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| 1 | Multi-disciplinary treatment for cholangiocellular carcinoma显示文摘Cholangiocarcinoma(CC)is rare malignant tumors composed of cells that resemble those of the biliary tract.It is notoriously difficult to diagnose,and is associated with a high mortality.Traditionally,CC is divided into intrahepatic and extraheaptic disease according to its location within the biliary tree.Intrahepatic cholangiocellular carcinoma(IH-CCC)or peripheral cholangiocellular carcinoma(CCC)appears within the second bifurcation of hepatic bile duct,and is the second most common primary liver cancer following hepatocellular carcinoma(HCC),IH-CCC or peripheral CCC often presents with advanced clinical features,and the cause for this cancer rise is still unclear.MRI,CT and PET provide useful diagnostic information in those patients.Surgical resection is the only chance for cure,with results depending on selected patients and careful surgical technique.Liver transplantation could offer long-term survival in selected patients when combined with chemotherapy.Chemotherapy,radiation therapy or combination therapies remain as the only treatment for inoperable patients.However,these are uniformly ineffective in patients' survival. | Mitsugi Shimoda Keiichi Kubota | 2007 | World Journal of Gastroenterology2007，13，10： | 17 |
| 2 | Erythropoietin ameliorates early ischemia-reperfusion injury following the Pringle maneuver显示文摘AIM:To investigate the protective effect of erythropoietin (Epo) against ischemia-reperfusion injury (IR/I) following the Pringle maneuver (PM),in comparison with conventional steroid administration in a prospective randomized trial. METHODS:Patients were randomized by age, sex, diagnosis, and surgical method, and assigned to three groups:(1) A steroid group (STRD, n= 9) who received 100 mg of hydrocortisone before PM, and on postoperative days 1, 2 and 3, followed by tapering until postoperative day 7; (2) An EPO1 group (n=10) who received 30 000 U of Epo before the PM and at the end of surgery; and (3) An EPO2 group (n=8) who received 60 000 U of Epo before the PM. Hemoglobin (Hb), hematocrit (Ht), aspartate aminotransferase (AST), alanine transaminase (ALT),lactate dehydrogenase (LDH), lactate, interleukin-6 (IL-6),and tumor necrosis factor(TNF)-α were measured before and just after (Day 0) surgery, and on postoperative days 1, 3, 7 and 14. RESULTS: There were no increases in Hb and Ht in the EPO1 and EPO2 groups. AST was signif icantly lower in EPO1 than in STRD on Day 0 (P=0.041), and lower in EPO1 than in STRD and EPO2 on Day 1 (P=0.018). ALT was signif icantly lower in EPO1 than in STRD and EPO2 on Day 0 (P=0.020) and Day 1 (P=0.004). There were no signif icant inter-group differences in the levels of LDH and lactate. IL-6 was signif icantly lower in EPO1 than in STRD and EPO2 on Day 0 (P=0.0036) and Day 1 (P=0.0451). TNF-α was signif icantly lower in EPO1 than in STRD and EPO2 on Day 0 (P=0.0006) and Day 1 (P<0.0001). Furthermore, hospitalization was signif icantly shorter in EPO1 and EPO2 than in STRD.CONCLUSION:Epo has greater potential than steroids to ameliorate IR/I after the PM. Epo at a dose of 30000 U, administered before PM and just after surgery, yields better results. | Masato Kato Tokihiko Sawada Junji Kita Mitsugi Shimoda Keiichi Kubota | 2010 | World Journal of Gastroenterology2010，16，38： | 11 |
| 3 | Metastatic basaloid-squamous cell carcinoma of the esophagus treated by 5-fluorouracil and cisplatin显示文摘Basaloid squamous cell carcinoma (BSC) of the esophagus is a rare malignant disease. We report here a patient with recurrent esophageal BSC,who was successfully treated by systemic chemotherapy containing 5-fluorouracil (5-FU) and cisplatin (CDDP). A 57-year-old woman was diagnosed as having squamous cell carcinoma of the esophagus upon endoscopic examination. Curative esophagectomy with lymph node dissection was performed under the thoracoscope. The pathological diagnosis of the surgical specimen was BSC. Five months after operation,the patient was diagnosed as having a recurrence of the BSC with metastases to the liver and spleen,and a right paraclavicular lymph node. She was given systemic chemotherapy consisting of continuous infusion of 800 mg/d of 5-FU and 3 h infusion of 20 mg/d of CDDP for 5 consecutive days every 4 wk. The metastatic lesions in the spleen and right paraclavicular lymph node disappeared,and the liver metastasis was apparently reduced in size after 2 courses of chemotherapy. The tumor regression was seen over 6 courses,with progression afterwards. Although subsequent treatment with CPT-11 and CDDP was not effective,docetaxel and vinorelbine temporarily controlled the tumor growth for 2 mo. 5-FU and CDDP combination may be useful for the patients with advanced BSC. | Yoshihiro Shibata Eishi Baba Hiroshi Ariyama Ryusuke Miki Nobumichi Ogami Shuji Arita Baoli Qin Hitoshi Kusaba Kenji Mitsugi Hirokazu Noshiro Takashi Yao Shuji Nakano | 2007 | World Journal of Gastroenterology2007，13，26： | 9 |
| 4 | Edaravone inhibits apoptosis caused by ischemia/reperfusion injury in a porcine hepatectomy model显示文摘AIM:To investigate the effect of E3-methyl-1-phenyl-2-pyrazolin-5-one (Edr) on hepatic ischemia-reperfusion (I/R) injury and liver regeneration in a porcine hepatectomy model.METHODS:One hour ischemia was induced by occluding the vessels and the bile duct of the right and median lobes.A 40% left hepatectomy was performed after reperfusion.Six animals received Edr (3 mg/kg per hour) intravenously and six control animals received saline just before reperfusion.Remnant liver volume,hemodynamics,aspartate aminotransferase (AST),alanine aminotransferase,lactate dehydrogenase and lactic acid,were compared between the groups.The expression of transforming growth factor (TGF1) and toll-like receptor (TRL) mRNA in hepatic tissues was examined using reverse transcription polymerase chain reaction.Apoptosis was demonstrated by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining,respectively.RESULTS:Serum AST (P = 0.029),and toll like receptor 4 level (P = 0.043) were significantly lower after 3 h in animals receiving Edr.In addition,TUNEL staining in Edr-treated pigs showed significantly fewer hepatocytes undergoing apoptosis compared with control pigs.After 1 mo,all factors were non-significantly different between the two groups.CONCLUSION:Edr is considered to reduce hepatic injury in the early stage of I/R injury in a porcine model. | Mitsugi Shimoda Yoshimi Iwasaki Toshie Okada Keiichi Kubota | 2012 | World Journal of Gastroenterology2012，18，27： | 8 |
| 5 | Three-dimensional virtual operations can facilitate complicated surgical planning for the treatment of patients with jaw deformities associated with facial asymmetry: a case report显示文摘This article describes a case we experienced in which good postsurgical facial profiles were obtained for a patient with jaw deformities associated with facial asymmetry,by implementing surgical planning with SimPlant OMS.Using this method,we conducted LF1 osteotomy,intraoral vertical ramus osteotomy(IVRO),sagittal split ramus osteotomy(SSRO),mandibular constriction and mandibular border genioplasty.Not only did we obtain a class I occlusal relationship,but the complicated surgery also improved the asymmetry of the frontal view,as well as of the profile view,of the patient.The virtual operation using three-dimensional computed tomography(3D-CT)could be especially useful for the treatment of patients with jaw deformities associated with facial asymmetry. | Shingo Hara Masaharu Mitsugi Takahiro Kanno Akihiko Nomachi Takehiko Wajima Yukihiro Tatemoto | 2013 | International Journal of Oral Science2013，5，3： | 6 |
| 6 | Placental transfer, lacteal transfer and plasma protein binding of gemcitabine 显示文摘 | Mitsugi K Seki H | 1994 | Xenobiotica1994，24，10： | 1 |
| 7 | Maxillary bone transportation inalveolar cleft-transport distraction osteogenesis for treatment ofalveolar cleft repair显示文摘 | Mitsugi M Ito O Alcalde RE | 2005 | Br J Plast Surg2005，58，5： | 1 |
| 8 | Corticotomy and compression osteogenesis in the posterior maxilla for treating severe anterior open bite显示文摘 | Kanno T Mitsugi M Furuki Y | | 0，，04： | 1 |
| 9 | Arthroscopic suture fixa-tion in patients with a tibial intercondylar eminence fracture using a simple device to penetrate the anterior cruciate ligament 显示文摘 | Aratake M Akamatsu Y Mitsugi N | 2014 | APSMART2014，1，2： | 1 |
| 10 | Effect of acetabular cup position and orientation in cemented total hip arthroplasty显示文摘 | Hirakawa K Mitsugi N Koshino T | 2001 | Clin Orthop Relat Res2001，，388： | 1 |
| 11 | Theory and Performance Evaluation of Group Coding of RFID Tags显示文摘 | Sato Y Mitsugi J Nakamura O | 2012 | IEEE Transactions on Automation Science and Engineering2012，9，3： | 1 |
| 12 | Mechanisms involved in suppression of ADAMTS4 expression in synoviocytes by high molecular weight hyaluronic acid显示文摘 | Yoshihiro Kataoka Wataru Ariyoshi Toshinori Okinaga Takeshi Kaneuji Sho Mitsugi Tetsu Takahashi Tatsuji Nishihara | 2013 | Biochemical and Biophysical Research Communications2013，，： | 1 |
| 13 | Computer-aided design provisionalization and implant insertion combined with optical scanning of plaster casts and computed tomography data显示文摘 | Shingo Hara Masaharu Mitsugi Takahiro Kanno Yukihiro Tatemoto | 2014 | Annals of Maxillofacial Surgery2014，，1： | 1 |
| 14 | Problems and prospects for combined chemotherapy with 5_Fu and low_dose DDP显示文摘 | Mitsugi K Nakarro S | 1999 | J Cancer Chemother1999，26，11： | 1 |
| 15 | Deployment analysis of large space antenna deployment analysis of large space antenna using flexible multibody dynamics simulation显示文摘 | Mitsugi J Ando K Senbokuya Y | | 0，，01： | 1 |
| 16 | Performance of Integrated FDG-PET/Contrast-enhanced CT in the Diagnosis of Recurrent Pancreatic Cancer: Comparison with Integrated FDG-PET/Non-contrast-enhanced CT and Enhanced CT显示文摘 | Kazuhiro Kitajima Koji Murakami Erena Yamasaki Yasushi Kaji Mitsugi Shimoda Keiichi Kubota Narufumi Suganuma Kazuro Sugimura | 2010 | Molecular Imaging and Biology2010，，4： | 1 |
| 17 | Shape control of the tension truss antenna显示文摘 | Jin Mitsugi Tetsuo Yasaka Koryo Miura | 1990 | AIAA Journal1990，28，2： | 1 |
| 18 | The benefits of the low intensity training显示文摘 | Hiroaki Tanaka Munehiro Shindo Mitsugi Motoyama | 1992 | Ann Physiol Anthropol1992，11，： | 1 |
| 19 | Effect of acetabular cup position and orientation in cemented total hip arthroplasty显示文摘 | Hirakawa K Mitsugi N Koshino T | 2001 | Clin Orthop Relat Res2001，，388： | 1 |
| 20 | Maxillary bone transportation in alveolar cleft-transport distraction osteogenesis for treatment of alveolar cleft repair 显示文摘 | Mitsugi M Ito O Alcaide RE | 2005 | Br J Plast Surg2005，58，5： | 1 |
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