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| 1 | Phytate:impact on environment and human nutrition.A challenge for molecular breeding显示文摘Phytic acid (PA) is the primary storage compound of phosphorus in seeds accounting for up to 80% of the total seed phosphorus and contributing as much as 1.5% to the seed dry weight. The negatively charged phosphate in PA strongly binds to metallic cations of Ca, Fe, K, Mg, Mn and Zn making them insoluble and thus unavailable as nutritional factors. Phytate mainly accumulates in protein storage vacuoles as globoids, predominantly located in the aleurone layer (wheat, barley and rice) or in the embryo (maize). During germination, phytate is hydrolysed by endogenous phytase(s) and other phosphatases to release phosphate, inositol and micronutrients to support the emerging seedling. PA and its derivatives are also implicated in RNA export, DNA repair, signalling, endocytosis and cell vesicular trafficking. Our recent studies on purification of phytate globoids, their mineral composition and dephytinization by wheat phytase will be discussed. Biochemical data for purified and characterized phytases isolated from more than 23 plant species are presented, the dephosphorylation pathways of phytic acid by different classes of phytases are compared, and the application of phytase in food and feed is discussed. | Lisbeth BOHN Anne S. MEYER Sren K. RASMUSSEN | 2008 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2008，9，3： | 30 |
| 2 | Ehealth:Low FODMAP diet vs Lactobacillus rhamnosus GG in irritable bowel syndrome显示文摘AIM:To investigate the effects of a low fermentable,oligosaccharides,disaccharides,monosaccharides and polyols diet(LFD)and the probiotic Lactobacillus rhamnosus GG(LGG)in irritable bowel syndrome(IBS).METHODS:Randomised,unblinded controlled trial on the effect of 6-wk treatment with LFD,LGG or a normal Danish/Western diet(ND)in patients with IBS fulfilling Rome III diagnostic criteria,recruited betweenNovember 2009 and April 2013.Patients were required to complete on a weekly basis the IBS severity score system(IBS-SSS)and IBS quality of life(IBS-QOL)questionnaires in a specially developed IBS web selfmonitoring application.We investigated whether LFD or LGG could reduce IBS-SSS and improve QOL in IBS patients.RESULTS:One hundred twenty-three(median age 37years,range:18-74 years),90(73%)females were randomised:42 to LFD,41 to LGG and 40 to ND.A significant reduction in mean±SD of IBS-SSS from baseline to week 6 between LFD vs LGG vs ND was revealed:133±122 vs 68±107,133±122 vs 34±95,P<0.01.Adjusted changes of IBS-SSS for baseline covariates showed statistically significant reduction of IBS-SSS in LFD group compared to ND(IBS-SSS score75;95%CI:24-126,P<0.01),but not in LGG compared to ND(IBS-SSS score 32;95%CI:18-80,P=0.20).IBS-QOL was not altered significantly in any of the three groups:mean±SD in LFD 8±18 vs LGG 7±17,LFD 8±18 vs ND 0.1±15,P=0.13.CONCLUSION:LFD is efficacious for patients with IBS. | Natalia Pedersen Nynne Nyboe Andersen Zsuzsanna Végh Lisbeth Jensen Dorit Vedel Ankersen Maria Felding Mette Hestetun Simonsen Johan Burisch Pia Munkholm | 2014 | World Journal of Gastroenterology2014，20，43： | 16 |
| 3 | Follow-up of patients with functional bowel symptoms treated with a low FODMAP diet显示文摘AIM: To investigate patient-reported outcomes from, and adherence to, a low FODMAP diet among patients suffering from irritable bowel syndrome and inflammatory bowel disease.METHODS: Consecutive patients with irritable bowel syndrome(IBS) or inflammatory bowel disease(IBD) and co-existing IBS fulfilling the ROME Ⅲ criteria, who previously attended an outpatient clinic for low FODMAP diet(LFD) dietary management and assessment by a gastroenterologist, were invited to participate in a retrospective questionnaire analysis. The questionnaires were sent and returned by regular mail and gathered information on recall of dietarytreatment, efficacy, symptoms, adherence, satisfaction, change in disease course and stool type, and quality of life. Before study enrolment all patients had to sign an informed written consent.RESULTS: One hundred and eighty patients were included, 131(73%) IBS and 49(27%) IBD patients. Median age was 43 years(range: 18-85) and 147(82%) were females. Median follow-up time was 16 mo(range: 2-80). Eighty-six percent reported either partial(54%) or full(32%) efficacy with greatest improvement of bloating(82%) and abdominal pain(71%). The proportion of patients with full efficacy tended to be greater in the IBD group than in the IBS group(42% vs 29%, P = 0.08). There was a significant reduction in patients with a chronic continuous disease course in both the IBS group(25%, P < 0.001) and IBD group(23%, P = 0.002) along with a significant increase in patients with a mild indolent disease course of 37%(P < 0.001) and 23%(P = 0.002), respectively. The proportion of patients having normal stools increased with 41% in the IBS group(P < 0.001) and 66% in the IBD group(P < 0.001). One-third of patients adhered to the diet and high adherence was associated with longer duration of dietary course(P < 0.001). Satisfaction with dietary management was seen in 83(70%) IBS patients and 24(55%) IBD patients. Eightyfour percent of patients lived on a modified LFD, where some foods rich in FODMAPs were reintroduced, and 16% followed the LFD by the book without deviations. Wheat, dairy products, and onions were the foods most often not reintroduced by patients.CONCLUSION: These data suggest that a diet low in FODMAPs is an efficacious treatment solution in the management of functional bowel symptoms for IBS and IBD patients. | Louise Maagaard Dorit V Ankersen Zsuzsanna Végh Johan Burisch Lisbeth Jensen Natalia Pedersen Pia Munkholm | 2016 | World Journal of Gastroenterology2016，22，15： | 8 |
| 4 | Ehealth monitoring in irritable bowel syndrome patients treated with low fermentable oligo-, di-, mono-saccharides and polyols diet显示文摘In the present study we report on changes in irritable bowel syndrome-severity scoring system(IBS-SSS)and irritable bowel syndrome-quality of life(IBS-QoL)in 19 IBS patients,aged 18 to 74 years(F/M:14/5),during 12 wk registering their symptoms on the webapplication(www.ibs.constant-care.dk).During a control period of the first 6-wk patients were asked to register their IBS-SSS and IBS-QoL on the web-application weekly without receiving any intervention.Thereafter,low fermentable oligo-,di-,mono-saccharides and polyols(FODMAP)diet(LFD)was introduced for the next6 wk while continuing the registration.Though a small sample size a significant improvement in disease activity(IBS-SSS)was observed during both the control period,median:278(range:122-377),P=0.02,and subsequently during the LFD period,median:151(range:29-334),P<0.01.The IBS-QoL solely changed significantly during the LFD period,median:67(37-120),P<0.01.The significant reduction in disease activity during the control period shows a positive effect of the web-application on IBS symptoms when presented as a'traffic light'.However adding the diet reduced IBSSSS to<150,inactive to mild symptoms.In the future results from larger scale trials are awaited. | Natalia Pedersen Zsuzsanna Vegh Johan Burisch Lisbeth Jensen Dorit Vedel Ankersen Maria Felding Nynne Nyboe Andersen Pia Munkholm | 2014 | World Journal of Gastroenterology2014，20，21： | 7 |
| 5 | Postoperative Cognitive Dysfunction Is Independent of Type of Surgery and Anesthetic显示文摘 | Lisbeth Evered David A. Scott Brendan Silbert Paul Maruff | 2011 | Anesthesia & Analgesia2011，，5： | 3 |
| 6 | Development of a Rapid Risk and Impact Assessment Tool to Enhance Response to Environmental Emergencies in the Early Stages of a Disaster: A Tool Developed by the European Multiple Environmental Threats Emergency NETwork (EMETNET) Project显示文摘Every year,numerous environmental disasters and emergencies occur across the globe with far-reaching impacts on human health and the environment.The ability to rapidly assess an environmental emergency to mitigate potential risks and impacts is paramount.However,collating the necessary evidence in the early stages of an emergency to conduct a robust risk assessment is a major challenge.This article presents a methodology developed to help assess the risks and impacts during the early stages of such incidents,primarily to support the European Union Civil Protection Mechanism but also the wider global community in the response to environmental emergencies.An online rapid risk and impact assessment tool has also been developed to promote enhanced collaboration between experts who are working remotely,considering the impact of a disaster on the environment and public health in the short,medium,and long terms.The methodology developed can support the appropriate selection of experts and assets to be deployed to affected regions to ensure that potential public health and environmental risks and impacts are mitigated whenever possible.This methodology will aid defensible decision making,communication,planning,and risk management,and presents a harmonized understanding of the associated impacts of an environmental emergency. | Emma-Jane Goode Eirian Thomas Owen Landeg Raquel Duarte-Davidson Lisbeth Hall Jolanda Roelofs Sjors Schulpen Arnout De Bruin Elisabeth Wigenstam Birgitta Liljedahl Annica Waleij Louise Simonsson Ann Göransson Nyberg | 2021 | International Journal of Disaster Risk Science2021，12，4： | 2 |
| 7 | Electrodialytic removal of heavy metals from municipal solid waste incineration fly ash using ammonium citrate as assisting agent显示文摘 | Anne Juul Pedersen Lisbeth M Ottosen Arne Villumsen | 2005 | Journal of Hazardous Materials2005，122，： | 1 |
| 8 | Colonic Drug Delivery显示文摘 | Peter J. Watts Lisbeth Lllum | 1997 | Drug Development and Industrial Pharmacy1997，，9： | 1 |
| 9 | Fueling Industrial Biotech- nology Growth with Bioethanol 显示文摘 | Otero J M Gianni P Lisbeth O | 2007 | Adv Biochem Eng/Biotech- nol2007，108，： | 1 |
| 10 | Fermentation of lignocellulosic hydrolysates for ethanol production显示文摘 | Lisbeth Olsson Barbel Hahn-hagerdal | 1996 | Enzyme Microb Technol1996，18，5： | 1 |
| 11 | Electrodialytic Removal of Heavy Metals from Different Fly Ashes Influence of Heavy Metal Speciation in the Ashes显示文摘 | Anne Juul Pedersen Lisbeth M Ottosen Arne Villumsen | 2003 | Journal of Hazardous Materials2003，100，： | 1 |
| 12 | Urinary 1-hydroxypyrene (1-HP) in environmental and occupational studies—A review显示文摘 | ?se M. Hansen Line Mathiesen Marie Pedersen Lisbeth E. Knudsen | 2007 | International Journal of Hygiene and Environmental Health2007，，5： | 1 |
| 13 | Removal of Cu, Pb and Zn in an applied electric field in calcareous and non-calcareous soils显示文摘 | Lisbeth M. Ottosen Henrik K. Hansen Alexandra B. Ribeiro Arne Villumsen | 2001 | Journal of Hazardous Materials2001，，3： | 1 |
| 14 | Test of experimental set-ups for electrodialytic removal of Ca, Zn, Pb and Cd from different contaminated harbour sediments显示文摘 | GUNVOR M N LISBETH M O ARNE V | 2005 | Engineering Geology2005，77，： | 1 |
| 15 | Persistence ectopic pregnancy after liner salpingotomy:a non-predictable complication to conservative surgery for tubal gestation显示文摘 | Otto LC Lisbeth N Nannie B | 2002 | Acta Obstet Gynecol Scand2002，81，11： | 1 |
| 16 | Intranasal delivery: Physicochemical and therapeutic aspects显示文摘 | Henry R. Costantino Lisbeth Illum Gordon Brandt Paul H. Johnson Steven C. Quay | 2007 | International Journal of Pharmaceutics2007，，1： | 1 |
| 17 | Complications of epilepsy surgery—A systematic review of focal surgical resections and invasive EEG monitoring显示文摘 | Walter J. Hader Jose Tellez‐Zenteno Amy Metcalfe Lisbeth Hernandez‐Ronquillo Samuel Wiebe Churl‐Su Kwon Nathalie Jette | 2013 | Epilepsia2013，，5： | 1 |
| 18 | Obstetric somatic and demographic risk factom for postpartum depressive symptoms显示文摘 | Ann J Lisbeth MD Angelsioo MD | 2010 | Am J Obstey Gynecol2010，99，： | 1 |
| 19 | Zearalenone contamination in corn for human consumption in the state of Tlaxcala,Mexico显示文摘 | Lisbeth GM Rafael CR | 2007 | Food Chem2007，100，： | 1 |
| 20 | Risk of Developing Adenomas and Carcinomas in the Ileal Pouch in Patients With Familial Adenomatous Polyposis显示文摘 | Pieter Friederich Andrea E. de Jong Lisbeth M. Mathus–Vliegen Eveline Dekker Han H. Krieken Jan Dees Fokko M. Nagengast Hans F.A. Vasen | 2008 | Clinical Gastroenterology and Hepatology2008，，11： | 1 |
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