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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Role of HSP-90 for increased nNOS-mediated vasodilation in mesenteric arteries in portal hypertension显示文摘AIM:To explore the role of heat shock protein-90 (HSP-90) for nitrergic vasorelaxation in the splanchnic circulation in rats with and without portal hypertension. METHODS: Neuronal nitric oxide synthase (nNOS) and HSP-90 were analyzed by immunofluorescence, western blotting and co-immunoprecipitation in the mesenteric vasculature and isolated nerves of portal-vein-ligated (PVL) rats and sham operated rats. In vitro perfused de-endothelialized mesenteric arterial vasculature was preconstricted with norepinephrine (EC80) and tested for nNOS-mediated vasorelaxation by periarterial nerve stimulation (PNS, 2-12 Hz, 45V) before and after incubation with geldanamycin (specific inhibitor of HSP-90 signalling, 3 μg/mL) or L-NAME (non-specific NOSblocker, 10-4 mol/L). RESULTS: nNOS and HSP-90 expression was significantly increased in mesenteric nerves from PVL as compared to sham rats. Moreover, nNOS and HSP-90 were visualized in mesenteric nerves by immunofluorescence and immunoprecipitation of nNOS co-immunoprecitated HSP-90 in sham and PVL rats. PNS induced a frequencydependent vasorelaxation which was more pronounced in PVL as compared to sham rats. L-NAME and geldanamycin markedly reduced nNOS-mediated vasorelaxation abrogating differences between the study groups. The effect of L-NAME and geldanamycin on nNOS-mediated vasorelaxation was significantly greater in PVL than in sham animals. However, no difference in magnitude of effect between L-NAME and geldanamycin was noted. CONCLUSION: HSP-90 acts as a signalling mediator of nNOS-dependent nerve mediated vascular responses in mesenteric arteries, and the increased nitrergic vasorelaxation observed in portal hypertension is mediated largely by HSP-90. | Lukas Moleda Lars Jurzik Matthias Froh Erwin Gbele Claus Hellerbrand Rainer H Straub Jürgen Schlmerich Reiner Wiest | 2010 | World Journal of Gastroenterology2010，16，15： | 4 |
| 3 | High Hepatic SCD1 Activity Is Associated with Low Liver Fat Content in Healthy Subjects under a Lipogenic Diet显示文摘 | Günther Silbernagel Marketa Kovarova Alexander Cegan Jürgen Machann Fritz Schick Rainer Lehmann Hans-Ulrich H?ring Norbert Stefan Erwin Schleicher Andreas Fritsche Andreas Peter | 2012 | The Journal of Clinical Endocrinology & Metabolism2012，，12： | 3 |
| 4 | Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial显示文摘 | Claus R?del Torsten Liersch Heinz Becker Rainer Fietkau Werner Hohenberger Torsten Hothorn Ullrich Graeven Dirk Arnold Marga Lang-Welzenbach Hans-Rudolf Raab Heiko Sülberg Christian Wittekind Sergej Potapov Ludger Staib Clemens Hess Karin Weigang-K?hler G | 2012 | Lancet Oncology2012，，7： | 2 |
| 5 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 6 | Topical anesthesia with PH adjusted versus standard indocaine 4% for corneal cataract surgery显示文摘 | Zehetmayer M Rainer G Turnheim K | 1997 | J Cataract Refract Surg1997，23，9： | 1 |
| 7 | Scientists'Transition to Academic Entrepreneurship显示文摘 | MAXIMILIAN G MART1N O RAINER K S | 2012 | Economic and Psychological Determinants2012，，7： | 1 |
| 8 | Broadband Dielectric Spec- troscopy Studies of Hyperbranched Polyglycerols显示文摘 | Abel G Ricardo D Rainer H | 2006 | Ma- cromolecular Chemistry and Physics2006，207，11： | 1 |
| 9 | Neuroendocrine immune mechanisms in rheumatic diseases显示文摘 | Johannes W.J Bijlsma Rainer H Straub Alfonse T Masi Robert G Lahita Maurizio Cutolo | 2002 | Trends in Immunology2002，，2： | 1 |
| 10 | The effect of a serotonin- induced dissociation between spiking and perisynaptic activity on BOLD-fMRI 显示文摘 | Rauch A Rainer G Logothetis NK | 2008 | Proc Natl Acad2008，105，67： | 1 |
| 11 | Can the full range of paramedic skills improve survival from out of hospital cardiac arrests? 显示文摘 | Mitchell R G Guly U M Rainer T H | 1997 | J Accid Emerg Med1997，14，5： | 1 |
| 12 | Laser Guiding of Electron Beams in the Advanced Test Accelerator显示文摘 | CAPORASO G J RAINER F MARTINE W E | 1986 | Phys Rev Lett1986，57，13： | 1 |
| 13 | Evolution of a tourmaline-bearing lawsonite eclogite from the Elekda? area (Central Pontides, N Turkey): evidence for infiltration of slab-derived B-rich fluids during exhumation显示文摘 | Rainer Altherr Gültekin Topuz Horst Marschall Thomas Zack Thomas Ludwig | | 0，，： | 1 |
| 14 | Immunohistochemical localization of the small proteoglycans decorin and biglycan in human intervertebral discs显示文摘 | Werner G?tz Sabine Barnert Rudolf Bertagnoli Nicolai Miosge Hans Kresse Rainer Herken | 1997 | Cell & Tissue Research1997，，1： | 1 |
| 15 | Ocular blood flow in patients infected with human immunodeficiency virus显示文摘 | Dejaco-Ruhswurm 1 Kiss B Rainer G | 2001 | Am J Ophthalmol2001，132，5： | 1 |
| 16 | Effect of a fixed dorzolamide-timolol combination on intraocular pressure after small-incision cataract surgery with Viscoat显示文摘 | Rainer G Menapace R Findl O | 2003 | J Cataract Refract Surg2003，29，9： | 1 |
| 17 | Comparison of 4 methods for quantifying posterior capsule opacification显示文摘 | Findl O Buehl W Menapace R Georgopoulos M Rainer G Siegl H | 2003 | JCataract Refract Surg2003，29，1： | 1 |
| 18 | Transcrip- tion analysis of arabidopsis membrane transporters and hormone pathways during developmental and induced leaf senescence 显示文摘 | Graaff V D G Rainer S Ania S | 2006 | Plant Physiology2006，141，2： | 1 |
| 19 | Assessment of optic disk blood flow in patients with open-angle glaucoma显示文摘 | Findl O Rainer G Dallinger S | 2000 | Am J Ophthalmol2000，130，5： | 1 |
| 20 | Comparison of differ ent vibrant soundbridge audioprocessors with conventional hearing aids显示文摘 | Ingo T Rainer OS Manfred G | 2002 | Otology & Neurotology2002，23，： | 1 |
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