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| 1 | 美国临床肿瘤学会IV期非小细胞肺癌化疗的临床实践指南更新显示文摘本文旨在为IV期非小细胞肺癌患者的治疗提供更新版推荐。本文资料检索源自2002年以来公布的相关随机试验文献。此指南范围限于化疗与生物治疗。更新委员会对这些文献进行了总结并提供了推荐更新。162篇文献符合标准被纳入参考。本推荐基于可改善总生存期的治疗方法。仅改善无进展生存期的治疗方法推动了对毒性及生存质量的监测。对于体力状态评分为0分或1分患者的一线治疗,可推荐以铂类为基础的细胞毒性药物的两药联用。对铂类治疗有禁忌的患者,可采用非铂类细胞毒性两药联合。对于体力状态评分为2分的患者,单一细胞毒性药物即可。对于疾病进展或经过4个周期的治疗仍对治疗无反应的患者,应停止一线细胞毒性化疗。即使在6个周期后患者对治疗仍有反应,亦应停止两药细胞毒性化疗。对于伴有明确的表皮生长因子受体(epidermal growth factor receptor,EGFR)突变的患者,可推荐一线采用吉非替尼治疗;对于EGFR突变为阴性或不明确的患者,细胞毒性化疗更佳。除具有特定临床特征的患者外,可推荐贝伐单抗与卡铂-紫杉醇联用。对于通过免疫组化证实EGFR阳性的肿瘤患者,可推荐西妥昔单抗与顺铂-长春瑞滨联用。多西紫杉醇、厄洛替尼、吉非替尼或培美曲塞被推荐作为二线治疗。对于未曾接受过厄洛替尼或吉非替尼治疗的患者,可推荐厄洛替尼作为三线治疗。现有数据不足以推荐常规三线采用细胞毒性药物。已有的证据也不足以推荐常规应用分子标记物选择化疗。 | Christopher G. AZZOLI Sherman Baker JR Sarah TEMIN William PAO Timothy ALIFF Julie BRAHMER David H. JOHNSON Janessa L. LASKIN Gregory MASTERS Daniel MILTON Luke NORDQUIST David G. PFISTER Steven PIANTADOSI Joan H. SCHILLER Reily SMITH Thomas J. SMITH John R. STRAWN David TRENT Giuseppe GIACCONE 丁燕(翻译) 南娟(翻译) 刘谦(翻译) 周清华(校对) 陈军(校对) | 2010 | 中国肺癌杂志2010，13，3： | 43 |
| 2 | RAS Is Regulated by the let-7 MicroRNA Family显示文摘 | Steven M. Johnson Helge Grosshans Jaclyn Shingara Mike Byrom Rich Jarvis Angie Cheng Emmanuel Labourier Kristy L. Reinert David Brown Frank J. Slack | 2005 | Cell2005，，5： | 5 |
| 3 | Colorectal cancer screening and surveillance: Clinical guidelines and rationale—Update based on new evidence显示文摘 | Sidney Winawer Robert Fletcher Douglas Rex John Bond Randall Burt Joseph Ferrucci Theodore Ganiats Theodore Levin Steven Woolf David Johnson Lynne Kirk Scott Litin Clifford Simmang | 2003 | Gastroenterology2003，，2： | 4 |
| 4 | Short-Segment Fixation of Lumbar Burst Fractures Using Pedicle Fixation at the Level of the Fracture显示文摘 | Andrew Mahar Choll Kim Michelle Wedemeyer Lance Mitsunaga Tim Odell Bryce Johnson Steven Garfin | 2007 | Spine2007，，14： | 3 |
| 5 | Optimal Code Generation for Expression Trees显示文摘 | Steven C Johnson | 1976 | Journal of the ACM1976，23，3： | 1 |
| 6 | Cognitive lock - in and the power law of practice 显示文摘 | JOHNSON ERIC J STEVEN BELLMAN ET AL | 2003 | Journal of Marketing2003，，2： | 1 |
| 7 | Dead-time effects on geiger-mode APD performance 显示文摘 | Philip Gatt Steven Johnson Terry Nichols | 2007 | SPIE2007，6550，65： | 1 |
| 8 | Risk of deep vein thrombosis following a single negative whole leg compression ultrasound:a systematic review and meta analysis 显示文摘 | Johnson SA Stevens SM Woller SC | 2010 | JAMA2010，303，5： | 1 |
| 9 | Acid Rereflux: A Review, Emphasizing Detection by Impedance, Manometry, and Scintigraphy, and the Impact on Acid Clearing Pathophysiology as Well as Interpreting the pH Record显示文摘 | Steven S. Shay Lawrence F. Johnson Joel E. Richter | 2003 | Digestive Diseases and Sciences2003，，： | 1 |
| 10 | Intranasal delivery: Physicochemical and therapeutic aspects显示文摘 | Henry R. Costantino Lisbeth Illum Gordon Brandt Paul H. Johnson Steven C. Quay | 2007 | International Journal of Pharmaceutics2007，，1： | 1 |
| 11 | Closed versus open endotracheal suctioning: Costs and physiologic consequences显示文摘 | KAREN L. JOHNSON PAUL A. KEARNEY STEVEN B. JOHNSON JUDY B. NIBLETT NANCY L. MACMILLAN REBECCA E. MCCLAIN | 1994 | Critical Care Medicine1994，，4： | 1 |
| 12 | Reconstructing three dimensional temperature and fluid velocity fields from acoustic transmission measure- ments 显示文摘 | JOHNSON Steven A GREENLEAF James F TANAKA M | 1997 | ISA Transactions1997，16，3： | 1 |
| 13 | Determining the crystal structure of cellulose ⅢⅠ by modeling显示文摘 | Zakhia M Ford Edwin D Stevens Glenn P Johnson | 2005 | Carbohydrate Research2005，340，： | 1 |
| 14 | White matter abnormalities in HIV-1 infection: A diffusion tensor imaging study显示文摘 | Nunzio Pomara David T. Crandall Steven J. Choi Glyn Johnson Kelvin O. Lim | 2001 | Psychiatry Research: Neuroimaging2001，，1： | 1 |
| 15 | Feasibility of pancreatectomy following high-dose proton therapy for unresectable pancreatic cancer显示文摘AIM To review surgical outcomes for patients undergoing pancreatectomy after proton therapy with concomitant capecitabine for initially unresectable pancreatic adenocarcinoma.METHODS From April 2010 to September 2013,15 patients with initially unresectable pancreatic cancer were treated withproton therapy with concomitant capecitabine at 1000 mg orally twice daily. All patients received 59.40 Gy(RBE) to the gross disease and 1 patient received 50.40 Gy(RBE) to high-risk nodal targets. There were no treatment interruptions and no chemotherapy dose reductions. Six patients achieved a radiographic response sufficient to justify surgical exploration,of whom 1 was identified as having intraperitoneal dissemination at the time of surgery and the planned pancreatectomy was aborted. Five patients underwent resection. Procedures included:Laparoscopic standard pancreaticoduodenectomy(n = 3),open pyloris-sparing pancreaticoduodenectomy(n = 1),and open distal pancreatectomy with irreversible electroporation(IRE) of a pancreatic head mass(n = 1). RESULTS The median patient age was 60 years(range,51-67). The median duration of surgery was 419 min(range,290-484),with a median estimated blood loss of 850 cm^3(range,300-2000),median ICU stay of 1 d(range,0-2),and median hospital stay of 10 d(range,5-14). Three patients were re-admitted to a hospital within 30 d after discharge for wound infection(n = 1),delayed gastric emptying(n = 1),and ischemic gastritis(n = 1). Two patients underwent R0 resections and demonstrated minimal residual disease in the final pathology specimen. One patient,after negative pancreatic head biopsies,underwent IRE followed by distal pancreatectomy with no tumor seen in the specimen. Two patients underwent R2 resections. Only 1 patient demonstrated ultimate local progression at the primary site. Median survival for the 5 resected patients was 24 mo(range,10-30).CONCLUSION Pancreatic resection for patients with initially unresectable cancers is feasible after high-dose [59.4 Gy(RBE)] proton radiotherapy with a high rate of local control,acceptable surgical morbidity,and a median survival of 24 mo. | Kathryn E Hitchcock R Charles Nichols Christopher G Morris Debashish Bose Steven J Hughes John A Stauffer Scott A Celinski Elizabeth A Johnson Robert A Zaiden Nancy P Mendenhall Michael S Rutenberg | 2017 | World Journal of Gastrointestinal Surgery2017，9，4： | 1 |
| 16 | Orthotopic liver transplantation for biliary papillomatosis显示文摘 | Kimberly L. Beavers Michael W. Fried Mark W. Johnson Steven L. Zacks David A. Gerber Susan M. Weeks Jeffrey H. Fair Pat Odell Roshan Shrestha | 2001 | Liver Transplantation2001，，3： | 1 |
| 17 | High-resolution MRI in theinvestigation of recurrent pain after lumbar discectomy显示文摘 | Cavanagh S Stevens J Johnson JR | 1993 | J BoneJoint Surg Br1993，4，： | 1 |
| 18 | Type-Ⅳ DCT DST and MDCT algorithms with reduced numbers of arithmetic operations 显示文摘 | Xuan Cheng shao Steven G Johnson | 2008 | Signal Processing2008，88，6： | 1 |
| 19 | Effect of Free stream Noise on Roughness-lnduced Transition for a Slender Cone 显示文摘 | Katya M Casper Heath B Johnson Steven P Schneider | 2011 | Journal of Spacecraft and Rockets2011，48，3： | 1 |
| 20 | CT findings in hepatoce]lular carcinoma: Correlation of tumor characteristics with causative factors, tumor size, and histologic tumor grade显示文摘 | Stevens WR Johnson CD Stephens DH | 1994 | Radiology1994，191，2： | 1 |
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