analytically. Finally, a group of curves of deviation and standard deviation of received power are plotted numerically. | WANG Xuesong , ZENG Yonghu, CHEN Zhijie , XU Zhenhai and LI Yongzhen( School of Electronic Science and Engineering, National University of Defense Technology, Changsha 410073, China Department of Foundation, National University of Defense Technology, Changsha 410073, China) | 2002 | Progress in Natural Science:Materials International2002，12，4： | 1 |
| 17 | CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function显示文摘 | Ya Guo Quan Xu Daniele Canzio Jia Shou Jinhuan Li David U. Gorkin Inkyung Jung Haiyang Wu Yanan Zhai Yuanxiao Tang Yichao Lu Yonghu Wu Zhilian Jia Wei Li Michael Q. Zhang Bing Ren Adrian R. Krainer Tom Maniatis Qiang Wu | 2015 | Cell2015，，： | 1 |
| 18 | Analysis of target RCS statisti-cally characteristics basic on x2 distribution显示文摘 | ZENG Yonghu WANG Guoyu | 2007 | Radar Science andTechnology2007，5，2： | 1 |
| 19 | Practice audits to reduce caesareans in a tertiary referral hospital in south- western China 显示文摘 | Runmei M Terence TL Yonghu S | 2012 | Bull World Health Organ2012，90，7： | 1 |
| 20 | Temperature dependence of GdVO 4 :Eu 3+ luminescence显示文摘 | Bo Liu Chaoshu Shi Qingli Zhang Yonghu Chen | 2002 | Journal of Alloys and Compounds2002，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员