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| 1 | Impaired coronary microvascular endothelial function in men with metabolic syndrome显示文摘AIM: To assess coronary endothelial function of conduit and resistance vessels in patients with metabolic syndrome (MS). METHODS: Seventy-eight men (mean age, 57 years) with chest pain and angiographically normal coronary arteries were included in the study. Patients with coronary spastic angina were excluded. Changes in coronary artery diameter and coronary blood flow (CBF) in response to acetylcholine (ACh) were determined using quantitative coronary angiography and Doppler velocity measurements. Coronary flow reserve was calculated as the ratio of coronary blood velocity after adenosine triphosphate infusion relative to baseline values. Patients were divided into two groups based on the presence or absence of MS. RESULTS: There were 24 patients in the MS group (31%). The increase in CBF in response to ACh infusion was impaired in the MS group (P < 0.0001) compared to the non-MS group, whereas changes in coronary artery diameter in response to ACh infusion did not differ between the two groups. Multivariate regression analysis revealed that MS was a significant factor associated with the lesser change in CBF induced by ACh infusion at 30 μg/min (P < 0.0001, r 2 = 0.46). CONCLUSION: Coronary endothelial dysfunction was present at the level of resistance vessels but not conduit vessels in the MS patients included in our study. | Hiroki Teragawa Naoya Mitsuba Kenji Nishioka Kentaro Ueda Shingo Kono Yukihito Higashi Kazuaki Chayama Yasuki Kihara | 2010 | World Journal of Cardiology2010，2，7： | 2 |
| 2 | Development of simulation technology for dynamic behavior of crankshaft system in otorcycle engines显示文摘 | Tadashi Niino Tatsuya Iwamoto Shingo Ueda | 2003 | JSAE Review2003，，： | 1 |
| 3 | Anti-High-Mobility Group Box Chromosomal Protein 1 Antibodies Improve Survival of Rats with Sepsis显示文摘 | Koichi Suda Yuko Kitagawa Soji Ozawa Yoshiro Saikawa Masakazu Ueda Masahito Ebina Shingo Yamada Satoru Hashimoto Shinji Fukata Edward Abraham Ikuro Maruyama Masaki Kitajima Akitoshi Ishizaka | 2006 | World Journal of Surgery2006，，9： | 1 |
| 4 | Simulaneous removal of phenol and ammonia by an activated sludge process with cross-flow filtration 显示文摘 | Takao Yamagishi Jader Leite Shingo Ueda | 2001 | Wat Res2001，35，13： | 1 |
| 5 | Simultaneous removal of phenol and ammonia by an activated sludge process with cross - flow filtration 显示文摘 | Takao Yamagishi Jader Leite Shingo Ueda | 2001 | War Res2001，35，13： | 1 |
| 6 | Myoepithelioma of the lung: Report of two cases and review of the literature显示文摘 | Masahiko Higashiyama Ken Kodama Hideoki Yokouchi Koji Takami Toshiyuki Kabuto Naoko Tsuji Masayuki Mano Shingo Ishiguro Takafumi Ueda Hideki Yoshikawa Masayuki Tatsuta | 1998 | Lung Cancer1998，，1： | 1 |
| 7 | Simuha-neous removal of phenol and ammonia by an activated sludge process with cross-flow filtration 显示文摘 | Takao Yamagishi Jader Leite Shingo Ueda | 2001 | Water Research2001，5，13： | 1 |
| 8 | A simple and rapid GC/MS method for the simultaneous determination of g aseous metabolites显示文摘 | KAZUO ISOBE KEISUKE KOBA SHINGO UEDA | 2011 | Journal of Microbiological Methods2011，84，： | 1 |
| 9 | Beneficial effect of an omega-6 PUFA-rich diet in non-steroidal anti-inflammatory drug-induced mucosal damage in the murine small intestine显示文摘AIM: To investigate the effect of a fat rich diet onnon-steroidal anti-inflammatory drug(NSAID)-induced mucosal damage in the murine small intestine.METHODS: C57BL6 mice were fed 4 types of diets with or without indomethacin.One group was fed standard laboratory chow.The other groups were fed a fat diet consisting of 8% w/w fat,beef tallow(rich in SFA),fish oil,(rich in omega-3 PUFA),or safflower oil(rich in omega-6 PUFA).Indomethacin(3 mg/kg) was injected intraperitoneally from day 8 to day 10.On day 11,intestines and adhesions to submucosal microvessels were examined.RESULTS: In the indomethacin-treated groups,mucosal damage was exacerbated by diets containing beef tallow and fish oil,and was accompanied by leukocyte infiltration(P < 0.05).The mucosal damage induced by indomethacin was significantly lower in mice fed the safflower oil diet than in mice fed the beef tallow or fish oil diet(P < 0.05).Indomethacin increased monocyte and platelet migration to the intestinal mucosa,whereas safflower oil significantly decreased monocyte and platelet recruitment(P < 0.05).CONCLUSION: A diet rich in SFA and omega-3 PUFA exacerbated NSAID-induced small intestinal damage via increased leukocyte infiltration.Importantly,a diet rich in omega-6-PUFA did not aggravate inflammation as monocyte migration was blocked. | Toshihide Ueda Ryota Hokari Masaaki Higashiyama Yuichi Yasutake Koji Maruta Chie Kurihara Kengo Tomita Shunsuke Komoto Yoshikiyo Okada Chikako Watanabe Shingo Usui Shigeaki Nagao Soichiro Miura | 2015 | World Journal of Gastroenterology2015，21，1： | 0 |
| 10 | Flow and geochemical modeling of drainage from Tomitaka mine,Miyazaki,Japan显示文摘The chemistry and flow of water in the abandoned Tomitaka mine of Miyazaki, western Japan were investigated. This mine is located in a non-ferrous metal deposit and acid mine drainage issues from it. The study was undertaken to estimate the quantities of mine drainage that needs to be treated in order to avoid acidification of local rivers, taking into account seasonal variations in rainfall. Numerical models aimed to reproduce observed water levels and fluxes and chemical variations of groundwater and mine drainage. Rock–water interactions that may explain the observed variations in water chemistry are proposed. The results show that:(1) rain water infiltrates into the deeper bedrock through a highly permeable zone formed largely by stopes that are partially filled with spoil from excavations(ore minerals and host rocks);(2) the water becomes acidic(p H from 3 to 4) as dissolved oxygen oxidizes pyrite;(3) along the flow path through the rocks, the redox potential of the water becomes reducing, such that pyrite becomes stable and p H of the mine drainage becomes neutral; and(4) upon leaving the mine, the drainage becomes acidic again due to oxidation of pyrite in the rocks. The present numerical model with considering of the geochemical characteristics can simulate the main variations in groundwater flow and water levels in and around the Tomitaka mine, and apply to the future treatment of the mine drainage. | Kohei Yamaguchi Shingo Tomiyama Hideya Metugi Hiroyuki Ii Akira Ueda | 2015 | Journal of Environmental Sciences2015，27，10： | 0 |
| 11 | Field measurements of absolute gravity in East Antarctica显示文摘This paper reports the results of field-based absolute gravity measurements aimed at detecting gravity change and crustal displacement caused by glacial isostatic adjustment.The project was initiated within the framework of the 53rd Japanese Antarctic Research Expedition(JARE53).Absolute gravity measurements,together with GPS measurements,were planned at several outcrops along the Prince Olav Coast and Sya Coast of East Antarctica,including at Syowa Station.Since the icebreaker Shirase(AGB 5003)was unable to moor alongside Syowa Station,operations were somewhat restricted during JARE53.However,despite this setback,we were able to complete measurements at two sites:Syowa Station and Langhovde.The absolute gravity value at the Syowa Station IAGBN(A)site,observed using an FG-5 absolute gravimeter(serial number 210;FG-5#210),was982 524 322.7±0.1μGal,and the gravity change rate at the beginning of 2012 was–0.26μGal?a-1.An absolute gravity value of 982535 584.2±0.7μGal was obtained using a portable A-10 absolute gravimeter(serial number 017;A-10#017)at the newly located site AGS01 in Langhovde. | Koichiro Doi Hideaki Hayakawa Takahito Kazama Toshihiro Higashi Shingo Osono Yoichi Fukuda Jun Nishijima Yuichi Aoyama Junichi Ueda | 2013 | Advances in Polar Science2013，24，4： | 0 |
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