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| 1 | Increased expression of tumor necrosis factor-a is associated with advanced colorectal cancer stages显示文摘AIM:To detect the expression of tumor necrosis factor-a(TNF-a)in colorectal cancer(CRC)cells among Saudi patients,and correlate its expression with clinical stages of cancer.METHODS:Archival tissue specimens were collected from 30 patients with CRC who had undergone surgical intervention at King Khalid University Hospital.Patient demographic information,including age and gender,tumor sites,and histological type of CRC,was recorded.To measure TNF-a m RNA expression in CRC,total RNA was extracted from tumor formalin-fixed,paraffinembedded,and adjacent normal tissues.Reverse transcription and reverse transcription polymerase chain reaction were performed.Colorectal tissue microarrays were constructed to investigate the protein expression of TNF-a by immunohistochemistry.RESULTS:The relative expression of TNF-a m RNA in colorectal cancer was significantly higher than that seen in adjacent normal colorectal tissue.High TNF-a gene expression was associated with StageⅢandⅣneoplasms when compared with earlier tumor stages(P=0.004).Eighty-three percent of patients(25/30)showed strong TNF-a positive staining,while only 10%(n=3/30)of patients showed weak staining,and 7%(n=2/30)were negative.We showed the presence of elevated TNF-a gene expression in cancer cells,which strongly correlated with advanced stages of tumor.CONCLUSION:High levels of TNF-a expression could be an independent diagnostic indicator of colorectal cancer,and targeting TNF-a might be a promising prognostic tool by assessment of the clinical stages of CRC. | Omar A Al Obeed Khayal A Alkhayal Abdulmalik Al Sheikh Ahmad M Zubaidi Mansoor-Ali Vaali-Mohammed Robin Boushey James H Mckerrow Maha-Hamadien Abdulla | 2014 | World Journal of Gastroenterology2014，20，48： | 8 |
| 2 | Whole body hyperthermiainductin of soulubel tumor necrosis factor receptros;implications forrheumatoid diseas显示文摘 | Robins HI Grosen E Katschinski DM el al | 1999 | J Rheumatol1999，26，12： | 1 |
| 3 | IOLs making cataract surgery safer for glaucoma patients显示文摘 | Robin AL | 2001 | Ocular Surg News2001，12，2： | 1 |
| 4 | Argon laser peripheral iridotomy in the treatment of primary angle closuer glaucoma显示文摘 | Robin AL Pollack IP | 1982 | Arch Ophthalmal1982，100，： | 1 |
| 5 | Molecular pathways: targeting the TGF-β pathway for cancer therapy显示文摘 | Smith AL Robin TP Ford HL | 2012 | Clin Cancer Res2012，18，17： | 1 |
| 6 | Female reproductive factors and eye disease in a rural South Indian Population :The Aravind Comprehensive Eye Survey显示文摘 | Nirmalan PK Katz J Robin AL | 2004 | Invest Ophthalmol Vis Sei2004，45，： | 1 |
| 7 | Adherence in glauco- ma: objective measurements of once-daily and adjunctive medi- cation use 显示文摘 | Robin AL Novack GD Covert DW | 2007 | Am J Ophthalmol2007，144，： | 1 |
| 8 | Social acceptability and behavior modification for treating deficit hyperactivity isorder显示文摘 | LIU C ROBIN AL | 1991 | PEDIATRICS1991，88，3： | 1 |
| 9 | Effect of laser gonioplasty on angle glaucoma显示文摘 | Robin AL | 1992 | Arch Ophthulmol1992，110，3： | 1 |
| 10 | Potential sexual transmission ofZika virus显示文摘 | Musso D Roche C Robin E e t al | 2015 | Emerg Infect Dis2015，2，2： | 1 |
| 11 | A prospective study of cognitive function and onset of dementia in cognitively healthy elders 显示文摘 | Robin Eh STorandt M0 Miller P ez al | 1998 | Arch Neurol1998，55，： | 1 |
| 12 | Increased intraocular pressure in the immediate postoperative period after extracapsular cataract extraction显示文摘 | Gross JG Meyer DR Robin AL | 1988 | Am J Ophthalmol1988，105，： | 1 |
| 13 | Novel insights on interactions between folate and lipid metabolism显示文摘 | Robin P. Silva Karen B. Kelly Ala Al Rajabi René L. Jacobs | 2014 | BioFactors2014，，3： | 1 |
| 14 | Family intervention for home-based problems of adoles?cents with attention-deficit/hyperactivity disorder显示文摘 | Robin AL | 2008 | Adolesc Med State Art Rev2008，19，2： | 1 |
| 15 | Increased intraocular pressure in immediate postoperation period after extra capsular catract extraction显示文摘 | Gross JG Meyer DR Robin Al | 1988 | Am J Ophthalmol1988，103，： | 1 |
| 16 | Patient-reported behavior and problems in using glaucoma medication 显示文摘 | Sleath B Robin AL Covert D | 2006 | Ophthalmology2006，113，3： | 1 |
| 17 | Increased intraocular pressure in the immediate postoperative period after extracapsular cataract extraction 显示文摘 | Gross JG Meyer DR Robin AL | 1998 | Am J Ophthalmol1998，105，4： | 1 |
| 18 | Argon laser peripheral iridotomies in thetreatment of primary angle-closure glaucoma: long-term follow-up 显示文摘 | Robin AL Pollack IP | 1982 | Arch Ophthalmol1982，100，6： | 1 |
| 19 | Mitomycin c-aug- mented trabeculectomy combined with single-site manual small-incision cataract surgerythrough a tunnel flap tech- nique显示文摘 | VENKATESH R SENGUPTA S ROBIN AL | 2012 | Asia Pac J Ophthalmol(Phila)2012，1，3： | 1 |
| 20 | Argon laser peripheral iridotomy in the treatment of primary angle closuer glaucoma显示文摘 | Robin AL Pollack IP | 1982 | Arch Ophthalmal1982，100，： | 1 |
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