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| 1 | Hepatitis B virus taxonomy and hepatitis B virus genotypes显示文摘Hepatitis B virus(HBV) is a member of the hepadnavirus family.Hepadnaviruses can be found in both mammals(orthohepadnaviruses) and birds(avihepadnaviruses).The genetic variability of HBV is very high.There are eight genotypes of HBV and three clades of HBV isolates from apes that appear to be additional genotypes of HBV.Most genotypes are now divided into subgenotypes with distinct virological and epidemiological properties.In addition,recombination among HBV genotypes increases the variability of HBV.This review summarises current knowledge of the epidemiology of genetic variability in hepadnaviruses and,due to rapid progress in the field,updates several recent reviews on HBV genotypes and subgenotypes. | Stephan Schaefer | 2007 | World Journal of Gastroenterology2007，13，1： | 42 |
| 2 | Differential effects on apoptosis induction in hepatocyte lines by stable expression of hepatitis B virus X protein显示文摘瞄准:肝炎 B 蛋白质 X (HBx ) 被显示了是弱 oncogenic 在试管内。HBx 的转变活动与肿瘤的功能压制的几的抑制或 p53 被连接了。我们学习了 HBx 是否可以在取决于房间类型的 p53 上有不同效果。方法:我们使用了人的肝细胞瘤房间线 HepG2 和使不朽的鼠科的 hepatocyte 线 AML12 并且稳定地分析了表示了 HBx 的生理的数量的 transfected 克隆。P53 被紫外照耀导致。结果:由紫外照耀的 p53 正式就职由 HBx 的稳定的表示是未受影响的。然而,变得被 p53 激活的 cyclin 激酶禁止者 p21 (waf/cip/sdi ) 的表示在 HBx 被影响转变房间线 AML12-HBx9,然而并非在 HepG2。在 AML-HBx9,房间, p21 (waf/cip/sdi ) 蛋白质表示和 p21 (waf/cip/sdi ) 抄写是 deregulated。而且, apoptosis 的过程在调查的二根房间线以相反的方法被影响。当 HBx 的稳定的表示提高了紫外照耀在 HepG2 房间导致的 apoptosis 时, apoptosis 在 HBx 被减少转变 AML12-HBx9。P53 镇压了从 HBV enhancer 的抄写我,当由紫外照耀从表示向量或在内长的 p53 的正式就职以后表示了时。由内长的 p53 的压抑由在两根房间线的稳定地表示的 HBx 部分是可逆的。结论:HBx 的稳定的表示导致取决于使用的房间线的紫外照耀导致的 apoptosis 的解除管制。而在癌的表示导出 hepatocyte 线 HBx,在一根使不朽的 hepatocyte 线, HBx 扮演了 anti-apoptotic 提高的 apoptosis。 | Nicola Fiedler Ellen Quant Ludger Fink Jianguang Sun Ralph Schuster Wolfram H Gerlich Stephan Schaefer | 2006 | World Journal of Gastroenterology2006，12，29： | 8 |
| 3 | Genotype-dependent activation or repression of HBV enhancer Ⅱ by transcription factor COUP-TF1显示文摘AIM: To study the expression of HBV enhancer Ⅱ by transcription factor COUP-TF1. METHODS: In order to study the regulation of HBV variants in the vicinity of the NRRE we cloned luciferase constructs containing the HBV enhancer Ⅱ from variants and from HBV genotypes A and D and cotransfected them together with expression vectors for COUP-TF1 into HepG2 cells. RESULTS: Our fi ndings show that enhancer Ⅱ of HBV genotype A is also repressed by COUP-TF1. In contrast, two different enhancer Ⅱ constructs of HBV genotype D were activated by COUP-TF1. The activation was independent of the NRRE because a natural variant with a deletion of nt 1763-1770 was still activated by COUP- TF1. CONCLUSION: Regulation of transcription of the HBV genome seems to differ among HBV genomes derived from different genotypes. These differences in transcriptional control among HBV genotypes may be the molecular basis for differences in the clinical course among HBV genotypes. | Silke F Fischer Katja Schmidt Nicola Fiedler Dieter Glebe Christian Schüttler Jianguang Sun Wolfram H Gerlich Reinald Repp Stephan Schaefer | 2006 | World Journal of Gastroenterology2006，12，37： | 2 |
| 4 | Histomorphologic Tumor Regression and Lymph Node Metastases Determine Prognosis Following Neoadjuvant Radiochemotherapy for Esophageal Cancer: Implications for Response Classification显示文摘 | Paul M. Schneider Stephan E. Baldus Ralf Metzger Martin Kocher Rudolf Bongartz Elfriede Bollschweiler Hartmut Schaefer Juergen Thiele Hans P. Dienes Rolf P. Mueller Arnulf H. Hoelscher | 2005 | Annals of Surgery2005，，5： | 2 |
| 5 | Diagnostic, prognostic and therapeutic implications of microRNAs in urologic tumors 显示文摘 | Schaefer A Stephan C Busch J | 2010 | Nat Rev Urol2010，7，5： | 1 |
| 6 | Diagnostic, prognostic and therapeutic implications of microRNAs in urologic tumors显示文摘 | Schaefer A Stephan C Busch J | 2010 | Nat Rev Urol2010，7，5： | 1 |
| 7 | Concurrent quantitation of the A and D genotypes of hepatitis B virus显示文摘 | Nikola Tanic Boban Stanojevic Nasta Tanic Stephan Schaefer Hubert G.M. Niesters Milena Bozic Bogomir Dimitrijevic | 2009 | Journal of Virological Methods2009，，2： | 1 |
| 8 | Blade Excitation in Pulse-Charged Mixed-Flow Turbocharger Turbines显示文摘 | Stephan M Senn Martin Seiler Ottmar Schaefer | 2011 | Journal of Turbomachinery2011，133，02： | 1 |
| 9 | Diagnostic, prognostic and therapeutic hnplicafions of microRNAs in urologic tumors显示文摘 | Schaefer A Stephan C Busch J | 2010 | Nat Rev Urol2010，7，5： | 1 |
| 10 | Statin-Induced Improvement of Endothelial Progenitor Cell Mobilization, Myocardial Neovascularization, Left Ventricular Function, and Survival After Experimental Myocardial Infarction Requires Endothelial Nitric Oxide Synthase显示文摘 | Ulf Landmesser Niels Engberding Ferdinand H. Bahlmann Arnd Schaefer Antje Wiencke Andre Heineke Stephan Spiekermann Denise Hilfiker-Kleiner Christian Templin Daniel Kotlarz Maja Mueller Martin Fuchs Burkhard Hornig Hermann Haller Helmut Drexler | 2004 | Circulation2004，，14： | 1 |
| 11 | Suppression of hepatitis B virus enhancer 1 and 2 by hepatitis C virus core protein显示文摘 | Christian G Schüttler Nicola Fiedler Katja Schmidt Reinald Repp Wolfram H Gerlich Stephan Schaefer | 2002 | Journal of Hepatology2002，，6： | 1 |
| 12 | Diagnostic,prognostic and therapeutic implications of microRNAs in urologic tumors显示文摘 | Schaefer A Stephan C Busch J Yousef G M Jung K | | 0，，： | 1 |
| 13 | Diagnostic, prognosticand therapeutic implications of microRNAs in urologic tumors 显示文摘 | Schaefer A Stephan C Busch J | 2010 | Nat Rev Urol2010，7，5： | 1 |
| 14 | Management of high blood pressure in children and adolescents: recommendations of the European Society of Hypertension显示文摘 | Empar Lurbe Renata Cifkova J Kennedy Cruickshank Michael J Dillon Isabel Ferreira Cecilia Invitti Tatiana Kuznetsova Stephane Laurent Giuseppe Mancia Francisco Morales-Olivas Wolfgang Rascher Josep Redon Franz Schaefer Tomas Seeman George Stergiou Elke Wü | 2009 | Journal of Hypertension2009，，9： | 1 |
| 15 | Molecular characterization and phylogenetic analysis of full-genome HBV subgenotype D3 sequences from Serbia显示文摘 | Boban Stanojevi? Carla Osiowy Stephan Schaefer Ksenija Bojovi? Jelena Blagojevi? Milica Ne?i? Shunichi Yamashita Gorana Stamenkovi? | 2011 | Infection Genetics and Evolution2011，，6： | 1 |
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