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| 1 | Adenoid cystic carcinoma of breast: Recent advances显示文摘Adenoid cystic carcinoma(ACC) of the breast is a rare special subtype of breast cancer characterized by the presence of a dual cell population of luminal and basaloid cells arranged in specific growth patterns. Most breast cancers with triple-negative, basal-like breast features(i.e., tumors that are devoid of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression, and express basal cell markers) are generally high-grade tumors with an aggressive clinical course. Conversely, while ACCs also display a triple-negative, basal-like phenotype, they are usually low-grade and exhibit an indolent clinical behavior. Many discoveries regarding the molecular and genetic features of the ACC, including a specific chromosomal translocation t(6;9) that results in a MYB-NFIB fusion gene, have been made in recent years. This comprehensive review provides our experience with ACC of the breast, as well as an overview of clinical, histopathological, and molecular genetic features. | Kosuke Miyai Mary R Schwartz Mukul K Divatia Rose C Anton Yong Wook Park Alberto G Ayala Jae Y Ro | 2014 | World Journal of Clinical Cases2014，2，12： | 16 |
| 2 | Endothelial progenitor cell differentiation using cryopreserved,umbilical cord blood-derived mononuclear cells显示文摘瞄准:调查 umbilicalcord 血(UCB ) 的 endothelial 区别潜力,我们导致了 endothelial 祖先房间(EPC ) 的区别 fromcryopreserved 导出 UCB 的 mononuclear 房间(MNC ).Methods:从 cryopreserved UCB 和 peripheralblood ( PB )的 MNC 在与为由 RT-PCR ,流动 cytometry ,和 immunocytochemistry analysis.The 的 14 d.EPC werecharacterized 的 endothelial 房间生长补充中等的 M199 是有教养的增长 ofdifferentiated EPC 被3-( 4,5-dimethylthiazol-2-yl )学习 -2,5-diphenyl-tetrazolium 溴化物( MTT )试金,并且脉管的 endothelial 生长因素( VEGF )集中用 导出UCB 的 EPC 的 ELISAkit.Characteristics 被测量与 导出PB 的 EPC.Res 的那些相比 numberof 塑造回合的房间泛泛地在 24 h 文化以后被纳入底部,并且 塑造numerousspindle 的房间开始在 d 上从塑造回合的出现了 7 个 .Those 房间 expressedendothelial 标记例如, Flt-l/VEGFR-1 , ecNOS , VE-cadherin , von Willebrand 因素,并且从 PB 和 UCB 的 EPC 的 endothelial 标记的 secretedVEGF.The 模式没证明 VEGF 的增长和分泌物的 strikingdifferences.The 结果也是 similar.Conclusion :与 endothelialcells.Those EPC 的质量在 -196 ° C 存储进房间的 Wesuccessfully 有教养的 UCB 房间能由激活提高 angiogenesis 的邻近的 endothelial cellsand 被用于 angiogenic 治疗学。 | Jun-ho JANG Sun-kyung KIM Jeong-eun CHOI Young-jin KIM Hyun-woo LEE Seok-yun KANG Joon-seong PARK Jin-hyuk CHOI Ho-yeong LIM Hugh C KIM | 2007 | Acta Pharmacologica Sinica2007，28，3： | 11 |
| 3 | 干扰素调节因子5通过损伤胞葬作用控制动脉粥样硬化病变中的坏死核心形成显示文摘髓系细胞是动脉粥样硬化病变发展和易损斑块形成的核心。动脉吞噬细胞吸收凋亡细胞(胞葬作用)的能力受损,可促进病变生长并建立坏死核心。干扰素调节因子(interferon regulatory factor,IRF)5是髓系细胞功能的重要调节因子。该研究试图确定IRF5是否影响动脉粥样硬化病变的形成和表型。方法:通过两种互补模型,研究IRF5在动脉粥样硬化中的作用: | Seneviratne AN Edsfeldt AO Cole JE Kassiteridi C Swart M Park I Green P Khoyratty TE Saliba DG Goddard ME Sansom SN Goncalves I Krams R Udalova IA Monaco C 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，8： | 9 |
| 4 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 5 | Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study显示文摘 | Hedy L Kindler Tatsuya Ioka Dirk J Richel Jaafar Bennouna Richard Létourneau Takuji Okusaka Akihiro Funakoshi Junji Furuse Young Suk Park Shinichi Ohkawa Gregory M Springett Harpreet S Wasan Peter C Trask Paul Bycott Alejandro D Ricart Sinil Kim Eric Van | 2011 | Lancet Oncology2011，，3： | 4 |
| 6 | Mimicking unfolding motion of a beetle hind wing显示文摘This paper presents an experimental research aiming to realize an artificial hind wing that can mimic the wing unfolding motion of Allomyrina dichotoma, an insect in coleopteran order. Based on the understanding of working principles of beetle wing folding/unfolding mechanisms, the hind wing unfolding motion is mimicked by a combination of creative ideas and state-of-art artificial muscle actuator. In this work, we devise two types of artificial wings and the successfully demonstrate that they can be unfolded by actuation of shape memory alloy wires to provide actuation force at the wing base and along the leading edge vein. The folding/unfolding mechanisms may provide an insight for portable nano/micro air vehicles with morphing wings. | MUHAMMAD Azhar PARK Hoon C HWANG Do Y BYUN Doyoung GOO Nam S | 2009 | Chinese Science Bulletin2009，54，14： | 3 |
| 7 | Response to strict and liberalized specific carbohydrate dietin pediatric Crohn's disease显示文摘AIM: To investigate the specific carbohydrate diet(SCD) as nutritional therapy for maintenance of remission in pediatric Crohn's disease(CD). METHODS: Retrospective chart review was conducted in 11 pediatric patients with CD who initiated the SCD as therapy at time of diagnosis or flare. Two groups defined as SCD simple(diet alone, antibiotics or 5-ASA) or SCD with immunomodulators(corticosteroids and/or stable thiopurine dosing) were followed for one year and compared on disease characteristics, laboratory values and anthropometrics.RESULTS: The mean age at start of the SCD was 11.8 ± 3.0 years(range 6.6-17.6 years) with five patients starting the SCD within 5 wk of diagnosis. Three patients maintained a strict SCD diet for the study period and the mean time for liberalization was 7.7 ± 4.0 mo(range 1-12) for the remaining patients. In both groups, hematocrit, albumin and ESR values improved while on strict SCD and appeared stable after liberalization(P-value 0.006, 0.002, 0.002 respectively). The majority of children gained in weight and height percentile while on strict SCD, with small loss in weight percentile documented with liberalization. CONCLUSION: Disease control may be attainable with the SCD in pediatric CD. Further studies are needed to assess adherence, impact on mucosal healing and growth. | Jennifer C Burgis Kaylie Nguyen KT Park Kenneth Cox | 2016 | World Journal of Gastroenterology2016，22，6： | 3 |
| 8 | A Novel Timing Estimation Method for OFDM Systems显示文摘 | Park B Cheon H Kang C | | 0，，： | 2 |
| 9 | 日粮中添加原花青素对猪生长性能和免疫应答的影响显示文摘本试验旨在研究日粮中添加原花青素对生长猪生长性能、血清特性和免疫功能的影响。试验1:32头杂交猪(初始体重19.2kg±0.3kg)随机分为4组,分别在基础日粮中添加0(对照组)、0.1%、0.01%、0.02%原花青素。试验期8周。结果表明,与对照组和0.1%原花青素组相比,添加0.01%、0.02%原花青素组可显著降低料重比(P<0.05),0.02%原花青素组血清肌酐浓度显著低于对照组和0.1%、0.01%原花青素组(P<0.05)。试验2:12头杂交猪(初始体重13.4kg±1.3kg)随机分为3组,分别在基础日粮中添加0(对照组)、0.02%、0.04%原花青素,同时用脂多糖(LPS)刺激试验猪,试验期4周。结果表明,LPS应激后24h,与对照组相比,0.04%原花青素组血小板浓度显著降低(P<0.05),此外,日粮中添加原花青素与否都可从培养的外周血单核细胞(PBMC)中检测到分泌的细胞因子;在LPS应激后的4h,与对照组(LPS-刺激PBMCs+PBS)相比,原花青素组(LPS-刺激PBMCs+原花青素)白介素-1β(IL-1β)、白介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平显著降低(P<0.05)。由此可知,日粮中添加原花青素可提高生长猪饲料转化率和抗炎性细胞因子含量。 | Park J C 武江利 | 2014 | 中国畜牧兽医2014，41，9： | 2 |
| 10 | Transformation of a texas cotton cultivar by using agrobacterium and the shoot apex显示文摘 | Zapata C Park SH EI-Zik KM | 1999 | Theor Appl Genet1999，98，92： | 2 |
| 11 | Photovoltaic properties of close-space sublinated CdTe solar cell显示文摘 | Han B W Park S C Ahn J H | 1998 | Solar Energy1998，64，5： | 2 |
| 12 | Direct cardiac and vascular action of adrenomedullin in conscious sheep 显示文摘 | PARKES D G MAY C N | 1997 | Br J Pharmacol1997，120，6： | 2 |
| 13 | Challenge to forty-fold expansion of biodegradable polyester foams using CO2 显示文摘 | Park C B Liu Y Naguib H E | 1999 | Cellular Polymers1999，18，6： | 2 |
| 14 | What is the most cost-effective strategy to screen for second primary colorectal cancers in male cancer survivors in Korea?显示文摘AIM:To identify a cost-effective strategy of second primary colorectal cancer (CRC) screening for cancer survivors in Korea using a decision-analytic model.METHODS: A Markov model estimated the clinical and economic consequences of a simulated 50-year-old male cancer survivors' cohort, and we compared the results of eight screening strategies: no screening, fecal occult blood test (FOBT) annually, FOBT every 2 years, sigmoidoscopy every 5 years, double contrast barium enema every 5 years, and colonoscopy every 10 years (COL10), every 5 years (COL5), and every 3 years (COL3). We included only direct medical costs, and our main outcome measures were discounted lifetime costs, life expectancy, and incremental cost-effectiveness ratio (ICER).RESULTS: In the base-case analysis, the non-dominated strategies in cancer survivors were COL5, and COL3. The ICER for COL3 in cancer survivors was $5593/life-year saved (LYS), and did not exceed $10000/LYS in one-way sensitivity analyses. If the risk of CRC in can- cer survivors is at least two times higher than that in the general population, COL5 had an ICER of less than $10500/LYS among both good and poor prognosis of index cancer. If the age of cancer survivors starting CRC screening was decreased to 40 years, the ICER of COL5 was less than $7400/LYS regardless of screening compliance.CONCLUSION: Our study suggests that more strict and frequent recommendations for colonoscopy such as COL5 and COL3 could be considered as economically reasonable second primary CRC screening strategies for Korean male cancer survivors. | Sang Min Park Sun-Young Kim Craig C Earle Seung-Yong Jeong Young Ho Yun | 2009 | World Journal of Gastroenterology2009，15，25： | 2 |
| 15 | Foaming of PS/wood-fiber composites using moisture as a blowing agent显示文摘 | Rizvi G Matuana L M Park C B | 2000 | Polymer Engineering and Science2000，40，10： | 2 |
| 16 | A novel system design for continuous processing of plastic/wood-fiber composite foams with improved cell morphology显示文摘 | Rizvi G M Pop-Iliev R Park C B | 2002 | Journal of Cellular Plastics2002，38，5： | 2 |
| 17 | The effect of talc on cell nucleation in extrusion foam processing of polypropylene with CO2 and isopentane显示文摘 | Park C B Cheung L K Song S W | 1998 | Cellular Polymers1998，17，4： | 2 |
| 18 | Thermal fronts and cross-frontal heat flux in the southern Huanghai Sea and the East China Sea显示文摘Synoptic features in/around thermal fronts and cross-frontal heat fluxes in the southern Huanghai/Yellow Sea and East China Sea (HES) were examined using the data collected from four airborne expendable bathythermograph surveys with horizontal approxmately 35 km and vertical 1 m(from the surface to 400 m deep) spacings.Since the fronts are strongly affected by HES current system, the synoptic thermal features in/around them represent the interaction of currents with surrounding water masses. These features can not be obtained from climatological data. The identified thermal features are listed as follows: (1) multiple boundaries of cold water, asymmetric thermocline intrusion, locally-split front by homogeneous water of approxmately 18 ℃, and mergence of the front by the Taiwan Warm Current in/around summertime southern Cheju-Changjiang/Yangtze front and Tsushima front; (2) springtime frontal eddy-like feature around Tsushima front; (3) year-round cyclonic meandering and summertime temperature-inversion at the bottom of the surface mixed layer in Cheju-Tsushima front; and (4) multistructure of Kuroshio front. In the Kuroshio front the mean variance of vertical temperature gradient is an order of degree smaller than that in other HES fronts.The southern Cheju-Changjiang front and Cheju-Tsushima front are connected with each other in the summer with comparable cross-frontal temperature gradient. However, cross-frontal heat flux and lateral eddy diffusivity are stronger in the southern Cheju-Changjiang front. The cross-frontal heat exchange is the largest in the mixing zone between the modified Huanghai Sea bottom cold water and the Tsushima Warm Current, which is attributable to enhanced thermocline intrusions. | PARK Sunghyea CHU Peter C | 2008 | Acta Oceanologica Sinica2008，27，5： | 2 |
| 19 | An efficient assumed strain element model with 6 dof per node for geometrically nonlinear shells显示文摘 | Park H C Cho C Lee S W | 1995 | Inter J Numer Methods Engrg1995，38，： | 2 |
| 20 | Electric load forecasting using an artificial neural network 显示文摘 | Park D C El-Sharkawi M A Marks R J | 1991 | IEEE Transactions on Power Systems1991，6，2： | 2 |
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