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| 1 | 肝脏移植治疗不可切除结直肠癌肝转移的前瞻性试验性研究显示文摘背景和目的无法手术切除的结直肠癌肝转移(Colorectal Liver Metastases,CLMs)患者预后差,存活时间极少超过5年。尽管对部分肝脏原发及继发恶性肿瘤患者施行肝脏移植可获得较佳的预后,但目前仍普遍认为,结直肠癌肝转移是肝移植的绝对禁忌证。1995年之前,曾针对结直肠癌肝转移患者进行过数例肝脏移植,但预后不良(5年生存率仅为18%),自此放弃对此类患者进行肝脏移植。然而,目前总体肝移植生存率较当时提高30%左右。基于此,结直肠癌肝转移患者肝移植后的5年生存率有望达到50%。因此,本试验性研究旨在探讨CLM患者在接受肝移植后的潜在长期生存获益。方法自2006年11月到2011年3月,在此项前瞻性、试验性研究中,共对21名无法切除的结直肠癌肝转移患者进行肝移植术。患者入选标准包括一般状况良好(ECOG 1分或以下)、结直肠癌伴无法切除的单纯肝转移、原发肿瘤已行根治性切除以及移植前接受过至少6周的化疗。结果入组的患者肝脏肿瘤负荷及原发肠癌T/N分期相异;肝移植术前,76%(16/21)患者存在至少一线化疗进展。Kaplan-Meier推算患者1、3及5年总体生存率分别为95%、68%及60%。与预期相同,移植术后复发转移现象普遍,21例中19例在中位时间6(2~24)个月内发生局部复发或转移。其中,单个肺转移灶7例;其余多部位(包括肺)转移者9例,包括移植肝新发转移7例,骨转移5例,卵巢或肾上腺转移3例,腹膜转移1例,腹主动脉旁淋巴结转移2例。2例发生直肠癌局部复发。然而,绝大多数的转移癌可经手术切除或射频治疗,且经过干预后,中位随访时间27个月(8~60个月),33%(7例)患者无病生存。肝移植术前肝脏肿瘤负荷、初次手术距肝移植的时间(肠癌切除距肝移植超过2年者生存获益更显著)以及化疗后肿瘤进展均为影响预后的显著性因素。结论研究结果表明,对于此类患者人群,肝移植术后总体生存率显著高于化疗,而化疗为该患者人群现有的唯一治疗方式。此外,本研究显示的总体生存率与可切除的结直肠癌肝转移患者以及接受再次肝移植的非恶性肿瘤患者情况相当。同时,对预后因素进行手术策略筛选,应可进一步改善患者预后。(临床研究注册编号ClinicalT rials.gov:NCT01311453)。 | Hagness M Foss A Line PD 张信华 | 2013 | 消化肿瘤杂志(电子版)2013，5，4： | 8 |
| 2 | Clinical outcomes of tricuspid valve repair accompanying left-sided heart disease显示文摘AIM To determine whether the need for additional tricuspid valve repair is an independent risk factor when surgery is required for a left-sided heart disease.METHODS One hundred and eighty patients(68 ± 12 years,79 males) underwent tricuspid annuoplasty.Cox proportionalhazards regression model for multivariate analysis was performed for variables found significant in univariate analyses.RESULTS Tricuspid regurgitation etiology was functional in 154 cases(86%),organic in 16 cases(9%),and mixed in10 cases(6%),respectively.Postoperative mortality at 30 days was 11.7%.Mean follow-up was 51.7 mo with survival at 5 years of 73.5%.Risk factors for mortality were acute endocarditis [hazard ratio(HR) = 9.22(95%CI:2.87-29.62),P < 0.001],ischemic heart disease requiring myocardial revascularization [HR = 2.79(1.26-6.20),P = 0.012],and aortic valve stenosis [HR = 2.6(1.15-5.85),P = 0.021].Significant predictive factors from univariate analyses were double-valve replacement combined with tricuspid annuloplasty [HR = 2.21(1.11-4.39),P = 0.003] and preoperatively impaired ejection fraction [HR = 1.98(1.04-3.92),P = 0.044].However,successful mitral valve repair showed a protective effect [HR = 0.32(0.10-0.98),P = 0.046].Additionally,in instances where tricuspid regurgitation required the need for concomitant tricuspid valve repair,mortality predictor scores such as Euroscore 2 could be shortened to a simple Euroscore-tricuspid comprised of only 7 inputs.The explanation may lie in the fact that significant tricuspid regurgitation following leftsided heart disease represents an independent risk factor encompassing several other factors such as pulmonary arterial hypertension and dyspnea.CONCLUSION Tricuspid annuloplasty should be used more often as a concomitant procedure in the presence of relevant tricuspid regurgitation,although it usually reveals an overly delayed correction of a left-sided heart disease. | Kasra Azarnoush Ahmad S Nadeemy Bruno Pereira Massoud A Leesar Céline Lambert Alaa Azhari Vedat Eljezi Nicolas Dauphin Etienne Geoffroy Lionel Camilleri | 2017 | World Journal of Cardiology2017，9，10： | 4 |
| 3 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 4 | Effect of yeast-supplemented feed on Salmonella and Campylobacter populations in broilers显示文摘 | LINE J E BAILEY J S COX N A | 1998 | Poultry Science1998，77，3： | 1 |
| 5 | The stiffness of agricultural tractor tyres显示文摘 | Lines J A Murphy K | 1991 | Journal of Terramechanics1991，28，1： | 1 |
| 6 | A machine for measuring the suspension characteristics of agricultural tyres 显示文摘 | Lines J A Young N A | 1989 | Journal of Terramechanics1989，26，34： | 1 |
| 7 | Nonpoint Source显示文摘 | Line D E Richar R A McLaughlin | 1997 | Water Envi- ronment Research1997，69，4： | 1 |
| 8 | A comparison of the shock index and conventional vital signs to identify acute, critical illness in the emergency department显示文摘 | RADY M Y SMITH LINE H A BLAKE H | 1994 | Am Emerg Med1994，24，： | 1 |
| 9 | Characterisation of tumour-associated antigens in colon cancer显示文摘 | SLUCKA Z STENGREVICS A | 2002 | Cancer Immunol Immunother2002，51，10： | 1 |
| 10 | Ultra- sound velocity measurement to determine lipid content in salmon muscle :the effects of myosepta显示文摘 | SHANNON R A PROBERT - SMITH P J LINES J | 2004 | Food Research International2004，37，： | 1 |
| 11 | Non-point source显示文摘 | Line D E Mclaughin R A Osmond D L | 1998 | Water Environment Research1998，70，4： | 1 |
| 12 | Experimental analysis of floc size distribution and hydrodynamics in a jar-test 显示文摘 | Bouyer D Line A Cockx A Do-quang Z | 2001 | Chemical Engineering Research and Design2001，79，8： | 1 |
| 13 | Identification of tumour antigens by serological analysis of cDNA expression cloning 显示文摘 | Li G Miles A Line A | 2004 | Cancer Immunol Immunother2004，53，3： | 1 |
| 14 | An automatic image-based system for estimating the mass of free-swimming fish显示文摘 | Lines J A Tillett R D Ross L G | 2001 | Computers and Electronics in Agriculture2001，31，2： | 1 |
| 15 | The effect of intravenous opioid patient-controlled analgesia with and without background infusion on respiratory depression: a Meta-analysis显示文摘 | GEORGE J A LINE E HANNA M N | 2010 | J Opioid Manag2010，6，1： | 1 |
| 16 | Nonpoint sources显示文摘 | Line D E Mclaughlin R A Osmond D L | 1998 | Water Environment Research1998，70，4： | 1 |
| 17 | Complications of intra-articular calca- nael Iractrues显示文摘 | LINE V A LEUNG J P F | 2001 | Clin Orthop Relat Res2001，，391： | 1 |
| 18 | Numerical Simulating and Physical Modeling of the Hydrodynamics in an Air-lift Internal Loop Reactor 显示文摘 | Cockx A Line A Rosustan M | 1997 | Chemical Engineering Science1997，52，2122： | 1 |
| 19 | Cooperative inversion of geophysical data 显示文摘 | Lines L Schultz A K Treitel S | 1987 | Expanded Abstracts of 57^th Annual International SEG Meeting1987，，： | 1 |
| 20 | Changes in water status in Peach buds on induction development and release from dormancy显示文摘 | EREZ A FAUST M LINE M J | 1998 | Scien- tia Horticulturae1998，73，23： | 1 |
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