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| 1 | Xyloglucan for Generating Tensile Stress to Bend Tree Stem显示文摘响应环境变化,被子植物树由形成紧张木头把他们的茎弄弯,它由充满纤维素的 G 组成(凝胶状) 在纤维房间的墙中的层并且在第二等的木部产生反常张力的应力。我们生产了转基因的白杨植物 overexpressing 在房间墙中减少每特定的多糖,,的几 endoglycanases 第二等的木部由主要、第二等的墙层组成。当水平地放了时,转基因的白杨 overexpressing xyloglucanase 的茎的基础区域不能独自在木部的紧张方面由于低紧张向上弯曲。在野类型的植物, xyloglucan 在多重 layering 期间在 G 层的内部表面被发现。在 situ xyloglucan endotransglucosylase ( XET ),活动证明整个 xyloglucan 的加入,潜在地因为墙紧缩,在内部表面层 S1 和 S2 开始了并且在整个G层开发被保留,当为墙松开的 xyloglucan heptasaccharide ( XXXG )的加入发生在膨胀地区的主要的墙中时。我们建议 xyloglucan 网络被 XET 增强形成在墙界限之间的一个进一步的连接并且分泌了 xyloglucans 以便承受在纤维素 G 层 microfibrils 以内创造的张力的压力。 | Kei'ichi Baba Yong Woo Park Tomomi Kaku Rumi Kaida Miyuki Takeuchi Masato Yoshida Yoshihiro Hosoo Yasuhisa Ojio Takashi Okuyama Toru Taniguchi Yasunori Ohmiya Teiji Kondo Ziv Shani Oded Shoseyov Tatsuya Awano Satoshi Serada Naoko Norioka Shigemi Norioka Takahisa Hayashi | 2009 | Molecular Plant2009，2，5： | 4 |
| 2 | Farinose fiavonoids are associated with high freezing tolerance in fairy primrose (Primula malacoides) plants显示文摘The deposition of surface(farinose)fiavonoids on aerial parts of some Primula species is a well-documented but poorly understood phenomenon.Here,we show thatfiavonoid deposition on the leaves and winter buds may contribute strongly to preventing freezing damage in these plants.The ice nucleation temperature of fairy primrose(Primula malacoides)leaves covered with naturalfiavone was approximately 6°C lower compared to those that had theirfiavone artificially removed.Additionally,farinosefiavonoids on the leaves reduced subsequent electrolyte leakage(EL)from the cells exposed to freezing temperatures.Interestingly,exogenous application offiavone at4 mg/g fresh weight to P.malacoides leaves,which had the originalfiavone mechanically removed,restored freezing tolerance,and diminished EL from the cells to pretreatment values.Our results suggest that farinosefiavonoids may function as mediators of freezing tolerance in P.malacoides,and exogenous application offiavone could be used to reduce freezing damage during sudden but predictable frost events in other plant species. | Ryutaro Isshiki Ivan Galis Shigemi Tanakamaru | 2014 | Journal of Integrative Plant Biology2014，56，2： | 3 |
| 3 | Biological efficacy of perpendicular type-I collagen protruded from TiO_(2)-nanotubes显示文摘The aim of this study was to evaluate the biological efficacy of a unique perpendicular protrusion of type-I collagen(Col-I)from TiO2 nanotubes(NT-EPF surface).We hypothesized that the NT-EPF surface would play bifunctional roles in stimulating plateletmediated fibroblast recruitment and anchoring fibroblast-derived Col-I to form a perpendicular collagen assembly,mimicking the connective tissue attachment around natural teeth for the long-term maintenance of dental implants.Ti surface modification was accomplished in two steps.First,TiO2 nanotubes(NT)array was fabricated via anodization.Diameters and depths of NTs were controlled by applied voltage and duration.Subsequently,an electrophoretic fusion(EPF)method was applied to fuse Col-I into nanotube arrays in a perpendicular fashion.Surface wettability was assessed by contact angle measurement.The bioactivity of modified TiO2 surfaces was evaluated in terms of NIH3T3 fibroblast attachment,platelet activation,and collagen extension.Early attachment,aggregation,and activation of platelets as well as release of platelet-related growth factors were demonstrated on NTEPF surfaces.Platelet-mediated NIH3T3 cells migration toward NT-EPF was significantly increased and the attached cells showed a typical fibrous morphology with elongated spindle shape.A direct linkage between pseudopod-like processes of fibroblasts to NTEPF surfaces was observed.Furthermore,the engineered EPF collagen protrusion linked with cell-derived collagen in a perpendicular fashion.Within the limitation of this in vitro study,the TiO2 nanotube with perpendicular Col-I surface(NT-EPF)promoted better cell attachment,induced a strong platelet activation which suggested the ability to create a more robust soft tissue seal. | Chia-Yu Chen David M.Kim Cliff Lee John Da Silva Shigemi Nagai Toshiki Nojiri Masazumi Nagai | 2020 | International Journal of Oral Science2020，12，4： | 3 |
| 4 | Epithelial cell adhesion efficacy of a novel peptide identified by panning on a smooth titanium surface显示文摘Epithelial attachment via the basal lamina on the tooth surface provides an important structural defence mechanism against bacterial invasion in combating periodontal disease. However, when considering dental implants, strong epithelial attachment does not exist throughout the titanium-soft tissue interface, making soft tissues more susceptible to peri-implant disease. This study introduced a novel synthetic peptide(A10) to enhance epithelial attachment. A10 was identified from a bacterial peptide display library and synthesized. A10 and protease-activated receptor 4-activating peptide(PAR4-AP, positive control) were immobilized on commercially pure titanium. The peptide-treated titanium showed high epithelial cell migration ability during incubation in platelet-rich plasma. We confirmed the development of dense and expanded BL(stained by Ln5) with pericellular junctions(stained by ZO1) on the peptide-treated titanium surface. In an adhesion assay of epithelial cells on A10-treated titanium, PAR4-AP-treated titanium, bovine root and non-treated titanium, A10-treated titanium and PAR4-AP-treated titanium showed significantly stronger adhesion than non-treated titanium. PAR4-AP-treated titanium showed significantly higher inflammatory cytokine release than non-treated titanium. There was no significant difference in inflammatory cytokine release between A10-treated and non-treated titanium. These results indicated that A10 could induce the adhesion and migration of epithelial cells with low inflammatory cytokine release. This novel peptide has a potentially useful application that could improve clinical outcomes with titanium implants and abutments by reducing or preventing peri-implant disease. | Hidemichi Kihara David M.Kim Masazumi Nagai Toshiki Nojiri Shigemi Nagai Chia-Yu Chen Cliff Lee Wataru Hatakeyama Hisatomo Kondo John Da Silva | 2018 | International Journal of Oral Science2018，10，3： | 2 |
| 5 | Regular arrangement of collecting venules:Does patient age affect its accuracy?显示文摘AIM:To address the diagnostic value of the regular arrangement of collecting venules(RAC)among old age patients. METHODS:A total of 390 consecutive patients whose Helicobacter pylori(H.pylori)status was known and who received upper gastrointestinal endoscopy,were retrospectively studied for the presence or absence of RAC as well as gastric mucosal atrophy.The sensitivity, specificity,positive predictive value,negative predic-tive value and accuracy of RAC to detect normal gastric mucosa were assessed and were compared among two different age groups of patients. RESULTS:The mean age±standard deviation(SD)of included patients(n=390),was 62.9±13 years.The sensitivity,specificity,positive predictive value,negative predictive value and accuracy of RAC to detect normal gastric mucosa were 91.7%,66.1%,18.8%,99%and 68.1%respectively.Although the sensitivity,specificity,positive predictive value,negative predictive value and accuracy of RAC among patients<60 years(n= 139)was 94.7%,71.2%,46.2%,98.1%and 76.1%,respectively,it was 80%,64.3%,5.1%,93%and 64.6%, respectively,among patients≥60 years(n=251). Younger Patients(<60 years),have highly significant rates of RAC sensitivity,positive predictive value,and accuracy(P≤0.001,≤0.001 and≤0.02,respectively).Older patients had highly significant rates of H. pylori infection and gastric mucosal atrophy(P≤0.01). CONCLUSION:Although RAC is a valuable sign for real-time identification of normal gastric mucosa,its accuracy seems to be affected by the patient's age. | Alshimaa Alaboudy Ashraf Elbahrawy Shigemi Matsumoto Ghada M Galal Tsutomu Chiba | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，6： | 2 |
| 6 | Use of ADME studies to confirm the safety of ε-polylysine as a preservative in food显示文摘 | Jun Hiraki Takafumi Ichikawa Shin-ichi Ninomiya Hideaki Seki Katsumi Uohama Hiroshi Seki Shigemi Kimura Yukio Yanagimoto James W Barnett | 2003 | Regulatory Toxicology and Pharmacology2003，，2： | 2 |
| 7 | Midamlam-atropine lollipop for pediatric premedication 显示文摘 | Shigemi K Kanbayashi Y Ohta T | 2000 | Masui2000，49，5： | 1 |
| 8 | American Journal of Kidney Diseases显示文摘 | Osamu Hotta Takashi Furuta Shigemi Chiba | 2002 | 39:493-5022002，39，： | 1 |
| 9 | Co-management in marine fisheries: the Japanese experience显示文摘 | Lim CP Matsuda Y Shigemi Y | 1995 | Coastal Management1995，23，： | 1 |
| 10 | Changes in endoscopic findings of gastritis after cure of H. pylori infection: Multicenter prospective trial显示文摘 | Mototsugu Kato Shuichi Terao Kyoichi Adachi Shigemi Nakajima Takashi Ando Norimasa Yoshida Noriya Uedo Kazunari Murakami Shuichi Ohara Masanori Ito Naomi Uemura Takuro Shimbo Hidenobu Watanabe Takahiro Kato Kazunori Ida | 2012 | Digestive Endoscopy2012，，3： | 1 |
| 11 | Midazolam-atropine lollipopfor pediatric premedication显示文摘 | Kanbayashi Y Ohta T | 2000 | Masui2000，49，5： | 1 |
| 12 | Physiological basis of differential response to salinity in rice cultivars显示文摘 | Shigemi Akita Gloria S. Cabuslay | 1990 | Plant and Soil1990，，2： | 1 |
| 13 | Primary structural features of rosaceous S-RNases associated with gametophytic self-incompatibility显示文摘 | Takeshi Ishimizu Toyohide Shinkawa Fumio Sakiyama Shigemi Norioka | 1998 | Plant Molecular Biology1998，，6： | 1 |
| 14 | Metabolism in rats with repeated dosing and effects on rat hepatic enzymes 显示文摘 | Naohiko Isobe Shigemi lto Yoshitaka Tomigahara | 1991 | Journal of Pesticide Science1991，16，2： | 1 |
| 15 | Metabolism of (R) - and (S) -isomers of ( E ) -1 - ( 2,4-dichlorophenyl ) -4,4-dimethyl- 2-( 1,2,4-triazol-1-yl ) -1 -penten-3-ol 显示文摘 | Naohiko Isobe Shigemi Ito Akira Yoshitake | 1991 | Journal of Pesticide Science1991，12，3： | 1 |
| 16 | Effects of melatonin on the proliferation and cisdiamminedicbloroplatinum (CDDP)sensitivity of cultured huinan ovarian cancer cells 显示文摘 | Masayuki Futagami Shigemi Sato Tomomi Sakamoto | 2001 | CynecolOncol2001，82，3： | 1 |
| 17 | Surface characterization and catalytic properties of La1?x -Sr x CoO3显示文摘 | Kenji Tabata Ikuo Matsumoto Shigemi Kohiki | 1987 | Journal of Materials Science1987，，5： | 1 |
| 18 | Bare metal stent implantation for in-stent restenosis with a drug-eluting stent显示文摘 | Hiroshi Matsuoka Hideo Kawakami Akira Ohshita Tamami Kohno Susumu Shigemi Hideki Okayama Jitsuo Higaki | 2009 | Journal of Cardiology2009，，1： | 1 |
| 19 | Clinical usefulness of and problems with three - dimensional CT angiography for evaluation of arteriosclerotic stenosis of the carotid artery: comparison with conventional angiography, MRA, and uhrasound sonography显示文摘 | Tetsuro S Shigemi F Yoshihiro M | 1999 | Surg Neurol1999，51，3： | 1 |
| 20 | Safety analysis of liposomal amphotericin B in adult patients: anaemia, thrombocytopenia, nephrotoxicity, hepatotoxicity and hypokalaemia 显示文摘 | Shigemi A Matsumoto K Ikawa K | 2011 | Int J Antimicrob Agents2011，38，5： | 1 |
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