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| 1 | Crowned dens syndrome developed after an endoscopic retrograde cholangiopancreatography procedure显示文摘We present a unique case of crowned dens syndrome(CDS) that developed after endoscopic retrograde cholangiopancreatography(ERCP) in a patient who presented with fever and neck pain. Administration of non-steroidal anti-inflammatory drugs was extremely effective for relieving fever and neck pain, and in the improvement of inflammatory markers. To the best of our knowledge, this is the first case report of CDS caused by an ERCP procedure. In a patient with fever and neck pain after an ERCP procedure, CDS should be considered in the differential diagnosis. | Hiroyasu Nakano Kazunari Nakahara Yosuke Michikawa Keigo Suetani Ryo Morita Nobuyuki Matsumoto Fumio Itoh | 2016 | World Journal of Gastroenterology2016，22，39： | 5 |
| 2 | Need for pancreatic stenting after sphincterotomy in patients with difficult cannulation显示文摘AIM:To investigate the need for pancreatic stenting after endoscopic sphincterotomy(EST)in patients with difficult biliary cannulation.METHODS:Between April 2008 and August 2013,2136 patients underwent endoscopic retrograde cholangiopancreatography(ERCP)-related procedures.Among them,55 patients with difficult biliary cannulation who underwent EST after bile duct cannulation using the pancreatic duct guidewire placement method(P-GW)were divided into two groups:a stent group(n=24;pancreatic stent placed)and a no-stent group(n=31;no pancreatic stenting).We retrospectively compared the two groups to examine the need for pancreatic stenting to prevent post-ERCP pancreatitis(PEP)in patients undergoing EST after biliary cannulation by P-GW.RESULTS:No differences in patient characteristics or endoscopic procedures were observed between the two groups.The incidence of PEP was 4.2%(1/24)and29.0%(9/31)in the Stent and no-stent groups,respectively,with the no-stent group having a significantly higher incidence(P=0.031).The PEP severity was mild for all the patients in the stent group.In contrast,8 had mild PEP and 1 had moderate PEP in the no-stent group.The mean serum amylase levels(means±SD)3 h after ERCP(183.1±136.7 vs 463.6±510.4 IU/L,P=0.006)and on the day after ERCP(209.5±208.7vs 684.4±759.3 IU/L,P=0.002)were significantly higher in the no-stent group.A multivariate analysis identified the absence of pancreatic stenting(P=0.045;odds ratio,9.7;95%CI:1.1-90)as a significant risk factor for PEP.CONCLUSION:In patients with difficult cannulation in whom the bile duct is cannulated using P-GW,a pancreatic stent should be placed even if EST has been performed. | Kazunari Nakahara Chiaki Okuse Keigo Suetani Yosuke Michikawa Shinjiro Kobayashi Takehito Otsubo Fumio Itoh | 2014 | World Journal of Gastroenterology2014，20，26： | 4 |
| 3 | Thrombomodulin in the management of acute cholangitisinduced disseminated intravascular coagulation显示文摘AIM: To evaluate the need for thrombomodulin(r TM) therapy for disseminated intravascular coagulation(DIC) in patients with acute cholangitis(AC)-induced DIC. METHODS: Sixty-six patients who were diagnosedwith AC-induced DIC and who were treated at our hospital were enrolled in this study. The diagnoses of AC and DIC were made based on the 2013 Tokyo Guidelines and the DIC diagnostic criteria as defined by the Japanese Association for Acute Medicine, respectively. Thirty consecutive patients who were treated with r TM between April 2010 and September 2013(r TM group) were compared to 36 patients who were treated without r TM(before the introduction of r TM therapy at our hospital) between January 2005 and January 2010(control group). The two groups were compared in terms of patient characteristics at the time of DIC diagnosis(including age, sex, primary disease, severity of cholangitis, DIC score, biliary drainage, and anti-DIC drugs), the DIC resolution rate, DIC score, the systemic inflammatory response syndrome(SIRS) score, hematological values, and outcomes. Using logistic regression analysis based on multivariate analyses, we also examined factors that contributed to persistent DIC. RESULTS: There were no differences between the r TM group and the control group in terms of the patients' backgrounds other than administration. DIC resolution rates on day 9 were higher in the r TM group than in the control group(83.3% vs 52.8%, P < 0.01). The mean DIC scores on day 7 were lower in the r TM group than in the control group(2.1 ± 2.1 vs 3.5 ± 2.3, P = 0.02). The mean SIRS scores on day 3 were significantly lower in the r TM group than in the control group(1.1 ± 1.1 vs 1.8 ± 1.1, P = 0.03). Mortality on day 28 was 13.3% in the r TM group and 27.8% in the control group; these rates were not significantly different(P = 0.26). Multivariate analysis identified only the absence of biliary drainage as significantly associated with persistent DIC(P < 0.01, OR = 12, 95%CI: 2.3-60). Although the difference did not reach statistical significance, primary diseases(malignancies)(P = 0.055, OR = 3.9, 95%CI: 0.97-16) and the non-use of r TM had a tendency to be associated with persistent DIC(P = 0.08, OR = 4.3, 95%CI: 0.84-22).CONCLUSION: The add-on effects of r TM are anticipated in the treatment of AC-induced DIC, although biliary drainage for AC remains crucial. | Keigo Suetani Chiaki Okuse Kazunari Nakahara Yosuke Michikawa Yohei Noguchi Midori Suzuki Ryo Morita Nozomi Sato Masaki Kato Fumio Itoh | 2015 | World Journal of Gastroenterology2015，21，2： | 4 |
| 4 | R spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutant显示文摘 | Kamata T Katsube K Michikawa M Yamada M Takada S Mizusawa H | 2004 | Biochim Biophys Acta2004，1676，： | 1 |
| 5 | Inositoi 1,4,5- trisphosphate receptors and calcium signaling显示文摘 | Michikawa T Miyawaki A Furuichi T et ai | 1996 | Crit Rev Neurobioi1996，，： | 1 |
| 6 | Differences in claudin synthesis in primary cultures of acinar cells from rat salivary gland are correlated with the specific three-dimensional organization of the cells显示文摘 | Qi B Fujita-Yoshigaki J Michikawa H | 2007 | Cell Tissue Res2007，329，1： | 1 |
| 7 | Does early orchidopexy prevent morphological changes in undescended testes? A perioperative assessment using ultrasonography显示文摘 | Michikawa T Matsufuji H Araki Y | 2008 | Urol Int2008，81，2： | 1 |
| 8 | One-leg standing test for elderly populations显示文摘 | Michikawa T Nishiwaki Y Takebayashi T | 2009 | J Orthop Sci2009，14，5： | 1 |
| 9 | Prevalence and factors associated with tinnitus : a community-based study of Japa- nese elders显示文摘 | Michikawa T Nishiwaki Y Kikuchi Y | 2010 | J Epidemio2010，20，4： | 1 |
| 10 | Honokiol increases ABCA1 expression level by activating retinoid X receptor β显示文摘 | Jung CG Horike H Cha BY Uhm KO Yamauchi R Yamaguchi T Hosono T Iida K Woo JT Michikawa M | | 0，，07： | 1 |
| 11 | Mechanistic basis of bell-shaped dependence of inositol 1, 4, 5-trisphosphate receptor gating on cytosolie calcium 显示文摘 | Shinohara T Michikawa T Enomoto M | 2011 | proceedings of the National Academy of Sciences of the United States of America2011，108，15： | 1 |
| 12 | Calmodulin inhibits inositol 1,4,5-trisphosphate-induced calcium release through the purified and reconstituted inositol 1,4,5-trisphosphate receptor type 1显示文摘 | Hirota J Michikawa T Natsume T | 1999 | FEBS Lett1999，456，2： | 1 |
| 13 | Hearing handicappredicts the development of depressive symptoms after 3 yearsin older community-dwelling Japanese显示文摘 | Saito H Nishiwaki Y Michikawa T | 2010 | Journal of the A-merican Geriatrics Society2010，58，： | 1 |
| 14 | A novel action of Alzheimer's amyloid β-protein(AB): oligomeric Aβ promotes lipid release 显示文摘 | Michikawa M Gong JS Fan QW | 2001 | J Neurosci2001，21，8： | 1 |
| 15 | Prevalence and risk factors of dry eye disease in Japan: Koumi study显示文摘 | Uchino M Nishiwaki Y Michikawa T | 2011 | Ophthalmology2011，118，12： | 1 |
| 16 | In-gel multiple displacement amplification of long DNA fragments diluted to the single molecule level 显示文摘 | Michikawa Y Sugahara K Suga T | 2008 | Analytical biochemistry2008，383，2： | 1 |
| 17 | Retinoic acid responsive gene product, Midkine, has neurotrophic functions of mouse spinal cord and dorsal root ganglion neurons in culture显示文摘 | Michikawa M Kikuchi S Muramatsu H | 1993 | Journal of Neuroscience Research1993，35，5： | 1 |
| 18 | Covered Metal Stenting for Malignant Lower Biliary Stricture with Pancreatic Duct Obstruction: Is Endoscopic Sphincterotomy Needed?显示文摘 | Kazunari Nakahara Chiaki Okuse Keigo Suetani Yosuke Michikawa Shinjiro Kobayashi Takehito Otsubo Fumio Itoh Peter V. Draganov | 2013 | Gastroenterology Research and Practice2013，，： | 1 |
| 19 | Aging-dependent large accumulation of point mutations in the human mtDNAcontrol region for replication 显示文摘 | Michikawa Y Mazzucchelli F Bresolin N | 1999 | Science1999，286，5441： | 1 |
| 20 | Prevalence and risk factors of dry eye disease in Japan: Koumi study显示文摘 | Uchino M Nishiwaki Y Michikawa T | 2011 | Ophthalmology2011，118，12： | 1 |
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