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| 1 | Gastric emptying evaluation by ultrasound prior colonoscopy:An easy tool following bowel preparation显示文摘AIM: To investigate the gastric emptying after bowel preparation to allow general anaesthesia. METHODS: A prospective, non-comparative, and nonrandomized trial was performed and registered on Eudra CT database(2011-002953-80) and on www.trial.gov(NCT01398098). All patients had a validated indication for colonoscopy and a preparation using sodium phosphate(NaP) tablets. The day of the procedure, patients took 4 tablets with 250 mL of water every 15 min, three times. The gastric volume wasestimated every 15 min from computed antral surfaces and weight according to the formula of Perlas et al(Anesthesiology, 2009). Colonoscopy was performed within the 6 h following the last intake.RESULTS: Thirty patients were prospectively included in the study from November 2011 to May 2012. The maximum volume of the antrum was 212 mL, achieved 15 min after the last intake. 24%, 67% and 92% of subjects had an antral volume below 20 mL at 60, 120 and 150 min, respectively. 81% of patients had a Boston score equal to 2 or 3 in each colonic segment. No adverse events leading to treatment discontinuation were reported.CONCLUSION: Gastric volume evaluation appeared to be a simple and reliable method for the assessment of gastric emptying. Data allow considering the NaP tablets bowel preparation in the morning of the procedure and confirming that gastric emptying is achieved after two hours, allowing general anaesthesia. | Romain Coriat Vanessa Polin Ammar Oudjit Franck Henri Marion Dhooge Sarah Leblanc Chantal Delchambre Anouk Esch Tessa Tabouret Maximilien Barret Frédéric Prat Stanislas Chaussade | 2014 | World Journal of Gastroenterology2014，20，37： | 6 |
| 2 | Therapeutic ACPA inhibits NET formation: a potential therapy for neutrophil-mediated inflammatory diseases显示文摘Excessive release of neutrophil extracellular traps(NETs)is associated with disease severity and contributes to tissue injury,followed by severe organ damage.Pharmacological or genetic inhibition of NET release reduces pathology in multiple inflammatory disease models,indicating that NETs are potential therapeutic targets.Here,we demonstrate using a preclinical basket approach that our therapeutic anti-citrullinated protein antibody(tACPA)has broad therapeutic potential.Treatment with tACPA prevents disease symptoms in various mouse models with plausible NET-mediated pathology,including inflammatory arthritis(IA),pulmonary fibrosis,inflammatory bowel disease and sepsis.We show that citrulline residues in the N-termini of histones 2A and 4 are specific targets for therapeutic intervention,whereas antibodies against other N-terminal post-translational histone modifications have no therapeutic effects.Because citrullinated histones are generated during NET release,we investigated the ability of tACPA to inhibit NET formation.tACPA suppressed NET release from human neutrophils triggered with physiologically relevant human disease-related stimuli.Moreover,tACPA diminished NET release and potentially initiated NET uptake by macrophages in vivo,which was associated with reduced tissue damage in the joints of a chronic arthritis mouse model of IA.To our knowledge,we are the first to describe an antibody with NET-inhibiting properties and thereby propose tACPA as a drug candidate for NET-mediated inflammatory diseases,as it eliminates the noxious triggers that lead to continued inflammation and tissue damage in a multidimensional manner. | Renato G.S.Chirivi Jos W.Gvan Rosmalen Maarten van der Linden Maximilien Euler Gonny Schmets Galina Bogatkevich Konstantinos Kambas Jonas Hahn Quinte Braster Oliver Soehnlein Markus H.Hoffmann Helmuth H.Gvan Es Jos M.H.Raats | 2021 | Cellular & Molecular Immunology2021，18，6： | 5 |
| 3 | A systematic review of the epidemiology of unrecorded alcohol consumption and the chemical composition of unrecorded alcohol显示文摘 | Jürgen Rehm Shalini Kailasapillai Elisabeth Larsen Maximilien X. Rehm Andriy V. Samokhvalov Kevin D. Shield Michael Roerecke Dirk W. Lachenmeier | 2014 | Addiction2014，，6： | 2 |
| 4 | How botulinum toxin in neurogenic detrusor overactivity can reduce upper urinary tract damage?显示文摘Intradetrusor injections of botulinum toxin are the cornerstone of medical treatment of neurogenic detrusor overactivity. The primary aim of this treatment is to ensure a low pressure regimen in the urinary bladder, but the mechanisms leading to long-term protection of the urinary tract remain poorly understood. In this paper, we highlight the potential benefits of intradetrusor injections of botulinum toxin regarding local effects on the bladder structures, urinary tract infections, stone disease, vesico ureteral reflux, hydronephrosis, renal function based on a comprehensive literature review. | Maximilien Baron Philippe Grise Jean-Nicolas Cornu | 2016 | World Journal of Nephrology2016，5，2： | 2 |
| 5 | Sonic hedgehog signaling by the Patched–Smoothened receptor complex显示文摘 | Maximilien Murone Arnon Rosenthal Frederic J. de Sauvage | 1999 | Current Biology1999，，2： | 1 |
| 6 | A framework and ontology for dynamic Web services selection显示文摘 | Maximilien E M Singh M P | 2004 | IEEE lnternet Computing2004，8，5： | 1 |
| 7 | A Framework and Ontology for Dynamic Web Service Selection显示文摘 | Maximilien E M Singh M P | 2004 | IEEE Internet Computing2004，，10： | 1 |
| 8 | Conceptual model of Web service reputation显示文摘 | Singh M P | 2002 | ACM SIGMOD Record2002，31，36： | 1 |
| 9 | A framework and ontology for dynam ie web services selection 显示文摘 | Maximilien E M Singh M P | 2004 | Internet computing2004，8，5： | 1 |
| 10 | A framework and ontology for dynamic web services selection 显示文摘 | Maximilien E M Singh M P | 2004 | IEEE Internet Computing2004，8，5： | 1 |
| 11 | Chemical mediation of bacterial surface colonisation by secondary metaboHtes from the red alga Delisea pulchra显示文摘 | Maximilien R de Nys R Holmstro'm C Gram L Givskov M Crass K Kjelleberg S & Steinberg PD | 1998 | Aquat Microb Ecol1998，15，： | 1 |
| 12 | Determination by nanoindentation of elastic modulus and hardness of pure constituents of Portland cement clinker显示文摘 | VELEZ K MAXIMILIEN S DAMIDOT D | 2001 | Cement and Concrete Research2001，31，4： | 1 |
| 13 | Duodenal gangliocytic paraganglioma with lymph node metastasis and an 8-year follow-up: a case report显示文摘 | Maximilien Barret Gabriel Rahmi Jean-Paul Duong van Huyen Bruno Landi Christophe Cellier Anne Berger | 2012 | European Journal of Gastroenterology & Hepatology2012，，1： | 1 |
| 14 | A framework and ontology for dynamic Web services selection显示文摘 | Maximilien EM | 2003 | IEEE Internet Computing2003，8，： | 1 |
| 15 | A framework andontology for dynamic web services selection显示文摘 | Maximilien E M Singh M P | 2004 | IEEE Internet Computing2004，8，5： | 1 |
| 16 | Study of the reactivity of clinkers by means of the conductometric test显示文摘 | MAXIMILIEN S PERA J CHABANNET M | 1997 | Cement and Concrete Research1997，27，1： | 1 |
| 17 | Therapeutic impact of low amplitude high frequency whole body vibrations on the osteogenesis imperfecta mouse bone显示文摘 | Maximilien V Sandra JS | 2013 | Bone2013，53，2： | 1 |
| 18 | A Framework and On- tology for Dynamic Web Services Selection 显示文摘 | Maximilien E M Singh M P | 2004 | IEEE Internet Computing2004，8，5： | 1 |
| 19 | Determination by nanoindentation of elastic modulus and hardness of pure constituents of Portland cement clinker 显示文摘 | VELEZ K MAXIMILIEN S DAMIDOT D | 2001 | Cem Concr Res2001，31，4： | 1 |
| 20 | Conceptual model of Web service reputation 显示文摘 | Maximilien E M Singh M P | 2002 | ACM SIGMOD Record2002，31，4： | 1 |
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