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| 1 | Effect of dietary supplementation of xylanase on apparent ileal digestibility of nutrients,viscosity of digesta,and intestinal morphology of growing pigs fed corn and soybean meal based diet显示文摘This study was to determine apparent ileal digestibility of acid detergent fiber(ADF), neutral detergent fiber(NDF), dry matter(DM), energy, organic matter(OM), crude ash, digesta viscosity, and gut morphology in nursery pigs fed diets containing xylanase(Lohmann Animal Nutrition GmbH, Cuxhaven, Germany). The diet(61% corn, 35% soybean meal, 1% poultry fat, and 3% minerals and vitamins) was mixed with 3 levels of xylanase(0,700, and 1400 LXU/kg). Thirty-six barrows(17.6 ± 3.3 kg) received one of 3 treatment diets based on a randomized complete block design with the initial body weight(BW) as a block. Pigs were individually housed and received experimental diets twice daily(0700 and 1700 h) at a fixed amount based on BW of pigs(0.09 x BW^(0.75) kg). Pigs were fed diets for 10 d, and chromium oxide(0.3%) was added to the diets from d 6 as an indigestible external marker. Pigs were euthanized at the end of d 10 for the collection of digesta and tissues. Jejunal digesta were centrifuged to measure viscosity using a viscometer(Brookfield Engineering Laboratories, Stoughton, MA). Diets and freeze-dried ileal digesta were used to measure ADF, NDF, and chromium to calculate apparent ileal digestibility of ADFand NDF. Villus height and crypt depth of jejunum were measured using a microscope(Fisher Scientific, Hampton, NH). Data were analyzed using polynomial contrasts in the MIXED procedure of SAS version 9.3(SAS Inc., Cary, NC, USA). Morphological measurements and ileal ADF digestibility were not affected by increasing xylanase. However, increasing xylanase supplementation from 0 to 1400 LXU/kg enhanced ileal digestibility of NDF(P < 0.042, linear) from 27.9 to 40.3%,DM(P < 0.006, linear) from 55.4 to 64.6%, OM(P < 0.006, linear) from 59.2 to 67.7%, and energy(P < 0.003,linear) from 58.8 to 68.0%. Viscosity of jejunal digesta decreased(P < 0.023) in a non-linear manner from 2.9 to 2.5 centipoises(cP). In conclusion, the usage of xylanase in corn and soybean meal based pig diets linearly enhanced digestibility of nutrients and affected viscosity of digesta in a non-linear manner. | Adsos Adami Passos Inkyung Park Peter Ferket Elke von Heimendahl Sung Woo Kim | 2015 | Animal Nutrition2015，，1： | 10 |
| 2 | Impacts of low level aflatoxin in feed and the use of modified yeast cell wall extract on growth and health of nursery pigs显示文摘This study was to investigate the effect of corn naturally contaminated with aflatoxins(AF)under the regulatory level on the growth performance and health of nursery pigs,and the efficiency of yeast cell wall based feed additive(YC)mainly composed ofβ-glucans and mannan oligosaccharide(MOS)(Integral A+,Alltech,Lexington,KY)in prevention of mycotoxicosis.Pigs(60 barrows and 60 gilts at 6.02 ± 0.83kg BW)were randomly allotted to 4 treatments in a randomized complete block design based on a 2×2 factorial arrangement with 10 pens(5 barrow and 5 gilt pens)per treatment and 3 pigs per pen.Pigs were fed experimental diets for 5 wk.First factor was AF(0 or 20 mg/kg in feed)and the second factor was YC(0 or 2 g/kg in feed).Feed intake and body weight were measured weekly,and blood samples were used to measure blood cell counts,immunoglobulin G(Ig G),tumor necrosis factor-a(TNF-a),oxidative damage status,and serological evaluation related to liver health.Aflatoxin decreased(P<0.05)the number of platelet count(247.4 to 193.5×10~3/μL),and it also tended to increase the level of albumin(P=0.055,3.46 to 3.63 g/d L),albumin:globulin ratio(P=0.050,2.09 to 2.37),and Ca(P=0.080,10.79 to 10.97 mg/d L).Yeast cell wall based feed additive increased(P < 0.05)ADG(493 to 524 g/d),and ADFI(796 to 846 g/d)of pigs whereas G:F was not affected,and it also tended to increase(P=0.055)albumin level(3.46 to 3.63 g/d L).Interactions(P < 0.05)on hemoglobin,hematocrit,and platelet count indicated that YC further increased their levels when pigs were eating AF contaminated feed.Interactions(P < 0.05)on urea nitrogen and blood urea N to creatinine ratio indicated that YC further decreased their levels when feed were contaminated with AF.In conclusion,low level of 20 mg AF/kg under the regulatory level had minor effects on hematology without affecting growth performance,however the supplementation of 2 g/kg YC as a source ofβ-glucans and MOS in feed can improve feed intake and therefore the growth of pigs. | Yawang Sun Inkyung Park Jiyao Guo Alexandra C.Weaver Sung Woo Kim | 2015 | Animal Nutrition2015，，3： | 8 |
| 3 | Impacts of energy feeds and supplemental protease on growth performance, nutrient digestibility, and gut health of pigs from 18 to 45 kg body weight显示文摘A total of 144 pigs with 18.4 ± 2.3 kg initial body weight(BW) at 6 wk of age were used in a 40-d trial to evaluate effects of protease(300,000 U/kg feed, BioResource International Inc., Durham, NC, USA) on growth performance, apparent ileal digestibility(AID) of nutrients, and gut health of pigs fed diets with sorghum. Pigs were randomly allotted to 4 treatments(12 pens per treatment, 3 pigs per pen) in a 2 x 2 factorial arrangement(corn or sorghum basal diets, and 0 or 0.05% protease as 2 factors) with sex and initial BW as blocks. Experimental period had phase 1(d 1 to 21) and phase 2(d 22 to 40). About 65%(phase 1) and 72%(phase 2) of cereal grains were used in corn or sorghum based diets. Both grains were ground to 400 μm. Body weight and feed intake were recorded weekly. On d 35, serum was collected to quantify tumor necrosis factor-a(TNF-a) and malondialdehyde(MDA). Titanium dioxide(0.3%) was added as an indigestible marker for an additional 4 d feeding. On d 40, 32 pigs(8 pigs per treatment)were euthanized to collect digesta from jejunum and ileum(for viscosity and AID), tissues(for morphology) and mucosa samples(for TNF-α and MDA) from duodenum, jejunum, and ileum. Replacing corn with sorghum in the diet increased(P < 0.05) overall average daily gain(from 756 to 787 g/day) and average daily feed intake(from 1,374 to 1,473 g/day), reduced(P < 0.05) overall gain:feed ratio(from0.553 to 0.537), and did not affect AID. Pigs fed diets with sorghum had lower(P < 0.05) MDA content in serum(from 14.61 to 6.48 μmol/L) and jejunum(from 1.42 to 0.91 μmol/g protein), and reduced(P < 0.05) villus height(from 492 to 396 μm) and crypt depth(from 310 to 257 μm) in jejunum. Dietary protease improved(P < 0.05) AID of crude protein(from 81.8% to 86.0%), decreased MDA level(from 1.20 to 0.98 μmol/g protein) in duodenum, and increased(P < 0.05) the ratio of villus height to crypt depth(from 1.08 to 1.21) in duodenum. Overall, use of sorghum fully replacing corn in diets could benefit pigs with enhanced growth and feed intake potentially by reducing oxidative stress, whereas feed efficiency was compromised. Supplementation of protease improved protein digestion and maintained gut health,irrespective of sorghum or corn based diets. | Hongyu Chen Shihai Zhang Inkyung Park Sung Woo Kim | 2017 | Animal Nutrition2017，，4： | 4 |
| 4 | A randomized phase II trial of S-1-oxaliplatin versus capecitabine–oxaliplatin in advanced gastric cancer显示文摘 | Gun Min Kim Hei-Cheul Jeung Sun Young Rha Hyo Song Kim Inkyung Jung Byung Ho Nam Kyung Hee Lee Hyun Cheol Chung | 2011 | European Journal of Cancer2011，，4： | 2 |
| 5 | Changes in the hyperelastic properties of endothelial cells induced by tumor necrosis factor 显示文摘 | Inkyung K Dinesh P Vassilis P | 2008 | Biophys J2008，94，5： | 1 |
| 6 | The adjuvant effect of a single dose of interleukin- 12 on murine immune responses to live or killed Brucella abortus strain RB51 显示文摘 | Lee Inkyung | 2000 | Vet Bull2000，70，3： | 1 |
| 7 | Application of Non-negative Matrix Factorization to Improve Profile-Profile Alignment Features for Fold Recognition and Remote Homolog Detection 显示文摘 | Jung Inkyung Lee Jaehyung Lee Soo-Young | 2008 | BMC Bioinformatics2008，9，8： | 1 |
| 8 | A randomized phase II trial of S-1-oxaliplatin versus capecitabine–oxaliplatin in advanced gastric cancer显示文摘 | Gun Min Kim Hei-Cheul Jeung Sun Young Rha Hyo Song Kim Inkyung Jung Byung Ho Nam Kyung Hee Lee Hyun Cheol Chung | 2011 | European Journal of Cancer2011，，4： | 1 |
| 9 | Coordinated expression of microRNA-155 and predicted target genes in diffuse large B-cell lymphoma显示文摘 | Deepak Rai Shailaja Karanti Inkyung Jung Patricia L.M. Dahia Ricardo C.T. Aguiar | 2008 | Cancer Genetics and Cytogenetics2008，，1： | 1 |
| 10 | CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function显示文摘 | Ya Guo Quan Xu Daniele Canzio Jia Shou Jinhuan Li David U. Gorkin Inkyung Jung Haiyang Wu Yanan Zhai Yuanxiao Tang Yichao Lu Yonghu Wu Zhilian Jia Wei Li Michael Q. Zhang Bing Ren Adrian R. Krainer Tom Maniatis Qiang Wu | 2015 | Cell2015，，： | 1 |
| 11 | Image Reporting and Characteriza- tion System for Ultrasound Features of Thyroid Nodules : Muhicentric Korean Retrospective Study 显示文摘 | Jin YK Inkyung J Jung HB | 2013 | Korean J Radiol2013，14，1： | 1 |
| 12 | Expression of human peroxiredoxin isoforms in response to cervical carcinogenesis显示文摘 | Kiyoon Kim Miran Yu Seulhee Han Inkyung Oh Young-Jun Choi Sungsoo Kim Kyungsik Yoon Minhyung Jung Wonchae Choe | 2009 | Oncology Reports2009，，6： | 1 |
| 13 | A randomized phase II trial of S-1-oxaliplatin versus capecitabine–oxaliplatin in advanced gastric cancer显示文摘 | Gun Min Kim Hei-Cheul Jeung Sun Young Rha Hyo Song Kim Inkyung Jung Byung Ho Nam Kyung Hee Lee Hyun Cheol Chung | 2011 | European Journal of Cancer2011，，4： | 1 |
| 14 | Relationship between leukoaraiosis and menopause in healthy middle-aged women显示文摘 | SEOK K S INKYUNG J SANG M L | 2013 | Fertility and Sterility2013，100，2： | 1 |
| 15 | Image reporting and characterization system for ultrasound features of thy- reid nodules: multicentric korean retrospective study 显示文摘 | Jin Yourtg Kwak Inkyung Jung Jung Hwan Baek | 2013 | Korean J Radiol2013，14，1： | 1 |
| 16 | Incidence, prevalence and risk of stroke in patients with Takayasu arteritis: a nationwide population-based study in South Korea显示文摘Background Takayasu arteritis(TAK)is a disease associated with increased risk of cardiovascular complications.We aimed to evaluate the incidence,prevalence and risk of stroke in patients with TAK.Methods Data from 1065 patients were obtained from a national database(2010–2018).The annual incidence and prevalence per 100000 persons were estimated using the registration population in the midst of every year,and the standardised incidence ratio(SIR)of stroke was compared with the general population based on the data from the 2006 national report for cardiovascular and cerebrovascular diseases.Age-adjusted incidence rate ratio(IRR)of stroke based on the time interval after diagnosis was also calculated.A time-dependent Cox regression was conducted to investigate predictive factors of stroke.Results The overall incidence rate of TAK ranged between 0.2 and 0.3/100000 person-years annually;the prevalence of TAK gradually increased,reaching 3.25/100000 person-years in 2018.Seventy-three(6.9%)patients experienced stroke during follow-up,and the risk of developing stroke was higher than the general population(overall SIR 7.39,95%CI 5.79 to 9.29;men:SIR 5.70,95%CI 2.84 to 10.20;women:SIR 7.06,95%CI 5.41 to 9.05).Most stroke events(90.9%)were cerebral infarction for men,whereas the proportion of cerebral infarction was lower(62.9%)in women.Over half of stroke events occurred within 6 months after diagnosis,and stroke was more common within 6 months of diagnosis compared with after 3 years in women(IRR 13.46,95%CI 6.86 to 26.40).In Cox regression analysis,age was the sole predictor of stroke(adjusted HR 1.02,95%CI 1.00 to 1.04,p=0.043).Conclusions The annual incidence of TAK was similar to the previous studies from Asia,and the risk of stroke increased in TAK.Different patterns of subtype and incidence of stroke were found according to sex,although age was the only predictor. | Sung Soo Ahn Minkyung Han Yong-Beom Park Inkyung Jung Sang-Won Lee | 2022 | Stroke & Vascular Neurology2022，7，2： | 0 |
| 17 | The impact factors of the risk index and diffusive dynamics of a SIS free boundary model显示文摘To discuss the impact factors on the spread of infectious diseases,we study a free boundary problem describing a SIS(susceptible-infected-susceptible)model in a heterogeneous environment.Firstly,the existence and uniqueness of the global solution are given.Then the basic reproduction number related to time is defined,and a spreading-vanishing dichotomy of infectious diseases is obtained.The impacts of the diffusion rate of infected individuals,expanding capability,and the scope and scale of initial infection on the spreading and vanishing of infectious disease are analyzed.Numerical simulations are given to show that the large expanding capability is unfavorable to the prevention and control of the disease. | Yachun Tong Inkyung Ahn Zhigui Lin | 2022 | Infectious Disease Modelling2022，7，4： | 0 |
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