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| 1 | Involvement of the TAGE-RAGE system in non-alcoholic steatohepatitis: Novel treatment strategies显示文摘Non-alcoholic fatty liver disease(NAFLD)is a major cause of liver disease around the world.It includes a spectrum of conditions from simple steatosis to non-alcoholic steatohepatitis(NASH)and can lead to fibrosis,cirrhosis,liver failure,and/or hepatocellular carcinoma.NAFLD is also associated with other medical conditions such as obesity,diabetes mellitus(DM),metabolic syn-drome,hypertension,insulin resistance,hyperlipidemia,and cardiovascular disease(CVD).In diabetes,chronic hyperglycemia contributes to the development of both macro-and microvascular conditions through a variety of metabolic pathways.Thus,it can cause a variety of metabolic and hemodynamic conditions,including upregulated advanced glycation end-products(AGEs)synthesis.In our previous study,the most abundant type of toxic AGEs(TAGE);i.e.,glyceraldehyde-derived AGEs,were found to make a significant contribution to the pathogenesis of DM-induced angiopathy.Furthermore,accumulating evidence suggests that the binding of TAGE with their receptor(RAGE)induces oxidative damage,promotes inflammation,and causes changes in intracellular signaling and the expression levels of certain genes in various cell populations including hepatocytes and hepatic stellate cells.All of these effects could facilitate the pathogenesis of hypertension,cancer,diabetic vascular complications,CVD,dementia,and NASH.Thus,inhibiting TAGE synthesis,preventing TAGE from binding to RAGE,and downregulating RAGE expression and/or the expression of associated effector molecules all have potential as therapeutic strategies against NASH.Here,we examine the contributions of RAGE and TAGE to various conditions and novel treatments that target them in order to prevent the development and/or progression of NASH. | Masayoshi Takeuchi Jun-ichi Takino Akiko Sakasai-Sakai Takanobu Takata Tadashi Ueda Mikihiro Tsutsumi Hideyuki Hyogo Sho-ichi Yamagishi | 2014 | World Journal of Hepatology2014，6，12： | 5 |
| 2 | Local recurrence after rectal endoscopic submucosal dissection: a case of tumor cell implantation显示文摘 | Takashi Inoue Hisao Fujii Fumikazu Koyama Tadashi Nakagawa Kazuaki Uchimoto Shinji Nakamura Takeshi Ueda Naoto Nishigori Keijiro Kawasaki Shinsaku Obara Takayuki Nakamoto Yoshiyuki Nakajima | 2014 | Clinical Journal of Gastroenterology2014，，1： | 1 |
| 3 | Immunoreactive e-cadherin, alpha-catenin,beta-catenin, and gamma-catenin proteins in hepatocellular carcinoma: Relationships with tumor grade, clinicopathologic parameters, and patients’ survival显示文摘 | Kanenori Endo Tsuyoshi Ueda Junichi Ueyama Tetsuo Ohta Tadashi Terada | 2000 | Human Pathology2000，，5： | 1 |
| 4 | Reevaluation of postoperative radiotherapy for thoracic esophageal carcinoma显示文摘 | Michinori Yamamoto Takashi Yamashita Toshiki Matsubara Tadashi Kitahara Kenji Sekiguchi Masahiko Furukawa Akiyoshi Uki Masao Kobayashi Emiko Tanaka Mamoru Ueda Toshifusa Nakajima | 1997 | International Journal of Radiation Oncology Biology Physics1997，，1： | 1 |
| 5 | Development of simulation technology for dynamic behavior of crankshaft system in otorcycle engines显示文摘 | Tadashi Niino Tatsuya Iwamoto Shingo Ueda | 2003 | JSAE Review2003，，： | 1 |
| 6 | Prognosis of Cough Variant Asthma: A Retrospective Analysis显示文摘 | Hisako Matsumoto Akio Niimi Masaya Takemura Tetsuya Ueda Rollin Tabuena Masafumi Yamaguchi Hirofumi Matsuoka Toyohiro Hirai Shigeo Muro Yutaka Ito Tadashi Mio Kazuo Chin Hideki Nishiyama Michiaki Mishima | 2006 | Journal of Asthma2006，，2： | 1 |
| 7 | Immunoreactive e-cadherin, alpha-catenin,beta-catenin, and gamma-catenin proteins in hepatocellular carcinoma: Relationships with tumor grade, clinicopathologic parameters, and patients’ survival显示文摘 | Kanenori Endo Tsuyoshi Ueda Junichi Ueyama Tetsuo Ohta Tadashi Terada | 2000 | Human Pathology2000，，5： | 1 |
| 8 | Immunoreactive e-cadherin, alpha-catenin,beta-catenin, and gamma-catenin proteins in hepatocellular carcinoma: Relationships with tumor grade, clinicopathologic parameters, and patients’ survival显示文摘 | Kanenori Endo Tsuyoshi Ueda Junichi Ueyama Tetsuo Ohta Tadashi Terada | 2000 | Human Pathology2000，，5： | 1 |
| 9 | Preoperative liver functional volumetry performed by 3D-99mTc-GSA scintigraphy/vascular fusion imaging using SYNAPSE VINCENT: a preliminary study显示文摘Aim:The present study was designed to evaluate the feasibility of preoperative liver functional volumetry performed by 3D-technetium-99m-diethylenetriaminepentaacetic acid-galactosyl-human serum albumin(99mTc-GSA)scintigraphy/vascular fusion imaging using SYNAPSE VINCENT and to examine the discrepancy between conventional and functional volumetry.Methods:The study group comprised 15 patients who underwent preoperative 3-dimensional(3D)-99mTc-GSA scintigraphy/vascular fusion imaging using SYNAPSE VINCENT software before hepatectomy between July 2014 and August 2015.The diagnosis was hepatocellular carcinoma(n=4),metastatic liver tumor(n=10),or intrahepatic cholangiocarcinoma(n=1).Right hepatectomy was performed in 2 patients,left hepatectomy in 3 patients,right posterior sectionectomy in 3 patients,segmentectomy in 2 patients,and partial hepatectomy in 4 patients.99mTc-GSA scintigraphy and computed tomography(CT)were performed to construct 3D-99mTc-GSA scintigraphy/vascular fused images.The conventional volume ratio of the planned resection region without tumor(%CT),and the functional volume ratio of the planned resection region without tumor(%GSA)were calculated.The discrepancy ratio was calculated as follows:discrepancy ratio=100-%GSA/%CT×100(%).Results:The%GSA(17.9±16.7%)was significantly lower than the%CT(21.5±17.6%)(P<0.036).In all except 2 patients,the%GSA was lower than the%CT.The discrepancy ratio ranged from-4%to 75%(median,20.7%).Conclusion:3D-99mTc-GSA scintigraphy/vascular fused images constructed using SYNAPSE VINCENT were useful for noninvasively performing functional liver volumetry in patients scheduled to undergo various patterns of hepatectomy.In planned resection regions without tumor,the functional volume ratio was about 20%lower than the conventional volume ratio. | Hiroshi Yoshida Hiroshi Makino Tadashi Yokoyama Hiroshi Maruyama Atsushi Hirakata Junji Ueda Yasuhiro Mamada Nobuhiko Taniai Eiji Uchida | 2016 | Hepatoma Research2016，2，1： | 1 |
| 10 | Lymphangioma of the jejunum and mesentery presenting with acute abdomen in an adult显示文摘 | Hitoshi Seki Tadashi Ueda Takamitsu Kasuya Hitoshi Kotanagi Toyokazu Tamura | 1998 | Journal of Gastroenterology1998，，1： | 1 |
| 11 | Reevaluation of postoperative radiotherapy for thoracic esophageal carcinoma显示文摘 | Michinori Yamamoto Takashi Yamashita Toshiki Matsubara Tadashi Kitahara Kenji Sekiguchi Masahiko Furukawa Akiyoshi Uki Masao Kobayashi Emiko Tanaka Mamoru Ueda Toshifusa Nakajima | 1997 | International Journal of Radiation Oncology, Biology, Physics1997，，1： | 1 |
| 12 | Prevalence of H elicobacter pylori Infection by Birth Year and Geographic Area in Japan显示文摘 | Junko Ueda Masahiko Gosho Yoshikatsu Inui Toru Matsuda Masatoshi Sakakibara Katsuhiro Mabe Shigemi Nakajima Tadashi Shimoyama Mitsugi Yasuda Takashi Kawai Kazunari Murakami Tomoari Kamada Motowo Mizuno Shogo Kikuchi Yingsong Lin Mototsugu Kato | 2014 | Helicobacter2014，，2： | 1 |
| 13 | Prognosis of Cough Variant Asthma: A Retrospective Analysis显示文摘 | Hisako Matsumoto Akio Niimi Masaya Takemura Tetsuya Ueda Rollin Tabuena Masafumi Yamaguchi Hirofumi Matsuoka Toyohiro Hirai Shigeo Muro Yutaka Ito Tadashi Mio Kazuo Chin Hideki Nishiyama Michiaki Mishima | 2006 | Journal of Asthma2006，，2： | 1 |
| 14 | Generation of glyceraldehyde-derived advanced glycation end-products in pancreatic cancer cells and the potential of tumor promotion显示文摘AIM To determine the possibility that diabetes mellitus promotes pancreatic ductal adenocarcinoma via glyceraldehyde(GA)-derived advanced glycation-end products(GA-AGEs).METHODS PANC-1,a human pancreatic cancer cell line,was treated with 1-4 mmol/L GA for 24 h. The cell viability and intracellular GA-AGEs were measured by WST-8 assay and slot blotting. Moreover,immunostaining of PANC-1 cells with an anti-GA-AGE antibody was performed. Western blotting(WB) was used to analyze the molecular weight of GA-AGEs. Heat shock proteins 90α,90β,70,27 and cleaved caspase-3 were analyzed by WB. In addition,PANC-1 cells were treated with GA-AGEs-bovine serum albumin(GA-AGEs-BSA),as a model of extracellular GA-AGEs,and proliferation of PANC-1 cells was measured.RESULTS In PANC-1 cells,GA induced the production of GA-AGEs and cell death in a dose-dependent manner. PANC-1 cell viability was approximately 40% with a 2 mmol/L GA treatment and decreased to almost 0% with a 4 mmol/L GA treatment(each significant difference was P < 0.01). Cells treated with 2 and 4 mmol/L GA produced 6.4 and 21.2 μg/mg protein of GA-AGEs,respectively(P <0.05 and P < 0.01). The dose-dependent production of some high-molecular-weight(HMW) complexes of HSP90β,HSP70,and HSP27 was observed following administration of GA. We considered HMW complexes to be dimers and trimers with GA-AGEs-mediated aggregation. Cleaved caspase-3 could not be detected with WB. Furthermore,10 and 20 μg/m L GA-AGEs-BSA was 27% and 34% greater than that of control cells,respectively(P < 0.05 and P < 0.01).CONCLUSION Although intracellular GA-AGEs induce pancreatic cancer cell death,their secretion and release may promote the proliferation of other pancreatic cancer cells. | takanobu takata tadashi ueda akiko sakasai-sakai masayoshi takeuchi | 2017 | World Journal of Gastroenterology2017，23，27： | 0 |
| 15 | Evaluation of gut dysbiosis using serum and fecal bile acid profiles显示文摘Dysbiosis in the intestinal microflora can affect the gut production of microbial metabolites,and toxic substances can disrupt the barrier function of the intestinal wall,leading to the development of various diseases.Decreased levels of Clostridium subcluster XIVa(XIVa)are associated with the intestinal dysbiosis found in inflammatory bowel disease(IBD)and Clostridium difficile infection(CDI).Since XIVa is a bacterial group responsible for the conversion of primary bile acids(BAs)to secondary BAs,the proportion of intestinal XIVa can be predicted by determining the ratio of deoxycholic acid(DCA)/[DCA+cholic acid(CA)]in feces orserum.For example,serum DCA/(DCA+CA)was significantly lower in IBD patients than in healthy controls,even in the remission period.These results suggest that a low proportion of intestinal XIVa in IBD patients might be a precondition for IBD onset but not a consequence of intestinal inflammation.Another report showed that a reduced serum DCA/(DCA+CA)ratio could predict susceptibility to CDI.Thus,the BA profile,particularly the ratio of secondary to primary BAs,can serve as a surrogate marker of the intestinal dysbiosis caused by decreased XIVa. | Tadakuni Monma Junichi Iwamoto Hajime Ueda Makoto Tamamushi Fumio Kakizaki Naoki Konishi Shoichiro Yara Teruo Miyazaki Takeshi Hirayama Tadashi Ikegami Akira Honda | 2022 | World Journal of Clinical Cases2022，10，34： | 0 |
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