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| 1 | Subchronic Oral Cadmium Exposure Exerts both Stimulatory and Suppressive Effects on Pulmonary Inflammation/Immune Reactivity in Rats显示文摘Objective The aim of this study is to investigate the effects of oral cadmium(Cd) ingestion on the pulmonary immune response. Methods Determination of Cd content in lungs and histopathological evaluation of the tissue was performed in rats following 30-day oral Cd administration(5 and 50 mg/L). Antioxidant enzyme defense(superoxide dismutase and catalase), cell infiltration, and production of tumor necrosis factor(TNF) and interferon(IFN)-γ, as well as the activity of myeloperoxidase(MPO), nitric oxide(NO), and various cytokines [interleukin(IL)-1β, IL-6, IL-10, and IL-17] were investigated. Results Cd caused tissue damage and cell infiltration in the lungs, and this damage was more pronounced at higher doses. Cd deposition resulted in lung inflammation characterized by a dose-dependent IL-1β increase in lung homogenates, increased TNF levels at both doses, and IL-6 stimulation at low doses with inhibition observed at higher doses. Cd exerted differential effects on lung leukocytes isolated by enzyme digestion, and these effects were characterized by a lack of change in the production of reactive oxygen and nitrogen species, an inhibition of IL-1β and TNF, and stimulation of MPO and IFN-γ. The higher capacity of Cd-exposed lung cells to respond to the opportunistic pathogen Staphylococcus epidermidis was demonstrated in vitro. Conclusion The potential of ingested Cd to exert both proinflammatory and immunosuppressive effects on pulmonary tissue inflammation and immune reactivity highlights the complex immunomodulatory actions of this metal. | KULAS Jelena NINKOV Marina TUCOVIC Dina POPOV Aleksandrov Aleksandra UKROPINA Mirela CAKIC MILOSEVIC Maja MUTIC Jelena KATARANOVSKI Milena MIKROV Ivana | 2019 | Biomedical and Environmental Sciences2019，32，7： | 4 |
| 2 | PET-guided IMRT for cervical carcinoma with positive para-aortic lymph nodes-a dose-escalation treatment planning study 显示文摘 | Mutic S Malyapa RS Grigsby PW | 2003 | International Journal of Radiation Oncology Bioliogu Physics2003，55，1： | 1 |
| 3 | Impact of FDG-PET on radiation therapy volume delineation in non-small-cell lung cancer显示文摘 | Bradley J Thorstad WL Mutic S | 2004 | Int J Radiat Oneol Biol Phys2004，59，1： | 1 |
| 4 | Impact of FDGPET on radiation therapy volume delineation in nonsmall cell lung cancer显示文摘 | Bradley J Thorstad W L Mutic S | 2004 | Int J Radiat Oncol Biol Phys2004，59，1： | 1 |
| 5 | A novel approach to over come hypoxic tumor resistance:Cu-ATSM-guided intensity-modu-lated radiation therapy显示文摘 | Chao KS Bosch WR Mutic S | 2001 | Int J Radiat Oncol Biol Phys2001，49，4： | 1 |
| 6 | Impact of FDG-PET on radiation therapy volume delineation in non-small-cell lung cancer显示文摘 | Bradley J Thorstad WL Mutic S | 2004 | Int J Radiat Oncol Biol Phys2004，59，1： | 1 |
| 7 | Quantitative dosimetrjc Verification of an IMRT planning and delivery system显示文摘 | Low DA Mutic S Dempsey JF | 1998 | Radiother Oncol1998，49，3： | 1 |
| 8 | PET guided IMRT for cervical carcinoma with positive para-aortic lymphnodes: A dose-escalation treatment planning study显示文摘 | Mutic S Malyapa RS Grigsby PW | 2003 | Int J Radiat Oncol Biol Phys2003，55，1： | 1 |
| 9 | A technique for the quanti- tative evaluation of dose distributions 显示文摘 | Low DA Harms WB Mutic S | 1998 | Med Phys1998，25，5： | 1 |
| 10 | A technique for the quanti- tative evaluation of dose distributions显示文摘 | LOW D A HARMS W B MUTIC S | 1998 | Medical Physics1998，30，5： | 1 |
| 11 | Treatment planning guidelines regarding the use of CT/PET-guided IMRT for cervical carcinoma with positive para-aortic lymphnodes显示文摘 | Esthappan J Mutic S Malyapa RS | 2004 | Int J Radiat Oncol Biol Phys2004，58，4： | 1 |
| 12 | A novel approach to overcome hypoxic tumor resistance:Cu-ATSM-guided intensity-modulated radiation therapy显示文摘 | Chao KS Bosch WR Mutic S | 2001 | Int J Radiat Oncol Biol Phys2001，49，4： | 1 |
| 13 | A technique for the quantitative evaluation of dose distributions显示文摘 | Low DA Harms MB Mutic S | | 0，，： | 1 |
| 14 | Abutment dosimetry for serial tomotherapy显示文摘 | Low DA Mutic S Dempsey JF | 2001 | Med Dosim2001，26，： | 1 |
| 15 | A Novel Approach to Overcome Hypoxic Tumor Resistance:Cu-ATSM-guided Intensity-modulated Radiation Therapy显示文摘 | Chao KS Bosch WR Mutic S | 2001 | Int J Radiat Oncol Biol Phys2001，49，4： | 1 |
| 16 | Adaptive brachytherapy treatment planning for cervical cancer using FDG-PET显示文摘 | Lin LL Mutic S Low DA et at | 2007 | Int J Radiat Oncol Biol Phys2007，67，1： | 1 |
| 17 | PET-guided threedimensional treatment planning of intracavitary gynecologic implants显示文摘 | Mutic S Grigsby PW Low DA | 2002 | Int J Radiat Oncol Biol Phys2002，52，： | 1 |
| 18 | Impact of FDG-PET on radiation therapy volume delineation in non-small-cell lung cancer 显示文摘 | Bradley J Thorstad WL Mutic S | 2004 | Int Radiat Oncol Biol Phys2004，59，1： | 1 |
| 19 | Physiologic FDG-PET threedimensional brachytherapy treatment planning for cervical cance显示文摘 | Malyapa RS Mutic S Low DA | 2002 | Int J Radiat Oncol Biol Phys2002，54，： | 1 |
| 20 | Quality assurance of serial tomotherapy for head and neck patient treatments显示文摘 | Low DA Chao KC Mutic S | 1998 | Int J Radiat Oncol Biol Phys1998，42，： | 1 |
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