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| 1 | Where were the monsoon regions and arid zones in Asia prior to the Tibetan Plateau uplift?显示文摘The impact of the Tibetan Plateau uplit on the Asian monsoons and inland arid climates is an important but also controversial question in studies of paleoenvironmental change during the Cenozoic. In order to achieve a good understanding of the background for the formation of the Asian monsoons and arid environments, it is necessary to know the characteristics of the distribution of monsoon regions and arid zones in Asia before the plateau uplit. In this study, we discuss in detail the paterns of distribution of the Asian monsoon and arid regions before the plateau uplit on the basis of modeling results without topography from a global coupled atmosphere–ocean general circulation model, compare our results with previous simulation studies and available biogeological data, and review the uncertainties in the current knowledge. Based on what we know at the moment, tropical monsoon climates existed south of 20?N in South and Southeast Asia before the plateau uplit, while the East Asian monsoon was entirely absent in the extratropics. hese tropical monsoons mainly resulted from the seasonal shits of the Inter-Tropical Convergence Zone. here may have been a quasi-monsoon region in central-southern Siberia. Most of the arid regions in the Asian continent were limited to the latitudes of 20–40?N, corresponding to the range of the subtropical high pressure year-around. In the meantime, the present-day arid regions located in the relatively high latitudes in Central Asia were most likely absent before the plateau uplit. he main results from the above modeling analyses are qualitatively consistent with the available biogeological data. hese results highlight the importance of the uplit of the Tibetan Plateau in the Cenozoic evolution of the Asian climate patern of dry–wet conditions. Future studies should be focused on efects of the changes in land–sea distribution and atmospheric CO2 concentrations before and ater the plateau uplit, and also on cross-comparisons between numerical simulations and geological evidence, so that a comprehensive understanding of the evolution of the Cenozoic paleoenvironments in Asia can be achieved. | Xiaodong Liu Qingchun Guo Zhengtang Guo Zhi-Yong Yin Buwen Dong Robin Smith | 2015 | National Science Review2015，2，4： | 12 |
| 2 | Efficacy of Lycium barbarum polysaccharide in adolescents with subthreshold depression: interim analysis of a randomized controlled study显示文摘Subthreshold depression is a highly prevalent condition in adolescents who are at high risk for developing major depressive disorder.In preclinical models of neurological and psychiatric diseases,Lycium barbarum polysaccharide(LBP)extracted from Goji berries had antidepressant effects including but not limited to anti-oxidative and anti-inflammatory properties.However,the effect of LBP on subthreshold depression is unclear.To investigate the clinical efficacy and safety of LBP for treating subthreshold depression in adolescents,we conducted a randomized,double-blind,placebo-controlled trial(RCT)with 29 adolescents with subthreshold depression recruited at The Fifth Affiliated Hospital of Guangzhou Medical University.The participants were randomly assigned to groups where they received either 300 mg LBP(LBP group,n=15,3 boys and 12 girls aged 15.13±2.17 years)or a placebo(placebo group,n=14,2 boys and 12 girls aged 15±1.71 years)for 6 successive weeks.Interim analyses revealed that the LBP group exhibited a greater change in Hamilton Depression Scale(HAMD-24)scores relative to the baseline and a higher remission rate(HAMD-24 total score≤7)at 6 weeks compared with the placebo group.Scores on the Beck Depression Inventory-II(BDI-II),Pittsburgh Sleep Quality Index(PSQI),Kessler Psychological Distress Scale(Kessler),and Screen for Child Anxiety-Related Emotional Disorders(SCARED)were similar between the LBP and placebo groups.No side effects related to the intervention were reported in either group.These results indicate that LBP administration reduced depressive symptoms in adolescents with subthreshold depression.Furthermore,LBP was well tolerated with no treatment-limiting adverse events.Clinical trials involving a larger sample size are needed to further confirm the anti-depressive effects of LBP in adolescents with subthreshold depression.This study was approved by the Medical Ethics Committee of the Fifth Affiliated Hospital of Guangzhou Medical University(Guangzhou,China;approval No.L2019-08)on April 4,2019 and was registered on ClinicalTrials.gov(identifier:NCT04032795)on July 25,2019. | Xiaoyue Li Xuan Mo Tao Liu Robin Shao Kayla Teopiz Roger S.McIntyre Kwok-Fai So Kangguang Lin | 2022 | Neural Regeneration Research2022，17，7： | 6 |
| 3 | Initial movement of the Karakorum Fault in western Tibet:constraints from SHRIMP U-Pb dating of zircons显示文摘The Karakorum Fault zone(KFZ)plays an important role in understanding the formation,evolvement and deformation of the Tibetan Plateau.The high-T dextral shearing metamorphic rocks,e.g.,mylonites or mylonitized gneisses-granites,locally crop out along the southeastern part of the KFZ in the Ayila Ri’gyüRange area.The SHRIMP U-Pb dating of the syn-kinematic crystallized zircons indicates that the initial age of the KFZ is^27 Ma,~10 Ma older than previous results.The extensive high-T dextral shearing along the KFZ started at least at 27-20 Ma,accompanied by the syn-kinematic emplacement of leuco-granites.Deformation and concomitant fluid circulation during shearing most likely occurred as early as at 25-13 Ma.The KFZ probably grew from southeast to northwest along the fault as a result of continuous convergence between the India plate and Eurasia plate. | LI HaiBing Franck VALLI LIU DunYi XU ZhiQin YANG JingSui Nicolas ARNAUD Paul TAPPONNIER Robin LACASSIN CHEN SongYong QI xuexiang | 2007 | Chinese Science Bulletin2007，52，8： | 6 |
| 4 | Continental drift, plateau uplift, and the evolutions of monsoon and arid regions in Asia, Africa, and Australia during the Cenozoic显示文摘Monsoon and arid regions in the Asia-Africa-Australia(A-A-A) realm occupy more than 60% of the total area of these continents. Geological evidence showed that significant changes occurred to the A-A-A environments of the monsoon and arid regions, the land-ocean configuration in the Eastern Hemisphere, and the topography of the Tibetan Plateau(TP) in the Cenozoic. Motivated by this background, numerical experiments for 5 typical geological periods during the Cenozoic were conducted using a coupled ocean-atmosphere general circulation model to systemically explore the formations and evolutionary histories of the Cenozoic A-A-A monsoon and arid regions under the influences of continental drift and plateau uplift. Results of the numerical experiments indicate that the timings and causes of the formations of monsoon and arid regions in the A-A-A realm were very different. The northern and southern African monsoons existed during the mid-Paleocene, while the South Asian monsoon appeared in the Eocene after the Indian Subcontinent moved into the tropical Northern Hemisphere. In contrast, the East Asian monsoon and northern Australian monsoon were established much later in the Miocene. The establishment of the tropical monsoons in northern and southern Africa, South Asia, and Australia were determined by both the continental drift and seasonal migration of the Inter-Tropical Convergence Zone(ITCZ), while the position and height of the TP were the key factor for the establishment of the East Asian monsoon. The presence of the subtropical arid regions in northern and southern Africa,Asia, and Australia depended on the positions of the continents and the control of the planetary scale subtropical high pressure zones, while the arid regions in the Arabian Peninsula and West Asia were closely related to the retreat of the Paratethys Sea. The formation of the mid-latitude arid region in the Asian interior, on the other hand, was the consequence of the uplift of the TP.These results from this study provide insight to the important roles played by the earth's tectonic boundary conditions in the formations and evolutions of regional climates during geological times. | Xiaodong LIU Buwen DONG Zhi-Yong YIN Robin S.SMITH Qingchun GUO | 2019 | Science China Earth Sciences2019，62，7： | 5 |
| 5 | Whole-blood sorting,enrichment and in situ immunolabeling of cellular subsets using acoustic microstreaming显示文摘Analyzing undiluted whole human blood is a challenge due to its complex composition of hematopoietic cellular populations,nucleic acids,metabolites,and proteins.We present a novel multi-functional microfluidic acoustic streaming platform that enables sorting,enrichment and in situ identification of cellular subsets from whole blood.This single device platform,based on lateral cavity acoustic transducers(LCAT),enables(1)the sorting of undiluted donor whole blood into its cellular subsets(platelets,RBCs,and WBCs),(2)the enrichment and retrieval of breast cancer cells(MCF-7)spiked in donor whole blood at rare cell relevant concentrations(10 mL^(−1)),and(3)on-chip immunofluorescent labeling for the detection of specific target cellular populations by their known marker expression patterns.Our approach thus demonstrates a compact system that integrates upstream sample processing with downstream separation/enrichment,to carry out multi-parametric cell analysis for blood-based diagnosis and liquid biopsy blood sampling. | Neha Garg Trisha M.Westerhof Vick Liu Robin Liu Edward L.Nelson Abraham P.Lee | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 6 | Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12显示文摘 | Birgit Oppmann Robin Lesley Bianca Blom Jackie C Timans Yuming Xu Brisdell Hunte Felix Vega Nancy Yu Jing Wang Komal Singh Francesca Zonin Elena Vaisberg Tatyana Churakova Man-ru Liu Daniel Gorman Janet Wagner Sandra Zurawski Yong-Jun Liu John S Abrams Ke | 2000 | Immunity2000，，5： | 2 |
| 7 | Total parenteral nutrition during acute pancreatitis: Clinical experience with 156 Patients显示文摘 | Arnold P. Robin M.D. Rebecca Campbell R.D. Colathur K. Palani M.D. Katherine Liu M.D. Philip E. Donahue M.D. Lloyd M. Nyhus M.D | 1990 | World Journal of Surgery1990，，5： | 2 |
| 8 | Lateral Internal Sphincterotomy is Superior to Topical Nitroglycerin for Healing Chronic Anal Fissure and does not Compromise Long-Term Fecal Continence: Six-Year Follow-Up of a Multicenter, Randomized, Controlled Trial显示文摘 | Carl J. Brown M.D. Daniel Dubreuil M.D. Laura Santoro B.Sc. Maria Liu B.Sc. Brenda I. O'Connor B.ScN. Robin S. McLeod M.D | 2007 | Diseases of the Colon & Rectum2007，，4： | 2 |
| 9 | Generation of hair cells by stepwise differentiation of embryonic stem cells显示文摘 | Li H Robin G Liu H | 2003 | PNAS2003，100，13： | 1 |
| 10 | Thyroid lymphoma: A case report and literature review显示文摘Thyroid lymphoma is an unusual pathology. Different subtypes of lymphoma can present as primary thyroid lymphoma. This review illustrates via imaging, findings and treatment the need for accurate diagnosis and timely treatment. Patients and methods: patient's chart, pathological findings and radiological images were reviewed in a retrospective analysis. Over several days, this 80 years old woman developed airway obstruction and rapid enlargement of her thyroid secondary to diffuse large B-cell lymphoma. She rapidly responded to her oncological protocol. Primary thyroid lymphoma is a rare disease. It is an important diagnosis to consider in patients presenting with rapidly enlarging neck masses. It is a treatable condition with fairly favorable overall survival even with the most aggressive histological subtypes. | Kinneri Mehta Cynthia Liu Roy A Raad Robin Mitnick Ping Gu David Myssiorek | 2015 | World Journal of Otorhinolaryngology2015，5，3： | 1 |
| 11 | Alternatives to hysterectomy for the treatment of excessive uterine bleeding显示文摘 | ROBINS J C LIU J | 2000 | Int J Clin Pract2000，54，： | 1 |
| 12 | Social acceptability and behavior modification for treating deficit hyperactivity isorder显示文摘 | LIU C ROBIN AL | 1991 | PEDIATRICS1991，88，3： | 1 |
| 13 | Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing显示文摘 | Robert D. Guzy Beatrice Hoyos Emmanuel Robin Hong Chen Liping Liu Kyle D. Mansfield M. Celeste Simon Ulrich Hammerling Paul T. Schumacker | 2005 | Cell Metabolism2005，，6： | 1 |
| 14 | Conversion of effector CD4^(+)T cells to a CD8^(+)MHC Ⅱ-recognizing lineage显示文摘CD4^(+)and CD8^(+)T cells are dichotomous lineages in adaptive immunity.While conventionally viewed as distinct fates that are fixed after thymic development,accumulating evidence indicates that these two populations can exhibit significant lineage plasticity,particularly upon TCR-mediated activation.We define a novel CD4^(-)CD8αβ^(+)MHC Ⅱ-recognizing population generated by lineage conversion from effector CD4^(+)T cells.CD4-CD8αβ^(+)effector T cells downregulated the expression of T helper cell-associated costimulatory molecules and inaeased the expression of cytotoxic T lymphocyte-associated cytotoxic molecules.This shift in functional potential corresponded with a CD8^(+)-lineage skewed transcriptional profile.TCRβ repertoire sequencing and in vivo genetic lineage tracing in acutely infected wild-type mice demonstrated that CD4^(-)CD8αβ^(+)effector T cells arise from fundamental lineage reprogramming of bona fide effector CD4^(+)T cells.Impairing autophagy via functional deletion of the initiating kinase Vps34 or the downstream enzyme Atg7 enhanced the generation of this cell population.These findings suggest that effector CD4^(+)T cells can exhibit a previously unreported degree of skewing towards the CD8^(+)T cell lineage,which may point towards a novel direction for HIV vaccine design. | Elizabeth Robins Ming Zheng Qingshan Ni Siqi Liu Chen Liang Baojun Zhang Jian Guo Yuan Zhuang You-Wen He Ping Zhu Ying Wan Qi-Jing Li | 2021 | Cellular & Molecular Immunology2021，18，1： | 1 |
| 15 | Fatigue, sleep, and circadian rhythms prior to chemotherapy for breast cancer显示文摘 | Sonia Ancoli-Israel Lianqi Liu Matthew R. Marler Barbara A. Parker Vicky Jones Georgia Robins Sadler Joel Dimsdale Mairav Cohen-Zion Lavinia Fiorentino | 2006 | Supportive Care in Cancer2006，，3： | 1 |
| 16 | Barium titanate ceramics prepared from conventional and microwave hydrothermal powers 显示文摘 | Shi-fang Liu Isaac Robin Abothu Sridhar Komameni | 1999 | Mater Lett1999，38，： | 1 |
| 17 | Factors affecting drinking water biofiltration 显示文摘 | Liu Xibo Peter M Huck Robin M Slawson | 2001 | American Water and WastewaterAssociation2001，90，12： | 1 |
| 18 | Fluoro, Alkylsulfanyl, and Alkylsulfonyl Leaving Groups in Suzuki Cross-Coupling Reactions of Purine 2'- Deoxynucleosides and Nucleosides显示文摘 | LIU J JQ ROBINS MJ | 2005 | Org lett2005，7，： | 1 |
| 19 | Design,synthesis,and insecticidal activities of phthalamides containing a hydrazone subsrtuere显示文摘 | Liu M Iwamoto S Robins L I | 2010 | J Agrie Food Chem2010，58，11： | 1 |
| 20 | Factors affecting drink- ing water biofihration显示文摘 | Liu X B Huck P M Robin M S | 2001 | J AWWA2001，90，12： | 1 |
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