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| 1 | Upper-gastrointestinal bleeding secondary to peptic ulcer disease:Incidence and outcomes显示文摘AIM:To evaluate the incidence,surgery,mortality,and readmission of upper gastrointestinal bleeding(UGIB)secondary to peptic ulcer disease(PUD).METHODS:Administrative databases identified all hospitalizations for UGIB secondary to PUD in Alberta,Canada from 2004 to 2010(n=7079)using the International Classification of Diseases Codes(ICD-10).A subset of the data was validated using endoscopy reports.Positive predictive value and sensitivity with 95%confidence intervals(CI)were calculated.Incidence of UGIB secondary to PUD was calculated.Logistic regression was used to evaluate surgery,in-hospital mortality,and 30-d readmission to hospital with recurrent UGIB secondary to PUD.Co-variants accounted for in our logistic regression model included:age,sex,area of residence(i.e.,urban vs rural),number of Charlson comorbidities,presence of perforated PUD,undergoing upper endoscopy,year of admission,and interventional radiological attempt at controlling bleeding.A subgroup analysis(n=6356)compared outcomes of patients with gastric ulcers to those with duodenal ulcers.Adjusted estimates are presented as odds ratios(OR)with95%CI.RESULTS:The positive predictive value and sensitivity of ICD-10 coding for UGIB secondary to PUD were85.2%(95%CI:80.2%-90.2%)and 77.1%(95%CI:69.1%-85.2%),respectively.The annual incidence between 2004 and 2010 ranged from 35.4 to 41.2 per100000.Overall risk of surgery,in-hospital mortality,and 30-d readmission to hospital for UGIB secondary to PUD were 4.3%,8.5%,and 4.7%,respectively.Interventional radiology to control bleeding was performed in 0.6%of patients and 76%of these patients avoided surgical intervention.Thirty-day readmission significantly increased from 3.1%in 2004 to 5.2%in 2010(OR=1.07;95%CI:1.01-1.14).Rural residents(OR rural vs urban:2.35;95%CI:1.83-3.01)and older individuals(OR≥65 vs<65:1.57;95%CI:1.21-2.04)were at higher odds of being readmitted to hospital.Patients with duodenal ulcers had higher odds of dying(OR=1.27;95%CI:1.05-1.53),requiring surgery(OR=1.73;95%CI:1.34-2.23),and being readmitted to hospital(OR=1.54;95%CI:1.19-1.99)when compared to gastric ulcers.CONCLUSION:UGIB secondary to PUD,particularly duodenal ulcers,was associated with significant morbidity and mortality.Early readmissions increased over time and occurred more commonly in rural areas. | Samuel Quan Alexandra Frolkis Kaylee Milne Natalie Molodecky Hong Yang Elijah Dixon Chad G Ball Robert P Myers Subrata Ghosh Robert Hilsden Sander Veldhuyzen van Zanten Gilaad G Kaplan | 2014 | World Journal of Gastroenterology2014，20，46： | 21 |
| 2 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 3 | Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3显示文摘 | Brooks P C Stromblad S Sanders L C | 1996 | Cell1996，85，5： | 4 |
| 4 | ATG16L1 and NOD2 polymorphisms enhance phagocytosis in monocytes of Crohn's disease patients显示文摘AIM:To investigate if the presence of relevant genetic polymorphisms has effect on the effectual clearance of bacteria by monocytes and granulocytes in patients with Crohn’s disease(CD).METHODS:In this study,we assessed the differential responses in phagocytosis by measuring the phagocytic activity and the percentage of active phagocytic monocytes and granulocytes in inflammatory bowel disease patients as well as healthy controls.As both autophagy related like 1(ATG16L1)and immunityrelated guanosine triphosphatase gene are autophagy genes associated with CD and more recently nucleo-tide-binding ligomerization domain-containing protein2(NOD2)has been identified as a potent inducer of autophagy we genotyped the patients for these variants and correlated this to the phagocytic reaction.The genotyping was done with restriction fragment length polymorphisms analysis and the phagocytosis was determined with the pHrodo?Escherichia coli Bioparticles Phagocytosis kit for flowcytometry.RESULTS:In this study,we demonstrate that analysis of the monocyte and granulocyte populations of patients with CD and ulcerative colitis showed a comparable phagocytic activity(ratio of mean fluorescence intensity)between the patient groups and the healthy controls.CD patients show a significantly higher phagocytic capacity(ratio mean percentage of phagocytic cells)compared to healthy controls(51.91%±2.85%vs 37.67%±7.06%,P=0.05).The extend of disease was not of influence.However,variants of ATG16L1(WT:2.03±0.19 vs homozygoot variant:4.38±0.37,P<0.009)as well as NOD2(C-ins)(heterozygous variant:42.08±2.94 vs homozygous variant:75.58±4.34(P=0.05)are associated with the phagocytic activity in patients with CD.CONCLUSION:Monocytes of CD patients show enhanced phagocytosis associated with the presence of ATG16L1 and NOD2 variants.This could be part of the pathophysiological mechanism resulting in the disease. | Simone CS Wolfkamp Caroline Verseyden Esther WM Vogels Sander Meisner Kirsten Boonstra Charlotte P Peters Pieter CF Stokkers Anje A te Velde | 2014 | World Journal of Gastroenterology2014，20，10： | 2 |
| 5 | Elastic and tensile behavior of nanocrystalline copper and palladium显示文摘 | Sanders P G Eastman J A Weertman J R | 1997 | Acta Mater1997，45，10： | 2 |
| 6 | The effect of the hurricane Katrina disaster on sexual behavior and access to reproductive care for young women in New Orleans显示文摘 | Kissinger P Schmidt N Sanders C | 2007 | Sex Transm Dis2007，34，11： | 1 |
| 7 | Operative treatment in 120 displaced intraarticular calcaneal fracture,results using aprognostic to mography scarl classification显示文摘 | Sanders R Fortin P Dispaqule T | 1993 | Clin Orthop1993，290，： | 1 |
| 8 | Operative treatment in 120 displaced intraarticular calcaneal fractures显示文摘 | Fortin P | 1993 | Clin Orthop1993，290，： | 1 |
| 9 | Operative treatment of intra-articular fractures of the calcaneus显示文摘 | Gregory P | 1995 | J Orthop Clin North(Am)1995，26，2： | 1 |
| 10 | Operative treatment in 120 displaced intraarticular Calcaneal fractures: results using a prognostic computed lomography scan classif-Ication显示文摘 | SANDERS R FORTIR P | 1993 | Clin Orthop Relat Res1993，，290： | 1 |
| 11 | Fractionated at rial electrograms during sinus rhythm:relationship to age,voltage,and conduction velocity显示文摘 | Roberts-Thomson KC Kistler PM Sanders P | 2009 | Heart Rhythm2009，6，5： | 1 |
| 12 | Absolute oral bioavailability and residues of florfenicol in the rainbow trout (Oncorynchus mykiss)显示文摘 | Pinault L P Millot L K Sanders P J | 1997 | J Vet Pharmacol Therap1997，20，1： | 1 |
| 13 | Role of nitric oxide synthesis in salt-sensitive hypertension in Dahl/Rapp rats显示文摘 | Chen P Sanders P | 1993 | Hypertension1993，22，： | 1 |
| 14 | Electrical remodeling ofthe atria in congestive heart failure : electrophysiological and elec-troanatomic mapping in humans显示文摘 | Sanders P Morton JB Davidson NC | 2003 | Circulation2003，108，12： | 1 |
| 15 | Microparticles: major transport vehicles for distinct microRNAs in circulation 显示文摘 | Diehl P Fricke A Sander L | 2012 | Cardiovasc Res2012，93，4： | 1 |
| 16 | Dexmedetomidine providescortical neuroprolection : impact on anaesthetic-induced neu-roapoptosis in the rat developing brain 显示文摘 | Sanders RD Sun P Patel S | 2010 | Acta AnaesthesiolScand2010，54，6： | 1 |
| 17 | No Significant Association of 14 Candidate Genes With Schizophrenia in a Large European Ancestry Sample: Implications for Psychiatric Genetics显示文摘 | Sanders Alan R Duan Jubao Levinson Douglas F Shi Jianxin He Deli Hou Cuiping Burrell Gregory J Rice John P Nertney Deborah A Olincy Ann Rozic Pablo Vinogradov Sophia Buccola Nancy G Mowry Bryan J Freedman Robert Amin Farooq Black Donald W | 2008 | The American Journal of Psychiatry2008，，4： | 1 |
| 18 | Polynomial time algo- rithms for multicast network code construction显示文摘 | Jaggi S Sanders P Chou P A | 2005 | IEEE Transactions on Information Theory2005，51，6： | 1 |
| 19 | Operative treatment in 120 displaced intraarticular calcaneal fractures: results using a prognostic computed tomography scan classification 显示文摘 | Sanders R Fortin P DiPasquale T | 1993 | Clin Orthop Relat Res1993，，290： | 1 |
| 20 | Operative treat of 120 dl plac intra-articular calaneal fractures:Results using a postic computed tomography scan classification显示文摘 | Fortin P Dipasquale T | 1993 | Clin Orthop1993，290，： | 1 |
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