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| 1 | 智能物联网AIoT研究综述显示文摘智能物联网(artificial intelligence of things,AIoT)是人工智能与物联网技术相融合的产物,这一新兴概念在智慧城市、智能家居、智慧制造、无人驾驶等领域得到了广泛应用。然而AIoT相关技术研究仍处于初级阶段,存在大量问题和挑战。首先简述了AIoT技术产生的背景,明晰其定义和应用场景。以此为契机,构建了一个新型的面向智能信息处理的云边端融合AIoT架构。在给出AIoT研究体系的基础上,详细探讨并比较了其各组成技术模块,包括AI融合IoT数据采集、复杂事件处理及协同、云边端融合研究、AI融合IoT安全及隐私保护和AI融合应用服务等方面的研究现状和解决方案。最后,论述了AIoT未来的研究方向和发展趋势。 | 吴吉义 李文娟 曹健 钱诗友 张启飞 BUYYA Rajkumar | 2021 | 电信科学2021，37，8： | 51 |
| 2 | Cloud computing and emerging IT platforms: Vision, hype, and reality for delivering computing as the 5th utility显示文摘 | Rajkumar Buyya Chee Shin Yeo Srikumar Venugopal James Broberg Ivona Brandic | 2008 | Future Generation Computer Systems2008，，6： | 5 |
| 3 | Effect of α-Ketoglutarate on Cyanide-induced Biochemical Alterations in Rat Brain and Liver显示文摘Objective To investigate the biochemical changes in rat brain and liver following acute exposure to a lethal dose of cyanide, and its response to treatment of α-ketoglutarate (α-KG) in the absence or presence of sodium thiosulfate (STS). Methods Female rats were administered 2.0 LD50 potassium cyanide (KCN; oral) in the absence or presence of pre-treatment (?10 min), simultaneous treatment (0 min) or post-treatment (+2-3 min) of α-KG (2.0 g/kg, oral) and/or STS (1.0 g/kg, intraperitoneal, ?15 min, 0 min or + 2-3 min). At the time of onset of signs and symptoms of KCN toxicity (2-4 min) and at the time of death (5-15 min), various parameters particularly akin to oxidative stress viz. cytochrome oxidase (CYTOX), superoxide dismutase (SOD), glutathione peroxidase (GPx), reduced glutathione (GSH) and oxidized glutathione (GSSG) in brain, and CYTOX, sorbitol dehydrogenase (SDH), alkaline phosphatase (ALP), GSH and GSSG in liver homogenate were measured. Results At both time intervals brain CYTOX, SOD, GPx, and GSH significantly reduced (percent inhibition compared to control) to 24%, 56%, 77%, and 65%, and 44%, 46%, 78%, and 57%, respectively. At the corresponding time points liver CYTOX and GSH reduced to 74% and 63%, and 44% and 68%, respectively. The levels of GSSG in the brain and liver, and hepatic ALP and SDH were unchanged. Pre-treatment and simultaneous treatment of α-KG alone or with STS conferred significant protection on above variables. Post-treatment was effective in restoring the changes in liver but failed to normalize the changes in the brain. Conclusions Oral treatment with α-KG alone or in combination with STS has protective effects on cyanide-induced biochemical alterations in rat brain and liver. | RAJKUMAR TULSAWANI R. BHATTACHARYA | 2006 | Biomedical and Environmental Sciences2006，19，1： | 4 |
| 4 | Impact of gout on in-hospital outcomes of acute coronary syndrome-related hospitalizations and revascularizations: Insights from the national inpatient sample显示文摘BACKGROUND Previous studies have established a role of gout in predicting risk and prognosis of cardiovascular diseases. However, large-scale data on the impact of gout on inpatient outcomes of acute coronary syndrome (ACS)-related hospitalizations and post-revascularization is inadequate. AIM To evaluate the impact of gout on in-hospital outcomes of ACS hospitalizations, subsequent healthcare burden and predictors of post-revascularization inpatient mortality. METHODS We used the national inpatient sample (2010-2014) to identify the ACS and goutrelated hospitalizations, relevant comorbidities, revascularization and postrevascularization outcomes using the ICD-9 CM codes. A multivariable analysis was performed to evaluate the predictors of post-revascularization in-hospital mortality. RESULTS We identified 3144744 ACS-related hospitalizations, of which 105198 (3.35%) also had gout. The ACS-gout cohort were more often older white males with a higher prevalence of comorbidities. Coronary artery bypass grafting was required more often in the ACS-gout cohort. Post-revascularization complications including cardiac (3.2% vs 2.9%), respiratory (3.5% vs 2.9%), and hemorrhage (3.1% vs 2.7%) were higher whereas all-cause mortality was lower (2.2% vs 3.0%) in the ACSgout cohort (P < 0.001). An older age (OR 15.63, CI: 5.51-44.39), non-elective admissions (OR 2.00, CI: 1.44-2.79), lower household income (OR 1.44, CI: 1.17- 1.78), and comorbid conditions predicted higher mortality in ACS-gout cohort undergoing revascularization (P < 0.001). Odds of post-revascularization inhospital mortality were lower in Hispanics (OR 0.45, CI: 0.31-0.67) and Asians (OR 0.65, CI: 0.45-0.94) as compared to white (P < 0.001). However, postoperative complications significantly raised mortality odds. Mean length of stay, transfer to other facilities, and hospital charges were higher in the ACS-gout cohort. CONCLUSION Although gout was not independently associated with an increased risk of postrevascularization in-hospital mortality in ACS, it did increase postrevascularization complications. | Rupak Desai Tarang Parekh Hemant Goyal Hee Kong Fong Dipen Zalavadia Nanush Damarlapally Rajkumar Doshi Sejal Savani Gautam Kumar Rajesh Sachdeva | 2019 | World Journal of Cardiology2019，11，5： | 4 |
| 5 | Identification of miR-802-5p and its involvement in type 2 diabetes mellitus显示文摘MicroRNAs(miRNA)are recently discovered endogenous,small noncoding RNAs(of 22 nucleotides)that play pivotal roles in gene regulation.They are involved in post-transcriptional control of gene expression.miRNAs are emerging as important regulators of cell proliferation,development,cancer formation,stress responses,cell death and physiological conditions.Increasing evidence has demonstrated the human miRNAs bind to their target mRNA sequences with perfect or near-perfect sequence complementarily.This provides a powerful strategy for discovering potential type 2 diabetes mellitus(T2DM)targets and gives the probability to exploit them for diagnostic and therapeutic causes.About 6%of the world population is affected by T2DM,and it is recognized as a global epidemic by the World Health Organization.At present there is no valid biomarker to control or manage T2DM.Therefore,the present study applied a mature sequence of miRNAs from publicly accessible databases to identify the miRNA from T2DM expressed sequence tags,and the results are detailed and discussed below. | Kaushik Vishnu Rajkumar Ganesh Lakshmanan Durairaj Sekar | 2020 | World Journal of Diabetes2020，11，12： | 4 |
| 6 | Studies on banana fruit quality and maturity stages using hyperspectral imaging显示文摘 | P. Rajkumar N. Wang G. EImasry G.S.V. Raghavan Y. Gariepy | 2011 | Journal of Food Engineering2011，，1： | 3 |
| 7 | Larvicidal and oviposition activity of Cassia obtusifolia Linn (Family: Leguminosae) leaf extract against malarial vector, Anopheles stephensi Liston (Diptera: Culicidae)显示文摘 | S. Rajkumar A. Jebanesan | 2009 | Parasitology Research2009，，2： | 3 |
| 8 | Seasonal variations of phytoplankton diversity in the Coleroon coastal waters,southeast coast of India显示文摘The results of an investigation carried out during June 2005 to May 2007 on physico-chemical parameters,species composition and community structure of phytoplankton including Chlorophyll a(Chl-a) at the Coleroon coastal waters(Southeast coast of India) are reported.Air and surface water temperatures(°C) varied from 25.1 to 30.1 and from 24.5 to 28.5 respectively.Salinity values varied from 6 to 28.5 and the pH ranged between 7.0 and 8.3.Variation in dissolved oxygen content was from 3.1 to 7.5 mg/dm-3 while the light extinction coefficient values(LEC) ranged between 3.1 and 10.1 cm.The ranges of inorganic nutrients(μmol/dm-3) viz.,nitrate,nitrite,phosphate and silicate were 10.1-23.4,1.2-8.9,0.2-3.1 and 55-125,respectively.The ranges of Chlorophyll a(μg/dm-3) values was 2.0-7.5.Presently,124 phytoplankton species representing different classes viz:Bacillariophyceae(77),Dinophyceae(19),Cyanophyceae(15),Chlorophyceae(10) and Chrysophyceae(3) were recorded.The phytoplankton cell abundance varied from 0.290 to 111.662 cells/cm-3,with peak diversity(3.38 bits/ind.) during summer season.The maximum abundance was found during summer season coinciding with the stable hydrographical conditions.The seasonal distribution and abundance of phytoplankton are discussed in relation to hydrographical parameters.Canonical Correspondence Analysis(CCA) was applied in this paper for discriminating environmental factors having effect on phytoplankton community at species level.Coleroon coastal water is subjected to long term fluctuations in physico-chemical parameters depending upon the seasonal tidal amplitude and freshwater influx resulting in a continuous exchange of organic,inorganic,plant and animal matters. | Thillai Rajasekar K Rajkumar M SUN Jun Ashok Prabu V Perumal P | 2010 | Acta Oceanologica Sinica2010，29，5： | 3 |
| 9 | Antioxidant and anti-neoplastic activities of Picrorhiza kurroa extracts显示文摘 | V. Rajkumar Gunjan Guha R. Ashok Kumar | 2010 | Food and Chemical Toxicology2010，，2： | 3 |
| 10 | Drugs as causative agents and therapeutic agents in inflammatory bowel disease显示文摘Ulcerative colitis and Crohn's disease are collectively known as inflammatory bowel diseases(IBD)which are chronic inflammatory disorders of gastrointestinal tract.The etiopathogenesis of IBD has been extensively studied but not fully revealed.Recent advances in physiology,molecular biology and pharmacology have provided some insight into the basic etiopathogenetic causes such as genetic,immunologic,etc.This review focuses on drugs involved in the cause of the disease and the investigational new drugs,current therapeutic strategies and their clinical benefits. | Phani Krishna Kondamudi Rajkumar Malayandi Chandramohan Eaga Deepika Aggarwal | 2013 | Acta Pharmaceutica Sinica B2013，3，5： | 2 |
| 11 | Post-appendectomy pelvic abscess with extended-spectrum beta-lactamase producing Escherichia coli : A case report and review of literature显示文摘BACKGROUND Appendicitis, the inflammation of the appendix, is the most common abdominal surgical emergency requiring expedient surgical intervention. Extendedspectrum beta-lactamases(ESBLs) are bacterial enzymes that catalyse the degradation of the betalactam ring of penicillins and cephalosporins(but without carbapenemase activity), leading to resistance of these bacteria to beta-lactam antibiotics. Recent increases in incidence of ESBL-producing bacteria have caused alarm worldwide. Proportion estimates of ESBLEnterobacteriaceae hover around 46% in China, 42% in East Africa, 12% in Germany, and 8% in the United States.CASE SUMMARY The impact of ESBL-producing bacteria on appendiceal abscesses and consequent pelvic abscesses are yet to be examined in depth. A literature review using the search words 'appendiceal abscesses' and 'ESBL Escherichia coli(E. coli)' revealed very few cases involving ESBL E. coli in any capacity in the context of appendiceal abscesses. This report describes the clinical aspects of a patient with appendicitis whodeveloped a postoperative pelvic abscess infected with ESBL-producing E. coli. In this report, we discuss the risk factors for contracting ESBL E. coli infection in appendicitis and post-appendectomy pelvis abscesses. We also discuss our management approach for postappendectomy ESBL E. coli pelvic abscesses, including drainage, pathogen identification, and pathogen characterisation. When ESBL E. coli is confirmed, carbapenem antibiotics should be promptly administered, as was done efficaciously with this patient. Our report is the first one in a developed country involving ESBL E. coli related surgical complications in association with a routine laparoscopic appendectomy.CONCLUSION Our report is the first involving ESBL E. coli and appendiceal abscesses, and that too consequent to laparoscopic appendectomy. | Andrew Tse Rajkumar Cheluvappa Selwyn Selvendran | 2018 | World Journal of Clinical Cases2018，6，16： | 2 |
| 12 | Effect of Pre-treatment of α-Ketoglutarate on Cyanide-induced Toxicity and Alterations in Various Physiological Variables in Rodents显示文摘Objective To investigate the effects of pre-treatment of α-ketoglutarate (α-KG) on cyanide-induced lethality and changes in various physiological parameters in rodents. Methods The LD50 of potassium cyanide (KCN) given orally (po), intraperitoneally (ip), subcutaneously (sc) or intravenously (iv) was determined in male mice, in the presence or absence α-KG given po, ip or iv. α-KG was administered 10, 20 or 40 min prior to KCN at 0.50, 1.0 or 2.0 g/kg by po or ip route, and at 0.10, 0.20 or 0.40 g/kg by iv route. Protection index (PI) was calculated as the ratio of LD50 of KCN in the presence of α-KG (protected animals) and LD50 of KCN in the absence of α-KG (unprotected animals). In a separate experiment, several physiological variables viz. mean arterial pressure (MAP), heart rate (HR), respiratory rate (RR), neuromuscular transmission (NMT) and rectal temperature (RT) were measured in anesthetized female rats pre-treated (-10 min) with po (2.0 g/kg) or iv (0.125 g/kg) α-KG and then administered sub-lethal (0.75 LD50) or lethal (2.0, 4.0 or 8.0 LD50) doses of KCN (po). Results PI of 4.52, 6.40 and 7.60 at -10 min, 3.20, 5.40 and 6.40 at -20 min, and 1.40, 3.20 and 5.40 at -40 min of po administration with α-KG was observed for 0.50, 1.0 and 2.0 g/kg doses, respectively, against KCN given by po route. When KCN was given ip, a PI of 3.38, 4.79 and 5.70 was observed for 0.50, 1.0 and 2.0 g/kg α-KG given ip (-10 min), respectively. A lower PI of 3.37, 2.83 and 2.38 was observed when KCN given sc was challenged by 2.0 g/kg α-KG given ip at -10, -20 or -40 min, respectively. Similarly, a PI of 3.37, 2.83 and 2.0 was noted when KCN given sc was antagonized by 2.0 g/kg α-KG given po at -10, -20 or -40 min, respectively. No appreciable protection was observed when lower doses of α-KG (ip or po) challenged KCN given by sc route. Pre-treatment of iv or po administration of α-KG did not afford any protection against KCN given po or iv route. Oral treatment of 0.75 LD50 KCN caused significant decrease in MAP and HR after 15 min, RR after 30 min and NMT after 60 min. There was no effect on RT. No reduction in MAP, HR, RR and RT was observed when rats received 2.0 or 4.0 LD50 KCN after pre-treatment of α-KG (po; 2.0 g/kg). However, no protection was observed on NMT. Protective efficacy of α-KG was not observed on MAP, HR, RR, and NMT decreased by 8.0 LD50 KCN. Decrease in MAP and NMT caused by 2.0 LD50 KCN (po) was resolved by iv administration of α-KG. Conclusions Cyanide antagonism by α-KG is best exhibited when both α-KG and KCN are given by po route. The protective effect of α-KG on cyanide-induced changes in several physiological parameters also indicates a promising role of α-KG as an alternative cyanide antidote. | RAJKUMAR TULSAWANI DEO KUMAR R.BHATTACHARYA | 2007 | Biomedical and Environmental Sciences2007，20，1： | 2 |
| 13 | Identification of SNP and InDel variations in the promoter and 5′ untranslated regions of γ-tocopherol methyl transferase(ZmVTE4) affecting higher accumulation of α-tocopherol in maize kernel显示文摘Deficiency of vitamin-E or tocopherol causes neurological and cardiovascular disorders in humans. Though maize kernel is rich in total tocopherol, the level of α-tocopherol possessing the highest vitamin-E activity is low. Mutant allele of ZmVTE4 with deletion of 7 bp and 118 bp (0/0: most favorable haplotype) in 5′UTR and promoter region, respectively significantly enhances α-tocopherol in maize kernel than wild type haplotype (7/118).α- tocopherol estimation in 15 diverse inbreds revealed that mean α-/γ-tocopherol and α-/ total-tocopherol was much higher in genotypes with favorable haplotype (1.51 and 0.41) than unfavorable class (0.19 and 0.13), respectively. However even within favorable class,α- tocopherol ranged from 4.76 to 30.07 μg g 1. Sequence analysis of part of 5′UTR and promoter of ZmVTE4 among the genotypes with favorable haplotype revealed 14 SNPs (SNP1 to SNP14) and eight InDels (InDel1 to InDel8). SNP7 at 606 bp (G to A), and InDels viz., InDel1 (27 bp), InDel4 (27 bp) and InDel8 (14 bp) differentiated low and high α-tocopherol accumulating inbreds with favorable haplotype. Hence the newly identified SNP and InDels in addition to the already reported InDels can be useful in selection of favorable genotypes with higher α-tocopherol in maize. | Abhijit Kumar Das Rashmi Chhabra Vignesh Muthusamy Hema Singh Chauhan Rajkumar Uttamrao Zunjare Firoz Hossain | 2019 | The Crop Journal2019，7，4： | 2 |
| 14 | Aqueous extract of Phyllanthus amarus inhibits chromium(VI)-induced toxicity in MDA-MB-435S cells显示文摘 | Gunjan Guha V. Rajkumar R. Ashok Kumar Lazar Mathew | 2009 | Food and Chemical Toxicology2009，，1： | 2 |
| 15 | Influence of Rice Genotypes on Folding and Spinning Behaviour of Leaffolder(Cnaphalocrocis medinalis) and Its Interaction with Leaf Damage显示文摘Folding and spinning behavior of Cnaphalocrocis medinalis(Guenee)(Lepidoptera: Pyralidae) in different categories of rice genotypes viz., resistant, susceptible, hybrid, scented, popular and wild rice genotypes were significantly different. Longer leaf selection time and folding time per primary fold; shorter primary fold and whole leaf fold; lower number of binds per primary fold and whole leaf fold were recorded in resistant and wild rice genotypes. In the correlation analysis, it was found that the leaf folding parameters were positively correlated to leaf folder damage whereas the leaf spinning parameters were negatively correlated. Similarly, the morphological characters differed significantly among the chosen genotypes and were related to leaffolder damage. The leaf width and total productive tiller number were positively correlated to leaffolder infestation. Results also indicated that the trichome density and length, leaf length and plant height might contribute to resistance whereas total number of green leaves had no effect on leaffolder infestation. In the scatter plot analysis between leaf folding and spinning characters and leaffolder damage, the genotypes were separated into four groups viz., resistant(TKM6, Ptb 33, LFR831311, Oryza rhizomatis and O. minuta), moderately resistant(ASD16 and CORH1), moderately susceptible(ADT36, Pusa Basmati and CB200290) and susceptible(IR36 and TN1). The present investigation proved that the leaf morphology viz., leaf length and width, plant height and trichome density and length may play a vital role in resistance against rice leaffolder. | M.PUNITHAVALLI N.M.MUTHUKRISHNAN M.BALAJI RAJKUMAR | 2013 | Rice science2013，20，6： | 2 |
| 16 | Review of 1027 Patients With Newly Diagnosed Multiple Myeloma显示文摘 | Robert A. Kyle Morie A. Gertz Thomas E. Witzig John A. Lust Martha Q. Lacy Angela Dispenzieri Rafael Fonseca S. Vincent Rajkumar Janice R. Offord Dirk R. Larson Matthew E. Plevak Terry M. Therneau Philip R. Greipp | 2003 | Mayo Clinic Proceedings2003，，1： | 2 |
| 17 | Cloud computing and emerging IT platforms: Vision, hype, and reality for delivering computing as the 5th utility显示文摘 | Rajkumar Buyya Chee Shin Yeo Srikumar Venugopal James Broberg Ivona Brandic | 2008 | Future Generation Computer Systems2008，，6： | 2 |
| 18 | Engaging the spikes: heparan sulfate facilitates SARS-CoV-2 spike protein binding to ACE2 and potentiates viral infection显示文摘In a recent report published in Cell,Clausen et al.1 reveal that heparan sulfate(HS)functions as a necessary cofactor for SARSCoV-2 binding to the ACE2 at the host cell membrane.Molecular analysis identified that HS interacts with the receptor-binding domain(RBD)at the SI subunit of the SARS-CoV-2 trimeric S-protein,which facilitates the opening of S-protein conformation for ACE2 binding. | Rajkumar Singh Kalra Ramesh Kandimalla | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 2 |
| 19 | Benthic Macrofaunal Assemblage in the Arid Zone Mangroves of Gulf of Kachchh-Gujarat显示文摘The total benthic macrofauna consisting of 62 species in 5 groups,viz. crustaceans(18),gastropods(17),bivalves(16),polychaetes(9) and fishes(2),was recorded in western Kachchh mangroves near Gujarat. The population densities of benthic macro-fauna ranged from 424 to 2393 ind.m-2,the diversity ranged from 1.84 to 2.45 bits ind.-1,the richness varied between 0.82 and 0.98,and the evenness varied between 0.64 and 0.81. Two maximum diversity values were recorded during winter and summer. The salin-ity ranged from 34 to 44,temperature varied between 17 and 37 ℃,and the acidity ranged from 7 to 8.9. | A. Saravanakumar J. Sesh Serebiah G. A. Thivakaran M. Rajkumar | 2007 | Journal of Ocean University of China2007，6，3： | 2 |
| 20 | Comparison of in-hospital outcomes between octogenarians and nonagenarians undergoing transcatheter aortic valve replacement: a propensity matched analysis显示文摘BackgroundAortic 阀门狭窄(作为) 在在 80 年上面的老病人是很普通的。在如此的病人的 Transcatheter 大动脉的阀门代替(TAVR ) 逐渐地正在被执行。寻求在与严重 AS.MethodThe 学习人口经历 TAVR 的九十至九十九岁的人估计死亡的 octogenarians 和九十至九十九岁的人和预言者之间的在里面医院结果差别的这研究从国家住院病人样品(网络信息服务) 被导出 2012-2014 使用 ICD-9 厘米过程为 TAVR 编码 35.05 和 35.06 的年。低于 80 岁的住院被排除。在执行倾向 20 以后匹配(1:2 ) ,在里面医院结果在匹配的队被比较。然后, multivariate 模型被开发在 nonagenarians.ResultsThere 分析在里面医院死亡的预言者是 11,630 个住院在八十至八十九岁并且在九十至九十九岁的人组的 5815 个住院。在里面医院死亡的主要结果(6% 对 4.1% , P 0.001 ) 在与 octogenarians 相比的九十至九十九岁的人是更高的。第二等的结果包括击(3.4%对2.8%, P 0.001 ),肾的失败(18.9%对17.3%, P 0.001 ),输血(35%对32.6%, P 0.001 ),脉管的复杂并发症(4.5%对3.5%, P 0.001 ),并且心律调整器培植(27.8%对24.8%, P 0.001 )在九十至九十九岁的人是更高的。在他们停留的长度没有差别。中部的费用(70,374 $ 对 65,381 $ , P 0.001 ) 与 nonagenarian.ConclusionsAlthough 在里面医院是稍微更高的死亡在九十至九十九岁的人是稍微更高的,它是可接受的。在死亡的这差别被更高的复杂并发症部分至少在九十至九十九岁的人解释。努力应该被成为能进一步在在这些组之间的在里面医院死亡缩小差别的复杂并发症到减少。 | Rajkumar Doshi Vaibhav Patel Priyank Shah | 2018 | Journal of Geriatric Cardiology2018，15，2： | 2 |
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