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| 1 | 关于痛风诊治决策的调查及相关因素分析显示文摘目的了解国内医生诊治痛风的决策并对相关因素进行分析。方法对197名医生进行了关于痛风诊治决策的现场问卷调查,同时收集答卷人的个人资料,通过双变量分析和多重Logistic回归分析模型,分析影响决策的相关因素。结果一共收回120份有效答卷。在诊断痛风时,94名医生(78.3%)认为应该检查患者的关节滑液。在治疗急性痛风发作时,如果患者肾功能良好,83名医生(69.2%)首选口服秋水仙碱;如果患者肾功能不全,50名医生(41.7%)首选皮质激素或促皮质激素。在降血尿酸治疗时,99名医生(82.5%)选择的指征不当,107名医生(89.2%)治疗开始得太早,92名医生(76.7%)用药的时间不够长。另外,在开始降血尿酸治疗的同时,仅有17名医生(14.2%)预防急性痛风的发作。多重Logistic回归分析发现痛风继续教育是医生采取正确诊断方法的相关因素。结论国内医生诊治痛风的决策与目前国际较为公认的意见并不一致,高质量的医学继续教育有可能提高医生诊治痛风的决策水平。 | 方卫纲 曾学军 李梦涛 Lan X Chen H Ralph Schumacher Jr 张奉春 | 2006 | 中华医学杂志2006，86，27： | 9 |
| 2 | Differential effects on apoptosis induction in hepatocyte lines by stable expression of hepatitis B virus X protein显示文摘瞄准:肝炎 B 蛋白质 X (HBx ) 被显示了是弱 oncogenic 在试管内。HBx 的转变活动与肿瘤的功能压制的几的抑制或 p53 被连接了。我们学习了 HBx 是否可以在取决于房间类型的 p53 上有不同效果。方法:我们使用了人的肝细胞瘤房间线 HepG2 和使不朽的鼠科的 hepatocyte 线 AML12 并且稳定地分析了表示了 HBx 的生理的数量的 transfected 克隆。P53 被紫外照耀导致。结果:由紫外照耀的 p53 正式就职由 HBx 的稳定的表示是未受影响的。然而,变得被 p53 激活的 cyclin 激酶禁止者 p21 (waf/cip/sdi ) 的表示在 HBx 被影响转变房间线 AML12-HBx9,然而并非在 HepG2。在 AML-HBx9,房间, p21 (waf/cip/sdi ) 蛋白质表示和 p21 (waf/cip/sdi ) 抄写是 deregulated。而且, apoptosis 的过程在调查的二根房间线以相反的方法被影响。当 HBx 的稳定的表示提高了紫外照耀在 HepG2 房间导致的 apoptosis 时, apoptosis 在 HBx 被减少转变 AML12-HBx9。P53 镇压了从 HBV enhancer 的抄写我,当由紫外照耀从表示向量或在内长的 p53 的正式就职以后表示了时。由内长的 p53 的压抑由在两根房间线的稳定地表示的 HBx 部分是可逆的。结论:HBx 的稳定的表示导致取决于使用的房间线的紫外照耀导致的 apoptosis 的解除管制。而在癌的表示导出 hepatocyte 线 HBx,在一根使不朽的 hepatocyte 线, HBx 扮演了 anti-apoptotic 提高的 apoptosis。 | Nicola Fiedler Ellen Quant Ludger Fink Jianguang Sun Ralph Schuster Wolfram H Gerlich Stephan Schaefer | 2006 | World Journal of Gastroenterology2006，12，29： | 8 |
| 3 | Guidelines for the Management of Aneurysmal Subarachnoid Hemorrhage: A Statement for Healthcare Professionals From a Special Writing Group of the Stroke Council, American Heart Association显示文摘 | Joshua B. Bederson E Sander Connolly H Hunt Batjer Ralph G. Dacey Jacques E. Dion Michael N. Diringer John E. Duldner Robert E. Harbaugh Aman B. Patel Robert H. Rosenwasser | 2009 | Stroke2009，，3： | 4 |
| 4 | Pancreatic cancer显示文摘 | Audrey Vincent Joseph Herman Rich Schulick Ralph H Hruban Michael Goggins | 2011 | The Lancet . 2011 (9791)2011，，： | 3 |
| 5 | Differentiating intraductal papillary mucinous neoplasms from other pancreatic cystic lesions显示文摘Intraductal papillary mucinous neoplasms(IPMN) can be difficult to distinguish from other cystic lesions of the pancreas.To understand better and discuss the current knowledge on this topic,the literature and the institutional experience at a large pancreatic disease center have been reviewed.A combination of preoperative demographic,historical,radiographic,laboratory data,as well as postoperative pathologic analyses can often distinguish IPMN from other lesions in the differential diagnosis. | Steven C Cunningham Ralph H Hruban Richard D Schulick | 2010 | World Journal of Gastrointestinal Surgery2010，2，10： | 3 |
| 6 | Pancreatic cancer显示文摘 | Audrey Vincent Joseph Herman Rich Schulick Ralph H Hruban Michael Goggins | 2011 | The Lancet2011，，9791： | 3 |
| 7 | Hyperuricemia and Incidence of Hypertension Among Men Without Metabolic Syndrome显示文摘 | Eswar Krishnan C Kent Kwoh H Ralph Schumacher Lewis Kuller | 2007 | Hypertension2007，，2： | 2 |
| 8 | Pancreatic cancer显示文摘 | Audrey Vincent Joseph Herman Rich Schulick Ralph H Hruban Michael Goggins | 2011 | The Lancet2011，，9791： | 2 |
| 9 | Targeted next‐generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas显示文摘 | Eliana Amato Marco dal Molin Andrea Mafficini Jun Yu Giuseppe Malleo Borislav Rusev Matteo Fassan Davide Antonello Yoshihiko Sadakari Paola Castelli Giuseppe Zamboni Anirban Maitra Roberto Salvia Ralph H Hruban Claudio Bassi Paola Capelli Rita T Lawlor Mi | 2014 | J. Pathol2014，，3： | 2 |
| 10 | Pancreatic cancer显示文摘 | Theresa Pluth Yeo Ralph H Hruban Steven D Leach Robb E Wilentz Taylor A Sohn Scott E Kern Christine A Iacobuzio-Donahue Anirban Maitra Michael Goggins Marcia I Canto Ross A Abrams Daniel Laheru Elizabeth M Jaffee Manuel Hidalgo Charles J Yeo | 2002 | Current Problems in Cancer2002，，4： | 2 |
| 11 | Pancreatic cancer显示文摘 | Audrey Vincent Joseph Herman Rich Schulick Ralph H Hruban Michael Goggins | 2011 | 2011 (9791)2011，，9791： | 2 |
| 12 | Growth and antrum formation of bovine preantral follicles in long-term culture in vitro 显示文摘 | Gutierrez C G Ralph J H Teller E E | 2000 | Biol Reprod2000，62，： | 2 |
| 13 | An Algorithmic Approach to the Diagnosis of Pancreatic Neoplasms显示文摘 | Klimstra David S Pitman Martha B Hruban Ralph H | 2009 | Archives of Pathology & Laboratory Medicine2009，，： | 2 |
| 14 | White loeoweed toxicity is facilitated by a fungal endophyte and nitrogen-fixing bacteria显示文摘 | Valdez Barillas J R Paschke M W Ralphs M H | 2007 | Ecology2007，88，7： | 1 |
| 15 | Ferulate cross-linking in cell walls isolated from maize cell suspensions 显示文摘 | Grabber J H Hatfield R D Ralph J | 1995 | Phytochemistry1995，40，： | 1 |
| 16 | A Time-Series Analysis of the Effect of Increased Copayments on the Prescription of Antidepressants, and Sedatives in Sweden from 1990 to 1999显示文摘 | Michael O Ralph C Ten'y H | 2003 | Clinical Therapeutics2003，25，4： | 1 |
| 17 | p-Coumaroylated syringyl units in maize lignin; implications for a-ether cleavage by thioacidolysis显示文摘 | Grabber J H Quideau S Ralph J | 1996 | Phytochemistry1996，43，7： | 1 |
| 18 | Larkspur chemistry:Toxic alkaloids in tall larkspurs显示文摘 | Manners GD Pfister JA Ralphs M H | 1992 | Range Manage1992，45，： | 1 |
| 19 | XLGs is a new type of G protein显示文摘 | Ralph K Julia M Wleland H | 1994 | Nature1994，372，： | 1 |
| 20 | A lite- rature review of the epidemiology and treatment of acute gout显示文摘 | KIM K Y RALPH S H HUNSCHE E | 2003 | Clin Ther2003，25，6： | 1 |
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