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| 1 | Surgical resection of a solitary para-aortic lymph node metastasis from hepatocellular carcinoma显示文摘Lymph node (LN) metastases from hepatocellular carcinoma (HCC) are considered uncommon. We describe the surgical resection of a solitary para-aortic LN metastasis from HCC. A 65-year-old Japanese man with B-type liver cirrhosis was admitted for the evaluation of a liver tumor. He had already undergone radiofrequency ablation, transcatheter arterial chemoembolization, and percutaneous ethanol injection therapy for HCC. Despite treatment, viable regions remained in segments 4 and 8. We performed a right paramedian sectionectomy with partial resection of the left paramedian section of the liver. Six months later, serum concentrations of alpha-fetoprotein (189 ng/mL) and PIVKA-2 (507 mAU/mL) increased. Enhanced com- puted tomography of the abdomen revealed a tumor (20 mm in diameter) on the right side of the abdominal aorta. Fluorine-18 fluorodeoxyglucose positron emission tomography revealed an increased standard uptake value. There was no evidence of recurrence in other regions. Esophagogastroduodenoscopy and colonoscopy revealed no malignant tumor in the gastrointestinal tract. Para-aortic LN metastasis from HCC was thus diagnosed. We performed lymphadenectomy. Histopathological examination revealed that the tumor was largely necrotic, with poorly differentiated HCC on its surface, which confirmed the suspected diagnosis. After 6 mo tumor marker levels were normal, with no evidence of recurrence. Our experience suggests that a solitary para-aortic LN metastasis from HCC can be treated surgically. | Junji Ueda Hiroshi Yoshida Yasuhiro Mamada Nobuhiko Taniai Sho Mineta Masato Yoshioka Youichi Kawano Tetsuya Shimizu Etsuko Hara Chiaki Kawamoto Keiko Kaneko Eiji Uchida | 2012 | World Journal of Gastroenterology2012，18，23： | 3 |
| 2 | Occult hepatitis B virus infection and surgical outcomes in non-B, non-C patients with curative resection for hepatocellular carcinoma显示文摘AIM To investigate the prevalence, clinicopathological characteristics and surgical outcomes of occult hepatitis B virus(HBV) infection(OBI) in patients with non-B, non-C(NBNC) hepatocellular carcinoma(HCC).METHODS This study retrospectively examined the cases of 78 NBNC patients with curative resection for HCC for whom DNA could be extracted from formalin-fixed paraffin-embedded tissue. OBI was determined by the HBV-DNA amplification of at least two different sets of primers by TaqM an realtime polymerase chain reaction. Possibly carcinogenetic factors such as alcohol abuse, diabetes mellitus, obesity and non-alcoholic steatohepatitis(NASH) were examined. Surgical outcomes were evaluated according to diseasefree survival(DFS), overall survival(OS) and diseasespecific survival(DSS).RESULTS OBI was found in 27/78 patients(34.6%) with NBNC HCC. The OBI patients were significantly younger than the non-OBI cases at the time of surgery(average age 63.0 vs 68.1, P = 0.0334) and the OBI cases overlapped with other etiologies significantly more frequently compared to the non-OBI cases(P = 0.0057). OBI had no impact on the DFS, OS or DSS. Only tumorrelated factors affected these surgical outcomes.CONCLUSION Our findings indicate that OBI had no impact on surgical outcomes. The surgical outcomes of NBNC HCC depend on early tumor detection; this reconfirms the importance of a periodic medical examination for individuals who have NBNC HCC risk factors. | Hiroki Koga Keita Kai Shinichi Aishima Atsushi Kawaguchi Koutaro Yamaji Takao Ide Junji Ueda Hirokazu Noshiro | 2017 | World Journal of Hepatology2017，9，35： | 2 |
| 3 | Baicalin induces apoptosis via mitochondrial pathway as prooxidant显示文摘 | Shugo Ueda Hajime Nakamura Hiroshi Masutani Tetsuro Sasada Arimichi Takabayashi Yoshio Yamaoka Junji Yodoi | 2002 | Molecular Immunology2002，，10： | 1 |
| 4 | Surgery for chronic pancreatitis decreases the risk for pancreatic cancer: A multicenter retrospective analysis显示文摘 | Junji Ueda Masao Tanaka Takao Ohtsuka Shoji Tokunaga Tooru Shimosegawa | 2012 | Surgery2012，，： | 1 |
| 5 | Preoperative liver functional volumetry performed by 3D-99mTc-GSA scintigraphy/vascular fusion imaging using SYNAPSE VINCENT: a preliminary study显示文摘Aim:The present study was designed to evaluate the feasibility of preoperative liver functional volumetry performed by 3D-technetium-99m-diethylenetriaminepentaacetic acid-galactosyl-human serum albumin(99mTc-GSA)scintigraphy/vascular fusion imaging using SYNAPSE VINCENT and to examine the discrepancy between conventional and functional volumetry.Methods:The study group comprised 15 patients who underwent preoperative 3-dimensional(3D)-99mTc-GSA scintigraphy/vascular fusion imaging using SYNAPSE VINCENT software before hepatectomy between July 2014 and August 2015.The diagnosis was hepatocellular carcinoma(n=4),metastatic liver tumor(n=10),or intrahepatic cholangiocarcinoma(n=1).Right hepatectomy was performed in 2 patients,left hepatectomy in 3 patients,right posterior sectionectomy in 3 patients,segmentectomy in 2 patients,and partial hepatectomy in 4 patients.99mTc-GSA scintigraphy and computed tomography(CT)were performed to construct 3D-99mTc-GSA scintigraphy/vascular fused images.The conventional volume ratio of the planned resection region without tumor(%CT),and the functional volume ratio of the planned resection region without tumor(%GSA)were calculated.The discrepancy ratio was calculated as follows:discrepancy ratio=100-%GSA/%CT×100(%).Results:The%GSA(17.9±16.7%)was significantly lower than the%CT(21.5±17.6%)(P<0.036).In all except 2 patients,the%GSA was lower than the%CT.The discrepancy ratio ranged from-4%to 75%(median,20.7%).Conclusion:3D-99mTc-GSA scintigraphy/vascular fused images constructed using SYNAPSE VINCENT were useful for noninvasively performing functional liver volumetry in patients scheduled to undergo various patterns of hepatectomy.In planned resection regions without tumor,the functional volume ratio was about 20%lower than the conventional volume ratio. | Hiroshi Yoshida Hiroshi Makino Tadashi Yokoyama Hiroshi Maruyama Atsushi Hirakata Junji Ueda Yasuhiro Mamada Nobuhiko Taniai Eiji Uchida | 2016 | Hepatoma Research2016，2，1： | 1 |
| 6 | S100A4 mRNA is a Diagnostic and Prognostic Marker in Pancreatic Carcinoma显示文摘 | Naoki Ikenaga Kenoki Ohuchida Kazuhiro Mizumoto Jun Yu Hayato Fujita Kohei Nakata Junji Ueda Norihiro Sato Eishi Nagai Masao Tanaka | 2009 | Journal of Gastrointestinal Surgery2009，，10： | 1 |
| 7 | Interaction between proliferating cell nuclear antigen (PCNA) and a DnaJ induced by DNA damage显示文摘 | Taichi Yamamoto Yoko Mori Toyotaka Ishibashi Yukinobu Uchiyama Tadamasa Ueda Tsuyu Ando Junji Hashimoto Seisuke Kimura Kengo Sakaguchi | 2005 | Journal of Plant Research2005，，2： | 1 |
| 8 | Impact of smoking habit on surgical outcomes in non-B non-C patients with curative resection for hepatocellular carcinoma显示文摘AIM To analyzed the correlation between smoking status and surgical outcomes in patients with non-B non-C hepatocellular carcinoma(NBNC-HCC), and we investigated the patients' clinicopathological characteristics according to smoking status.METHODS We retrospectively analyzed the consecutive cases of 83 NBNC-HCC patients who underwent curative surgical treatment for the primary lesion at Saga University Hospital between 1984 and December 2012. We collected information about possibly carcinogenic factors such as alcohol abuse, diabetes mellitus, obesity and smoking habit from medical records. Smoking habits were subcategorized as never, ex- and current smoker at the time of surgery. The diagnosis of nonalcoholic steatohepatitis(NASH) was based on both clinical information and pathological confirmation.RESULTS Alcohol abuse, diabetes mellitus, obesity and NASH had no significant effect on the surgical outcomes. Current smoking status was strongly correlated with both overall survival(P = 0.0058) and disease-specific survival(P = 0.0105) by multivariate analyses. Subset analyses revealed that the current smokers were significantly younger at the time of surgery(P = 0.0002) and more likely to abuse alcohol(P = 0.0188) and to have multiple tumors(P = 0.023).CONCLUSION Current smoking habit at the time of surgical treatment is a risk factor for poor long-term survival in NBNC-HCC patients. Current smokers tend to have multiple HCCs at a younger age than other patients. | Keita Kai Hiroki Koga Shinichi Aishima Atsushi Kawaguchi Koutaro Yamaji Takao Ide Junji Ueda Hirokazu Noshiro | 2017 | World Journal of Gastroenterology2017，23，8： | 0 |
| 9 | EVIDENCE FOR AROMATIC sp^2 C-H…O=C INTRAMOLECULAR INTERACTION IN PYRIDINO AND BENZOBENZANTHRONE SKELETONS显示文摘EVIDENCEFORAROMATICsp~2C-H…O=CINTRAMOLECULARINTERACTIONINPYRIDINOANDBENZOBENZANTHRONESKELETONS￥ZeperABLIZ(DepartmentofChemist?.. | Zeper ABLIZ (Department of Chemistry, Xin Jiang University, Urumchi 830046) Hiroshi MORIYAMA and Junji AOKI (Department of Chemistry, Toho University, Funabashi, Chiba 274, Japan) Toyotoshi UEDA (Department of Chemistry, Meisei University, Hino, Tokyo 19 | 1995 | Chinese Chemical Letters1995，6，5： | 0 |
| 10 | Existence of aromatic sp^2 C-H…O = C intramolecular interaction similar to hydrogen bond显示文摘A ’H NMR signal shifted drastically to down field (δ - 10.0) at the bay area and in dose proximity to C = O group for H-1 was observed through complete assignments of 1H NMR spectra for pyridino- and benzobenzanthrones. It is concluded that this phenomenon is due not only to the anisotropy effect of C=O plus aromatic ring current effect, but also to the electrostatic attraction of C-H (δ+)…O(δ-)=C interaction. The evidence for the sp2C-H…O = C intramolecular interaction similar to hydrogen bond has also been given by EI-MS and MS/MS (CID) spectroscopy and IR spectroscopy, as well as MNDO-PM3 calculations. This new kind of interaction might be called ’quasi-hydrogen bond’. | Zeper Abliz Hiroshi Moriyama Junji Aoki Toyotoshi Ueda | 1996 | Science China Chemistry1996，39，3： | 0 |
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