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| 1 | Histone modifications and alcohol-induced liver disease:Are altered nutrients the missing link?显示文摘Alcoholism is a major health problem in the United States and worldwide,and alcohol remains the single most significant cause of liver-related diseases and deaths.Alcohol is known to influence nutritional status at many levels including nutrient intake,absorption,utilization,and excretion,and can lead to many nutritional disturbances and deficiencies.Nutrients can dramatically affect gene expression and alcohol-induced nutrient imbalance may be a major contributor to pathogenic gene expression in alcohol-induced liver disease(ALD).There is growing interest regarding epigenetic changes,including histone modifications that regulate gene expression during disease pathogenesis.Notably,modifications of core histones in the nucleosome regulate chromatin structure and DNA methylation,and control gene transcription.This review highlights the role of nutrient disturbances brought about during alcohol metabolism and their impact on epigenetic histone modifications that may contribute to ALD.The review is focused on four critical metabolites,namely,acetate,S-adenosylmethionine,nicotinamide adenine dinucleotide and zinc that are particularly relevant to alcohol metabolism and ALD. | Akshata Moghe Swati Joshi-Barve Smita Ghare Leila Gobejishvili Irina Kirpich Craig J McClain Shirish Barve | 2011 | World Journal of Gastroenterology2011，17，20： | 6 |
| 2 | Inhibition of methionine adenosyltransferase II induces FasL expression, Fas-DISC formation and caspase-8-dependent apoptotic death in T leukemic cells显示文摘蛋氨酸 adenosyltransferase II (地席 II ) 是在细胞的新陈代谢的关键酶并且从 L 蛋氨酸和 ATP 催化 S-adenosylmethionine (一样) 的形成。正常休息 T 淋巴细胞举办最小的地席 II 活动,而白血病的房间显著地显示出的激活的增殖的 T 淋巴细胞和转变 T 提高了地席 II 活动。这个工作被执行在白血病的 T 房间的幸存检验地席 II 活动和一样的生合成的角色。在一样的层次的地席 II 和结果的减少的抑制提高了 FasL mRNA 和蛋白质的表示,并且导致了圆盘(导致发信号的建筑群的死亡) 有 FADD (联系船边交货的死亡域) 和 procaspase-8 招募的形成,以及 caspase-8 激活的伴随物增加和在 c 扭动的减少铺平。开始船边交货的发信号由地席 II 抑制导致了被观察经由出价劈开连接到 mitochondrial 小径并且最终在这些房间导致增加的 caspase-3 激活和 DNA 破碎。而且,堵住地席 2A mRNA 表示,它编码地席 II 的催化子单元,用一条小介入的 RNA 途径提高了 FasL 表示和房间死亡,验证在 T 白血病的房间的幸存的地席 II 活动的必要性质。 | Tanvi S Jani Leila Gobejishvili Prachi T Hote Aditya S Barve Swati Joshi-Barve Giorgi Kharebava Jill Suttles Theresa Chen Craig J McClain Shirish Barve | 2009 | Cell Research2009，19，3： | 5 |
| 3 | Lactobacillus rhamnosus GG reduces hepatic TNFα production and inflammation in chronic alcohol-induced liver injury显示文摘 | Yuhua Wang Yanlong Liu Irina Kirpich Zhenhua Ma Cuiling Wang Min Zhang Jill Suttles Craig McClain Wenke Feng | 2013 | The Journal of Nutritional Biochemistry2013，，： | 4 |
| 4 | 农业生物技术的安全性评价显示文摘转基因作物自1995年开始引入种植,以满足日益增长的粮食和饲料需求。转基因作物用于人类食物和动物饲料需要进行全面的安全性评价,首先从DNA水平考虑,包括插入宿主基因组的是什么DNA,插入的位置和稳定性如何?其次,考虑DNA编码蛋白的安全性及其对作物的潜在效应,确保转入的新蛋白从毒性、致敏性和环境各方面的评价都是安全的,此外,用于食品或动物饲料加工的谷物需要评价其营养成分,必要时还要确定其非预期效应。为给转基因作物的安全性评价提供依据,需要对转基因作物与非转基因对照物进行成分等实质同性分析,质谱及基于抗体的新技术能够对包括内源性致敏原在内的作物成分进行更精确的分析。监管指南文件中提出了许多分析方法及其用途,有一些是全球公认的文件(如食品法典委员会提出的文件)。有些国家的监管机构推荐在某些情况下使用动物模型,但是在转基因作物的安全性评价中,动物模型的使用没有依据。试验方法的质量控制和标准化可以通过采用良好实验室规范来达成,是高质量数据的保证。监管机构对转基因作物的安全性测试方法的要求越来越多,根据目前的评价结果,已经登记的转基因作物与非转基因对照物同等安全。 | Scott McClain Wendelyn Jones 贺晓云 Gregory Ladics Andrew Bartholomaeus Alan Raybould Petra Lutter 徐海滨 王雪 | 2015 | 中华预防医学杂志2015，49，1： | 3 |
| 5 | Lactobacillus rhamnosusGG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injury显示文摘 | Yuhua Wang Yanlong Liu Anju Sidhu Zhenhua Ma Craig McClain Wenke Feng | 2012 | AJP: Gastrointestinal and Liver Physiology2012，，1： | 3 |
| 6 | Mechanisms and cell signaling in alcoholic liver disease显示文摘 | Juliane I. Beier Craig J. McClain | 2010 | Biological Chemistry2010，，11： | 3 |
| 7 | Probiotics restore bowel flora and improve liver enzymes in human alcohol-induced liver injury: a pilot study显示文摘 | Irina A. Kirpich Natalia V. Solovieva Svetlana N. Leikhter Natalia A. Shidakova Oxsana V. Lebedeva Pavel I. Sidorov Tatjana A. Bazhukova Andrej G. Soloviev Shirish S. Barve Craig J. McClain Matt Cave | 2008 | Alcohol2008，，8： | 2 |
| 8 | Probiotics restore bowel flora and improve liver enzymes in human alcohol-induced liver injury: a pilot study显示文摘 | Irina A. Kirpich Natalia V. Solovieva Svetlana N. Leikhter Natalia A. Shidakova Oxsana V. Lebedeva Pavel I. Sidorov Tatjana A. Bazhukova Andrej G. Soloviev Shirish S. Barve Craig J. McClain Matt Cave | 2008 | Alcohol2008，，8： | 2 |
| 9 | Adipocyte iron regulates adiponectin and insulin sensitivity显示文摘 | Gabrielsen J Scott Gao Yan Simcox Judith A Huang Jingyu Thorup David Jones Deborah Cooksey Robert C Gabrielsen David Adams Ted D Hunt Steven C Hopkins Paul N Cefalu William T McClain Donald A | 2012 | EN2012，，10： | 2 |
| 10 | A Randomized, Double-Blinded, Placebo-Controlled Multicenter Trial of Etanercept in the Treatment of Alcoholic Hepatitis显示文摘 | Nicholas C. Boetticher Craig J. Peine Paul Kwo Gary A. Abrams Tushar Patel Bashar Aqel Lisa Boardman Gregory J. Gores William S. Harmsen Craig J. McClain Patrick S. Kamath Vijay H. Shah | 2008 | Gastroenterology2008，，6： | 2 |
| 11 | Physiology and pathophysiology of dendritic cells 显示文摘 | Mcclain KL Talpaz M | 1997 | Hum Pathol1997，28，5： | 1 |
| 12 | Diethylnitmsamine-induced hepatocarcinogenesis in rats:a theoretical study显示文摘 | Travis CC McClain TW Birkner PD | 1991 | Toxicol Appl Pharmacol1991，109，2： | 1 |
| 13 | Design of interference fits via finite el- ement method显示文摘 | Zhang Y McClain B Fang X D | 2000 | International Journal of Mechanical Sciences2000，42，： | 1 |
| 14 | Effects of growth and insulin treatment on the levels of insulin receptors and their mRNA in HepG2 cells显示文摘 | Hatada EN Mcclain DA Potter E | 1989 | J Biol Chem1989，264，12： | 1 |
| 15 | Highenergy diets,fatty acids and endothelial cell function:implications for atherosclerosis显示文摘 | Hennig B Toborek M McClain CJ | 2001 | J Am Coll Nutr2001，20，2： | 1 |
| 16 | Practice guidelines for medical nutrition therapy provided by dietitians for persons with non-insulin dependent diabetes mellitus 显示文摘 | MONK A BARRY B MCCLAIN K | 1995 | J Am Diet Assoc1995，95，： | 1 |
| 17 | Oxidative stress - induced apoptosis prevented by Trolox 显示文摘 | Forrest VJ Kang YH McClain DE | 1994 | Free Redical Biology and Medicing1994，16，5： | 1 |
| 18 | Maternal insufflation during the second trimester equivalent produces hypercapnia,acidosis,and prolonged hypoxia in fetal sheep显示文摘 | Uemura K McClaine RJ de la Fuente SG | 2004 | Anesthesiology2004，101，6： | 1 |
| 19 | Comparative Performance of AVHRR based Multi-channel Sea Surface Temperature显示文摘 | Mcclain E P Pichel W G Whon C C | 1985 | Journal of Geophysical Research1985，20，11： | 1 |
| 20 | Advances in alcoholic liver disease显示文摘 | Beier J I Arteel G E McClain C J | 2011 | Curt Gastroenterol Rep2011，13，1： | 1 |
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