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| 1 | Constipation-predominant irritable bowel syndrome: A review of current and emerging drug therapies显示文摘Irritable bowel syndrome(IBS) is a highly prevalent medical condition that adversely affects patient quality of life and constitutes a significant economic burden on healthcare resources. A large proportion of patients suffer from the constipation subtype of IBS(IBS-C), most commonly afflicting older individuals and those with a lower socioeconomic status. Conventional pharmacologic and nonpharmacologic treatment options have limited efficacies and/or significant adverse events, which lead to increased long-term health care expenditures. Failure to effectively treat IBS-C patients over the past decades has largely been due to a poor understanding of disease pathophysiology, lack of a global view of the patient, and an inappropriate selection of patients and treatment endpoints in clinical trials. In recent years, however, more effective and safer drugs have been developed for the treatment of IBS-C. The advancement in the area of pharmacologic treatment is based on new knowledge of the pathophysiologic basis of IBS-C and the development of drugs with increased selectivity within pharmacologic classes with recognized efficacies. This narrative review covers the spectrum of available drugs and their mechanisms of action, as well as the efficacy and safety profiles of each as determined in relevant clinical trials that have investigated treatment options for IBS-C and chronic constipation. A brief summary of laxative-based treatment options is presented, followed by up-to-date assessments for three classes of drugs: prokinetics, prosecretory agents, and bile acid modulators. | Khaled A Jadallah Susan M Kullab David S Sanders | 2014 | World Journal of Gastroenterology2014，20，27： | 9 |
| 2 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 3 | Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3显示文摘 | Brooks P C Stromblad S Sanders L C | 1996 | Cell1996，85，5： | 4 |
| 4 | Evaluation of C-Reactive Protein Measurement for Assessing the Risk and Prognosis in Ischemic Stroke: A Statement for Health Care Professionals From the CRP Pooling Project Members显示文摘 | Mario Di Napoli Markus Schwaninger Roberto Cappelli Elena Ceccarelli Giacinto Di Gianfilippo Cristina Donati Hedley C.A. Emsley Sandro Forconi Stephen J. Hopkins Luca Masotti Keith W. Muir Anna Paciucci Francesca Papa Sabina Roncacci Dirk Sander Kerstin S | 2005 | Stroke2005，，6： | 2 |
| 5 | Architecture and IC implementation of a digital VRM controller显示文摘 | Peterchev A V Xiao Jinwen Sanders S R | 2003 | IEEE Transactions on Power Electronics2003，18，1： | 1 |
| 6 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 7 | CD4+ T,but not CD8+ or B,lymphocytes mediate facial motoneuron survival after facial nerve transection显示文摘 | Serpe CJ Coers S Sanders VM | 2003 | Brain Behav Immun2003，17，5： | 1 |
| 8 | An evaluation of automode, a computer-controlled ventilator mode, with the Siemens Servo 300A ventilator, using a porcine model显示文摘 | Holt S J Sanders RC Thurman TL | 2001 | Respir Care2001，46，1： | 1 |
| 9 | CD4+T,but not CD8+or B,lymphocytes mediate facial motoneuron survival after facial nerve transection显示文摘 | Serpe CJ Coers S Sanders VM | 2003 | Brain Rehav Immun2003，17，5： | 1 |
| 10 | Effect of fructose feeding on insulin secretion and insulin action in the rat显示文摘 | Zavaroni I Sander S Scott S | 1980 | Metabolism1980，29，： | 1 |
| 11 | Lyapunov-based control for switched power converters显示文摘 | Sanders S R Verghese G C | 1992 | IEEE Transactions on Power Electronics1992，7，1： | 1 |
| 12 | Cloning and expression profiling of testis-expressed microRNAs 显示文摘 | RO S PARK C SANDERS K M | 2007 | Developmental biology2007，311，2： | 1 |
| 13 | Pure and mixed gas CH4 and n-C4 H10 sorption and dilation inpoly (dimethylsiloxane) 显示文摘 | Raharjo R D Freeman B D Sanders E S | 2007 | J Membr Sci2007，292，： | 1 |
| 14 | Determination of organic acids in Vaccinium berry standard reference materials显示文摘 | Phillips M M Case R J Rimmer C A Sander L C Sharpless K E Wise S A Yen J H | 2010 | Analytical and Bioanalytical Chemistry2010，398，1： | 1 |
| 15 | Guidelines on smallbowel enterosco- py and capsule endoscopy in adults显示文摘 | Sidhu R Sanders D S Morris A J | 2008 | Gut2008，57，1： | 1 |
| 16 | Dexmedetomidine providescortical neuroprolection : impact on anaesthetic-induced neu-roapoptosis in the rat developing brain 显示文摘 | Sanders RD Sun P Patel S | 2010 | Acta AnaesthesiolScand2010，54，6： | 1 |
| 17 | Polynomial time algo- rithms for multicast network code construction显示文摘 | Jaggi S Sanders P Chou P A | 2005 | IEEE Transactions on Information Theory2005，51，6： | 1 |
| 18 | Systematic investigation of cracks in encapsulated solar cells after mechanical loading显示文摘 | Sander M Dietrich S Pander M | 2013 | Solar Energy Materials and Solar Cells2013，111，： | 1 |
| 19 | Fundamental impor- tance of Na+-Ca2+ exchange for the pacemaking mechanism in guinea-pig sino-atrial node显示文摘 | Sanders L Rakovic S Lowe M | 2006 | J Physiol2006，571，3： | 1 |
| 20 | Optimal State-Space Lumping in MarkowChains显示文摘 | Derisavi S Hermanns H Sanders W H | 2003 | Inf Proe Letters2003，87，6： | 1 |
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