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| 1 | General review of magnetic resonance elastography显示文摘Magnetic resonance elastography(MRE) is an innovative imaging technique for the non-invasive quantification of the biomechanical properties of soft tissues via the direct visualization of propagating shear waves in vivo using a modified phase-contrast magnetic resonance imaging(MRI) sequence. Fundamentally,MRE employs the same physical property that physicians utilize when performing manual palpation- that healthy and diseased tissues can be differentiated on the basis of widely differing mechanical stiffness. By performing 'virtual palpation ',MRE is able to provide information that is beyond the capabilities of conventional morphologic imaging modalities. In an era of increasing adoption of multi-parametric imaging approaches for solving complex problems,MRE can be seamlessly incorporated into a standard MRI examination to provide a rapid,reliable and comprehensive imaging evaluation at a single patient appointment. Originally described by the Mayo Clinic in 1995,the technique represents the most accurate non-invasive method for the detection and staging of liver fibrosis and is currently performed in more than 100 centers worldwide. In this general review,the mechanical properties of soft tissues,principles of MRE,clinical applications of MRE in the liver and beyond,and limitations and future directions of this discipline-are discussed. Selected diagrams and images are provided for illustration. | Gavin Low Scott A Kruse David J Lomas | 2016 | World Journal of Radiology2016，8，1： | 5 |
| 2 | Gan Shen Fu Fang ameliorates liver fibrosis in vitro and in vivo by inhibiting the inflammatory response and extracellular signalregulated kinase phosphorylation显示文摘BACKGROUND Liver fibrosis is a common health problem worldwide and there is still a lack of effective medicines.The Chinese herbal medicine,Gan Shen Fu Fang(GSFF)is composed of salvianolic acid B and diammonium glycyrrhizinate.In this study,we observed the effects of GSFF on liver fibrosis in vivo and in vitro in an attempt to provide some hope for the treatment.AIM To observe the effects of GSFF on liver fibrosis in vivo and in vitro and investigate the mechanism from the perspective of the inflammatory response and extracellular signal-regulated kinase(ERK)phosphorylation.METHODS Common bile duct-ligated rats were used for in vivo experiments.Hepatic stellate cells-T6(HSC-T6)cells were used for in vitro experiments.Hematoxylin and eosin staining and Masson staining,biochemical assays,hydroxyproline(Hyp)assays,enzyme-linked immunoasorbent assay and western blotting were performed to evaluate the degree of liver fibrosis,liver function,the inflammatory response and ERK phosphorylation.The CCK8 assay,immunofluorescence and western blotting were applied to test the effect of GSFF on HSC-T6 cell activation and determine whether GSFF had an effect on ERK phosphorylation in HSC-T6 cells.RESULTS GSFF improved liver function and inhibited liver fibrosis in common bile ductligated rats after 3 wk of treatment,as demonstrated by histological changes,hydroxyproline assays and collagen I concentrations.GSFF alleviated inflammatory cell infiltration and reduced the synthesis of pro-inflammatory cytokines[tumor necrosis factor-α(TNF-α)and interlukin-1β]and NF-κB.In addition,GSFF decreased ERK phosphorylation.In vitro,GSFF inhibited the viability of HSC-T6 cells with and without transforming growth factorβ1(TGF-β1)stimulation and decreased the synthesis of collagen I.GSFF had the greatest effect at a concentration of 0.5μmol/L.GSFF inhibited the expression ofα-smooth muscle actin(α-SMA),a marker of HSC activation,in HSC-T6 cells.Consistent with the in vivo results,GSFF also inhibited the phosphorylation of ERK and downregulated the expression of NF-κB.CONCLUSION GSFF inhibited liver fibrosis progression in vivo and HSC-T6 cell activation in vitro.These effects may be related to an alleviated inflammatory response and downregulated ERK phosphorylation. | Qing-Hong Du Chu-Jun Zhang Wei-Hong Li Yan Mu Ya Xu Scott Lowe Lin Han Xue Yu Shu-Yan Wang Yu Li Jian Li | 2020 | World Journal of Gastroenterology2020，26，21： | 2 |
| 3 | Marginal mandibular nerve injury during neck dissection and its impact on patient perception of appearance 显示文摘 | Batstone MD Scott B Lowe D | 2009 | Head Neck2009，31，5： | 1 |
| 4 | Bcl-2 Mediates Chemoresistance in Matched Pairs of Primary Eμ-myc Lymphomas in Vivo显示文摘 | Clemens A Schmitt Scott W Lowe | 2001 | Blood Cells, Molecules and Diseases2001，，1： | 1 |
| 5 | Presence and hazards of nutrients and emerging organic micropollutants from sewage lagoon discharges into Dead Horse Creek, Manitoba, Canada显示文摘 | Jules C. Carlson Julie C. Anderson Jennifer E. Low Pascal Cardinal Scott D. MacKenzie Sarah A. Beattie Jonathan K. Challis Renae J. Bennett Stephanie S. Meronek Rebecca P.A. Wilks William M. Buhay Charles S. Wong Mark L. Hanson | 2012 | Science of the Total Environment2012，，： | 1 |
| 6 | Marginal mandibular nerve injury during neck dissection and its impact on patients perception of appearance显示文摘 | Batstone MD Scott B Lowe D | 2009 | Head neck2009，31，5： | 1 |
| 7 | An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer显示文摘 | Lars Zender Wen Xue Johannes Zuber Camile P. Semighini Alexander Krasnitz Beicong Ma Peggy Zender Stefan Kubicka John M. Luk Peter Schirmacher W. Richard McCombie Michael Wigler James Hicks Gregory J. Hannon Scott Powers Scott W. Lowe | 2008 | Cell2008，，5： | 1 |
| 8 | Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16 INK4a显示文摘 | Manuel Serrano Athena W Lin Mila E McCurrach David Beach Scott W Lowe | 1997 | Cell1997，，5： | 1 |
| 9 | Effect of lifestyle activities on alzheimer disease biomarkers and cognition显示文摘 | Prashanthi Vemuri Timothy G. Lesnick Scott A. Przybelski David S. Knopman Rosebud O. Roberts Val J. Lowe Kejal Kantarci Mathew L. Senjem Jeffrey L. Gunter Bradley F. Boeve Ronald C. Petersen Clifford R. Jack | 2012 | Ann Neurol2012，，5： | 1 |
| 10 | Apoptosis and Therapy显示文摘 | Clemens A Schmitt Scott W Lowe | 1999 | The Journal of Pathology1999，187，1： | 1 |
| 11 | Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16 INK4a显示文摘 | Manuel Serrano Athena W Lin Mila E McCurrach David Beach Scott W Lowe | 1997 | Cell1997，，： | 1 |
| 12 | Object class recognition with many local features显示文摘 | Scott Helmer David G Lowe | 2004 | International Journal of Computer Vision2004，，： | 1 |
| 13 | Apoptosis in cancer显示文摘 | Scott W Lowe Athena W Lin | 2000 | Carcinogenesis2000，21，3： | 1 |
| 14 | MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia显示文摘 | Chong Chen Yu Liu Amy R. Rappaport Thomas Kitzing Nikolaus Schultz Zhen Zhao Aditya S. Shroff Ross A. Dickins Christopher R. Vakoc James E. Bradner Wendy Stock Michelle M. LeBeau Kevin M. Shannon Scott Kogan Johannes Zuber Scott W. Lowe | 2014 | Cancer Cell2014，，5： | 1 |
| 15 | Texture and color enhancement imaging for detecting colorectal adenomas: Good, but not good enough显示文摘Texture and color enhancement imaging(TXI)has been developed as a novel image-enhancing endoscopy.However,the effectiveness of TXI detecting adenomas is inferior to narrow band imaging.Thus,future studies will need to focus on investigating the feasibility of such combination in clinical settings in order to provide patients with more accurate diagnoses. | Ying Wang Chen-Yu Sun Lowe Scott Dan-Dan Wu Xia Chen | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，7： | 1 |
| 16 | Apoptosis显示文摘 | Ricky W. Johnstone Astrid A. Ruefli Scott W. Lowe | 2002 | Cell2002，，2： | 1 |
| 17 | The Patients Concerns Inventory in head and neck cancer: Comparison between self-completed paper and touch screen versions in the clinic setting显示文摘 | Barry Scott Naseem Ghazali Derek Lowe Fazilet Bekiroglu Simon N. Rogers | 2013 | European Journal of Oncology Nursing2013，，： | 1 |
| 18 | Apoptosis显示文摘 | Ricky W. Johnstone Astrid A. Ruefli Scott W. Lowe | 2002 | Cell2002，，2： | 1 |
| 19 | Experience-Based Quality Control of Clinical Intensity-Modulated Radiotherapy Planning显示文摘 | Kevin L. Moore R. Scott Brame Daniel A. Low Sasa Mutic | 2011 | International Journal of Radiation Oncology Biology Physics2011，，2： | 1 |
| 20 | Factors associated with restricted mouth opening and its relationship to health-related quality of life in patients attending a Maxillofaeial Oncology clinic 显示文摘 | Scott B Bntterworth C Lowe D | 2008 | Oral Oncol2008，44，5： | 1 |
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