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| 1 | 在在一个第三级的肝中心的 hepatocellular 癌的对比超声: 第一印度经验显示文摘 AIM: To assess the role of contrast enhanced ultrasonography in evaluation of hepatocellular carcinoma (HCC) at the first Indian tertiary liver center. METHODS: Retrospective analysis of contrast enhanced ultrasound (CEUS) examinations over 24 mo for diagnosis, surveillance, characterization and follow up of 50 patients in the context of HCC was performed. The source and indication of referrals, change in referral rate, accuracy and usefulness of CEUS in a tertiary liver center equipped with a 64 slice dual energy computer tomography (CT) and 3 tesla magnetic resonance imaging (MRI) were studied. Sonovue (BR1, Bracco, Italy, a second generation contrast agent) was used for contrast US studies. Contrast enhanced CT/MRI or both were performed in all patients. The findings were taken as a baseline reference and correlation was done with respect to contrast US. Contrast enhanced MRI was performed using hepatocyte specific gadobenate dimeglumine (Gd-BOPTA). Iomeron (400 mg; w/v) was used for dynamic CT examinations. RESULTS: About 20 (40%) of the examinations were referred from clinicians for characterization of a mass from previous imaging. About 15 (30%) were performed for surveillance in chronic liver disease; 5 (10%) examinations were performed for monitoring lesions after radiofrequency ablation (RFA); 3 (6%) were post trans-arterial chemoembolization (TACE) assessments and 3 (6%) were patients with h/o iodinated contrast allergy. About 2(4%) were performed on hemodynamically unstable patients in the intensive care with raised alpha fetoprotein and 2(4%) patients were claustrophobic. The number of patients referred from clinicians steadily increased from 12 in the first 12 mo of the study to 38 in the last 12 mo. CEUS was able to diagnose 88% of positive cases of HCC as per reference standards. In the surveillance group, specificity was 53.3% vs 100% by CT/MRI. Post RFA and TACE specificity of lesion characterization by CEUS was 100% in single/large mass assessment, similar to CT/MRI. For non HCC lesions such as regenerative and dysplastic nodules, the specificity was 50% vs 90% by CT/MRI. The positive role of CEUS in imaging spectrum of HCC included a provisional urgent diagnosis of an incidentally detected mass. It further led to a decrease in time for further management. A confident diagnosis on CEUS was possible in cases of characterization of an indeterminate mass, in situations where the patient was unfit for CT/MRI, was allergic to iodinated contrast or had claustrophobia, etc.CEUS was also cost effective, radiation free and an easy modality for monitoring post RFA or TACE lesions. CONCLUSION: CEUS is a valuable augmentation to the practice of ultrasonography, and an irreplaceable modality for confounding cases and interpretation of indeterminate lesions in imaging of HCC. | Shalini Thapar Laroia Simranjeet Singh Bawa Deepak Jain Amar Mukund Shiv Sarin | 2013 | World Journal of Radiology2013，5，6： | 5 |
| 2 | Pharmacogenetic studies update in type 2 diabetes mellitus显示文摘Type 2 diabetes mellitus(T2DM) is a silent progressive polygenic metabolic disorder resulting from ineffective insulin cascading in the body. World-wide, about 415 million people are suffering from T2DM with a projected rise to 642 million in 2040. T2DM is treated with several classes of oral antidiabetic drugs(OADs) viz. biguanides, sulfonylureas, thiazolidinediones, meglitinides, etc. Treatment strategies for T2DM are to minimize long-term micro and macro vascular complications by achieving an optimized glycemic control. Genetic variations in the human genome not only disclose the risk of T2DM development but also predict the personalized response to drug therapy. Inter-individual variability in response to OADs is due to polymorphisms in genes encoding drug receptors, transporters, and metabolizing enzymes for example, genetic variants in solute carrier transporters(SLC22A1, SLC22A2, SLC22A3, SLC47A1 and SLC47A2) are actively involved in glycemic/HbA1c management of metformin. In addition, CYP gene encoding Cytochrome P450 enzymes also play a crucial role with respect to metabolism of drugs. Pharmacogenetic studies provide insights on the relationship between individual genetic variants and variable therapeutic outcomes of various OADs. Clinical utility of pharmacogenetic study is to predict the therapeutic dose of various OADs on individual basis. Pharmacogenetics therefore, is a step towards personalized medicine which will greatly improve the efficacy of diabetes treatment. | Shalini Singh Kauser Usman Monisha Banerjee | 2016 | World Journal of Diabetes2016，7，15： | 5 |
| 3 | Effect of operating parameters on coal gasification显示文摘 | Akanksha Mishra Shalini Gautam Tripurari Sharma | 2018 | International Journal of Coal Science & Technology2018，5，2： | 5 |
| 4 | 间充质的干细胞的隔离和描述源于人的胎盘组织显示文摘 AIM: To explore the feasibility of placenta tissue as a reliable and efficient source for generating mesenchymal stem cells (MSC). METHODS: MSC were generated from human placenta tissue by enzymatic digestion and mechanical dissociation. The placenta MSC (PLC-MSC) were characterized for expression of cell surface markers, embryonic stem cell (ECS) gene expression and their differentiation ability into adipocytes and osteocytes. The immunosuppressive properties of PLC-MSC on resting and phytohemagglutinin (PHA) stimulated allogenic T cells were assessed by means of cell proliferation via incorporation of tritium thymidine (3H-TdR). RESULTS: The generated PLC-MSC appeared as spindle-shaped cells, expressed common MSC surface markers and ESC transcriptional factors. They also differen-tiated into adipogenic and osteogenic lineages when induced. However, continuous cultivation up to passage 15 caused changes in morphological appearance and cellular senescence, although the stem cell nature of their protein expression was unchanged. In terms of their immunosuppressive properties, PLC-MSC were unable to stimulate resting T cell proliferation; they inhibited the PHA stimulated T cells in a dose dependent manner through cell to cell contact. In our study, MSC generated from human placenta exhibited similar mesenchymal cell surface markers; MSC-like gene expression pattern and MSC-like differentiation potential were comparable to other sources of MSC. CONCLUSION: We suggest that placenta tissues can serve as an alternative source of MSC for future experimental and clinical studies. | Shalini Vellasamy Pratheep Sandrasaigaran Sharmili Vidyadaran Elizabeth George Rajesh Ramasamy | 2012 | World Journal of Stem Cells2012，4，6： | 5 |
| 5 | The catalytic activity of transition metal oxide nanoparticles on thermal decomposition of ammonium perchlorate显示文摘The catalytic proficiency of three MONs for AP thermal decomposition was studied in this work.A chemical co-precipitation method was used for synthesis of MONs(CuZnO,CoZnO,and NiZnO)and their characterization carried out by utilizing XRD,FTIR,and SEM.The TGA/DSC technique was employed for the investigation of the catalytic proficiency of MONs on the AP.The DSC data were used for measuring activation energy of catalyzed AP by using Ozawa,Kissinger,and Starink method.The MONs were much sensitive for AP decomposition,and the performance of AP decomposition was further improved.Among all the MONs,the CuZnO exhibits higher catalytic action than others and decomposition temperature of AP is descending around 117℃ by CuZnO.The reduction in the activation energy was noticed after the incorporation of MONs in AP. | Jalpa A. Vara Pragnesh N. Dave Shalini Chaturvedi | 2019 | Defence Technology(防务技术)2019，15，4： | 4 |
| 6 | Flat Absorber Phosphorous Black Nickel Coatings for Space Applications显示文摘A new process of flat absorber black nickel alloy coating was developed on stainless steel by electrodeposition from a bath containing nickel,zinc and ammonium sulphates;thiocyanate and sodium hypophosphite for space applications.Coating process was optimized by investigating the effects of plating parameters,viz concentration of bath constituents,current density,temperature,pH and plating time on the optical properties of the black deposits.Energy dispersive X-ray spectroscopy showed the inclusion of about 6% phosphorous in the coating.The scanning electron microscopy studies revealed the amorphous nature of the coating.The corrosion resistance of the coatings was evaluated by the electrochemical impedance spectroscopy (EIS) and linear polarization (LP) techniques.The results revealed that,phosphorous addition confers better corrosion resistance in comparison to conventional black nickel coatings.The black nickel coating obtained from hypophosphite bath provides high solar absorptance (α s) and infrared emittance (ε IR) of the order of 0.93.Environmental stability to space applications was established by the humidity and thermal cycling tests. | V.Maria Shalini P.Arockiasamy R.Uma Rani A.K.Sharma | 2012 | Journal of Materials Science & Technology2012，28，2： | 3 |
| 7 | Effect of Punica granatum peel extract on learning and memory in rats显示文摘Objective:To evaluate potential memory enhancing effect of Punica granatum peel extract on rats.Methods:Healthy adult male albino rats of Wistar strain were used.Each group of 6 rats were administered either distilled water or 50 mg/kg of extract or 100 mg/kg of extract for 15 days and subjected to passive avoidance test or T-maze test.In the next phase rats were administered distilled water or 100 mg/kg of extract for 15 days and the rats were given injection diazepam before subjecting them to the tests.Results:The overall performance was better in test groups compared to control groups.Among the test groups,100 mg/kg rats performed better than 50 mg/kg.The effect on spatial learning parameters like mean number of alternations and mean percentage bias was more marked compared to retention testing parameters like latency. 100 mg/kg Punica extract treated group also improved performance of diazepam treated rats. Conclusions:There is a definite trend of memory improvement by Punica granatum peel with effects being more marked on spatial learning tendency and long term memory than on retention capacity. | Shalini Adiga Prabhav Trivedi Ravichandra V Debashree Deb Forum Mehta | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，9： | 3 |
| 8 | Anthropogenic emissions of non-methane volatile organic compounds in China显示文摘 | Zbigniew Klimont David G. Streets Shalini Gupta Janusz Cofala Fu Lixin Yoichi Ichikawa | 2002 | Atmospheric Environment2002，，8： | 2 |
| 9 | Effect of cadmium on lipid peroxidation, superoxide anion generation and activities of antioxidant enzymes in growing rice seedlings显示文摘 | Kavita Shah Ritambhara G Kumar Shalini Verma R.S Dubey | 2001 | Plant Science2001，，6： | 2 |
| 10 | A systematic review of the epidemiology of unrecorded alcohol consumption and the chemical composition of unrecorded alcohol显示文摘 | Jürgen Rehm Shalini Kailasapillai Elisabeth Larsen Maximilien X. Rehm Andriy V. Samokhvalov Kevin D. Shield Michael Roerecke Dirk W. Lachenmeier | 2014 | Addiction2014，，6： | 2 |
| 11 | Black carbon emissions in China显示文摘 | David G. Streets Shalini Gupta Stephanie T. Waldhoff Michael Q. Wang Tami C. Bond Bo Yiyun | 2001 | Atmospheric Environment2001，，25： | 2 |
| 12 | Increased fecal viral content associated with obesity in mice显示文摘AIM: To investigate the presence of total gut viral content in obese mice, and establish correlation with obesity associated metabolic measures and gut microbiome.METHODS: Fresh fecal samples were collected from normal and obese(Leptin deficient Lep^(ob/ob)) mice. Total viral DNA and RNA was isolated and quantified for establishing the correlation with metabolic measures and composition of gut bacterial communities.RESULTS: In this report, we found that obese mice feces have higher viral contents in terms of total viral DNA and RNA(P < 0.001). Interestingly, these increased viral DNA and RNA content were tightly correlated with metabolic measures, i.e., body weight, fat mass and fasting blood glucose. Total viral content were positively correlated with firmicutes(R^2 > 0.6), whilst negatively correlated with bacteroidetes and bifidobacteria. CONCLUSION: This study suggests the strong correlation of increased viral population into the gut of obese mice and opens new avenues to explore the role of gut virome in pathophysiology of obesity. | Hariom Yadav Shalini Jain Ravinder Nagpal Francesco Marotta | 2016 | World Journal of Diabetes2016，7，15： | 2 |
| 13 | Black carbon emissions in China显示文摘 | David G. Streets Shalini Gupta Stephanie T. Waldhoff Michael Q. Wang Tami C. Bond Bo Yiyun | 2001 | Atmospheric Environment2001，，25： | 2 |
| 14 | Layered inorganic nanocomposites: A promising carrier for 5-fluorouracil (5-FU)显示文摘 | Bhavesh D. Kevadiya Tapan A. Patel Devendrasinh D. Jhala Rahul P. Thumbar Harshad Brahmbhatt Maharshi P. Pandya Shalini Rajkumar Prasant K. Jena Ghanshyam V. Joshi Pankaj K. Gadhia C.B. Tripathi Hari C. Bajaj | 2012 | European Journal of Pharmaceutics and Biopharmaceutics2012，，： | 2 |
| 15 | Structural and electrical characterization of erbium oxide films grown on Si(100) by low-pressure metalorganie chemical vapor deposition 显示文摘 | SINGH M P THAKUR C S SHALINI K | 2003 | Appl Phys Lett2003，83，： | 1 |
| 16 | Induction of Systemic Resistance in Plants Against Viruses by a Basic Protein from Clerodendrum aculeatum Leaves显示文摘 | VERMA H N SHALINI SRIVASTAVA VARSHA | 1996 | Phytopathology1996，，86： | 1 |
| 17 | Therapeutic potential of pterostilbene against pancreatic beta-cell apoptosis mediated through Nrf2显示文摘 | Bhakkiyalakshmi E Shalini D Sekar TV | 2014 | Br J Pharmacol2014，171，7： | 1 |
| 18 | Darcy free convection induced by a vertical wavy surface in a thermally stratified porous medium显示文摘 | Rathish Kumar B V Shalini M | 2004 | International Journal of Heat Mass Transfer2004，47，： | 1 |
| 19 | Analysis of groundwater quality using fuzzy synthetic evaluation 显示文摘 | Sudhir Dahiya Bupinder Singh Shalini Gaur | 2007 | Journal of Hazardous Materials2007，147，3： | 1 |
| 20 | Applications of nano catalyst in new era显示文摘 | Shalini C Pragnesh N D Shah N K | 2011 | Journal of Saudi Chemical Society2011，1，15： | 1 |
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