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| 1 | Acute pancreatitis successfully diagnosed by diffusion-weighted imaging: A case report显示文摘Diffusion-weighted imaging (DWI) is an established diagnostic method of acute stroke. The latest advances in magnetic resonance imaging (MRI) technology have greatly expanded the utility of DWI in the examination of various organs. Recent studies have revealed the usefulness of DWI for imaging of the liver, kidney, ovary, and breast. We report a patient with acute pancreatitis detected by DWI and discussed the efficacy of DWI in diagnosing acute pancreatitis. A 50-year old man presented with a primary complaint of abdominal pain. We performed both DWI and computed tomography (CT) for this patient. The signal intensity in a series of DWI was measured and the apparent diffusion coefficient (ADC) values were calculated to differentiate inflammation from normal tissue. Two experienced radiologists evaluated the grade of acute pancreatitis by comparing the CT findings. Initially, the pancreas and multiple ascites around the pancreas produced a bright signal and ADC values were reduced on DWI. As the inflammation decreased, the bright signal faded to an iso-signal and the ADC values returned to their normal level. There was no difference in the abilities of DWI and CT images to detect acute pancreatitis. However, our case indicates that DWI can evaluate the manifestations of acute pancreatitis using no enhancement material andhas the potential to replace CT as a primary diagnostic strategy for acute pancreatitis. | Satoshi Shinya Takamitsu Sasaki Yoshifumi Nakagawa Zhang Guiquing Fumio Yamamoto Yuichi Yamashita | 2008 | World Journal of Gastroenterology2008，14，35： | 16 |
| 2 | Familial pancreatic cancer: Concept, management and issues显示文摘Familial pancreatic cancer (FPC) is broadly defined as two first-degree-relatives with pancreatic cancer (PC) and accounts for 4%-10% of PC. Several genetic syndromes, including Peutz-Jeghers syndrome, hereditary pancreatitis, hereditary breast-ovarian cancer syndrome(HBOC), Lynch syndrome, and familial adenomatous polyposis (FAP), also have increased risks of PC, but the narrowest definition of FPC excludes these known syndromes. When compared with other familial tumors, proven genetic alterations are limited to a small proportion (<20%) and the familial aggregation is usually modest. However, an ethnic deviation (Ashkenazi Jewish>Caucasian) and a younger onset are common also in FPC. In European countries, 'anticipation' is reported in FPC families, as with other hereditary syndromes; a trend toward younger age and worse prognosis is recognized in the late years. The resected pancreases of FPC kindred often show multiple pancreatic intraepithelial neoplasia (Pan IN) foci, with various K-ras mutations, similar to colorectal polyposis seen in the FAP patients. As with HBOC patients, a patient who is a BRCA mutation carrier with unresectable pancreatic cancer (accounting for 0%-19% of FPC patients) demonstrated better outcome following platinum and Poly (ADP-ribose) polymerase inhibitor treatment. Western countries have established FPC registries since the 1990 s and several surveillance projects for highrisk individuals are now ongoing to detect early PCs. Improvement in lifestyle habits, including non-smoking, is recommended for individuals at risk. In Japan, the FPC study group was initiated in 2013 and the Japanese FPC registry was established in 2014 by the Japan Pancreas Society. | Hiroyuki Matsubayashi Kyoichi Takaori Chigusa Morizane Hiroyuki Maguchi Masamichi Mizuma Hideaki Takahashi Keita Wada Hiroko Hosoi Shinichi Yachida Masami Suzuki Risa Usui Toru Furukawa Junji Furuse Takamitsu Sato Makoto Ueno Yoshimi Kiyozumi Susumu Hijioka Nobumasa Mizuno Takeshi Terashima Masaki Mizumoto Yuzo Kodama Masako Torishima Takahisa Kawaguchi Reiko Ashida Masayuki Kitano Keiji Hanada Masayuki Furukawa Ken Kawabe Yoshiyuki Majima Toru Shimosegawa | 2017 | World Journal of Gastroenterology2017，23，6： | 5 |
| 3 | Exploiting DNA repair pathways for tumor sensitization,mitigation of resistance,and normal tissue protection in radiotherapy显示文摘More than half of cancer patients are treated with radiotherapy,which kills tumor cells by directly and indirectly inducing DNA damage,including cytotoxic DNA double-strand breaks(DSBs).Tumor cells respond to these threats by activating a complex signaling network termed the DNA damage response(DDR).The DDR arrests the cell cycle,upregulates DNA repair,and triggers apoptosis when damage is excessive.The DDR signaling and DNA repair pathways are fertile terrain for therapeutic intervention.This review highlights strategies to improve therapeutic gain by targeting DDR and DNA repair pathways to radiosensitize tumor cells,overcome intrinsic and acquired tumor radioresistance,and protect normal tissue.Many biological and environmental factors determine tumor and normal cell responses to ionizing radiation and genotoxic chemotherapeutics.These include cell type and cell cycle phase distribution;tissue/tumor microenvironment and oxygen levels;DNA damage load and quality;DNA repair capacity;and susceptibility to apoptosis or other active or passive cell death pathways.We provide an overview of radiobiological parameters associated with X-ray,proton,and carbon ion radiotherapy;DNA repair and DNA damage signaling pathways;and other factors that regulate tumor and normal cell responses to radiation.We then focus on recent studies exploiting DSB repair pathways to enhance radiotherapy therapeutic gain. | Jac A.Nickoloff Lynn Taylor Neelam Sharma Takamitsu A.Kato | 2021 | Cancer Drug Resistance2021，4，2： | 4 |
| 4 | Contribution of the toxic advanced glycation end-productsreceptor axis in nonalcoholic steatohepatitis-related hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is one of the most common malignancies worldwide. The main etiologies of HCC are hepatitis B virus and hepatitis C virus(HCV), and non-hepatitis B/non-hepatitis C HCC(NBNCHCC) has also been identified as an etiological factor. Although the incidence of HCV-related HCC in Japan has decreased slightly in recent years, that of NBNC-HCC has increased. The onset mechanism of NBNC-HCC, which has various etiologies, remains unclear; however, nonalcoholic steatohepatitis(NASH), a severe form of nonalcoholic fatty liver disease, is known to be an important risk factor for NBNC-HCC. Among the different advanced glycation end-products(AGEs) formed by the Maillard reaction, glyceraldehyde-derived AGEs, the predominant components of toxic AGEs(TAGE), have been associated with NASH and NBNC-HCC, including NASH-related HCC. Furthermore, the expression of the receptor for AGEs(RAGE) has been correlated with the malignant progression of HCC. Therefore, TAGE induce oxidative stress by binding with RAGE may, in turn, lead to adverse effects, such as fibrosis and malignant transformation, in hepatic stellate cells and tumor cells during NASH or NASH-related HCC progression. The aim of this review was to examine the contribution of the TAGE-RAGE axis in NASH-related HCC. | Jun-ichi Takino Kentaro Nagamine Takamitsu Hori Akiko Sakasai-Sakai Masayoshi Takeuchi | 2015 | World Journal of Hepatology2015，7，23： | 4 |
| 5 | Small invasive ductal carcinoma of the pancreas distinct from branch duct intraductal papillary mucinous neoplasm显示文摘Endoscopic ultrasonography(EUS)is a highly sensitive diagnostic method for the detection of small pancreatic carcinomas.Recently,there have been some reports describing the utility of contrast-enhanced harmonic EUS(CEH-EUS)which uses sonographic contrast agent for differentiation of a pancreatic mass.This report describes a case of small adenocarcinoma of the pancreas distinct from branch duct intraductal papillary mucinous neoplasm(IPMN)in which investigation by EUS took place every 6 mo and diagnosis was made accurately by additional CEH-EUS during the follow- up of the branch duct IPMN.A 68-year-old female was admitted to our hospital because of a branch duct IPMN in the pancreatic body.She had been followedup by EUS every 6 mo.However,after 2 years EUSdemonstrated a low echoic area distinct from the branch duct IPMN which was vaguely discernible by EUS,and accurate sizing and differential diagnosis were considered difficult on the EUS imaging.CHEUS with Sonazoid revealed a hypovascular tumor and we suspected small pancreatic carcinoma.The histopathological diagnosis was adenocarcinoma (10 mm)in the pancreatic tail,distinct from the branch duct IPMN of the pancreatic body.EUS and CEH-EUS may play an important role in the correct diagnosis of small pancreatic tumors,including synchronous and metachronous occurrence of IPMN and ductal adenocarcinoma of the pancreas. | Hiroki Sakamoto Masayuki Kitano Takamitsu Komaki Hajime Imai Ken Kamata Masatomo Kimura Yoshifumi Takeyama Masatoshi Kudo | 2009 | World Journal of Gastroenterology2009，15，43： | 2 |
| 6 | Characterization of intra-abdominal lesions of undetermined origin by contrast-enhanced harmonic EUS (with videos)显示文摘 | Yu Xia Masayuki Kitano Masatoshi Kudo Hajime Imai Ken Kamata Hiroki Sakamoto Takamitsu Komaki | 2010 | Gastrointestinal Endoscopy2010，，3： | 2 |
| 7 | Peritoneal metastasis inhibition by linoleic acid with activation of PPARγ in human gastrointestinal cancer cells显示文摘 | Takamitsu Sasaki Kiyomu Fujii Kazuhiro Yoshida Hideo Shimura Tomonori Sasahira Hitoshi Ohmori Hiroki Kuniyasu | 2006 | Virchows Archiv2006，，4： | 1 |
| 8 | Transmesosigmoid Hernia: Report of a Case显示文摘 | Takamitsu Sasaki Koutaro Sakai Daisuke Fukumori Masayuki Sato Hitoshi Ohmori Fumio Yamamoto | 2002 | Surgery Today2002，，12： | 1 |
| 9 | Characterization of a cellulase containing a family 30 carbohydrate-binding module (CBM) derived from Clostridium thermocellum celJ:importance of the CBM to cellulose hydrolysis显示文摘 | Takamitsu A Rie A Akiyoshi T | 2003 | Journal of Bacteriology2003，185，2： | 1 |
| 10 | Acquired resistance to gefitinib: The contribution of mechanisms other than the T790M, MET, and HGF status显示文摘 | Takamitsu Onitsuka Hidetaka Uramoto Naohiro Nose Mitsuhiro Takenoyama Takeshi Hanagiri Kenji Sugio Kosei Yasumoto | 2009 | Lung Cancer2009，，2： | 1 |
| 11 | Rapid stabi - lization of vulnerable carotid plaque within 1 month of pitavastatin treatment in patients with acute coronary syndrome显示文摘 | Takamitsu N Junei O Yoshinobu K | 2008 | J Cardiovasc Pharmacol2008，51，： | 1 |
| 12 | Exposure to phthalate esters from indoor environment 显示文摘 | Takamitsu Otake Jun Yoshinaga Yukio Yanagisawa | 2004 | Journal of Exposure Analysis and Environmental Epidemiology2004，14，7： | 1 |
| 13 | InAsSb thick epilayers applied to long wavelength photoconductors显示文摘InAs0.052Sb0.948 epilayers with cutoff wavelengths longer than 8 μm were successfully grown on InAs substrates using melt epitaxy (ME). Scanning electron microscopy observations show that the interface between the epilayers and substrates is flat, indicating the good quality of the epilayers, and the thickness of the epilayers is 40 μm. Photoconductors were fabricated using InAs 0.052Sb0.948 thick epilayers grown by ME. Ge optical lenses were set on the photoconductors. At room temperature, the photoresponse wavelength range was 2-10 μm. The peak detectivity D*λp reached 5.4 × 109 cm·Hz 1/2 ·W-1 for the immersed detectors. The detectivity D*was 9.3 × 108 and 1.3 × 108 cm·Hz 1/2 ·W-1 at the wavelength of 8 and 9 μm, respectively. The good performance of the uncooled InAsSb detectors was experimentally validated. | Yu-zhu Gao Xiu-ying Gong Guang-hui Wu Yan-bin Feng Takamitsu Makino Hirofumi Kan Tadanobu Koyama Yasuhiro Hayakawa | 2013 | International Journal of Minerals,Metallurgy and Materials2013，20，4： | 1 |
| 14 | Outbreaks of Edwardsiella ictaluri infection in AYU Plecoglossus altivelis in Japanese rivers显示文摘 | Takamitsu S Takashi K Motohiko S | 2008 | Fish Pathol2008，，43： | 1 |
| 15 | Acquired resistance to gefitinib: The contribution of mechanisms other than the T790M, MET, and HGF status显示文摘 | Takamitsu Onitsuka Hidetaka Uramoto Naohiro Nose Mitsuhiro Takenoyama Takeshi Hanagiri Kenji Sugio Kosei Yasumoto | 2009 | Lung Cancer2009，，2： | 1 |
| 16 | Surgical outcomes of posterior thoracic interbody fusion for thoracic disc herniations显示文摘 | Ryoji Yamasaki Shinya Okuda Takafumi Maeno Takamitsu Haku Motoki Iwasaki Takenori Oda | 2013 | European Spine Journal2013，，11： | 1 |
| 17 | Design and synthesis of a highly selective, orally active and potent anaplastic lymphoma kinase inhibitor (CH5424802)显示文摘 | Kazutomo Kinoshita Kohsuke Asoh Noriyuki Furuichi Toshiya Ito Hatsuo Kawada Sousuke Hara Jun Ohwada Takuho Miyagi Takamitsu Kobayashi Kenji Takanashi Toshiyuki Tsukaguchi Hiroshi Sakamoto Takuo Tsukuda Nobuhiro Oikawa | 2011 | Bioorganic & Medicinal Chemistry2011，，3： | 1 |
| 18 | Detection of alginate oligosaccharides from mollusks 显示文摘 | TAKAMITSU CHAKA HIDETO AKIMI AKIHIRO SHIBATA | 2006 | Biosci Biotechnol Biochem2006，70，11： | 1 |
| 19 | Anthraquinone derivative emodin inhibits tumor- associated angiogenesis through inhibition of extracellular signal-regulated kinase 1/2 phosphorylation 显示文摘 | Tatsuya Kaneshiro Takamitsu Morioka Morihiko lnamine | 2006 | European Journal of Pharmacology2006，553，： | 1 |
| 20 | Drug Related Genetic Polymorphisms Affecting Adverse Reactions to Methotrexate, Vinblastine, Doxorubicin and Cisplatin in Patients With Urothelial Cancer 显示文摘 | Norihiko Tsuchiya Takamitsu Inoue Shintaro Narita | 2008 | The Journal of Urolo gy2008，180，6： | 1 |
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