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| 1 | Helicobacter pylori associated chronic gastritis,clinical syndromes,precancerous lesions,and pathogenesis of gastric cancer development显示文摘Helicobacter pylori(H.pylori)infection is well known to be associated with the development of precancerous lesions such as chronic atrophic gastritis(AG),or gastric intestinal metaplasia(GIM),and cancer.Various molecular alterations are identified not only in gastric cancer(GC)but also in precancerous lesions.H.pylori treatment seems to improve AG and GIM,but still remains controversial.In contrast,many studies,including meta-analysis,show that H.pylori eradication reduces GC.Molecular markers detected by genetic and epigenetic alterations related to carcinogenesis reverse following H.pylori eradication.This indicates that these changes may be an important factor in the identification of high risk patients for cancer development.Patients who underwent endoscopic treatment of GC are at high risk for development of metachronous GC.A randomized controlled trial from Japan concluded that prophylactic eradication of H.pylori after endoscopic resection should be used to prevent the development of metachronous GC,but recent retrospective studies did not show the tendency.Patients with precancerous lesions(molecular alterations)that do not reverse after H.pylori treatment,represent the'point of no return'and may be at high risk for the development of GC.Therefore,earlier H.pylori eradication should be considered for preventing GC development prior to the appearance of precancerous lesions. | Jiro Watari Nancy Chen Peter S Amenta Hirokazu Fukui Tadayuki Oshima Toshihiko Tomita Hiroto Miwa Kheng-Jim Lim Kiron M Das | 2014 | World Journal of Gastroenterology2014，20，18： | 60 |
| 2 | Vitamin D and autoimmune thyroid diseases显示文摘The role of vitamin D as an immune modulator has been emphasized in recent years,and low levels of the hormone were observed in several autoimmune diseases including multiple sclerosis and systemic lupus erythematosus.Vitamin D mediates its effect though binding to vitamin D receptor(VDR),and activation of VDR-responsive genes.While VDR gene polymorphism was found to associate with autoimmune thyroid diseases(AITDs),few studies examined levels of vitamin D in these patients and those that did yielded conflicting results.We therefore undertook to evaluate the levels of vitamin D in patients with AITDs compared to patients with non-AITDs and healthy controls.Serum vitamin D(25-OH)levels were measured in 50 patients with AITDs,42 patients with non-AITDs and 98 healthy subjects,utilizing the LIAISON chemiluminescence immunoassay(DiaSorin,Saluggia,Italy).VitaminD deficiency was designated at levels lower than 10 ng/ml.Antithyroid antibodies,thyroid functions and demographic parameters were evaluated in all patients.The prevalence of vitamin D deficiency was significantly higher in patients with AITDs compared with healthy individuals(72% versus 30.6%;P<0.001),as well as in patients with Hashimoto’s thyroiditis compared to patients with non-AITDs(79% versus 52%;P<0.05).Vitamin D deficiency also correlated to the presence of antithyroid antibodies(P=0.01)and abnormal thyroid function tests(P=0.059).Significantly low levels of vitamin D were documented in patients with AITDs that were related to the presence of anti thyroid antibodies and abnormal thyroid function tests,suggesting the involvement of vitamin D in the pathogenesis of AITDs and the advisability of supplementation. | Shaye Kivity Nancy Agmon-Levin Michael Zisappl Yinon Shapira Endre V Nagy Katalin Danko Zoltan Szekanecz Pnina Langevitz Yehuda Shoenfeld | 2011 | Cellular & Molecular Immunology2011，8，3： | 47 |
| 3 | 西酞普兰及人际心理治疗对合并抑郁症的冠心病患者的影响——加拿大心脏病人群抗抑郁药及心理治疗疗效随机试验(CREATE)显示文摘背景:目前鲜有随机对照试验就冠心病(coronary artery disease,CAD)患者重度抑郁症的治疗效果进行评估,亦无试验同时对抗抑郁药和短期心理治疗进行评估。
目的:在同时患有CAD及重度抑郁症的患者中明确选择性5.羟色胺再摄取抑制剂(西酞普兰)及人际心理治疗(interpersonal psychotherapy,IPT)在减少抑郁症状方面的短期效果。 | Francois Lespérance Nancy Frasure-Smith Diana Koszycki 顾佳(译) | 2007 | 美国医学会杂志(中文版)2007，26，4： | 36 |
| 4 | 指南2.0:为成功制定指南而系统研发的全面清单显示文摘背景虽然当前已有一些评估卫生保健指南可靠性的工具,但仍缺乏针对制定指南实际步骤的指导。针对指南制定者们所需考虑的相关资源和工具,我们系统研发了一份全面的条目清单,但这并不意味着每篇指南都需遵守该清单的所有条目。方法我们检索了国际指南制定机构的指南制定手册、指南的指南(主要是来自国际和国家机构以及专业学会的方法学报告),以及提供系统指导的最新文章。经过反复评价这些资料,尽可能全面地罗列和提取条目,并制定与指南有关的重要主题。通过反复讨论,我们对条目进行评价以去重和补漏,同时邀请指南制定专家对所增加的条目进行修改并提出建议。结果我们制定了一份包含18个主题、146个条目的清单,并建立了帮助指南制定者应用这些条目的网站。这些主题和条目涵盖了指南从规划、完成、实施和评估的全过程。最终的清单版本也包括了培训所需的资料以及应用这些条目时用到的方法学参考文献的链接。解释本清单将提供给指南制定者用作参考。仔细考虑清单中的条目将有助于指南的制定、实施和评估,我们也将会通过大众反馈来修订并持续更新清单。 | Holger J. Schunemann Wojtek Wiercioch Itziar Etxeandia Maicon Falavigna Nancy Santesso Reem Mustafa Matthew Ventresca Romina Brignardello-petersen] Kaja-Triin Laisaar Sergio Kowalski Tejan Baldeh Yuan Zhang Uiia Raid Ignacio Neumann Susan L. Norris Judith Thornton Robin Harbour Shaun Treweek Gordon Guyatt Pablo Alonso-Coello Marge Reinap Jan Brozek Andrew Oxman Elie A. Akl | 2014 | 中国循证医学杂志2014，14，9： | 26 |
| 5 | Pathophysiology of constipation in the older adult显示文摘This review provides information on the definition of constipation, normal continence and defecation and a description of the pathophysiologic mechanisms of constipation. In addition, changes in the anatomy and physiology of the lower gastrointestinal tract associated with aging that may contribute to constipation are described. MEDLINE (1966-2007) and CINAHL (1980-2007) were searched. The following MeSH terms were used: constipation/etiology OR constipation/ physiology OR constipation/physiopathology) AND (age factors OR aged OR older OR 80 and over OR middle age). Constipation is not well defined in the literature. While self-reported constipation increases with age, findings from a limited number of clinical studies that utilized objective measures do not support this association. Dysmotility and pelvic floor dysfunction are important mechanisms associated with constipation. Changes in GI function associated with aging appear to be relatively subtle based on a limited amount of conflicting data. Additional research is warranted on the effects of aging on GI function, as well as on the timing of these changes. | G Lindsay McCrea Christine Miaskowski Nancy A Stotts Liz Macera Madhulika G Varma | 2008 | World Journal of Gastroenterology2008，14，17： | 21 |
| 6 | 水生生态系统中的氮显示文摘从淡水到河口、沿海和海水系统的连续统一体中,水生生态系统对营养富集和营养比变化的反应各不相同。尽管在淡水系统里,人们认为磷是浮游植物生产的限制性营养元素,但大气中氮的影响和它对淡水酸化所起的作用却可以是有害的。从河口到海岸带的连续统一体中,随着盐的梯度和季节不同,在氮、磷、硅之间出现多元的营养限制,但是,一般认为氮是浮游植物生物量积累的主要限制性营养元素。在氮和磷通量、浮游植物初级生产及渔业产量之间有确切的、非线性的正相关关系。流向河口、海岸和海洋系统的营养负载超过了营养富集后生产活动的同化能力,以及水质发生恶化时,存在着各种阈值。其影响包括有害和有毒藻类的滋生、混浊度增加,随后是沉水植物消失、缺氧、生态系统功能瓦解,栖息地丧失、生物多样性丧失、食物网变换,以及捕捞渔业的损失。 | Nancy N.Rabalais 李康民 | 2002 | AMBIO-人类环境杂志2002，31，2： | 20 |
| 7 | Thymoma and autoimmunity显示文摘The thymus is a central lymphatic organ that is responsible for many immunological functions,including the production of mature,functional T cells and the induction of self-tolerance.Benign or malignant tumors may originate from the thymus gland,with thymoma being the most common and accounting for 50% of anterior mediastinal tumors.Malignancies linked to thymoma include the loss of self-tolerance and the presence of autoimmunity.In this review,we compiled the current scientific evidence detailing the various interactions between thymoma and autoimmune diseases,including myasthenia gravis,systemic lupus erythematosus,inappropriate antidiuretic hormone secretion,pure red cell aplasia,pernicious anemia,pemphigus and autoimmune thyroid diseases.In recent years,several mechanisms have been proposed to explain these interactions.Most are based on the assumption that the‘sick’thymus,like the‘normal’thymus,can generate mature T cells;however,the T cells generated by the sick thymus are impaired and thus may exert cellular autoreactivity.Here,we present several theories that may shed light on the loss of self-tolerance associated with this epithelial tumor of the thymus. | Shahar Shelly Nancy Agmon-Levin Arie Altman Yehuda Shoenfeld | 2011 | Cellular & Molecular Immunology2011，8，3： | 19 |
| 8 | 雌性川金丝猴尿中生殖激素变化的研究显示文摘用人促黄体生成素/绒毛膜促性腺激素诊断药盒及雌激素诊断药盒,定期测定4只雌性川金丝猴尿中黄体生成素和绒毛膜促性腺激素的活性及其与雌激素含量的关系。实验证明,两种人用诊断药盒可以测出金丝猴尿中的促黄体生成素(LH)/绒毛膜促性腺激素(CG)及雌激素(E)的变化情况。基本上反映了金丝猴的卵泡形成、排卵和黄体生成的时间以及妊娠的情况。LH/CG及E,每月有一个大的峰值,其后1-4天内有月经或尿潜血出现。妊娠初期LH/CG急剧上升,持续一个月达到最高峰后即急剧下降。E在LH/CG下降后开始升高,持续3-4个月达到最高峰,高峰下降后半个月左右分娩,分娩后重新升高,但低于原水平。金丝猴的繁殖行为,主要表现为邀配和交配,9-12月频率最高。根据LH/CG曲线的变化可以推断受精的大约日期。 | 戚汉君 梁冰 鲍文永 贾玉春 浜夏樹 NANCY M.CZEKALA NANCY C. HARVEY | 1995 | 兽类学报1995，15，2： | 17 |
| 9 | Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells显示文摘外长的 dopaminergic 神经原(DA 神经原) 的移植是为治疗 Parkinson 的疾病(PD ) 的一条有希望的途径。然而,主要跌倒块是施主 DA 神经原的可靠来源的缺乏。这里,我们证明五 transcriptional 因素 Mash1, Ngn2, Sox2, Nurr1,和 Pitx3 的联合直接并且有效地装改编人成纤维细胞进 DA 像神经原的房间。为为 DA 神经原的各种各样的标记积极的染色的 reprogrammed 房间。他们也显示出典型 DA 举起和生产性质。而且,他们展出了 DA 神经原特定的 electrophysiological 侧面。最后,他们在一个老鼠 PD 模型提供了征兆的地势。因此,我们的直接 reprogrammed DA 像神经原的房间是为 PD 的房间代替治疗的有希望的来源。 | Xinjian Liu Fang Li Elizabeth A Stubblefield Barbara Blanchard Toni L Richards Gaynor A Larson Yujun He Qian Huang Aik-Choon Tan Dabing Zhang Timothy A Benke John R Sladek Nancy R Zahniser Chuan-Yuan Li | 2012 | Cell Research2012，22，2： | 14 |
| 10 | Bilirubin in coronary artery disease:Cytotoxic or protective?显示文摘Bilirubin has traditionally been considered a cytotoxic waste product.However,recent studies have shown bilirubin to have anti-oxidant,anti-inflammatory,vasodilatory,anti-apoptotic and anti-proliferative functions.These properties potentially confer bilirubin a new role of protection especially in coronary artery disease(CAD),which is a low grade inflammatory process exacerbated by oxidative stress.In fact,recent literature reports an inverse relationship between serum concentration of bilirubin and the presence of CAD.In this article,we review the current literature exploring the association between levels of bilirubin and risk of CAD.We conclude that current evidence is inconclusive regarding the protective effect of bilirubin on CAD.A causal relationship between low serum bilirubin level and increased risk of CAD is not currently established. | Nancy Gupta Tavankit Singh Rahul Chaudhary Sushil K Garg Gurprataap Singh Sandhu Varun Mittal Rahul Gupta Roxana Bodin Sachin Sule | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 14 |
| 11 | 2-Year GLOBE Trial Results: Telbivudine Is Superior to Lamivudine in Patients With Chronic Hepatitis B显示文摘 | Yun–Fan Liaw Edward Gane Nancy Leung Stefan Zeuzem Yuming Wang Ching Lung Lai E. Jenny Heathcote Michael Manns Natalie Bzowej Junqi Niu Steven–Huy Han Seong Gyu Hwang Yilmaz Cakaloglu Myron J. Tong George Papatheodoridis Yagang Chen Nathaniel A. Brown Efs | 2009 | Gastroenterology2009，，2： | 13 |
| 12 | 鼻咽癌调强放射治疗进展显示文摘调强放射治疗技术日趋成熟,鼻咽癌是最适于调强放射治疗的肿瘤之一。Ⅱ期临床研究结果显示,IMRT技术优于传统放射技术,IMRT技术提高了鼻咽癌的局部区域性控制率和总生存率,并改善了生存质量。准确勾画靶区和正常组织是保证鼻咽癌IMRT疗效的前提。本文将讨论鼻咽癌的靶区勾画、给量方式、临床治疗结果及治疗相关毒副反应。 | 孔琳 Nancy Y.Lee | 2008 | 中国癌症杂志2008，18，9： | 12 |
| 13 | Hepatoprotective effect of silymarin显示文摘The use of medicinal plants in treating illnesses has been reported since ancestral times.In the case of hepatic diseases,several species such as Silybum marianum,Phyllanthus niruri,and Panus giganteus(Berk.)have been shown to ameliorate hepatic lesions.Silymarin is a natural compound derived from the species Silybum marianum,which is commonly known as Milk thistle.This plant contains at least seven flavoligands and the flavonoid taxifolin.The hepatoprotective and antioxidant activity of silymarin is caused by its ability to inhibit the free radicals that are produced from the metabolism of toxic substances such as ethanol,acetaminophen,and carbon tetrachloride.The generation of free radicals is known to damage cellular membranes and cause lipoperoxidation.Silymarin enhances hepatic glutathione and may contribute to the antioxidant defense of the liver.It has also been shown that silymarin increases protein synthesis in hepatocytes by stimulating RNA polymerase I activity.A previous study on humans reported that silymarin treatment caused a slight increase in the survival of patients with cirrhotic alcoholism compared with untreated controls. | Nancy Vargas-Mendoza Eduardo Madrigal-Santillán ngel Morales-González Jaime Esquivel-Soto Cesar Esquivel-Chirino Manuel García-Luna y González-Rubio Juan A Gayosso-de-Lucio José A Morales-González | 2014 | World Journal of Hepatology2014，6，3： | 12 |
| 14 | Bedside ultrasound in the diagnosis of nonalcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)is the most common liver disease in the United States.While the American Association for the Study of Liver Diseases guidelines define NAFLD as hepatic steatosis detected either on histology or imaging without a secondary cause of abnormal hepatic fat accumulation,no imaging modality is recommended as standard of care for screening or diagnosis.Bedside ultrasound has been evaluated as a non-invasive method of diagnosing NAFLD with the presence of characteristic sonographic findings.Prior studies suggest characteristic sonographic findings for NAFLD include bright hepatic echoes,increased hepatorenal echogenicity,vascular blurring of portal or hepatic vein and subcutaneous tissue thickness.These sonographic characteristics have not been shown to aid bedside clinicians easily identify potential cases of NAFLD.While sonographic findings such as attenuation of image,diffuse echogenicity,uniform heterogeneous liver,thick subcutaneous depth,and enlarged liver filling of the entire field could be identifiedby clinicians from bedside ultrasound.The accessibility,ease of use,and low-side effect profile of ultrasound make bedside ultrasound an appealing imaging modality in the detection of hepatic steatosis.When used with appropriate clinical risk factors and steatosis involves greater than 33%of the liver,ultrasound can reliably diagnose NAFLD.Despite the ability of ultrasound in detecting moderate hepatic steatosis,it cannot replace liver biopsy in staging the degree of fibrosis.The purpose of this review is to examine the diagnostic accuracy,utility,and limitations of ultrasound in the diagnosis of NAFLD and its potential use by clinicians in routine practices. | Nancy Khov Amol Sharma Thomas R Riley | 2014 | World Journal of Gastroenterology2014，20，22： | 11 |
| 15 | 远程护理教育的实施与评估显示文摘对在国内首次服务于护理教育的远程教育网络作全面考察并评估 ,用自行设计的调查表 ,对与远程教学课程传输有关的各类人员 (包括管理者、授课教师、技术人员、学历教育和继续教育学员 )进行询问调查。结果 :学历教育学员对远程教育大部分指标的评价均达到中等或满意以上 ,对教师的评定和各门课程的满意度均达到满意以上 ,但远程组满意程度低于医科大学组 ;86 .0 %以上的继续教育学员认为 :远程教育增加了继续教育的机会 ,远程教学内容新、容易理解 ,对护理知识的积累和护理技能的提高有帮助。 93.4%教师认为远程教学与课堂教学质量无差别。 89.9%的被调查者对远程教育表示支持。而在师生互动交流、声音图像传输、板书效果等方面遇到一些挑战 ,有待进一步改进。结论 :远程护理教育在国内的首次实施效果颇佳 ,提示应加强各部门之间的协调与合作 ,尽快提高各类人员运用远程设备的能力 ,使远程护理教育网络在护理人员的学历和继续教育中发挥更大的作用。 | 邹道慧 Nancy Edwards Betty Cragg Jean Dunning 罗茂红 宋丽欣 | 2002 | 护理研究2002，16，5： | 11 |
| 16 | Indoleamine 2,3-dioxygenase (IDO) is essential for dendritic cell activation and chemotactic responsiveness to chemokines显示文摘Indoleamine 2, 3-dioxygenase (IDO) is a rate-limiting enzyme for the tryptophan catabolism. In human and murine cells, IDO inhibits antigen-specific T cell proliferation in vitro and suppresses T cell responses to fetal alloantigens during murine pregnancy. In mice, IDO expression is an inducible feature of specific subsets of dendritic cells (DCs), and is important for T cell regulatory properties. However, the effect of IDO and tryptophan deprivation on DC func- tions remains unknown. We report here that when tryptophan utilization was prevented by a pharmacological inhibitor of IDO, 1-methyl tryptophan (1MT), DC activation induced by pathogenic stimulus lipopolysaccharide (LPS) or inflam- matory cytokine TNF-α was inhibited both phenotypically and functionally. Such an effect was less remarkable when DC was stimulated by a physiological stimulus, CD40 ligand. Tryptophan deprivation during DC activation also regu- lated the expression of CCR5 and CXCR4, as well as DC responsiveness to chemokines. These results suggest that tryptophan usage in the microenvironment is essential for DC maturation, and may also play a role in the regulation of DC migratory behaviors. | Shih Ling HWANG Nancy Pei-Yee CHUNG Jacqueline Kwai-Yi CHAN Chen-Lung Steve LIN | 2005 | Cell Research2005，15，3： | 11 |
| 17 | Different patterns of intestinal response to injury after arterial,venous or arteriovenous occlusion in rats显示文摘AIM:To investigate the differences in injury patterns caused by arterial, venous or arteriovenous mesenteric occlusion.METHODS: Male Wistar rats were separated equally into four groups. Occlusion was performed by clamping the superior mesenteric artery (A), the mesenteric vein (V) or both (AV) for 30 min, followed by 60 min of reperfusion. A control group received sham surgery only. Intestinal sections were examined for histological damage and serum tumor necrosis factor-α (TNF-α), endothelin-1 (ET-1), P-selectin, antithrombin (AT) and soluble intracellular adhesion molecule-1(ICAM-1) concentrations were measured. RESULTS: All groups showed signif icant mucosal injury compared to controls. Furthermore, mucosal injury was significantly more severe in the V and AV groupscompared to the A group (3.6±0.55, 3.4±0.55 and 2±0.71, respectively, P=0.01). ICAM-1 was similarly elevated in all groups, with no significant differences between the groups. P-selectin levels were significantly elevated in the V and AV groups but not the A group (1.4±0.5 ng/mL, 2.52±0.9 ng/mL and 0.02±0.01 ng/mL, respectively, P=0.01) and ET-1 was significantly elevated in the A and V groups but not the AV group (0.32±0.04 pg/mL, 0.36±0.05 pg/mL and 0.29±0.03 pg/mL, respectively, P=0.01) compared to sham controls. AT CONCLUSION:Different patterns of response to ischemia/reperfusion are associated with venous, arterial or arteriovenous occlusion. Venous and arteriovenous occlusion was associated with the most severe alterations. | Francisco Javier Guzmán-de la Garza Carlos Rodrigo Cámara-Lemarroy Gabriela Alarcón-Galván Paula Cordero-Pérez Linda Elsa Muoz-Espinosa Nancy Esthela Fernández-Garza | 2009 | World Journal of Gastroenterology2009，15，31： | 10 |
| 18 | Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2008 update显示文摘 | Yun-Fan Liaw Nancy Leung Jia-Horng Kao Teerha Piratvisuth Edward Gane Kwang-Hyub Han Richard Guan George K. K. Lau Stephen Locarnini | 2008 | Hepatology International2008，，3： | 10 |
| 19 | Multi-isotopic system geochronology of low temperature eclogite from Huangzhen,Southern Dabie Terrain显示文摘Zircon U-Pb thermal ionization mass-spectrometer (TIMS) and secondary ion mass-spectrometer (SIMS) dating, mica and amphibole 40Ar-39Ar dating and mineral Sm-Nd isotopic compositions of Huangzhen low temperature eclogite and country granitic gneiss are carried out. The zircon U-Pb weighted average SIMS age is (231.6±9.7) Ma for one eclogite. The mica Ar-39Ar isochron age is (232.6±2.1) Ma and the lowest plateau age is (221.7±2.4) 40 Ma from same sample. U-Pb TIMS concordant ages from other eclogite zircons are from (221.3 ±1.4) Ma to (222.5±2.3) Ma. U-Pb SIMS low intercept age from country granitic gneiss is (221 ±35) Ma. The retrograde amphibole Ar-39Ar isochron age is (205.9±1.0) Ma. Except for mica, 40 which may contain excess Ar, all the ages represent peak and retrograde metamorphism of low 40 temperature eclogites. It is indicated that the Huangzhen low temperature eclogites differ from Xiongdian low temperature eclogites of north of the Northern Dabie Terrain in metamorphic ages. Huangzhen low temperature eclogites share one coherent HP-UHP terrain with high temperature eclogites from Southern Dabie Terrain and they may have differences in subduction depth and cooling rates during exhumation. | CHEN Daogong1, E. Deloule2, CHENG Hao1, XIA Qunke1 & WU Yuanbao1 1. School of Earth and Space Sciences, University of Science and Technology of China, Hefei 230026, China 2. CRPG-CNRS Nancy, 54501, France | 2004 | Science China Earth Sciences2004，47，10： | 9 |
| 20 | 艾滋病相关卡波西肉瘤104例临床表现、治疗及疗效分析显示文摘目的:提高肿瘤科医师对艾滋病相关卡波西肉瘤的诊断及处理能力。方法:收集作者援助博茨瓦纳期间所诊治的艾滋病相关卡波西肉瘤患者共104例,对其临床表现、治疗方法及疗效进行分析总结。结果:临床表现以皮损为主(90.4%)。以阿霉素、博莱霉素、长春碱类、依托泊甙等单药或者联合方案的临床获益率为87.5%。其中Good risk组为90.9%,Poor risk组为68.7%,P<0.05。肺部未受累组为94.0%,肺部受累组为60.0%,P<0.05。CD4细胞数:临床获益组治疗前(210.5±135.8)/μl,治疗后(290.7±140.6)/μl,P<0.05;疾病进展组治疗前(180.2±141.5)/μl,治疗后(171.5±88.7)/μl,P>0.05。结论:皮损是最为常见的临床症状,以阿霉素等传统药物为主的化疗方案仍是经济有效的治疗方案。ACTG分期及肺部受累情况是影响疗效的重要因素。CD4可作为疗效观察指标。 | 朱晋峰 Kumar Saurabha Nancy Kablay Duduetsang Chebani | 2014 | 现代肿瘤医学2014，22，9： | 9 |
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