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| 1 | Systematic review and meta-analysis on the association of tuberculosis in Crohn's disease patients treated with tumor necrosis factor-α inhibitors(Anti-TNFα)显示文摘AIM To perform a meta-analysis on the risk of developing Mycobacterium tuberculosis(TB) infection in Crohn's disease(CD) patients treated with tumor necrosis factoralpha(TNFα) inhibitors.METHODS A meta-analysis of randomized, double-blind, placebocontrolled trials of TNFα inhibitors for treatment of CD in adults was conducted. Arcsine transformation of TB incidence was performed to estimate risk difference. A novel epidemiologically-based correction(EBC) enabling inclusions of studies reporting no TB infection cases in placebo and treatment groups was developed to estimate relative odds.RESULTS Twenty-three clinical trial studies were identified, including 5669 patients. Six TB infection cases were reported across 5 studies, all from patients receiving TNFα inhibitors. Eighteen studies reported no TB infection cases in placebo and TNFα inhibitor treatment arms. TB infection risk was significantly increased among patients receiving TNFα inhibitors, with a risk difference of 0.028(95%CI: 0.0011-0.055). The odds ratio was 4.85(95%CI: 1.02-22.99) with EBC and 5.85(95%CI: 1.13-30.38) without EBC.CONCLUSION The risk of TB infection is higher among CD patients receiving TNFα inhibitors. Understanding the immunopathogenesis of CD is crucial, since using TNFα inhibitors in these patients could favor mycobacterial infections, particularly Mycobacterium avium subspecies paratuberculosis, which ultimately could worsen their clinical condition. | Brent L Cao Ahmad Qasem Robert C Sharp Latifa S Abdelli Saleh A Naser | 2018 | World Journal of Gastroenterology2018，24，25： | 4 |
| 2 | 急性儿茶酚胺暴露引起可逆的无心脏细胞再生的心肌细胞损伤显示文摘儿茶酚胺增加心脏收缩力,但暴露于高浓度儿茶酚胺或长时间暴露可引起心脏损伤。最近的一项研究表明,小鼠单次皮下注射异丙肾上腺素(isoproterenol,ISO;200 mg/kg)导致急性心肌细胞死亡(8%-10%),但在1个月之内心脏完整修复。心脏再生是通过内源性原癌基因蛋白质cKit+心脏干细胞介导新的心肌细胞形成。 | 刘莉 叶鹏 Wallner M Duran JM Mohsin S Troupes CD Vanhoutte D Borghetti G Vagnozzi RJ Gross P Yu D Trappanese DM Kubo H Toib A Sharp TE Harper SC Volkert MA Starosta T Feldsott EA Berretta RM Wang T Barbe MF Molkentin JD Houser SR | 2016 | 中华高血压杂志2016，24，8： | 4 |
| 3 | Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1–2 trial显示文摘 | Xin Shelley Wang Laurence D Rhines Almon S Shiu James N Yang Ugur Selek Ibrahima Gning Ping Liu Pamela K Allen Syed S Azeem Paul D Brown Hadley J Sharp David C Weksberg Charles S Cleeland Eric L Chang | 2012 | Lancet Oncology2012，，4： | 2 |
| 4 | Prognostic value of baseline FDG uptake on PET-CT in esophageal carcinoma显示文摘AIM: To evaluate the influence of baseline maximum standardized uptake value(SUVmax) on survival in a cohort of patients, undergoing positron emission tomography-computed tomography(PET-CT) scan for esophageal carcinoma. METHODS: The pre-treatment SUVmax numeric reading was determined in patients with confirmed esophageal or junctional cancer having PET-CT scan during the time period 1st January 2007 until 31 st July 2012. A minimum follow up of 12 mo was required. Patients were subdivided into quartiles according to SUVmax value and the influence of SUVmax on survival was assessed using univariate and multivariate analysis. The following pre-treatment factors were investigated: patient characteristics, tumor characteristics and planned treatment. RESULTS: The study population was 271 patients(191male) with esophageal or junctional carcinoma. The median age was 65 years(range 40-85) and histologic subtype was adenocarcinoma in 197 patients and squamous carcinoma in 74 patients. The treatment intent was radical in 182 and palliative in 89 patients. SUVmax was linked to histologic subtype(P = 0.008), tumor site(P = 0.01) and Union for International Cancer Control(UICC) stage(P < 0.001). On univariate analysis, prognosis was significantly associated with SUVmax(P = 0.001), T-stage(P < 0.001) and UICC stage(P < 0.001). On multivariate analysis, only T-stage and UICC stage remained significant. CONCLUSION: Pretreatment SUVmax was not a useful marker in isolation for determining prognosis of patients with esophageal carcinoma. | Omar S Al-Taan Amar Eltweri David Sharpe Peter M Rodgers Sukhbir S Ubhi David J Bowrey | 2014 | World Journal of Gastrointestinal Oncology2014，6，5： | 2 |
| 5 | Herbicides OK for turfgrass with harvesting delay after application显示文摘 | Sharpe S | 1988 | Highlights of Agricultural Research1988，35，2： | 2 |
| 6 | Cholesterol and blood pressure loeing effects of immune milk显示文摘 | SARP S J GAMBLE G D SHARP D N | 1994 | Am J Clin Nutr1994，59，： | 2 |
| 7 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 8 | The impact of postnatal depression on boys'intellectual development 显示文摘 | Sharp D Hay DF Pawlby S | 1995 | J Child Psycol Psychiatry1995，36，8： | 1 |
| 9 | Prevention of SIV rectal transmission and priming of T cell responses in macaques after local pre-exposure application of tenofovir gel 显示文摘 | Cranage M Sharpe S Herrera C | 2008 | PLoS Med2008，5，8： | 1 |
| 10 | Activities of several noveloxazolidinones against Mycobacterium tuberculosis in a murine model显示文摘 | Cynamon M H Klemens S P Sharpe C A | 1999 | Atimicrob AgentsChemother1999，43，： | 1 |
| 11 | Molecular identification of the ischemic penumbra 显示文摘 | Weinstein PR Hong S Sharp FR | 2004 | Stroke2004，35，11： | 1 |
| 12 | Expression and Regulation of Lhx6 and Lhx7, a Novel Subfami?ly of LIM Homeodomain Encoding Genes, Suggests a Role in Mammalian Head Development显示文摘 | GRIGORIOU M TUCKER A S SHARPE P T | 1998 | Development1998，125，11： | 1 |
| 13 | Plasma fibrinogen andcoronar y heart disease in elderly Japanese-American men 显示文摘 | Sharp D S Abbott R D Burchfied C M | 1996 | Arterioscler Thromb Vase Biol1996，16，2： | 1 |
| 14 | Pediatrics:diagnosis of neuroblastoma显示文摘 | Sharp S E Gelfand M J Shulkin B L | 2011 | Semin Nucl Med2011，41，5： | 1 |
| 15 | Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increased HDL levels显示文摘 | Zhong S Sharp DS Grove JS | 1996 | J Clin Invest1996，97，： | 1 |
| 16 | Photodynamic therapy with verteporfin for choroidal neovascularisation due to age-related macular degeneration and other causes:a New Zealand outcomes study显示文摘 | Sharp DM Lai S Markey CM | 2007 | Clinical and Experimental Ophthamology2007，35，： | 1 |
| 17 | Agency theory and escalation of commitment:do small national culture difference matter? 显示文摘 | SALTER S SHARP D | 2001 | The International Journal of Accounting2001，36，1： | 1 |
| 18 | Wild ducks are he reservoir for only a limited number of influenza A subtype显示文摘 | Sharp G Kawaoka Y Wright S M | 2005 | Epidemiol Infect2005，110，： | 1 |
| 19 | Optimal linear time-invariant preview steering control for motorcycles显示文摘 | R S Sharp | 2006 | Vehicle System Dynamics2006，44，9： | 1 |
| 20 | Induction of antibody responses to African horse sickness virus (AHSV) in ponies after vaccination with recombinant modified vaccinia Ankara (MVA)显示文摘 | Chiam R Sharp E Maan S | 2009 | PLoS One2009，4，6： | 1 |
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