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| 1 | Role of endoscopic therapy in early esophageal cancer显示文摘Esophageal carcinoma is a highly lethal cancer associated with high morbidity and mortality. Esophageal squamous cell carcinoma and esophageal adenocarcinoma are the two distinct histological types. There has been significant progress in endoscopic diagnosis and treatment of early stages of cancer using resection and ablation techniques, as shown in several trials in the recent past. Earlier detection of esophageal cancer and advances in treatment modalities have lead to improvement in the 5-year survival from 5% to about 20% in the past decade. Endoscopic eradication therapy is the preferred modality of treatment in cancer limited to mucosal layer of the esophagus as there is very low risk of lymph node metastasis, leading to high cure rates, low risk of recurrence and with few adverse effects. The most common adverse events seen are strictures, bleeding and rarely perforation which can be endoscopically managed. In patients with recurrent advanced disease or invasive tumor, esophagectomy with lymph node dissection remains the mainstay of treatment. There is debate on post-endoscopic surveillance with some studies suggesting closer follow up with upper endoscopy every 6 mo for the first 1-2 years and then annually for the 3 years while others recommending the appropriate action only if symptoms or other abnormalities develop. Overall, the field of endoscopic therapy is still evolving and focus should be placed on careful patient selection using a multidisciplinary approach. | Sonika Malik Gautam Sharma Madhusudhan R Sanaka Prashanthi N Thota | 2018 | World Journal of Gastroenterology2018，24，35： | 10 |
| 2 | Endoscopic therapy for Barrett's esophagus and early esophageal cancer:Where do we go from here?显示文摘Since Barrett's esophagus is a precancerous condition,efforts have been made for its eradication by various ablative techniques.Initially,laser ablation was attempted in non-dysplastic Barrett's esophagus and subsequently,endoscopic ablation using photodynamic therapy was used in Barrett's patients with high-grade dysplasia who were poor surgical candidates.Since then,various ablative therapies have been developed with radiofrequency ablation having the best quality of evidence.Resection of dysplastic areas only without complete removal of entire Barrett's segment is associated with high risk of developing metachronous neoplasia.Hence,the current standard of management for Barrett's esophagus includes endoscopic mucosal resection of visible abnormalities followed by ablation to eradicate remaining Barrett's epithelium.Although endoscopic therapy cannot address regional lymph node metastases,such nodal involvement is present in only 1% to 2% of patients with intramucosal adenocarcinoma in Barrett esophagus and therefore is useful in intramucosal cancers.Post ablation surveillance is recommended as recurrence of intestinal metaplasia and dysplasia have been reported.This review includes a discussion of the technique,efficacy and complication rate of currently available ablation techniques such as radiofrequency ablation,cryotherapy,argon plasma coagulation and photodynamic therapy as well as endoscopic mucosal resection.A brief discussion of the emerging technique,endoscopic submucosal dissection is also included. | Tavankit Singh Madhusudhan R Sanaka Prashanthi N Thota | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 9 |
| 3 | Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function显示文摘AIM: To assess and compare the esophageal function after peroral endoscopic myotomy(POEM) vs other conventional treatments in achalasia.METHODS: Chart review of all achalasia patients who underwent POEM, laparoscopic Heller myotomy(LHM) or pneumatic dilation(PD) at our institution between January 2012 and March 2015 was performed. Patient demographics, type of achalasia, prior treatments, pre- and post-treatment timed barium swallow(TBE) and high-resolution esophageal manometry(HREM) findings were compared between the three treatment groups. Patients who had both pre- and 2 mo posttreatment TBE or HREM were included in the final analysis. TBE parameters compared were barium column height, width and volume of barium remaining at 1 and 5 min. HREM parameters compared were basal lower esophageal sphincter(LES) pressures and LES-integrated relaxation pressures(IRP). Data are presented as mean ± SD, median [25th, 75 th percentiles] or frequency(percent). Analysis of variance, KruskalWallis test, Pearsons χ~2 test and Fishers Exact tests were used for analysis.RESULTS: A total of 200 achalasia patients were included of which 36 underwent POEM, 22 underwent PD and 142 underwent LHM. POEM patients were older(55.4 ± 16.8 years vs 46.5 ± 15.7 years, P = 0.013) and had higher BMI than LHM(29.1 ± 5.9 kg/m^2 vs 26 ± 5.1 kg/m^2, P = 0.012). More number of patients in POEM and PD groups had undergone prior treatments compared to LHM group(72.2% vs 68.2% vs 44.3% respectively, P = 0.003). At 2 mo post-treatment, all TBE parameters including barium column height, width and volume remaining at 1 and 5 min improved significantly in all three treatment groups(P = 0.01 to P < 0.001) except the column height at 1 min in PD group(P = 0.11). At 2 mo post-treatment, there was significant improvement in basal LES pressure and LES-IRP in both LHM(40.5 mm Hg vs 14.5 mm Hg and 24 mm Hg vs 7.1 mm Hg respectively, P < 0.001) and POEM groups(38.7 mm Hg vs 11.4 mm Hg and 23.6 mm Hg vs 6.6 mm Hg respectively, P < 0.001). However, when the efficacy of three treatments were compared to each other in terms of improvement in TBE or HREM parameters at 2 mo, there was no significant difference(P > 0.05).CONCLUSION: POEM, PD and LHM were all effective in improving esophageal function in achalasia at shortterm. There was no difference in efficacy between the three treatments. | Madhusudhan R Sanaka Umar Hayat Prashanthi N Thota Ramprasad Jegadeesan Monica Ray Scott L Gabbard Neha Wadhwa Rocio Lopez Mark E Baker Sudish Murthy Siva Raja | 2016 | World Journal of Gastroenterology2016，22，20： | 7 |
| 4 | Cryotherapy in the management of premalignant and malignant conditions of the esophagus显示文摘Endoscopic cryotherapy is a relatively new thermal ablative modality used for the treatment of neoplastic lesions of the esophagus. It relies on cycles of rapid cooling and thawing to induce tissue destruction with a cryogen(liquid nitrogen or carbon dioxide) leading to intra and extra-cellular damage. Surgical treatment was once considered the standard therapeutic intervention for neoplastic diseases of the esophagus and is associated with considerable rates of morbidity and mortality. Several trials that evaluated cryotherapy in Barrett's esophagus(BE) associated neoplasia showed reasonable efficacy rates and safety profile. Cryotherapy has also found applications in the treatment of esophageal cancer, both for curative and palliative intent. Cryotherapy has also shown promising results as salvage therapy in cases refractory to radiofrequency ablation treatment. Cryoballoon focal ablation using liquid nitrogen is a novel mode of cryogen delivery which has been used for the treatment of BE with dysplasia and squamous cell carcinoma. Most common side effects of cryotherapy reported in the literature include mild chest discomfort, esophageal strictures and bleeding. In conclusion, cryotherapy is an effective and safe method for the treatment of esophageal neoplastic processes, ranging from early stages of low grade dysplasia to esophageal cancer. | Pooja Lal Prashanthi N Thota | 2018 | World Journal of Gastroenterology2018，24，43： | 5 |
| 5 | Vitamin D in esophageal cancer: Is there a role for chemoprevention?显示文摘Vitamin D has emerged as a promising anti-cancer agent due to its diverse biological effects on tumor differentiation, apoptosis and suppression of cellular proliferation. Current evidence suggests a protective role of vitamin D in colon cancer. The effect of vitamin D on esophageal cancer remains controversial. Multiple studies investigated the association between vitamin D and esophageal cancer, employing different modes of assessment of vitamin D status such as serum 25-hydroxyvitamin D levels, vitamin D dietary intake or exposure to ultraviolet B(UVB) radiation. Genetic variations of the vitamin D receptor(VDR) gene and VDR expression in esophageal specimens have also been investigated. Ecological studies evaluating exposure to UVB radiation yielded an inverse correlation with esophageal cancer. When vitamin D dietary intake was assessed, direct association with esophageal cancer was observed. However, circulating 25-hydroxyvitamin D concentrations showed inconsistent results. In this review article, we present a detailed summary of the current data on the effects of vitamin D on various histological subtypes of esophageal cancer and their precursor lesions. Well-powered prospective studies with accurate measurement of vitamin D status are needed before chemoprevention with vitamin D is recommended, as current evidence does not support a chemopreventive role of vitamin D against esophageal cancer. Future studies looking at the incidence of esophageal cancer in patients with pre-cancerous lesions(Barrett's esophagus and squamous cell dysplasia) receiving vitamin D supplementation are needed. | Carol Rouphael Afrin Kamal Madhusudhan R Sanaka Prashanthi N Thota | 2018 | World Journal of Gastrointestinal Oncology2018，10，1： | 5 |
| 6 | Resection of early esophageal neoplasms: The pendulum swings from surgical to endoscopic management显示文摘Esophageal cancer is a highly lethal disease and is the sixth leading cause of cancer related mortality in the world.The standard treatment is esophagectomy which is associated with significant morbidity and mortality.This led to development of minimally invasive,organ sparing endoscopic therapies which have comparable outcomes to esophagectomy in early cancer.These include endoscopic mucosal resection and endoscopic submucosal dissection.In early squamous cell cancer,endoscopic submucosal dissection is preferred as it is associated with cause specific 5-year survival rates of 100%for M1 and M2 tumors and 85%for M3 and SM1 tumors and low recurrence rates.In early adenocarcinoma,endoscopic resection of visible abnormalities is followed by ablation of the remaining flat Barrett’s mucosa to prevent recurrences.Radiofrequency ablation is the most widely used ablation modality with others being cryotherapy and argon plasma coagulation.Focal endoscopic mucosal resection followed by radiofrequency ablation leads to eradication of neoplasia in 93.4%of patients and eradication of intestinal metaplasia in 73.1%of patients.Innovative techniques such as submucosal tunneling with endoscopic resection are developed for management of submucosal tumors of the esophagus.This review includes a discussion of various endoscopic techniques and their clinical outcomes in early squamous cell cancer,adenocarcinoma and submucosal tumors.An overview of comparison between esophagectomy and endoscopic therapy are also presented. | Vedha Sanghi Hina Amin Madhusudhan R Sanaka Prashanthi N Thota | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，10： | 4 |
| 7 | Healthcare utilization and costs associated with gastroparesis显示文摘AIM To use a national database of United States hospitals to evaluate the incidence and costs of hospital admissions associated with gastroparesis.METHODS We analyzed the National Inpatient Sample Database(NIS)for all patients in whom gastroparesis(ICD-9 code:536.3)was the principal discharge diagnosis during the period,1997-2013.The NIS is the largest publicly available all-payer inpatient care database in the United States.It contains data from approximately eight million hospital stays each year.The statistical significance of the difference in the number of hospital discharges,length of stay and hospital costs over the study period was determined by regression analysis.RESULTS In 1997,there were 3978 admissions with a principal discharge diagnosis of gastroparesis as compared to16460 in 2013(P<0.01).The mean length of stay for gastroparesis decreased by 20%between 1997 and 2013from 6.4 d to 5.1 d(P<0.001).However,during this period the mean hospital charges increased significantly by 159%from$13350(after inflation adjustment)per patient in 1997 to$34585 per patient in 2013(P<0.001).The aggregate charges(i.e.,'national bill') for gastroparesis increased exponentially by 1026%from$50456642±4662620 in 1997 to$568417666±22374060 in 2013(P<0.001).The percentage of national bill for gastroparesis discharges(national bill for gastroparesis/total national bill)has also increased over the last 16 years(0.0013%in 1997 vs 0.004%in2013).During the study period,women had a higher frequency of gastroparesis discharges when compared to men(1.39/10000 vs 0.9/10000 in 1997 and 5.8/10000vs 3/10000 in 2013).There was a 6-fold increase in the discharge diagnosis of gastroparesis amongst type 1 DM and 3.7-fold increase amongst type 2 DM patients over the study period(P<0.001).CONCLUSION The number of inpatient admissions for gastroparesis and associated costs have increased significantly over the last 16 years.Inpatient costs associated with gastroparesis contribute significantly to the national healthcare bill.Further research on cost-effective evaluation and management of gastroparesis is required. | Vaibhav Wadhwa Dhruv Mehta Yash Jobanputra Rocio Lopez Prashanthi N Thota Madhusudhan R Sanaka | 2017 | World Journal of Gastroenterology2017，23，24： | 3 |
| 8 | Effect of interface on mid-infrared photothermal response of MoS2 thin film grown by pulsed laser deposition显示文摘这研究报导在上中间红外线(中间 -- 红外) 多层的瞬间 2 的 photothermal 反应在上成年的薄电影水晶(p 类型硅和 c-axis-oriented 单身者水晶蓝宝石) 并且非结晶(Si/SiO 2 和 Si/SiN ) 由搏动的激光免职(PLD ) 的底层。当照耀与时,瞬间 2 电影的 photothermal 反应在瞬间 2 电影的抵抗作为变化被测量一中间 -- 红外(7 ~ 8.2 m ) 来源。我们显示出那提高瞬间 2 的抵抗(TCR ) 的温度系数薄电影由通过底层和生长条件的一种合适的选择控制电影底层接口是可能的。PLD 种的薄电影用 X 光检查衍射,拉曼,原子力量显微镜学, X 光检查光电子显微镜学,和传播电子被描绘显微镜学。高分辨率的传播电子显微镜学(HRTEM ) 图象证明瞬间 2 电影与不合身的衣服脱臼以一种 layer-by-layer 方式在蓝宝石底层上成长。当这些电影在有一颗钻石的底层上是成年的时,层生长形态学被破坏立方的结构(例如,硅) 因为成双的生长形成。非结晶的底层上的生长形态学例如 Si/SiO 2 或 Si/SiN,是很不同的。硅上的 PLD-grown 瞬间 2 电影显示出更高的 TCR (在 296 K 的 2.9% K 1) ,更高中间 -- 红外敏感(R/R =5.2%) ,并且更高的 responsivity (8.7 V 湡杯湥牥瑡牯吗?? | Ankur Goswami Priyesh Dhandaria Soupitak Pal Ryan McGee Faheem Khan Zeljka Antic Ravi Gaikwad Kovur Prashanthi Thomas Thundat | 2017 | Nano Research2017，10，10： | 2 |
| 9 | Lymphocytic esophagitis: Still an enigma a decade later显示文摘Lymphocytic esophagitis (LE) is a clinicopathologic entity first described by Rubio et al in 2006. It is defined as peripapillary intraepithelial lymphocytosis with spongiosis and few or no granulocytes on esophageal biopsy. This definition is not widely accepted and the number of lymphocytes needed to make the diagnosis varied in different studies. Multiple studies have described potential clinical associations and risk factors for LE, such as old age, female gender and smoking history. This entity was reported in inflammatory bowel disease in the pediatric population but not in adults. Other associations include gastroesophageal reflux disease and primary esophageal motility disorders. The most common symptom is dysphagia, with a normal appearing esophagus on endoscopy, though esophageal rings, webs, nodularities, furrows and strictures have been described. Multiple treatment modalities have been used such as proton pump inhibitors and topical steroids. Esophageal dilation seems to be therapeutic when dysphagia is present along with esophageal narrowing secondary to webs, rings or strictures. The natural history of the disease remains unclear and needs to be better delineated. Overall, lymphocytic esophagitis seems to have a chronic and benign course, except for two cases of esophageal perforation in the literature, thought to be secondary to this entity. | Carol Rouphael Ilyssa O Gordon Prashanthi N Thota | 2017 | World Journal of Gastroenterology2017，23，6： | 2 |
| 10 | 食管闭锁和气管食管瘘患儿的长期结局显示文摘目的:评估食管闭锁合并(或不合并)气管食管瘘(EA/TEF)患儿的长期(不局限于儿童时期)并发症和临床结局。本研究旨在通过临床症状、诊断试验和治疗干预评估一家三甲医院EA/TEF患儿吞咽和呼吸系统并发症。方法:纳入2011-2014年间先天性EA/TEF患儿,收集这些患儿的人口统计特征、疾病分类和分型、临床症状、影像学、内镜下及支气管镜下发现及其治疗情况。结果:共计43例患儿纳入研究,其中以白人居多,中位年龄8岁(四分位间距320岁)。20例(62.5%,20/32)为C型异常(EA合并远端TEF)。21例(48.8%)有烧心症状,19例(44.1%)有反酸症状,31例(72.1%)吞咽固体食物困难。26例患儿接受钡餐检查,其中17例(65.4%)狭窄,20例(76.9%)动力不足,4例(15.4%)出现复发瘘。30例患儿接受上消化道内镜检查,其中21例(70.0%)发现狭窄,6例(20.0%)出现需外科干预的复发瘘。8例患儿行胃底折叠术。呼吸功能评估显示31例(72.1%)患儿有咳嗽和气梗,32例有呼吸困难和哮喘,19例(44.2%)患儿有反复的呼吸系统感染。其他发现包括气管软化(86.7%)和限制性肺病(54.5%)。结论:EA/TEF患儿残留的食管和气管具有较高的病理风险,需要长期随访来监测临床症状和治疗反应。 | Richard H.Cartabuke Rocio Lopez Prashanthi N.Thota | 2016 | Gastroenterology Report2016，4，4： | 2 |
| 11 | Risk for esophageal neoplasia in B arrett’s esophagus patients with mucosal changes indefinite for dysplasia显示文摘 | Bela Horvath Prabhdeep Singh Hao Xie Prashanthi N Thota Daniela S Allende Rish K Pai Deepa T Patil Thomas P Plesec John R Goldblum Xiuli Liu | 2015 | J Gastroenterol Hepatol2015，，： | 2 |
| 12 | Photocatalytic degradation of Azure and Sudan dyes using nano TiO2 显示文摘 | Aarthi T Prashanthi Narahari Giridhar Madras | 2007 | J Hazard Materi2007，149，3： | 1 |
| 13 | A broad-spectrum organophosphate pesticide O, O-dimethyl O-4-nitrophenyl phosphorothioate (methyl parathion) adversely affects the structure and function of male accessory reproductive organs in the rat 显示文摘 | Narayana K Prashanthi N Nayanatara A | 2006 | Environmental Toxicology and Pharmacology2006，22，： | 1 |
| 14 | A broad -spectrum organophosphate pesticide O, O-dimethyl O-4-nltrophenyl phosphorothioate (methyl parathion ) adversely affects the structure and function of male accessory reproductive organs in the rat显示文摘 | Narayana K Prashanthi N Nayanatara A | 2006 | Environmental Toxicology and Pharmacology2006，22，3： | 1 |
| 15 | Clinical outcomes in patients with a diagnosis of “indefinite for dysplasia” in Barrett’s esophagus: a multicenter cohort study显示文摘 | Preetika Sinh Rajeswari Anaparthy Patrick Young Srinivas Gaddam Prashanthi Thota Gokulakrishnan Balasubramanian Mandeep Singh April Higbee Sachin Wani Neil Gupta Amit Rastogi Sharad Mathur Ajay Bansal John Horwhat Brooks Cash Gary Falk David Lieberman Joh | 2015 | Endoscopy2015，，： | 1 |
| 16 | Bio- ethanol fermentation of concentrated rice straw hydrolysate using co-culture of Saccharomyces cerevisiae and Pichia stipitis 显示文摘 | Yadav K S Naseeruddin S Prashanthi G S | 2011 | Bioresource Technology2011，102，11： | 1 |
| 17 | Transforming cerebrospinal fluid Aβ42 measures into calculated Pittsburgh compound B units of brain Aβ amyloid显示文摘 | Stephen D. Weigand Prashanthi Vemuri Heather J. Wiste Matthew L. Senjem Vernon S. Pankratz Paul S. Aisen Michael W. Weiner Ronald C. Petersen Leslie M. Shaw John Q. Trojanowski David S. Knopman Clifford R. Jack | 2011 | Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association2011，，2： | 1 |
| 18 | Cyclophilin A Promotes Cardiac Hypertrophy in Apolipoprotein E–Deficient Mice显示文摘 | Kimio Satoh Patrizia Nigro Asad Zeidan Nwe Nwe Soe Fabrice Jaffré Masayoshi Oikawa Michael R. O?Dell Zhaoqiang Cui Prashanthi Menon Yan Lu Amy Mohan Chen Yan Burns C. Blaxall Bradford C. Berk | 2011 | Arteriosclerosis Thrombosis and Vascular Biology2011，，5： | 1 |
| 19 | Cognitively stimulating activities to keep dementia at bay显示文摘 | Prashanthi Vemuri Elizabeth C. Mormino | 2013 | Neurology2013，，4： | 1 |
| 20 | Effect of lifestyle activities on alzheimer disease biomarkers and cognition显示文摘 | Prashanthi Vemuri Timothy G. Lesnick Scott A. Przybelski David S. Knopman Rosebud O. Roberts Val J. Lowe Kejal Kantarci Mathew L. Senjem Jeffrey L. Gunter Bradley F. Boeve Ronald C. Petersen Clifford R. Jack | 2012 | Ann Neurol2012，，5： | 1 |
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