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| 1 | Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer显示文摘Inflammatory bowel diseases are characterised by inflammation that compromises the integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has evolved complex mechanisms to control and regulate bacterial interactions with the mucosal surface. Apical tight junction proteins are critical in the maintenance of epithelial barrier function and control of paracellular permeability. The characterisation of alterations in tight junction proteins as key players in epithelial barrier function in inflammatory bowel diseases is rapidly enhancing our understanding of critical mechanisms in disease pathogenesis as well as novel therapeutic opportunities. Here we give an overview of recent literature focusing on the role of tight junction proteins, in particular claudins, in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer. | Jonathan Landy Emma Ronde Nick English Sue K Clark Ailsa L Hart Stella C Knight Paul J Ciclitira Hafid Omar Al-Hassi | 2016 | World Journal of Gastroenterology2016，22，11： | 39 |
| 2 | Reduction of Cancer Risk With an Oral Supplement of Selenium显示文摘The hypothesis that a dietary Supplement of selenium (Se) may reduce cancer risk was tested experimetally in humans. Patients with histories of basal/squarnous cell carcinomas of the skin were assigned randomly in double-blind fashion to dally oral supplements of either Seenriched yeast (200 μg Se/day), or a low-Se yeast placebo. A total of 1312 patients recruited in 1983-1990 were followed with regular dermatologic examinations through 1993 for a total of 8269 person-years of observation. Skin cancer diagnoses were confirmed histologically.Plasma Se concentration was determined at 6-12 months intervals. All deaths and patient-reported illnesses were recorded; reported cancers were confirmed and documented by consultation with the patient medical care providers. The results indicate that Se did not significantly affect the primary endpoints: incidences of recurrent basal/squarnous cell carcinomas of the skin. However, Setreatment was associated with reductions in several secondary endpoints:total mortality, mortality from all cancers combined, as well as the incidence of all cancers combined, lung cancer, colorectal cancer and prostate cancer. The consistencies of these associations over time, between study clinics and for the leading cancer sltes strongly suggests benefits of Se-supplementation for this cohort of patients, supporting the hypopthesis that supplemental Se can reduce cancer risk. Although Se did no shown protective effects against nonmelanoma skin cancers, the suggested reductions in risks to other frequent cancers demand further evaluation in well controlled cliflical intervention | G·F·COMBSJR L·C·CLARK 等 | 1997 | Biomedical and Environmental Sciences1997，10，2： | 21 |
| 3 | 木薯产品营养成分的分析与比较研究显示文摘本试验对3种木薯产品及玉米对照样品的主要营养成分包括粗蛋白质、粗脂肪、粗纤维、粗灰分、无氮浸出物、总淀粉、支链淀粉、直链淀粉、氨基酸、非淀粉多糖、矿物质的含量及其体外干物质和淀粉消化率、淀粉颗粒特征等指标进行了比较研究。结果表明,与玉米对照相比,木薯产品粗蛋白质和氨基酸含量较低,蛋白质品质低劣;木薯粒粗脂肪、粗纤维、粗灰分含量均显著高于玉米(P<0.05);木薯渣无氮浸出物含量显著低于木薯干(P<0.05),而粗灰分和粗纤维含量均显著高于木薯干和玉米(P<0.05);木薯干和木薯粒的总淀粉含量与玉米相当,但直链淀粉/支链淀粉比值显著低于玉米(P<0.05),木薯渣中抗性淀粉含量显著高于其他木薯产品和玉米对照(P<0.05),玉米淀粉粒形态为不规则多面体,而木薯淀粉粒形态似球形;木薯产品中钙、钾、铁和锰的含量均显著高于玉米(P<0.05),而磷和锌的含量均显著低于玉米(P<0.05);玉米中可溶性非淀粉多糖(SNSP)含量显著低于3种木薯产品,且木薯渣中SNSP含量显著高于木薯干和木薯粒(P<0.05);木薯渣中不溶性非淀粉多糖含量显著高于木薯干和木薯粒(P<0.05),且其不溶性半乳糖的含量显著高于其他木薯产品及玉米(P<0.05);木薯粒干物质和淀粉消化率均显著高于木薯干、木薯渣和玉米(P<0.05),木薯渣干物质和淀粉消化率均显著低于玉米和木薯干(P<0.05)。本研究结果对木薯产品在饲料中的应用有一定的指导意义。 | 唐德富 Iji P Choct M 汝应俊 宋淑玉 Clarke K L | 2014 | 中国畜牧兽医2014，41，9： | 15 |
| 4 | 母猪难产的应对措施显示文摘当今猪生产系统中母猪难产并不常见,所占比例不到1%。母猪临近分娩时,大约每隔30~60分钟需进行产前观察。如果清楚母猪正常分娩过程,母猪出现难产时可第一时间采取相关措施。分娩前要保证分娩环境清洁和干燥(图1);预产期前1~5天将妊娠母猪赶往分娩栏(图2)。 | Singleton W Amass S F Clark L K 朱勇文 | 2012 | 养猪2012，，1： | 4 |
| 5 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 6 | The prevalence and etiology of elevated aminotransferase levels in the United States显示文摘 | Jeanne M Clark Frederick L Brancati Anna Mae Diehl | 2003 | The American Journal of Gastroenterology2003，，5： | 2 |
| 7 | Circular voided slab stiffness显示文摘 | ELLIOT G CLARK L A | 1982 | Journal of the Structural Division ASCE1982，108，11： | 2 |
| 8 | p38 mitogen-actiated protein kinase regulates cycloxxygenase - 2 mRNA stability and transcription in ipopolysacharide-treated human monocytes显示文摘 | Dean J L Brook M Clark A R | 1999 | J Biol Chen1999，274，： | 1 |
| 9 | Bevacizumab in combination with oxaliplatin - based chemotherapy as first - line therapy in metastatic colorectal cancer: a randomized phase Ⅲ study显示文摘 | SALTZ L B CLARKE S DIAZ -RUBIO E | 2008 | J Clin Oncol2008，26，12： | 1 |
| 10 | Ex Vivo adipose tissue engineering by human marrow stromal cell seeded gelat in sponge 显示文摘 | Hong L Peptan I Clark P | 2005 | Ann Biomed Eng2005，33，4： | 1 |
| 11 | Ceil contact as an independent factor moduletating cardiac myocytes hypertrophy and survival in long-term primary culture显示文摘 | Clark W A Decker M L Janes D M | 1998 | J Mol Cell Cardiol1998，30，： | 1 |
| 12 | Matemal exporsure to genisteinduring pregnancy increases carcinogen - induced mammary tumorigenesis in feinale rat offspring 显示文摘 | Hilakivi · Clarke L Cho E Onojafe I | 1999 | Oncelogy Reports1999，6，10： | 1 |
| 13 | Fixed abrasive diamond wire machining-part Ⅰ:process monitoring and wire tension force显示文摘 | Shih A J Hardin C W Lemaster R L McSpadden S B | 2003 | International Journal Machine Tools & Manufacture2003，43，： | 1 |
| 14 | Oxidative renaturation of lysozyme at high concentrations显示文摘 | Hevehan D L Clark E D B | 1997 | Biotech and Bioeng1997，54，3： | 1 |
| 15 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 16 | Catalytic aspects of the steam reforming of hydrocarbons in in- ternal reforming fuel cells显示文摘 | Clarke S H Dicks A L Pointon K | 1997 | Catalysis Today1997，38，： | 1 |
| 17 | Use of a peptide rather than free amino acid nitrogen source in chemically defined 'elemental' diets显示文摘 | SILK D B A FAIRCLOUGH P D CLARK M L | 1980 | Journal of Parenteral and Enteral Nutrition1980，4，： | 1 |
| 18 | Preferential interaction of Salmonella typhimurium with mouse Peyer's patch M cells显示文摘 | CLARK M A JEPSON M A SIMMONS N L | 1994 | Res Microbiol1994，145，7： | 1 |
| 19 | Design, synthesis, and anfiviral activity of 2'-deoxy- 2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication显示文摘 | CLARK L J HOLLECKER L MASON C J | 2005 | J Med Chem2005，48，17： | 1 |
| 20 | Catalytic spans of the steam reforming of hydrocarbons in internal reforming fuel cells显示文摘 | CLARKE S H DICKS A L POINTON K | 1997 | Catal Today1997，38，4： | 1 |
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